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Critical Care

[Preprint] RCT: Full-dose/therapeutic anticoagulation provides no benefit in critically ill patients with Covid-19

14 Mar, 2021 | 20:59h | UTC

Therapeutic Anticoagulation in Critically Ill Patients with Covid-19-Preliminary Report – medRxiv

Commentary: PulmCrit Wee – Therapeutic anticoagulation for COVID ICU patients: Is the heparin vial half empty, or half full?

Related (results on moderately ill patients): [Not published yet] Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials

 

Study: Healthcare settings did not increase the risk for Covid-19 infection among health care workers in the US. Exposure outside the workplace was the strongest risk factor for SARSCoV2 seropositivity

14 Mar, 2021 | 20:41h | UTC

Risk Factors Associated With SARS-CoV-2 Seropositivity Among US Health Care Personnel – JAMA Network Open

Commentaries: Healthcare settings do not increase risk for Covid-19 infection spread – University of Maryland School of Medicine AND Did Healthcare Workers Catch Covid In Or Outside The Hospital? – MedicalResearch.com AND Community Covid-19 Risk Higher Than Workplace Risk for Health Care Personnel – Physician’s Weekly

 

Commentary on Twitter

 

Drug dosing in the critically ill obese patient: a focus on medications for hemodynamic support and prophylaxis

12 Mar, 2021 | 08:08h | UTC

Drug dosing in the critically ill obese patient: a focus on medications for hemodynamic support and prophylaxis – Critical Care

 

Consensus Statement: Preoperative management of endocrine, hormonal, and urologic medications

11 Mar, 2021 | 08:04h | UTC

Preoperative Management of Endocrine, Hormonal, and Urologic Medications: Society for Perioperative Assessment and Quality Improvement (SPAQI) Consensus Statement – Mayo Clinic Proceedings

 

M-A: Early tracheostomy may lower the rates of ventilator-associated pneumonia and ventilator duration in critically ill patients

12 Mar, 2021 | 08:09h | UTC

Association of Early vs Late Tracheostomy Placement With Pneumonia and Ventilator Days in Critically Ill Patients: A Meta-analysis – JAMA Otolaryngology-Head & Neck Surgery

Author interview: Early vs Late Tracheotomy for Pneumonia and Ventilator Days

 

 

AHA Scientific Statement | Opioid-Associated Out-of-Hospital Cardiac Arrest: Distinctive Clinical Features and Implications for Health Care and Public Responses

11 Mar, 2021 | 08:07h | UTC

Opioid-Associated Out-of-Hospital Cardiac Arrest: Distinctive Clinical Features and Implications for Health Care and Public Responses: A Scientific Statement From the American Heart Association – Circulation

 

ERS Guideline: Management of hospitalized adults with COVID-19

12 Mar, 2021 | 08:36h | UTC

Management of hospitalised adults with coronavirus disease-19 (COVID-19): A European Respiratory Society living guideline – European Respiratory Journal

 

COVID-19 and liver disease: mechanistic and clinical perspectives

12 Mar, 2021 | 08:29h | UTC

COVID-19 and liver disease: mechanistic and clinical perspectives – Nature Reviews Gastroenterology & Hepatology

 

Update to living systematic review on covid-19 in pregnancy

12 Mar, 2021 | 08:28h | UTC

Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis – The BMJ

News release: Update to living systematic review on covid-19 in pregnancy – The BMJ

 

[Press release – not published yet] Monoclonal antibodies reduced hospitalizations and death in Phase 3 trial for early COVID-19

11 Mar, 2021 | 08:41h | UTC

Press release: Lilly’s bamlanivimab and etesevimab together reduced hospitalizations and death in Phase 3 trial for early COVID-19

Commentary: Eli Lilly’s combo therapy for COVID-19 cuts serious illness and death in large study – Reuters

 

Death rate 64% higher with B117 COVID variant, study finds

11 Mar, 2021 | 08:38h | UTC

Death rate 64% higher with B117 COVID variant, study finds – CIDRAP

News release: Variant B.1.1.7 of COVID-19 associated with a significantly higher mortality rate, research shows – University of Bristol

Original Study: Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study – The BMJ

 

[Preprint] RECOVERY trial: Convalescent plasma does not improve outcomes in patients admitted to hospital with COVID-19

11 Mar, 2021 | 08:43h | UTC

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial – medRxiv

 

Commentary on Twitter (thread – click for more)

 

State of the Art Review | Severe covid-19 pneumonia: pathogenesis and clinical management

11 Mar, 2021 | 08:37h | UTC

Severe covid-19 pneumonia: pathogenesis and clinical management – The BMJ

 

