Critical Care | Page 20 of 82 | Links Medicus Content Curation & Alerts in Medicine

RCT | Effect of early mobilization on long-term cognitive impairment in critical illness

17 Feb, 2023 | 13:07h | UTC

Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial – The Lancet Respiratory Medicine (free registration required)

Early Active Mobilization during Mechanical Ventilation in the ICU – New England Journal of Medicine (link to abstract – $ for full-text)

Ten Overlooked Mistakes During Early Mobilisation in the Intensive Care Unit – ICU Management & Practice

Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis – Critical Care

Commentary on Twitter

NEW Research—Early mobilisation might improve long-term cognitive impairment in ICU survivors after MV, but the increased risk of adverse events in the intervention group should be noted

Read the RCT from Bhakti Patel & colleagues here: https://t.co/DeqraodGXq #SCCM2023 pic.twitter.com/RMDhE7UxPM

— The Lancet Respiratory Medicine (@LancetRespirMed) January 21, 2023

M-A | The rate and assessment of muscle wasting during critical illness

17 Feb, 2023 | 12:55h | UTC

The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis – Critical Care

Commentary on Twitter

A Review published in @Crit_Care analyzes the data of ICU muscle wasting studies and reports that critically ill patients lose nearly 2% of skeletal muscle per day during the first week of ICU admission.https://t.co/qW5jzbWRSk

— BMC (@BioMedCentral) January 8, 2023

Acute pain management pearls: a focused review for the hospital clinician

17 Feb, 2023 | 12:42h | UTC

Acute Pain Management Pearls: A Focused Review for the Hospital Clinician – Healthcare

RCT | Rivaroxaban shows promise compared to Enoxaparin in the acute phase of an acute coronary syndrome

16 Feb, 2023 | 15:20h | UTC

Effect of Rivaroxaban vs Enoxaparin on Major Cardiac Adverse Events and Bleeding Risk in the Acute Phase of Acute Coronary Syndrome: The H-REPLACE Randomized Equivalence and Noninferiority Trial – JAMA Network Open

Invited Commentary: Rivaroxaban for Patients With Acute Coronary Syndromes—Where Do We Stand? – JAMA Network Open

Commentary on Twitter

The H-REPLACE RCT: short-term rivaroxaban (5mg 2x/day) was noninferior to enoxaparin in safety + efficacy during 6-month follow-up among patients with acute coronary syndrome who missed the primary reperfusion window and before selective revascularization. https://t.co/TIHOwGSWjJ

— JAMA Network Open (@JAMANetworkOpen) February 10, 2023

Guideline | Diagnosis and management of subarachnoid hemorrhage caused by a ruptured aneurysm

16 Feb, 2023 | 15:23h | UTC

Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and management – National Institute for Health and Care Excellence

Regulations on palliative sedation: an international survey across eight European countries

16 Feb, 2023 | 15:17h | UTC

Regulations on palliative sedation: an international survey across eight European countries – European Journal of Public Health

M-A | Efficacy of endovascular therapy for basilar and vertebral artery occlusion

16 Feb, 2023 | 14:50h | UTC

Efficacy of endovascular therapy for basilar and vertebral artery occlusion: A systematic review and meta-analysis of randomized controlled trials – European Journal of Internal Medicine

RCTs | Thrombectomy improved recovery in basilar artery stroke but increased procedural complications and hemorrhages.

Registry-based cohort study: Endovascular treatment vs. best medical management in acute basilar artery occlusion strokes.

RCT: Endovascular therapy for stroke due to basilar-artery occlusion – “endovascular therapy and medical therapy did not differ significantly with respect to a favorable functional outcome”.

SR | Prognostic models for mortality risk in patients requiring ECMO

15 Feb, 2023 | 15:49h | UTC

Prognostic models for mortality risk in patients requiring ECMO – Intensive Care Medicine

Review | Indications, clinical impact, and complications of critical care transesophageal echocardiography

15 Feb, 2023 | 15:45h | UTC

Indications, Clinical Impact, and Complications of Critical Care Transesophageal Echocardiography: A Scoping Review – Journal of Intensive Care Medicine

Retrospective Study | Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome

15 Feb, 2023 | 15:40h | UTC

Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome – Critical Care

SR | Predisposing and precipitating factors associated with delirium

15 Feb, 2023 | 15:38h | UTC

Predisposing and Precipitating Factors Associated With Delirium: A Systematic Review – JAMA Network Open

Consensus Paper | ED management of patients with alcohol intoxication, alcohol withdrawal, and alcohol use disorder

14 Feb, 2023 | 11:05h | UTC

Emergency Department Management of Patients with Alcohol Intoxication, Alcohol Withdrawal, and Alcohol Use Disorder: A White Paper Prepared for the American Academy of Emergency Medicine – The Journal of Emergency Medicine

Cohort study | Epidemiology and outcomes of hospital-acquired bloodstream infections in ICU patients

14 Feb, 2023 | 10:44h | UTC

Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study – Intensive Care Medicine (if the link is paywalled, try this one)

