Emergency Medicine
PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?
28 Feb, 2021 | 20:43h | UTCEditorial: Navigating treatment approaches for presumed ESBL-producing infections
Commentary on Twitter (thread – click for more)
?NEW? PRO-CON Debate on the role of carbapenems in infections caused by Enterobacterales resistant to ceftriaxone. #AMR @BSACandJAC @IDdocAdi @ABsteward
— JAC-AMR (@jac_amr) February 24, 2021
Cohort study: A single conventional Troponin combined with HEART score may be as good as serial measurements for safe discharge of patients with chest pain in the ED
26 Feb, 2021 | 08:32h | UTCEditorial: Troponin Testing in the Emergency Department—When 2 Become 1
Commentary: Single Troponin Test May Be Enough for Safe Discharge of Chest Pain Patients – TCTMD
RCT: Dimenhydrinate and metoclopramide equally effective in the treatment of nausea due to vertigo
26 Feb, 2021 | 08:12h | UTCComparison of efficacy dimenhydrinate and metoclopramide in the treatment of nausea due to vertigo; a randomized study – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Position Paper: Management of drug-induced liver injury
25 Feb, 2021 | 08:27h | UTC
Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone
24 Feb, 2021 | 02:25h | UTCEffect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter
Related: The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis (study and commentaries)
Commentary on Twitter
VICTAS trial now in @JAMA_current. Is this the final nail in the coffin for HAT in sepsis? https://t.co/kDdmnIdC6s
— UGAC3 (@ugac3) February 23, 2021
Diverticulitis: Observational study in outpatients suggests amoxicillin-clavulanate is a safe and effective option compared with metronidazole-fluoroquinolone
24 Feb, 2021 | 02:16h | UTCCommentaries: Amoxicillin-clavulanate safe and effective compared with metronidazole-with-fluoroquinolone for diverticulitis – American College of Physicians AND Study supports fluoroquinolone-sparing treatment for diverticulitis – CIDRAP
RCT: Topical intranasal tranexamic acid does not reduce the need for nasal packing in epistaxis
21 Feb, 2021 | 22:02h | UTCThe Use of Tranexamic Acid to Reduce the Need for Nasal Packing in Epistaxis (NoPAC): Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary on Twitter
TXA wasn't better than placebo in epistaxis in this well done RCT https://t.co/qA3yEXyvaM
Excellent work @adamreuben + team
Many of us (myself included) believed TXA a game changer in epistaxis
This trial must make us reexamine our practice pic.twitter.com/5QQsihlGC6
— Anand Swaminathan (@EMSwami) February 20, 2021
FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias
23 Feb, 2021 | 02:03h | UTCFDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT
FDA Safety Alert: Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration
Related: “Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients – New England Journal of Medicine (study and commentaries)
Editorial: Prophylactic anticoagulation for patients in hospital with covid-19
23 Feb, 2021 | 01:59h | UTCProphylactic anticoagulation for patients in hospital with covid-19 – The BMJ
Related: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19
RCT: Five oral analgesics (including opioids) are equally effective for the treatment of acute musculoskeletal extremity pain in the emergency department
21 Feb, 2021 | 21:39h | UTCA Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Hot off the Press: A Randomized Trial Comparing the Efficacy of
Five Oral Analgesics for Treatment of Acute
Musculoskeletal Extremity Pain in the Emergency
Department https://t.co/qfUNn2TgZM @benjaminbwf pic.twitter.com/BzVM3W5F0L— AnnalsofEM (@AnnalsofEM) December 30, 2020
SOFA score is not accurate enough for mortality prediction in severely ill patients with COVID-19 pneumonia
19 Feb, 2021 | 02:44h | UTC
Commentary on Twitter
'The discriminant accuracy of the #SOFA score for
mortality prediction in patients prior to intubation for#COVID-19 pneumonia was poor and significantly inferior to simply using age.' Age, apparently can't be used because 'discrimination'. #bioethics https://t.co/QJIxqupoVx— udo schuklenk ?️??????? (@schuklenk) February 17, 2021
RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19
18 Feb, 2021 | 03:20h | UTCEditorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer
In this RCT a single high dose of #vitaminD3 (100K IU) raised mean serum 25OH D levels but had no effect on hospital LOS (primary outcome), in-hospital mortality, ICU admission, or need for mechanical ventilation (secondary outcomes) https://t.co/eozVaYnb25
— JAMA (@JAMA_current) February 17, 2021
Video: Emergency intubation in Covid-19
18 Feb, 2021 | 03:16h | UTCEmergency Intubation in Covid-19 – New England Journal of Medicine
Patient characteristics and clinical outcomes of Type 1 vs. Type 2 myocardial infarction
18 Feb, 2021 | 02:54h | UTCPatient Characteristics and Clinical Outcomes of Type 1 Versus Type 2 Myocardial Infarction – Journal of the American Academy of Cardiology (link to abstract – $ for full-text)
Commentary on Twitter
What are the patient characteristics & clinical outcomes of type 1 vs type 2 #cvMI in the U.S.? Over 200K+ are analyzed. Find out in this week’s issue of #JACC: https://t.co/trgZtKgbOy @CianPMcCarthy @mvaduganathan @JJheart_doc #HFWeek2021 #HeartMonth #CardioTwitter pic.twitter.com/dCdinfeNwE
— JACC Journals (@JACCJournals) February 16, 2021
Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest
17 Feb, 2021 | 01:32h | UTC
Commentary on Twitter
#COVID19 was involved in at least 10% of all out-of-hospital cardiac arrests (OHCA) and 16% of intra-hospital cardiac arrests (IHCA) and, among #COVID_19 cases, 30-day mortality was increased 3.4-fold in OHCA & 2.3-fold in IHCA https://t.co/uS6rzTXuew#EHJ #ESCYoung @ehj_ed pic.twitter.com/QisuU9rsLT
— European Society of Cardiology Journals (@ESC_Journals) February 5, 2021
Incidence rate and clinical impacts of arrhythmia following COVID-19: a systematic review and meta-analysis of 17,435 patients
17 Feb, 2021 | 01:31h | UTC
How effective is magnesium in for the treatment of migraine?
