Emergency Medicine
Review | Management of cardiogenic shock after acute coronary syndromes
18 Apr, 2023 | 13:27h | UTCManagement of cardiogenic shock after acute coronary syndromes – BJA Education
Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU
17 Apr, 2023 | 13:19h | UTCGuidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)
Executive Summary: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)
National clinical guideline for stroke for the UK and Ireland
17 Apr, 2023 | 13:15h | UTCNational clinical guideline for stroke for the UK and Ireland – Stroke Working Party (Full PDF here)
SR | Oral direct thrombin inhibitors vs. conventional anticoagulants for the treatment of pulmonary embolism
17 Apr, 2023 | 13:02h | UTC
ESO expedited recommendation on tenecteplase for acute ischemic stroke
10 Apr, 2023 | 13:44h | UTCRelated:
RCT | Tenecteplase noninferior to alteplase in acute ischemic cerebrovascular events
RCT: Tenecteplase vs. alteplase for the management of acute ischemic stroke.
Randomized Controlled Trial: Tenecteplase vs Alteplase before Thrombectomy for Ischemic Stroke
M-A | High-flow nasal cannula vs. noninvasive positive pressure ventilation in acute hypoxic respiratory failure
10 Apr, 2023 | 13:37h | UTC
RCT | Routine invasive approach fails to benefit frail older adults with non–ST-segment elevation acute myocardial infarction
6 Apr, 2023 | 13:23h | UTCEffect of Routine Invasive vs Conservative Strategy in Older Adults With Frailty and Non–ST-Segment Elevation Acute Myocardial Infarction: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary on Twitter
A routine invasive strategy did not improve clinical outcomes in frail patients with NSTEMI. Future trials should confirm whether a policy of watchful observation rather than routine invasive management may be effective for these patients. https://t.co/N4hAXg5fid
— JAMA Internal Medicine (@JAMAInternalMed) March 6, 2023
Cohort Study | Maternal cardiac arrest: occurrence, survival, and influencing factors
6 Apr, 2023 | 12:59h | UTCCardiac Arrest During Delivery Hospitalization: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
Cardiac Arrest During Delivery Hospitalization – American College of Cardiology
Cardiac Arrest During Childbirth Is Rare, But Some Women Face Higher Risks – HealthDay
Commentary on Twitter
https://twitter.com/AnnalsofIM/status/1636095275545632768
Cohort Study | Multimodal prediction of favorable outcome after cardiac arrest
6 Apr, 2023 | 13:01h | UTC
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia
5 Apr, 2023 | 13:45h | UTC
Commentary on Twitter
Management of severe community-acquired pneumonia: @EuroRespSoc @ESICM @ESCMID @ALATorax international guidelines
➡️ evidence-based recommendations for diagnosis, empirical treatment, ABTs
➡️ current knowledge gaps
➡️ recommendations for future research
🖇️ https://t.co/qhe1wlgN9t pic.twitter.com/LMNCbauYfs— Intensive Care Medicine (@yourICM) April 4, 2023
Review | Diagnosis and treatment of acute myocarditis
5 Apr, 2023 | 13:40h | UTCDiagnosis and Treatment of Acute Myocarditis: A Review – JAMA (free for a limited period)
RCT | Endovascular treatment vs. no treatment after 6-24h in ischemic stroke patients with collateral flow on CT angiography
5 Apr, 2023 | 13:38h | UTCEndovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT | Comparable results in endovascular therapy using general anesthesia vs. procedural sedation for stroke treatment
4 Apr, 2023 | 13:45h | UTCOutcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke: The AMETIS Randomized Clinical Trial – JAMA Neurology (free for a limited period)
See also: Visual Abstract
Related: M-A | General Anesthesia vs. to Non-GA in endovascular thrombectomy for ischemic stroke
RCT | Comparable efficacy of cefotaxime, ceftriaxone, and ciprofloxacin in treating spontaneous bacterial peritonitis
3 Apr, 2023 | 14:01h | UTCSummary: This multicenter, prospective, open-label, randomized controlled trial compared the efficacy of cefotaxime, ceftriaxone, and ciprofloxacin as initial treatments for spontaneous bacterial peritonitis (SBP) in patients with cirrhosis and ascites. The study included 261 patients aged 16 to 75, with liver cirrhosis, ascites, and a polymorphonuclear cell count of >250/mm3. Researchers performed follow-up paracentesis at 48 hours to evaluate the assigned antibiotics, and assessed resolution rates at 120 and 168 hours of treatment.
