Chest Medicine
Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots
12 Mar, 2021 | 08:32h | UTCSee also: More European nations pause AstraZeneca vaccine use as blood clot reports investigated – CNN AND Denmark, Norway and Iceland suspend AstraZeneca COVID shots after blood clot reports – Reuters
Commentary on Twitter
Denmark has temporarily suspended use of the Oxford-AstraZeneca covid-19 vaccine as a precautionary move after reports of blood clots. But the EMA and the UK’s regulatory body say there is no indication that vaccination is linked to thromboembolic events https://t.co/sW8GRqcnLg
— The BMJ (@bmj_latest) March 11, 2021
Update to living systematic review on covid-19 in pregnancy
12 Mar, 2021 | 08:28h | UTCNews release: Update to living systematic review on covid-19 in pregnancy – The BMJ
Perspective | Long Covid isn’t as unique as we thought
12 Mar, 2021 | 08:27h | UTCLong Covid isn’t as unique as we thought – Vox
CDC Interim Recommendations for Fully Vaccinated People: An Important First Step
12 Mar, 2021 | 08:22h | UTCCDC Interim Recommendations for Fully Vaccinated People: An Important First Step – JAMA
Original Guidance and Commentaries: New CDC Guideline for fully vaccinated individuals says people can get together indoors without masks. Precautions should continue in public.
USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk
10 Mar, 2021 | 08:28h | UTCRecommendation Statement: Screening for Lung Cancer – US Preventive Services Task Force
Editorials: Broadened Eligibility for Lung Cancer Screening: Challenges and Uncertainty for Implementation and Equity – JAMA AND Expanded Access to Lung Cancer Screening—Implementing Wisely to Optimize Health – JAMA Network Open AND New USPSTF Guidelines for Lung Cancer Screening: Better but Not Enough – JAMA Surgery AND The 2021 US Preventive Services Task Force Recommendation on Lung Cancer Screening: The More Things Stay the Same… – JAMA Oncology
[Press release – not published yet] Monoclonal antibodies reduced hospitalizations and death in Phase 3 trial for early COVID-19
11 Mar, 2021 | 08:41h | UTCPress release: Lilly’s bamlanivimab and etesevimab together reduced hospitalizations and death in Phase 3 trial for early COVID-19
Commentary: Eli Lilly’s combo therapy for COVID-19 cuts serious illness and death in large study – Reuters
Death rate 64% higher with B117 COVID variant, study finds
11 Mar, 2021 | 08:38h | UTCDeath rate 64% higher with B117 COVID variant, study finds – CIDRAP
News release: Variant B.1.1.7 of COVID-19 associated with a significantly higher mortality rate, research shows – University of Bristol
Original Study: Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study – The BMJ
Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk
11 Mar, 2021 | 08:35h | UTCOriginal study: Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study – Anaesthesia
Commentary on Twitter
Reported by > 100 news organisations and > 200k Twitter impressions in just a few hours!
Here is the new @CovidSurg infographic! Time to establish timing of surgery guidelines?@aneelbhangu @dnepo @JoanaffSimoes #FOAMed
🔗https://t.co/mRnV7U6u1w pic.twitter.com/BmKlxf9ZIK
— 𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 (@Anaes_Journal) March 10, 2021
[Preprint] RECOVERY trial: Convalescent plasma does not improve outcomes in patients admitted to hospital with COVID-19
11 Mar, 2021 | 08:43h | UTC
Commentary on Twitter (thread – click for more)
RECOVERY Pre-print:
Convalescent plasma does not improve survival in patients hospitalised with COVID-19 in this randomised controlled trial involving 11,558 patients:https://t.co/36YZwJNY3Q pic.twitter.com/sKR095n1PC
— Martin Landray (@MartinLandray) March 10, 2021
State of the Art Review | Severe covid-19 pneumonia: pathogenesis and clinical management
11 Mar, 2021 | 08:37h | UTCSevere covid-19 pneumonia: pathogenesis and clinical management – The BMJ
Clinical Decisions | Doctor, How Long Should I Isolate?