Commentary on Twitter

Hospital‑acquired bloodstream infections in #ICU, @EuroBact2
🧫mainly due to Gram -, widespread carbapenem resistant, DTR pathogens
🧫resistance associated w longer delays to adequate ABT therapy
At day-28
🧫mortality 37%
🧫16.1% discharged alive from 🏥
🖇️https://t.co/0T4FK2mxc5 pic.twitter.com/e0u50hMKqO

— Intensive Care Medicine (@yourICM) February 11, 2023

Cohort Study | Global epidemiology of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases

14 Feb, 2023 | 10:43h | UTC

Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study – The Lancet Microbe

M-A | Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia

14 Feb, 2023 | 10:43h | UTC

Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia: A systematic review and meta-analysis – Clinical Infectious Diseases

Commentary on Twitter

Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia: A systematic review and meta-analysis

✅ Just Accepted
🆓 Freely Available
🔗 https://t.co/a8SYDUM8UH pic.twitter.com/L5niNTVIUd

— Clinical Infectious Diseases (@CIDJournal) February 9, 2023

Review | Anisocoria in the ED: pathophysiology, evaluation, and management

14 Feb, 2023 | 10:41h | UTC

Anisocoria in the ED: Pathophysiology, Evaluation, and Management – emDocs

RCT | Tenecteplase noninferior to alteplase in acute ischemic cerebrovascular events

13 Feb, 2023 | 12:59h | UTC

Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

RCTs | Endovascular therapy improves functional outcomes in large ischemic strokes, but increases bleeding and vascular complications

13 Feb, 2023 | 13:00h | UTC

Study 1: Trial of Endovascular Thrombectomy for Large Ischemic Strokes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Major international study finds thrombectomy highly effective treatment for large strokes – University Hospitals Cleveland Medical Center

Study 2: Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct – New England Journal of Medicine (link to abstract – $ for full-text)

M-A | Tenecteplase vs. alteplase for treatment of acute ischemic stroke

13 Feb, 2023 | 12:57h | UTC

Tenecteplase vs. alteplase for treatment of acute ischemic stroke: A systematic review and meta-analysis of randomized trials – Frontiers in Neurology

Perspective | Five new realities in critical care for patients with cancer

13 Feb, 2023 | 12:53h | UTC

Five new realities in critical care for patients with cancer – Intensive Care Medicine

Consensus Conference: Critically ill cancer patient’s resuscitation.

Raising awareness for time-limited trial discussion upon ICU triage and admission.

Trends in clinical profiles, organ support use and outcomes of patients with cancer requiring unplanned ICU admission: a multicenter cohort study

Commentary on Twitter

New realities in critical care for pts with cancer
1️⃣ serious illness no longer means end of life
2️⃣ novel cancer therapies: changing outcomes but creating new diseases
3️⃣ take fresh look at ARF
4️⃣ goals of care & time‑limited trial
5️⃣ look beyond #ICU
📖 https://t.co/ZRNQD6AMIw pic.twitter.com/5QoYVSq5Br

— Intensive Care Medicine (@yourICM) February 10, 2023

Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations

13 Feb, 2023 | 12:44h | UTC

Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup – Critical Care

M-A | Complications of percutaneous tracheostomy in critically ill adults with obesity

13 Feb, 2023 | 12:37h | UTC

Complication Rate of Percutaneous Dilatational Tracheostomy in Critically Ill Adults With Obesity: A Systematic Review and Meta-analysis – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)

Brief Review | Double sequential external defibrillation for refractory ventricular fibrillation

13 Feb, 2023 | 12:35h | UTC

Double sequential external defibrillation for refractory ventricular fibrillation – Intensive Care Medicine

Commentary on Twitter

🫀Refractory Vfib
⚡️ vector change defibrillation
⚡️ double sequential external defibrillation
exciting & innovative strategies that can improve survival for patients presenting with refractory VF: time will tell if will be broadly implemented/embraced
🖇️ https://t.co/uUktOHdGEl pic.twitter.com/aiOtMMX2nT

— Intensive Care Medicine (@yourICM) February 9, 2023

Review | Advanced point-of-care bedside monitoring for acute respiratory failure

13 Feb, 2023 | 12:32h | UTC

Advanced Point-of-care Bedside Monitoring for Acute Respiratory Failure – Anesthesiology

Commentary on Twitter

Advanced respiratory monitoring involves several mini- or noninvasive tools, applicable at bedside, that have the potential to support clinicians in the management of acute respiratory failure. Learn more about the personalization of ventilatory strategy: https://t.co/RP4LAsdQHM pic.twitter.com/KFlwxDthe9

— Anesthesiology (@_Anesthesiology) February 10, 2023

RCT | Argatroban plus Alteplase not better than Alteplase alone in patients with acute ischemic stroke

10 Feb, 2023 | 13:59h | UTC

Effect of Argatroban Plus Intravenous Alteplase vs Intravenous Alteplase Alone on Neurologic Function in Patients With Acute Ischemic Stroke: The ARAIS Randomized Clinical Trial – JAMA (free for a limited period)

Commentary on Twitter

Among patients with acute ischemic #stroke who received intravenous alteplase, argatroban was not significantly associated with better neurologic function. https://t.co/s9BDEvRvFA pic.twitter.com/HIRnGmiWMU

— JAMA (@JAMA_current) February 9, 2023

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