16 Feb, 2021 | 01:48h | UTCHow Effective is Magnesium in your MAGraine Cocktail? – Journal Feed
Original study: MAGraine: Magnesium compared to conventional therapy for treatment of migraines – American Journal of Emergency Medicine
Review: Diagnostics for SARS-CoV-2 infections
16 Feb, 2021 | 02:20h | UTCDiagnostics for SARS-CoV-2 infections – Nature Materials
Potential health and economic impacts of dexamethasone treatment for patients with COVID-19
16 Feb, 2021 | 02:10h | UTC
Commentary on Twitter
RCTs Save Live$
DEXA saves live$
Potential health&economic impacts of dexamethasone treatment for #COVID19 patients
The study estimate that between July & Dec 2020, for ??, ~12,000 lives could be saved & ~650,000 lives saved globally over the same time https://t.co/B7jVa5Xc0s pic.twitter.com/mI0wPVUj4C— Antibiotic Steward? Bassam Ghanem (@ABsteward) February 10, 2021
Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19
15 Feb, 2021 | 01:18h | UTCCommentaries: Preventive blood thinning drugs could reduce COVID hospital deaths – London School of Hygiene & Tropical Medicine AND Preventive blood thinning drugs linked to reduced risk of death in COVID-19 patients – The BMJ AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre AND
Commentary on Twitter
Blood thinning drugs are now linked to a reduced risk of death for COVID19 patients. Those given preventive blood thinners (prophylactic anticoagulants) within 24 hours of hospital admission for Covid were less likely to die. New report in the BMJ https://t.co/KQqQ3Zoj8B pic.twitter.com/6wJj8mEucw
— delthia ricks ? (@DelthiaRicks) February 12, 2021
Small RCT: No effect from Zinc and Vitamin C supplementation among ambulatory patients with SARS-CoV-2 infection
15 Feb, 2021 | 01:20h | UTCCommentaries: Vitamin C, zinc don’t lessen Covid-19 symptoms, study finds – CNN AND Supplements for the Treatment of Mild COVID-19—Challenging Health Beliefs With Science From A to Z – JAMA Network Open AND Zinc, vitamin C show no effect for COVID-19 in small study – CIDRAP AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre
Commentary on Twitter
RCT finds high-dose zinc, ascorbic acid (vitamin C), or both, did not significantly decrease the duration of symptoms in ambulatory patients with #COVID19 vs standard of care. @DesaiMilindY @ClevelandClinic @ErinMichos @miguelcainzos23 #VisualAbstract https://t.co/ahcc2awJB8
— JAMA Network Open (@JAMANetworkOpen) February 12, 2021
Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US
15 Feb, 2021 | 01:13h | UTCAuthor interview: COVID-19 Vaccine Safety–Anaphylaxis and Allergic Reactions – JAMA
Commentary on Twitter
More than 17.5 million doses of Pfizer & Moderna vaccine were administered between Dec 14 – Jan 18, in USA.
Only 66 cases of anaphylaxis were reported & all but 1 case occurred within 11 min of vaccination.
0 deaths.https://t.co/P1YJISkHZE
— Isaac Bogoch (@BogochIsaac) February 12, 2021
RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections
12 Feb, 2021 | 02:02h | UTCDelayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)
Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP
RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19
12 Feb, 2021 | 02:25h | UTCNews release: Tocilizumab reduces deaths in patients hospitalised with COVID-19 – University of Oxford
Commentary: Tocilizumab cuts death rate in severe COVID-19, study finds – CIDRAP
Commentary on Twitter
?RECOVERY pre-print:
Tocilizumab
– reduces mortality
– shortens hospital stay
– reduces progression to invasive mechanical ventilationClear benefits on top of corticosteroids
Good news!https://t.co/dal17tQG5b
— Martin Landray (@MartinLandray) February 11, 2021
Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults
11 Feb, 2021 | 01:48h | UTCSee also: Pediatric Extracorporeal Cardiopulmonary Resuscitation ELSO Guidelines – ASAIO Journal
Commentary on Twitter
#ECPR in adults @ELSOOrg guidelines
?pt selection, timing & location
?rationale for VA #ECPR
?cannula/cannulation
?#ACLS modifications
?establishing #ECMO & specific post CA care
?coronary angiography/PCI & imaging
?weaning@asaiojournal #FOAMecmo https://t.co/uDrPuSTTpg pic.twitter.com/A1ri9mn56s— M Velia Antonini (@FOAMecmo) February 1, 2021