Chest Medicine
[Preprint] Study suggests immunity to the Coronavirus may last years
18 Nov, 2020 | 09:20h | UTCImmunological memory to SARS-CoV-2 assessed for greater than six months after infection – bioRxiv
Commentaries: Immunity to the Coronavirus May Last Years, New Data Hint – New York Times AND Could coronavirus immunity last YEARS? Study finds even survivors who had mild COVID-19 are protected for at least 8 months and their immune ‘memory’ may last MUCH longer – Daily Mail AND COVID-19: Study Suggests Durable Immune Response After SARS-CoV-2 Infection – NEJM Journal Watch
Commentary from the author on Twitter (thread – click for more)
1/ Our pre-print on immune memory to SARS-CoV-2 is out today. To our knowledge, this is the largest such study for any acute infection.
The upshot is that there is substantial immune memory after COVID-19.
Lots of stuff in this manuscript.https://t.co/lSAyZp0XiK@SetteLab
— Prof. Shane Crotty (@profshanecrotty) November 17, 2020
ATS Guideline: Home oxygen therapy for adults with chronic lung disease
18 Nov, 2020 | 09:13h | UTC
[Press release – not published yet] Moderna’s COVID-19 vaccine candidate shows 94.5% protection in an interim analysis of the phase 3 COVE study
17 Nov, 2020 | 09:55h | UTCPress release: Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study
See also: Moderna Announces Longer Shelf Life for its COVID-19 Vaccine Candidate at Refrigerated Temperatures
Commentaries: What Moderna’s Covid-19 vaccine results mean for ending the pandemic – Vox AND Moderna follows Pfizer with exciting vaccine news – how to read these dramatic developments – The Conversation AND Moderna’s COVID Vaccine Is 95% Effective – Independent NIH-Appointed Board Assessment – Higher Storage Temperature Make It Even Better News – Health Policy Watch AND Moderna’s Vaccine News “Encouraging” But Won’t Solve Immediate Problem of Virus Surge in Europe & Americas – WHO – Health Policy Watch AND COVID vaccine excitement builds as Moderna reports third positive result – Nature AND Moderna’s Covid-19 vaccine is strongly effective, early look at data show – STAT AND With strong data on two Covid-19 vaccines, we have more answers about the road ahead — and questions too – STAT AND Early data show Moderna’s COVID vaccine 94.5% effective – CIDRAP AND A Note Of Caution On Moderna’s Promising Covid-19 Vaccine News – Forbes AND Promising Interim Results from Clinical Trial of NIH-Moderna COVID-19 Vaccine – NIH News Releases AND Moderna: Covid vaccine shows nearly 95% protection – BBC AND Latest vaccine success is good news but high price may restrict access – The Guardian AND ‘Just beautiful’—Another COVID-19 vaccine, from newcomer Moderna, succeeds in large-scale trial – Science AND Moderna trial success gives world more hope in race to end pandemic – Reuters AND Expert reaction to Moderna announcement of its phase 3 vaccine interim results – Science Media Centre
CDC Report: 9% readmitted after Covid-19 hospitalization. Risk factors were age ≥65 y, chronic medical conditions, recent hospitalization before Covid-19, and discharge to a skilled nursing facility or with home health care
17 Nov, 2020 | 09:46h | UTCCommentary: 9 percent readmitted after index COVID-19 hospitalization – MedicalXpress AND One in 11 coronavirus patients discharged from a hospital is readmitted within two months, suggesting long-lasting effects of the infection, CDC report warns – Daily Mail
Commentary on Twitter
A new @CDCMMWR finds 9% of the more than 100,000 patients discharged after being hospitalized for #COVID19 were readmitted to the same hospital within 2 months. Learn more: https://t.co/s96NXLxQUE. pic.twitter.com/ugJq9f1gHP
— CDC (@CDCgov) November 9, 2020
Review: Prone positioning for patients with hypoxic respiratory failure related to COVID-19
17 Nov, 2020 | 09:41h | UTC
Commentary on Twitter
What's the evidence for prone positioning for patients with respiratory distress related to #COVID19? A new review answers pressing questions about this common intervention: https://t.co/dh15AuUpD0 #ICU #CriticalCare pic.twitter.com/Y8TzactS70
— CMAJ (@CMAJ) November 11, 2020
