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Critical Care

Case series: Adjunct immune globulin for vaccine-induced thrombotic thrombocytopenia.

10 Jun, 2021 | 09:46h | UTC

Adjunct Immune Globulin for Vaccine-Induced Thrombotic Thrombocytopenia – New England Journal of Medicine

 

[Preprint] RECOVERY trial finds aspirin does not improve survival for patients hospitalized with COVID-19.

9 Jun, 2021 | 08:28h | UTC

News Release: RECOVERY trial finds aspirin does not improve survival for patients hospitalised with COVID-19 – University of Oxford

Original Study: Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial – medRxiv

 

Commentary on Twitter (thread – click for more)

 

Short review: Neurological complications of COVID-19.

8 Jun, 2021 | 09:36h | UTC

Neurological complications of COVID-19 – Intensive Care Medicine

 

Commentary on Twitter

 

The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – careful use of antibiotics and corticosteroids and closely monitoring blood glucose levels are some of the strategies suggested by the authors.

8 Jun, 2021 | 09:34h | UTC

The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – Annals of Internal Medicine

 

Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – Uncontrolled diabetes mellitus was the most common underlying disease; improper glucocorticoid use was independently associated with the disease.

8 Jun, 2021 | 09:33h | UTC

Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – CDC Emerging Infectious Diseases

Commentary: COVID19: Secondary Infections Still a Big Challenge in India – News Click

 

Commentary on Twitter

 

Time-to-positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicenter randomized control trial.

8 Jun, 2021 | 09:21h | UTC

Time-to-positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicentre randomised control trial – Clinical Microbiology and Infections

 

Commentary on Twitter

 

RCT: In patients hospitalized with Covid-19 with elevated D-Dimer, a full-dose anticoagulation strategy based on rivaroxaban (full-dose heparins in unstable patients) + rivaroxaban to day 30 was not better than prophylactic anticoagulation and increased bleeding risk.

7 Jun, 2021 | 00:01h | UTC

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial – The Lancet

Related: #ACC21 – [Not published yet] RCT: Among hospitalized patients with Covid-19 and elevated D-Dimer, therapeutic anticoagulation with Rivaroxaban 20 mg was not associated with improved outcomes and resulted in increased major bleeding.

 

Commentary on Twitter

https://twitter.com/RenatoDLopes1/status/1400962037610582026

 

Case report: Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).

6 Jun, 2021 | 23:55h | UTC

Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT) – Journal of Thrombosis and Haemostasis

Commentary: COVID-19 vaccination: Thrombosis can be prevented by prompt treatment, researchers report – Medical University of Vienna

 

RCT: Early, intensive mobilization poststroke may harm patients.

6 Jun, 2021 | 23:45h | UTC

Fatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke – Neurology

 

M-A: The benefit of dysphagia screening in adult patients with stroke.

6 Jun, 2021 | 23:43h | UTC

The Benefit of Dysphagia Screening in Adult Patients With Stroke: A Meta‐Analysis – Journal of the American Heart Association

 

Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

4 Jun, 2021 | 10:43h | UTC

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study – The Lancet Microbe

Commentaries: Very high use of antibiotics in COVID-19 treatment could be reduced – University of Glasgow AND More evidence of frequent antibiotic use noted in COVID patients – CIDRAP AND Covid-19: Antimicrobial use was high during first wave despite bacterial co-infections being rare, study finds – The BMJ

Related: Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT

 

Commentary on Twitter (thread – click for more)

 

M-A: Prehospital Tranexamic Acid reduces mortality among bleeding trauma patients without increasing the risk of venous thromboembolism.

6 Jun, 2021 | 23:34h | UTC

The impact of prehospital TXA on mortality among bleeding trauma patients: A systematic review and meta-analysis – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)

Commentary: Prehospital TXA for Trauma – Meta-analysis – JournalFeed

 

In a Mendelian randomization study, researchers found no genetic evidence to support an association between Vitamin D levels and COVID-19 susceptibility, severity, or hospitalization.

4 Jun, 2021 | 10:35h | UTC

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study – PLOS Medicine

Commentary: Vitamin D may not provide protection from COVID-19 susceptibility or disease severity, study suggests – PLOS

Related: Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19. AND RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

 

Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients.

4 Jun, 2021 | 10:26h | UTC

Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients – Annals of Intensive Care

 

RCT: No benefit from passive leg raising during cardiopulmonary resuscitation in out-of-hospital cardiac arrest.

4 Jun, 2021 | 10:28h | UTC

Clinical outcomes and safety of passive leg raising in out-of-hospital cardiac arrest: a randomized controlled trial – Critical Care

 

Commentary on Twitter

 

M-A: In hypoxemic non-hypercapnic patients, early extubation followed by noninvasive ventilation can reduce the total number of days of invasive mechanical ventilation (mean difference, − 2.04 days), without effects in ICU mortality.

4 Jun, 2021 | 10:27h | UTC

Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials – Critical Care

 

Diagnosis and management of diabetes insipidus for the internist: an update

4 Jun, 2021 | 10:22h | UTC

Diagnosis and management of diabetes insipidus for the internist: an update – Journal of Internal Medicine

 

What We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – “the Delta variant may soon become the most dominant COVID strain in the world and lead to rapid outbreaks in countries without high vaccination rates”.

3 Jun, 2021 | 11:05h | UTC

What We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – Intelligencer

 

Commentary on Twitter

 

Guideline: Diagnosis and management of acute lower gastrointestinal bleeding.

3 Jun, 2021 | 10:49h | UTC

Diagnosis and management of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Endoscopy

 

Observational study suggests ceftriaxone is similarly effective to benzylpenicillin for the treatment of neurosyphilis, potentially decreasing the length of hospital stay (mean 13.8 days vs. 8.9 days).

31 May, 2021 | 08:06h | UTC

Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

RCT: First-attempt intubation success is increased with the use an endotracheal tube + stylet vs. an endotracheal tube alone.

27 May, 2021 | 08:16h | UTC

Effect of the use of an endotracheal tube and stylet versus an endotracheal tube alone on first-attempt intubation success: a multicentre, randomised clinical trial in 999 patients – Intensive Care Medicine

 

Commentary on Twitter

 

[Preprint] Meta-analysis of RCT: Ivermectin for the treatment of COVID-19 – no effect on all-cause mortality, length of stay, or viral clearance

26 May, 2021 | 08:41h | UTC

Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – medRxiv

 

Commentary on Twitter

 

RCT: Continuous infusion of 20% hypertonic saline does not improve neurological outcomes in patients with traumatic brain injury

26 May, 2021 | 08:22h | UTC

Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial – JAMA (free for a limited period)

 

Commentary on Twitter

 

Short review: Diagnosis and management of acute respiratory distress syndrome

26 May, 2021 | 08:19h | UTC

Diagnosis and management of acute respiratory distress syndrome – Canadian Medical Association Journal

 

Commentary on Twitter

 

M-A: Prokinetics may improve tolerance to gastric feeding to some extent in critically ill adults.

26 May, 2021 | 08:16h | UTC

The efficacy and safety of prokinetics in critically ill adults receiving gastric feeding tubes: A systematic review and meta-analysis – PLOS One

 

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