Critical Care
PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?
28 Feb, 2021 | 20:43h | UTCEditorial: Navigating treatment approaches for presumed ESBL-producing infections
Commentary on Twitter (thread – click for more)
🔥NEW🔥 PRO-CON Debate on the role of carbapenems in infections caused by Enterobacterales resistant to ceftriaxone. #AMR @BSACandJAC @IDdocAdi @ABsteward
— JAC-AMR (@jac_amr) February 24, 2021
Position Paper: Management of drug-induced liver injury
25 Feb, 2021 | 08:27h | UTC
ICU-based renal replacement therapy
25 Feb, 2021 | 08:23h | UTCICU-Based Renal Replacement Therapy – Critical Care Medicine
Commentary on Twitter
Renal Replacement in #ICU
📌history/development
📌(fast) evolution of tech & machines
📌pivotal role of nursing
📌mode: CRRT vs IHD
📌CRRT & blood purification
📌peds & neonates #PedsICU
📌complications
📌anticoagulation@CritCareMed #FOAMcc #FOANed #CCC50 https://t.co/NxC88pbIB6 pic.twitter.com/OGVkwkrjLi— M Velia Antonini (@FOAMecmo) February 4, 2021
Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone
24 Feb, 2021 | 02:25h | UTCEffect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter
Related: The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis (study and commentaries)
Commentary on Twitter
VICTAS trial now in @JAMA_current. Is this the final nail in the coffin for HAT in sepsis? https://t.co/kDdmnIdC6s
— UGAC3 (@ugac3) February 23, 2021
How the COVID-19 pandemic will change the future of critical care
24 Feb, 2021 | 02:49h | UTCHow the COVID-19 pandemic will change the future of critical care – Intensive Care Medicine
Commentary on Twitter
Will #COVID19 change critical care?
➡️approach to crises
➡️flexible #ICU capacity/staff & safer design
➡️efficient supply/use of PPE, devices, consumables, meds
➡️triage principles
➡️communication
➡️end‐of‐life
➡️#AI, registries, agile collaborative RCTshttps://t.co/0aWmhQxItm pic.twitter.com/qFZCi4eYwM— Intensive Care Medicine (@yourICM) February 23, 2021
M-A: The diagnostic accuracy of noninvasive methods to measure the intracranial pressure
23 Feb, 2021 | 01:14h | UTC
FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias
23 Feb, 2021 | 02:03h | UTCFDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT
FDA Safety Alert: Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration
Related: “Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients – New England Journal of Medicine (study and commentaries)
Editorial: Prophylactic anticoagulation for patients in hospital with covid-19
23 Feb, 2021 | 01:59h | UTCProphylactic anticoagulation for patients in hospital with covid-19 – The BMJ
Related: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19
Intensive care management of patients with COVID-19: a practical approach
21 Feb, 2021 | 22:34h | UTCRelated Guideline: Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update AND Infographic
SOFA score is not accurate enough for mortality prediction in severely ill patients with COVID-19 pneumonia
19 Feb, 2021 | 02:44h | UTC
Commentary on Twitter
'The discriminant accuracy of the #SOFA score for
mortality prediction in patients prior to intubation for#COVID-19 pneumonia was poor and significantly inferior to simply using age.' Age, apparently can't be used because 'discrimination'. #bioethics https://t.co/QJIxqupoVx— udo schuklenk 🏳️🌈🇨🇦🇦🇺🇩🇪 (@schuklenk) February 17, 2021
Review: Oxygen administration for patients with ARDS
19 Feb, 2021 | 02:24h | UTCOxygen administration for patients with ARDS – Journal of Intensive Care
RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19
18 Feb, 2021 | 03:20h | UTCEditorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer
In this RCT a single high dose of #vitaminD3 (100K IU) raised mean serum 25OH D levels but had no effect on hospital LOS (primary outcome), in-hospital mortality, ICU admission, or need for mechanical ventilation (secondary outcomes) https://t.co/eozVaYnb25
— JAMA (@JAMA_current) February 17, 2021
M-A: The effect of convalescent plasma therapy on COVID-19 patient mortality
18 Feb, 2021 | 03:07h | UTCRelated study (not published yet) with conflicting results: RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19 (news release and commentary)
Video: Emergency intubation in Covid-19
18 Feb, 2021 | 03:16h | UTCEmergency Intubation in Covid-19 – New England Journal of Medicine
Patient characteristics and clinical outcomes of Type 1 vs. Type 2 myocardial infarction
18 Feb, 2021 | 02:54h | UTCPatient Characteristics and Clinical Outcomes of Type 1 Versus Type 2 Myocardial Infarction – Journal of the American Academy of Cardiology (link to abstract – $ for full-text)
Commentary on Twitter
What are the patient characteristics & clinical outcomes of type 1 vs type 2 #cvMI in the U.S.? Over 200K+ are analyzed. Find out in this week’s issue of #JACC: https://t.co/trgZtKgbOy @CianPMcCarthy @mvaduganathan @JJheart_doc #HFWeek2021 #HeartMonth #CardioTwitter pic.twitter.com/dCdinfeNwE
— JACC Journals (@JACCJournals) February 16, 2021
Short review: Acute CV complications of hematopoietic stem cell transplantation
18 Feb, 2021 | 02:40h | UTCAcute CV Complications of Hematopoietic Stem Cell Transplantation – American College of Cardiology
Ocular MRI findings in patients with severe COVID-19
17 Feb, 2021 | 01:42h | UTCCommentaries: New COVID-19 side effect: MRI links severe infection to dangerous eye problems – Health Imaging AND MRI illuminates COVID-19’s negative impact on the eyes – AuntMinnie AND Windows of Infection: MRI Reveals COVID-19-Linked Eye Abnormalities – Diagnostic Imaging
Cardiac arrest in COVID-19: characteristics and outcomes of in- and out-of-hospital cardiac arrest
17 Feb, 2021 | 01:32h | UTC
Commentary on Twitter
#COVID19 was involved in at least 10% of all out-of-hospital cardiac arrests (OHCA) and 16% of intra-hospital cardiac arrests (IHCA) and, among #COVID_19 cases, 30-day mortality was increased 3.4-fold in OHCA & 2.3-fold in IHCA https://t.co/uS6rzTXuew#EHJ #ESCYoung @ehj_ed pic.twitter.com/QisuU9rsLT
— European Society of Cardiology Journals (@ESC_Journals) February 5, 2021
Incidence rate and clinical impacts of arrhythmia following COVID-19: a systematic review and meta-analysis of 17,435 patients
17 Feb, 2021 | 01:31h | UTC
Study: Obesity and risk of catheter-related infections in the ICU
16 Feb, 2021 | 01:46h | UTC
Commentary on Twitter
Obesity & intravascular catheter‑related infections in #ICU, post hoc analysis of 4 multicentric RCTs, largest dataset ever collected:
BMI ≥ 40? ⬆️risk!!
Preventive strategies, notably catheter care/dressing disruption, should focus on this pt population.https://t.co/ZxBFAxz2Je pic.twitter.com/7GHov7ewkr— Intensive Care Medicine (@yourICM) February 1, 2021
Potential health and economic impacts of dexamethasone treatment for patients with COVID-19
16 Feb, 2021 | 02:10h | UTC
Commentary on Twitter
RCTs Save Live$
DEXA saves live$
Potential health&economic impacts of dexamethasone treatment for #COVID19 patients
The study estimate that between July & Dec 2020, for 🇬🇧, ~12,000 lives could be saved & ~650,000 lives saved globally over the same time https://t.co/B7jVa5Xc0s pic.twitter.com/mI0wPVUj4C— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 10, 2021
Opinion: RECOVERY confirms benefit of tocilizumab combined with dexamethasone
16 Feb, 2021 | 02:09h | UTCPulmCrit – RECOVERY confirms benefit of toci combined with dexamethasone
Original study: RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19 (study and commentaries)
Consensus guidelines on perioperative management of suspected malignant hyperthermia or susceptible patients
15 Feb, 2021 | 00:56h | UTC
Randomized trial: Procalcitonin to reduce long-term infection-associated adverse events in sepsis
15 Feb, 2021 | 00:43h | UTC
Cohort study: Early initiation of prophylactic anticoagulation linked to reduced mortality in patients admitted to hospital with Covid-19
15 Feb, 2021 | 01:18h | UTCCommentaries: Preventive blood thinning drugs could reduce COVID hospital deaths – London School of Hygiene & Tropical Medicine AND Preventive blood thinning drugs linked to reduced risk of death in COVID-19 patients – The BMJ AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre AND
Commentary on Twitter
Blood thinning drugs are now linked to a reduced risk of death for COVID19 patients. Those given preventive blood thinners (prophylactic anticoagulants) within 24 hours of hospital admission for Covid were less likely to die. New report in the BMJ https://t.co/KQqQ3Zoj8B pic.twitter.com/6wJj8mEucw
— delthia ricks 🔬 (@DelthiaRicks) February 12, 2021