Treatment of community-acquired pneumonia in immunocompromised adults: A consensus statement regarding initial strategies
17 Nov, 2020 | 09:40h | UTCEditorial: Management of Community-Acquired Pneumonia in Immunocompromised Adults – CHEST
Systematic review: Evidence-based practices for acute respiratory failure and Acute Respiratory Distress Syndrome
17 Nov, 2020 | 09:37h | UTCCommentary: Best practices for mechanical ventilation in patients with ARDS, COVID-19 – University of Michigan
Practice Pointer: Using antibiotics wisely for respiratory tract infection in the era of covid-19
16 Nov, 2020 | 01:48h | UTCUsing antibiotics wisely for respiratory tract infection in the era of covid-19 – The BMJ
Commentary on Twitter
When should patients with respiratory tract infections be assessed in person and when should you prescribe antibiotics based on best available evidence? This Practice Pointer offers guidance in the era of covid-19https://t.co/k6LoYPWmsv pic.twitter.com/rtIrjplyv0
— The BMJ (@bmj_latest) November 15, 2020
Covid-19: Inhaled Nebulized Interferon Beta-1a shows potential for hospitalized patients in preliminary trial
13 Nov, 2020 | 09:33h | UTC
Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19
13 Nov, 2020 | 09:35h | UTCEditorial: COVID-19 Infection—Preventing Clinical Deterioration
Long Covid: Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection
13 Nov, 2020 | 09:27h | UTCCommentary: Half of recovered COVID-19 patients report lingering fatigue – CIDRAP
Long Covid: 2 months after being hospitalized for Covid-19, many patients persisted symptomatic and did not resume normal activities
13 Nov, 2020 | 09:28h | UTCSixty-Day Outcomes Among Patients Hospitalized With COVID-19 – Annals of Internal Medicine
Commentary on Twitter
New Mich. hospital data: Of people admitted with COVID, 70% were alive and home 60 days later.
Of those who'd been working, 40% either lost their job or were still too sick to work.
It's not just the deaths; it's the health and economic damage. https://t.co/wMGkJw5KSF pic.twitter.com/8EbHktTxRX
— Atul Gawande (@Atul_Gawande) November 12, 2020
Case report: Persistence and evolution of SARS-CoV-2 in an immunocompromised host
13 Nov, 2020 | 09:24h | UTC
Commentary on Twitter (thread – click for more)
This summer, we partnered with the clinical team of an immunosuppressed patient with recurrent COVID and multiple hospitalizations. His NP swab VL reached 1 billion copies 5 months after initial dx. The team's Q: is this pt being re-infected w/ COVID? 1/ https://t.co/vkVerBUUPg
— Jonathan Li (@DrJLi) November 12, 2020
Perspective: Many younger adults need to take Covid-19 more seriously as demographics shift
13 Nov, 2020 | 09:25h | UTCYounger Adults Caught in COVID-19 Crosshairs as Demographics Shift – JAMA
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/jenabbasi/status/1326909913805828100
Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus
13 Nov, 2020 | 09:19h | UTC
Older age and frailty are frequently associated with atypical and unspecific COVID-19 presentations, including functional decline, acute mental change, and hypotension
12 Nov, 2020 | 09:22h | UTC
Commentary on Twitter
DIVERGENT: age, #frailty, and presentations of #COVID19
Typical symptoms were uncommon in frail and older
patients; they were more likely to experience functional decline and key features of delirium. #geriatrics @geronsociety @OxfordJournals #gerontolhttps://t.co/jRhwvacsVm pic.twitter.com/9zhHZjsSoy— Marlon Aliberti (@marlon_aliberti) November 5, 2020
Wearing cloth or disposable surgical face masks has no effect on vigorous exercise performance in healthy individuals
12 Nov, 2020 | 09:21h | UTCCommentary: Face masks don’t hinder breathing during exercise, study finds – University of Saskatchewan
Why do COVID death rates seem to be falling? Correct use of corticosteroids, hard-won experience, younger patients, and reduced strain on hospitals are all possibilities
12 Nov, 2020 | 09:16h | UTCWhy do COVID death rates seem to be falling? – Nature
[Preprint] Validation of home oxygen saturation as a marker of clinical deterioration in patients with suspected COVID-19: Even small deflections in oxygen saturations of 1-2% below 96% confer an increased mortality risk.