Pregnancy and COVID: what the data say

10 Mar, 2021 | 08:39h | UTC

Pregnancy and COVID: what the data say – Nature

 

Restricting daily chest radiography in the ICU: Implementing evidence-based medicine to decrease utilization

9 Mar, 2021 | 02:25h | UTC

Restricting Daily Chest Radiography in the Intensive Care Unit: Implementing Evidence-Based Medicine to Decrease Utilization – Journal of the American College of Radiology

Commentary: Curbing daily use of chest x-ray in ICU cuts major costs – AuntMinnie (free registration required)

 

Commentary on Twitter

 

Report: Risk of death from Covid-19 significantly increased in countries where most are overweight

9 Mar, 2021 | 02:52h | UTC

Report: COVID-19 and Obesity: The 2021 Atlas

Commentaries: Covid-19 death rates 10 times higher in countries where most adults are overweight, report finds – CNN AND Covid-19: Highest death rates seen in countries with most overweight populations – The BMJ AND Covid-19: We must tackle obesity and health inequalities in order to build back better – The BMJ Opinion AND COVID-19 Death Rates 10 Times Higher in Countries Where Most Are Overweight – HealthDay

 

CDC study: Body mass index and risk for COVID-19–related hospitalization, intensive care unit admission, invasive mechanical ventilation, and death

9 Mar, 2021 | 02:54h | UTC

Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death — United States, March–December 2020 – CDC Morbidity and Mortality Weekly Report

Commentaries: CDC: Obese adults at higher risk for hospitalization, death from COVID-19 – UPI AND Obesity a Big Risk Factor for Severe COVID-19, Study Confirms – HealthDay

 

Colchicine and COVID-19: a Tale of Two Trials

9 Mar, 2021 | 02:51h | UTC

Colchicine and COVID-19: a Tale of Two Trials – CVCT CardioBrief

Study 1: RECOVERY trial: Colchicine arm stopped for lack of efficacy in patients hospitalized with COVID-19

Study 2: [Preprint] Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19

 

[Preprint] Systematic review: Characteristics of SARS-CoV-2 reinfection vs. persistent COVID-19

9 Mar, 2021 | 02:44h | UTC

SARS-CoV-2 Sequence Characteristics of COVID-19 Persistence and Reinfection – medRxiv

Commentary: How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection? – News Medical

 

Ten things to consider when implementing rationing guidelines during a pandemic

9 Mar, 2021 | 02:46h | UTC

Ten things to consider when implementing rationing guidelines during a pandemic – Intensive Care Medicine

 

Commentary on Twitter

 

Study: Balanced crystalloids vs. saline in critically ill adults with hyperkalemia or acute kidney injury

9 Mar, 2021 | 02:05h | UTC

Can We Use LR for Hyperkalemia? – Journal Feed

Original study: Balanced Crystalloids versus Saline in Critically Ill Adults with Hyperkalemia or Acute Kidney Injury: Secondary Analysis of a Clinical Trial – American Journal of Respiratory and Critical Care Medicine

 

Systematic review: High‐flow nasal cannula for respiratory support in adult intensive care patients

7 Mar, 2021 | 19:31h | UTC

High‐flow nasal cannula for respiratory support in adult intensive care patients – Cochrane Library

Summary: High-flow nasal cannulae for breathing support in adult intensive care patients – Cochrane Library

 

RECOVERY trial: Colchicine arm stopped for lack of efficacy in patients hospitalized with COVID-19

7 Mar, 2021 | 20:16h | UTC

RECOVERY trial closes recruitment to colchicine treatment for patients hospitalised with COVID-19 – University of Oxford

Commentary: Cochicine does not improve mortality in COVID19 – St Emlyn’s

 

Commentary on Twitter

 

[Preprint] Genomics and epidemiology of a novel SARS-CoV-2 lineage P.1 – “P.1 may be 1.4–2.2 times more transmissible and 25-61% more likely to evade protective immunity elicited by previous infection with non-P.1 lineages”

7 Mar, 2021 | 20:05h | UTC

Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil – medRxiv

Commentary: Brazil variant can reinfect virus survivors; COVID-19 vaccine antibodies pass into breast milk – Reuters

 

[Preprint] Increased risk of hospitalization associated with infection with SARS-CoV-2 Lineage B.1.1.7 in Denmark

7 Mar, 2021 | 19:46h | UTC

Increased Risk of Hospitalisation Associated with Infection with SARS-CoV-2 Lineage B.1.1.7 in Denmark – The Lancet

 

Commentary on Twitter (thread – click for more)

 

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