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Critical Care

Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report.

12 Jul, 2021 | 01:41h | UTC

Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report – Annals of the American Thoracic Society

 

M-A: Comparative efficacy and safety of vancomycin, linezolid, tedizolid, and daptomycin in treating patients with suspected or proven complicated skin and soft tissue infections.

9 Jul, 2021 | 09:57h | UTC

Comparative Efficacy and Safety of Vancomycin, Linezolid, Tedizolid, and Daptomycin in Treating Patients with Suspected or Proven Complicated Skin and Soft Tissue Infections: An Updated Network Meta-Analysis – Infectious Diseases and Therapy

 

Commentary on Twitter

 

Assessment and management of cardiovascular disease in the intensive care unit.

9 Jul, 2021 | 09:54h | UTC

Assessment and management of cardiovascular disease in the intensive care unit – Heart

 

Case series: therapeutic plasma exchange in 3 patients with vaccine-induced immune thrombotic thrombocytopenia.

8 Jul, 2021 | 09:17h | UTC

Therapeutic Plasma Exchange in Vaccine-Induced Immune Thrombotic Thrombocytopenia – New England Journal of Medicine

 

Commentary on Twitter

 

Review: Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS.

8 Jul, 2021 | 09:01h | UTC

Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS – Intensive Care Medicine

 

Commentary on Twitter

 

Predictors of death and new disability after critical illness: a multicenter prospective cohort study.

8 Jul, 2021 | 08:59h | UTC

Predictors of death and new disability after critical illness: a multicentre prospective cohort study – Intensive Care Medicine

 

Commentary on Twitter

 

M-A: Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 – “The 4% absolute risk reduction in mortality from 25% to 21% with IL-6 inhibition added to glucocorticoids may not translate to patients with a lower baseline mortality risk and likely do not justify the additional expense and risk for toxicities for patients hospitalized with modest oxygen requirements and a stable clinical course (from editorial)”.

7 Jul, 2021 | 09:02h | UTC

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis – JAMA

Editorial: IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19: Who, When, and How? – JAMA

Commentaries: Interleukin-6 antagonists improve outcomes in hospitalised COVID-19 patients – King’s College London AND WHO advises 2 monoclonal antibodies for severe COVID – CIDRAP

 

Commentary on Twitter (thread – click for more)

https://twitter.com/msh_manu/status/1412473073715056645

 

A living WHO guideline on drugs for covid-19 – interleukin-6 receptor blockers are now recommended for patients with severe or critical covid-19.

7 Jul, 2021 | 09:03h | UTC

A living WHO guideline on drugs for covid-19 – The BMJ

 

Commentary on Twitter

 

WHO recommends life-saving interleukin-6 receptor blockers for COVID-19 and urges producers to join efforts to rapidly increase access – “These are the first drugs found to be effective against COVID-19 since corticosteroids were recommended by WHO in September 2020”.

7 Jul, 2021 | 09:00h | UTC

WHO recommends life-saving interleukin-6 receptor blockers for COVID-19 and urges producers to join efforts to rapidly increase access – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.

7 Jul, 2021 | 08:52h | UTC

Systematic review and meta-analysis of randomised controlled trials testing the safety and efficacy of convalescent plasma in the treatment of coronavirus disease 2019 (COVID-19): Evidence-base for practise and implications for research – Transfusion Medicine

 

RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.

6 Jul, 2021 | 10:16h | UTC

Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19) a randomized, double-blind, placebo-controlled trial – BMC Infectious Diseases

Commentary: Ivermectin: balance of evidence shows no significant benefit against Covid-19 – MSN News

Related: Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”. AND Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”. AND Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials AND RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19

 

Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians.

6 Jul, 2021 | 10:21h | UTC

Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians – Nature Medicine

 

Editorial | Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions.

6 Jul, 2021 | 10:14h | UTC

Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions – Intensive Care Medicine

 

Commentary on Twitter

 

Energetic dysfunction in sepsis: a narrative review.

6 Jul, 2021 | 10:06h | UTC

Energetic dysfunction in sepsis: a narrative review – Annals of Intensive Care

 

M-A of observational studies: the association between surgical fixation of hip fractures within 24 hours and mortality.

6 Jul, 2021 | 10:01h | UTC

The association between surgical fixation of hip fractures within 24 hours and mortality: a systematic review and meta-analysis – The Bone & Joint Journal (link to abstract – $ for full-text)

 

CDC Report: Underlying medical conditions and severe illness among 540,667 adults hospitalized with COVID-19, March 2020–March 2021.

5 Jul, 2021 | 02:40h | UTC

Underlying Medical Conditions and Severe Illness Among 540,667 Adults Hospitalized With COVID-19, March 2020–March 2021 – Centers for Disease Control and Prevention

 

Commentary on Twitter

 

RCT: Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19 – no difference in intubation rates compared to standard care.

5 Jul, 2021 | 02:24h | UTC

Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial – Critical Care

Related: Feasibility and Physiological Effects of Prone Positioning in Non-intubated Patients with Acute Respiratory Failure due to COVID-19

 

Seminar | Acute respiratory distress syndrome.

5 Jul, 2021 | 01:57h | UTC

Acute respiratory distress syndrome – The Lancet

 

Review | Perioperative cardiac risk reduction in noncardiac surgery.

5 Jul, 2021 | 01:45h | UTC

Perioperative Cardiac Risk Reduction in Noncardiac Surgery – Mayo Clinic Proceedings

 

Acute kidney injury in the critically ill: an updated review on pathophysiology and management.

5 Jul, 2021 | 01:49h | UTC

Acute kidney injury in the critically ill: an updated review on pathophysiology and management – Intensive Care Medicine

 

Commentary on Twitter

 

M-A: Decision-making authority during Tele-ICU care reduces mortality and length of stay.

5 Jul, 2021 | 01:18h | UTC

Decision-Making Authority During Tele-ICU Care Reduces Mortality and Length of Stay—A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

 

Vaccine-induced immune thrombotic thrombocytopenia (VITT) – a novel clinico-pathological entity with heterogeneous clinical presentations.

2 Jul, 2021 | 11:39h | UTC

Vaccine-induced immune thrombotic thrombocytopenia (VITT) – a novel clinico-pathological entity with heterogeneous clinical presentations – British Journal of Haematology

Commentary: Blood clots related to AstraZeneca/Oxford vaccine can be mitigated with early detection – MedicalXpress

 

Delirium in COVID-19: can we make the unknowns knowns?

2 Jul, 2021 | 11:17h | UTC

Delirium in COVID-19: can we make the unknowns knowns? – Intensive Care Medicine

 

Commentary on Twitter

 

Perspective | Why no one is sure if Delta is deadlier – “The variants are spreading faster, but they don’t necessarily have incentive to kill more often”.

1 Jul, 2021 | 09:52h | UTC

Why No One Is Sure If Delta Is Deadlier – The Atlantic

 

AHA Scientific Statement: Managing atrial fibrillation in patients with heart failure and reduced ejection fraction.

1 Jul, 2021 | 09:46h | UTC

Managing Atrial Fibrillation in Patients With Heart Failure and Reduced Ejection Fraction: A Scientific Statement From the American Heart Association – Circulation: Arrhythmia and Electrophysiology

Commentary: The Chicken or the Egg – Atrial Fibrillation and Heart Failure with Reduced Ejection Fraction: Importance of Early AF Treatment – American Heart Association

Top Things to Know: Managing Atrial Fibrillation in Patients With Heart Failure and Reduced Ejection Fraction

 

Commentary on Twitter

 

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