Critical Care | Page 7 of 78 | Links Medicus Content Curation & Alerts in Medicine

Expert Consensus | Nephrotoxic potential of 195 medications in the non-intensive care setting

1 Jun, 2023 | 12:14h | UTC

Expert Consensus on the Nephrotoxic Potential of 195 Medications in the Non-intensive Care Setting: A Modified Delphi Method – Drug Safety

Consensus Paper | Organ donation in the surgical ICU

1 Jun, 2023 | 12:12h | UTC

Organ donation in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document – Trauma Surgery & Acute Care Open

M-A | Noninvasive ventilation in patients with acute hypoxemic respiratory failure

1 Jun, 2023 | 12:11h | UTC

Noninvasive ventilation in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis of randomized controlled trials – Scientific Reports

RCT | Prophylactic platelet transfusion reduces CVC-related bleeding in patients with platelets 10-50 K/mm³

31 May, 2023 | 14:20h | UTC

Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Research from Amsterdam UMC shows that the bottom has been reached in restrictive blood transfusion policy – Amsterdam University Medical Centers

Commentary on Twitter

Withholding of prophylactic platelet transfusion before CVC placement in pts with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority & resulted in more CVC-related bleeding events than prophylactic platelet transfusion.

— NEJM (@NEJM) May 27, 2023

RCT | Early initiation of DOACs not statistically superior to later use in atrial fibrillation-related stroke

31 May, 2023 | 14:17h | UTC

Early versus Later Anticoagulation for Stroke with Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

ELAN: Early DOACs Safe, May Help After Ischemic Stroke in AF Patients – TCTMD

Early Versus Late Initiation of Direct Oral Anticoagulants in Post-Ischemic Stroke Patients With Atrial Fibrillation – ELAN – American College of Cardiology

Commentary on Twitter

Late breaking at #ESOC2023: In the ELAN trial, the estimated incidence of stroke, systemic embolism, hemorrhage, or death was 2.8 percentage points lower to 0.5 percentage points higher with early than with later use of direct oral anticoagulants. Full results:

— NEJM (@NEJM) May 24, 2023

RCT | P2Y12 inhibitors don’t improve outcomes in critically ill COVID-19 patients

31 May, 2023 | 14:13h | UTC

Effect of P2Y12 Inhibitors on Organ Support–Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

Guidelines | Management of ascites in liver disease

31 May, 2023 | 14:08h | UTC

Asia–Pacific association for study of liver guidelines on management of ascites in liver disease – Hepatology International

Review | How to approach acute thrombosis and thrombocytopenia

31 May, 2023 | 14:03h | UTC

How to approach acute thrombosis and thrombocytopenia – Clinical Medicine Journal

M-A | Variation in central venous oxygen saturation to evaluate fluid responsiveness

31 May, 2023 | 14:01h | UTC

Variation in central venous oxygen saturation to evaluate fluid responsiveness: a systematic review and meta-analysis – Critical Care

Cohort Study | Prevalence and risk factors of significant persistent pain symptoms after critical care illness

31 May, 2023 | 14:00h | UTC

Prevalence and risk factors of significant persistent pain symptoms after critical care illness: a prospective multicentric study – Critical Care

M-A | Diagnostic accuracy of point-of-care ultrasound for shock

31 May, 2023 | 13:51h | UTC

Diagnostic accuracy of point-of-care ultrasound for shock: a systematic review and meta-analysis – Critical Care

Review | Intravenous fluids in critically ill patients: when less is better

31 May, 2023 | 13:45h | UTC

Intravenous Fluids in Critically Ill Patients: When Less is Better – ICU Management & Practice

RCT | Sulbactam-durlobactam non-inferior to colistin in reducing 28-day mortality from carbapenem-resistant ABC

30 May, 2023 | 12:08h | UTC

Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK) – The Lancet Infectious Diseases (link to abstract – $ for full-text)

News Release: Novel antibiotic succeeds in trial against hospital-acquired pneumonia – Rutgers University

RCT | Care bundle with intensive blood pressure control improves outcomes in acute cerebral hemorrhage

30 May, 2023 | 12:04h | UTC

The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial – The Lancet

News Release: Tens of thousands of lives a year could be saved by new treatment protocol for brain hemorrhage – George Institute for Global Health

Review | Spurious electrolyte and acid-base disorders in the patient with cancer

30 May, 2023 | 11:43h | UTC

Spurious Electrolyte and Acid-Base Disorders in the Patient With Cancer: A Review – American Journal of Kidney Diseases

Commentary on Twitter

Spurious Electrolyte and Acid-Base Disorders in the Patient With Cancer: A Review https://t.co/i9jPRxBdkz (FREE) @raad_chowdhury @NephroMD @bdubNephro @PITTRenal pic.twitter.com/FbhovMDHd7

— AJKD (@AJKDonline) May 27, 2023

RCT | Preliminary evidence for right median nerve stimulation in awakening from acute traumatic coma

30 May, 2023 | 11:36h | UTC

Acute traumatic coma awakening by right median nerve electrical stimulation: a randomised controlled trial – Intensive Care Medicine

Commentary on Twitter

? Unlocking consciousness: important data on @yourICM but results should be replicated ideally by multicentric trial w blind intervention + including detailed data on WLSM as long-term outcome by validated metric.
?️ https://t.co/nvLl9A84oD

Refers to
?️ https://t.co/VifPF3wTvI pic.twitter.com/0Sqpu56Mov

— Intensive Care Medicine (@yourICM) May 22, 2023

Review | Posterior circulation ischemic stroke diagnosis and management

30 May, 2023 | 11:30h | UTC

Posterior circulation ischaemic stroke diagnosis and management – Clinical Medicine Journal

AHA/ASA Guideline for the management of patients with aneurysmal subarachnoid hemorrhage

29 May, 2023 | 11:16h | UTC

2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association – Stroke

Top Things to Know: 2023 Aneurysmal Subarachnoid Hemorrhage Guideline – American Heart Association

Commentary on Twitter

2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association https://t.co/IHZRkTR25t @American_Heart @American_Stroke @AHAScience @BrianHoh1 @drdangayach @CPDerdeyn pic.twitter.com/I2JdXnHuXp

— Stroke AHA/ASA (@StrokeAHA_ASA) May 23, 2023