12 Nov, 2020 | 09:18h | UTC
Commentary on Twitter
*BREAKING* First paper examining home oxygen saturation in COVID confirmed cases as a trigger for initial hospital assessment. We need to rapidly implement a hybrid community-hospital COVID Oximetry@home #COVIDvirtualward @richardhorton1 @bmj_latest https://t.co/0SjrUT0Tjw pic.twitter.com/0TgPPRUBqv
— Matt Inada-Kim (@mattinadakim) November 8, 2020
Prone position in ARDS patients: why, when, how and for whom
12 Nov, 2020 | 09:11h | UTCProne position in ARDS patients: why, when, how and for whom – Intensive Care Medicine
Commentary on Twitter
Prone position in #ARDS
➡️ effects: chest wall/lung mechanics, ventilation, perfusion, gas exchange
➡️ hemodynamics
➡️ whom & when? indications/contraindications
➡️ ventilator settings
➡️ how to perform bedside
➡️ impact on outcomes
➡️ unanswered questionshttps://t.co/rCU7QOQSlw pic.twitter.com/rpBK8kRE9W— Intensive Care Medicine (@yourICM) November 10, 2020
Derivation and validation of the HA2T2 (Hypoxia, Age, Troponin) COVID‐19 mortality risk score
11 Nov, 2020 | 09:18h | UTC
Commentary on Twitter
Predicting in-hospital mortality among patients with #COVID19 using the simple HA2T2 (hypoxia, age and troponin) score. https://t.co/FTDceIijZl @KevinManocha @bradpeltzer @MonikaSafford @ParagGoyalMD @JAHA_AHA @WeillCornell @nyphospital pic.twitter.com/vGTNSg8wyO
— Jim Cheung (@DrJCheungEP) November 10, 2020
Podcast on chronic cough. Don’t be afraid to try empiric therapies! PPIs for GERD, antihistamines and intranasal steroids for post-nasal drip, and inhaled corticosteroids for post-viral cough are generally low-risk and will treat many cases.
11 Nov, 2020 | 09:04h | UTC#241 Chronic Cough – The Curbsiders Internal Medicine Podcast
News Release [Not Published Yet]: Vaccine candidate 90% effective against Covid-19 according to manufacturer
10 Nov, 2020 | 09:41h | UTCNews Release: Pfizer and Biontech announce vaccine candidate against Covid-19 achieved success in first interim analysis from phase 3 study
Commentaries: What Pfizer’s landmark COVID vaccine results mean for the pandemic – Nature AND Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate – The BMJ AND Covid vaccine: First ‘milestone’ vaccine offers 90% protection – BBC AND Hopes rise for end of pandemic as Pfizer says vaccine is 90% effective – The Guardian AND Four reasons for encouragement based on Pfizer’s Covid-19 vaccine results – STAT AND Expert reaction to Pfizer and BioNTech reporting interim results from phase 3 COVID-19 vaccine trial – Science Media Centre
Another study shows hydroxychloroquine does not benefit adults hospitalized with COVID-19
10 Nov, 2020 | 09:39h | UTCEditorial: Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science
Commentary: Hydroxychloroquine does not benefit adults hospitalized with COVID-19 – NIH News Releases
Patients with Covid-19 and myocardial injury have increased in-hospital mortality, particularly if echocardiographic abnormalities are present
10 Nov, 2020 | 09:37h | UTC