The primary endpoint, resolution rates at 120 hours, showed no statistically significant difference between the groups: 67.8% for cefotaxime, 77.0% for ceftriaxone, and 73.6% for ciprofloxacin. One-month mortality rates were also similar. The study concluded that these antibiotics are equally effective as initial treatments for SBP, particularly for community-acquired infections, when administered based on response-guided therapy.
Article: Response-Guided Therapy With Cefotaxime, Ceftriaxone, or Ciprofloxacin for Spontaneous Bacterial Peritonitis: A Randomized Trial: A Validation Study of 2021 AASLD Practice Guidance for SBP – American Journal of Gastroenterology (free for a limited period)
Review | Acute respiratory distress syndrome, mechanical ventilation, and inhalation injury in burn patients
3 Apr, 2023 | 13:38h | UTC
M-A | Incidence and prognostic role of pleural effusion in patients with pulmonary embolism
31 Mar, 2023 | 13:40h | UTC
Review | Evaluation and management of hypernatremia in adults
30 Mar, 2023 | 14:20h | UTC
Update on the management of acute pancreatitis
30 Mar, 2023 | 14:10h | UTCUpdate on the management of acute pancreatitis – Current Opinion in Critical Care
Related:
Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis – New England Journal of Medicine
Acute Pancreatitis: Diagnosis and Treatment – Drugs
Evidence-Based Disposition of Acute Pancreatitis – emDocs
Pancreatitis – National Institute for Health and Care Excellence
Research: Endoscopic or Surgical Step-up Approach for Infected Necrotising Pancreatitis
Evidence-Based Approach to the Surgical Management of Acute Pancreatitis – The Surgery Journal
Brief Review | Acute mesenteric ischemia
30 Mar, 2023 | 13:44h | UTCAcute mesenteric ischaemia – British Journal of Surgery
M-A | Incidence of multiple organ failure in adult polytrauma patients
30 Mar, 2023 | 13:30h | UTC
M-A | Aggressive IV hydration may increase mortality risk in severe acute pancreatitis
29 Mar, 2023 | 13:26h | UTCSummary: This systematic review and meta-analysis investigated the outcomes of aggressive and non-aggressive intravenous hydration in patients with severe and non-severe acute pancreatitis (AP). The study included nine randomized controlled trials with a total of 953 participants.
The findings revealed that aggressive intravenous hydration significantly increased mortality risk in severe AP cases, and fluid-related complication risk in both severe and non-severe AP cases. However, the study has some limitations, as only one study with 249 participants was judged to have a low risk of bias in all domains, while the remaining eight studies had non-low risk of bias, raising concerns about the reliability of the findings.
Despite these concerns, the findings still suggest that more conservative intravenous fluid resuscitation protocols for AP may be preferable. Further research with more rigorous study designs is needed to provide robust evidence on the effectiveness of different intravenous hydration strategies in treating acute pancreatitis.
Review | Supplemental oxygen and noninvasive ventilation
29 Mar, 2023 | 13:18h | UTCSupplemental oxygen and noninvasive ventilation – European Respiratory Review
Practice Guidance | On-site treatment of avalanche victims
28 Mar, 2023 | 14:48h | UTC
Acute heart failure: diagnostic–therapeutic pathways and preventive strategies — a real-world clinician’s guide
28 Mar, 2023 | 14:45h | UTC
M-A | Examining shorter antibiotic treatment durations for community acquired pneumonia in adults
27 Mar, 2023 | 13:29h | UTCSummary: The systematic review and duration-effect meta-analysis included nine randomized trials with a total of 2,399 patients, analyzing antibiotic treatment durations for community-acquired pneumonia (CAP) in adults. The primary outcome was clinical improvement on day 15, with secondary outcomes including all-cause mortality, serious adverse events, and clinical improvement on day 30.
The study found that shorter treatment durations (3–9 days) were likely to be non-inferior to the standard 10-day treatment, and no significant difference in all-cause mortality or serious adverse events was observed. The study suggests that a 3–5 day treatment duration likely offers the optimal balance between efficacy and treatment burden if patients are clinically stable. However, the results are limited by the small number of included studies, the overall moderate-to-high risk of bias, and the varying severity of CAP among patients in the studies. Therefore, further research focusing on the shorter duration range is required.
Related: