Critical Care
Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis
7 Mar, 2021 | 19:00h | UTC
Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases
7 Mar, 2021 | 18:58h | UTC
Scientific Statement: Invasive management of acute myocardial infarction complicated by cardiogenic shock
5 Mar, 2021 | 08:33h | UTC
Respiratory microbiome in mechanically ventilated patients: a narrative review
5 Mar, 2021 | 08:14h | UTC
Commentary on Twitter
Respiratory microbiome on mechanical ventilation:
➡️definition
➡️state of the art: lung bacterial microbiota in #ICU, invasive mechanical ventilation, #ARDS, lung nosocomial infections & VAP, lung mycobiota, virome
➡️perspectives & clinical applicationshttps://t.co/fO7ggoJNUk pic.twitter.com/0W8hLNkuSO— Intensive Care Medicine (@yourICM) February 9, 2021
RCT: Mixed findings with Terlipressin plus Albumin for the treatment of Type 1 hepatorenal syndrome
4 Mar, 2021 | 08:35h | UTCTerlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Albumin provides no benefit to hospitalized patients with decompensated cirrhosis
4 Mar, 2021 | 08:37h | UTCA Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Albumin provides no benefit to hospitalized patients with advanced liver disease – University College London
RCT: Inspiratory muscle training with an electronic resistive loading device improves prolonged weaning outcomes
4 Mar, 2021 | 08:10h | UTCInspiratory Muscle Training With an Electronic Resistive Loading Device Improves Prolonged Weaning Outcomes in a Randomized Controlled Trial – Critical Care Medicine (link to abstract – $ for full-text)
Commentaries on Twitter
In 101 patients on MV, inspiratory muscle training vs T-piece led to better maximal inspiratory pressure, weaning success, and 60d-survival.
Thanks to @CritCareReviews https://t.co/8RR9e8nDVm— Peter Nydahl (@NydahlPeter) January 2, 2021
Inspiratory muscle training in patients on prolonged weaning increases muscle strength and is associated with a higher 60d survival rate and successful weaning. Another contribution from Brazilian physiotherapy! Kudos to @brunoguimaraesp and team! https://t.co/LEw7vGSZey
— Angelo Roncalli (@curso_vm) December 25, 2020
COVID-19 research in critical care: the good, the bad, and the ugly
3 Mar, 2021 | 08:49h | UTCCOVID-19 research in critical care: the good, the bad, and the ugly – Intensive Care Medicine
Commentary on Twitter
Challenges, achievements, directions of critical care research in #pandemic, from early small #COVID19 studies (incomplete/inconsistent data), to large-scale registries, through overlapping/competing & underpowered trials, often with poor LMIC involvement.https://t.co/EyEui4pKPi pic.twitter.com/jUDXAVaD5z
— Intensive Care Medicine (@yourICM) March 1, 2021
More transmissible and evasive SARS-CoV-2 variant growing rapidly in Brazil
3 Mar, 2021 | 08:53h | UTCOriginal study (preprint): Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil
Commentaries: Covid Brazil variant ‘may spread more easily’ – BBC AND Brazil coronavirus variant: what is it and why is it a concern? An expert explains – The Conversation
Using Bayesian Methods to Augment the Interpretation of Critical Care Trials. An Overview of Theory and Example Reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial
3 Mar, 2021 | 08:36h | UTC
Commentary on Twitter
I love this paper on Bayes.
Aren’t trials just like medical tests: they update our prior knowledge or beliefs?
If you can discuss a trial using its p-wave or confidence intervals, why not its posterior probabilities given *justified* priors.
(Yes, I am enthralled!) https://t.co/w1ym9jgQD5
— John Mandrola, MD (@drjohnm) March 1, 2021
RCT: High flow oxygen does not change the risk of mortality in patients with a suspected acute coronary syndrome
3 Mar, 2021 | 08:37h | UTC
Commentary on Twitter
Supplementary high flow oxygen given for ischaemic symptoms to patients with suspected acute coronary syndrome was not associated with a change in 30 day mortality, finds new #BMJResearchhttps://t.co/CDhfFyVL88
— The BMJ (@bmj_latest) March 2, 2021
M-A: Role of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage
3 Mar, 2021 | 08:16h | UTCRole of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage – A systematic review, meta-analysis and trial sequential analysis – World Neurosurgery (link to abstract – $ for full-text)
Studies: Secondary infections in patients with severe COVID-19
2 Mar, 2021 | 02:05h | UTCSecondary Infections in Patients with Severe COVID-19 – NEJM Journal Watch
Review: Cardiovascular biomarkers in patients with COVID-19
2 Mar, 2021 | 02:07h | UTC
Commentary on Twitter
Cardiovascular #biomarkers in patients with #COVID19 – review article by @escardio Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association #ACVC_ESC https://t.co/9Mcx24fX8y#EHJACVC #cardiotwitter #medtwitter pic.twitter.com/y7kD2Oylrj
— European Society of Cardiology Journals (@ESC_Journals) March 1, 2021
Serious bradycardia and Remdesivir for COVID-19: a new safety concern
2 Mar, 2021 | 02:06h | UTC
Commentary on Twitter
⛔A new safety concern⛔
New 🔥 post-marketing study @CMIJournal suggests that the use of remdesivir is significantly associated with an increased risk of reporting serious bradycardia compared with HCQ,LPV/RTV, tocilizumab or glucocorticoids #IDTwitter https://t.co/npLMchifEM— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 27, 2021
Consensus Document: Venous thromboembolism prophylaxis in the trauma intensive care unit
2 Mar, 2021 | 01:52h | UTC
Guideline: Treatment of methicillin-resistant Staphylococcus aureus (MRSA)
2 Mar, 2021 | 01:50h | UTC
Commentary on Twitter
We're delighted to publish the first update of UK #MRSA guidelines in more than a decade. Please share with your contacts & colleagues .
Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UKhttps://t.co/3o3OVIdLuB #JACAMRNews #IDtwitter pic.twitter.com/GGlv1C1T1g
— JAC-AMR (@jac_amr) February 4, 2021
Cohort study: Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury
2 Mar, 2021 | 01:34h | UTCRecovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury – JAMA Neurology (free for a limited period)
Editorial: Holding Out Hope After Traumatic Brain Injury (free for a limited period)
Commentary on Twitter
In this study in @JAMANeuro:
most individuals who became comatose after moderate/severe traumatic brain injury recovered consciousness and ~50% regained functional independence, cautioning early decisions to withdraw/withhold treatment in these patients. https://t.co/jIz38AwCXO— Saleh Almenawer, MD (@SalehAlmenawer) March 1, 2021
Teleneurology-enabled determination of death by neurologic criteria after cardiac arrest or severe neurologic injury
2 Mar, 2021 | 01:32h | UTCTeleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury – Neurology (link to abstract – $ for full-text)
M-A: Treatment with convalescent plasma is not associated with better outcomes in patients with Covid-19
28 Feb, 2021 | 21:51h | UTCEditorial: Emerging Lessons From COVID-19 for the US Clinical Research Enterprise
Commentary on Twitter
Just out: Our meta-analysis in @JAMA_current
"Among patients with COVID-19, treatment with convalescent plasma compared with control was not associated with improved survival or other positive clinical outcomes"https://t.co/tRqpd9v67m
— Lars G. Hemkens (@LGHemkens) February 26, 2021
Editorial | Twenty Lessons from 2020: With a Focus on the ICU Perspective
28 Feb, 2021 | 21:44h | UTCTwenty Lessons from 2020: With a Focus on the ICU Perspective – ICU Management & Practice
RCT: Baclofen reduces agitation in patients with unhealthy alcohol use receiving mechanical ventilation, but results in a longer time receiving mechanical ventilation and more extended ICU stay
28 Feb, 2021 | 21:09h | UTCEditorial: Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU
Video presentation: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder
Commentary on Twitter
In this phase 3 RCT, high-dose baclofen reduced agitation-related events vs placebo in patients with unhealthy alcohol use receiving mechanical ventilation; considering the modest effect & secondary endpoints & adverse events, further research is needed https://t.co/gHWEqZKfFv
— JAMA (@JAMA_current) February 23, 2021
RCT: Balanced opioid-free anesthesia with Dexmedetomidine resulted in a greater incidence of serious adverse events, especially hypoxemia and bradycardia
28 Feb, 2021 | 21:03h | UTC
RCT: An intensive blood pressure lowering strategy after successful endovascular therapy in acute ischemic stroke did not reduce radiographic intraparenchymal hemorrhage rates
28 Feb, 2021 | 20:59h | UTCSafety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19
26 Feb, 2021 | 08:48h | UTC
Commentary on Twitter
Why do 2 randomized trials of tocilizumab, an interleukin-6 blocker, for severe covid-19, have opposite results?
Today @NEJMhttps://t.co/g8LCrhhpLyhttps://t.co/BcN3wOwsl0 pic.twitter.com/sLrQUYI1pf— Eric Topol (@EricTopol) February 25, 2021