11 Mar, 2021 | 08:21h | UTCDoctor, How Long Should I Isolate? – New England Journal of Medicine
Attributes and predictors of long COVID
11 Mar, 2021 | 08:25h | UTCAttributes and predictors of long COVID – Nature
Commentary on Twitter
https://twitter.com/ASPphysician/status/1369617507405946881
Audio Interview: The implications of changes in the structural biology of SARS-CoV-2
11 Mar, 2021 | 08:20h | UTC
More data suggesting a single dose of SARS-CoV-2 mRNA vaccine may be enough in seropositive individuals
11 Mar, 2021 | 08:18h | UTCRelated: Studies: Single dose of vaccine acts as ‘booster’ in those with prior COVID-19 infection (studies and commentary) AND Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2 – JAMA
M-A: Serological evidence of human infection with SARS-CoV-2
10 Mar, 2021 | 08:42h | UTCInvited Commentary: COVID-19 serosurveys for public health decision making – The Lancet Global Health
Commentary on Twitter (thread – click for more)
Now out: our systematic review and meta-analysis on seroprevalence surveys for SARS-CoV-2 is now out @LancetGH, collaboration with Hongjie Yu and team @FudanUniv. #COVID19. A short thread: 1/n https://t.co/EHLTc9AUCq
— Daniel T Leung (@GlobalGutHealth) March 9, 2021
Lab study shows Pfizer/BioNTech COVID-19 vaccine can also neutralize B.1.351, P1 and B.1.1.7 variants
10 Mar, 2021 | 08:43h | UTCNeutralizing Activity of BNT162b2-Elicited Serum – New England Journal of Medicine
Commentaries: Expert reaction to NEJM correspondence paper looking at the neutralising activity of the Pfizer-BioNTech vaccine against SARS-CoV-2 variants in the lab – Science Media Centre AND Pfizer/BioNTech COVID-19 vaccine neutralizes Brazil variant in lab study – Reuters
Study: Home testing for COVID-19 could prevent infections and reduce deaths at justifiable cost
10 Mar, 2021 | 08:40h | UTCNews release: Home testing for COVID-19 could prevent infections and reduce deaths at justifiable cost – Yale University
Original study: Clinical and Economic Effects of Widespread Rapid Testing to Decrease SARS-CoV-2 Transmission – Annals of Internal Medicine
Commentary on Twitter
Model-based analysis by @ADPaltiel, Amy Zheng of @YaleMed and @PaulSaxMD of @BrighamWomens.
A nationwide program of frequent home testing and self-isolation could greatly reduce total #COVID19 infections and mortality at a justifiable cost https://t.co/8AglZQXpuL. pic.twitter.com/5gQV3i0NxG
— Annals of Int Med (@AnnalsofIM) March 8, 2021
The role of C-reactive protein as a prognostic marker in COVID-19
10 Mar, 2021 | 08:38h | UTC
Pregnancy and COVID: what the data say
10 Mar, 2021 | 08:39h | UTCPregnancy and COVID: what the data say – Nature
Study Commentary | Single-dose Oxford–AstraZeneca COVID-19 vaccine followed by a 12-week booster
10 Mar, 2021 | 08:36h | UTCSingle-dose Oxford–AstraZeneca COVID-19 vaccine followed by a 12-week booster – The Lancet
Original study and news release: 3-month interval between first and second dose of Oxford COVID-19 vaccine results in higher vaccine efficacy than 6-week interval
Opinion | The Differences Between the Vaccines Matter
10 Mar, 2021 | 08:33h | UTCThe Differences Between the Vaccines Matter – Vox
Restricting daily chest radiography in the ICU: Implementing evidence-based medicine to decrease utilization
9 Mar, 2021 | 02:25h | UTCCommentary: Curbing daily use of chest x-ray in ICU cuts major costs – AuntMinnie (free registration required)
Commentary on Twitter
"Changing ordering practices in the adult ICUs to align with established evidence-based guidelines resulted in a 37% decrease in the utilization of portable chest radiography." https://t.co/waUQNdAM2i @JACRJournal pic.twitter.com/eKGDwgWCM8
— Rich Duszak, MD (@RichDuszak) July 9, 2020
RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia
9 Mar, 2021 | 02:29h | UTCShort-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
Editorial: Rightsizing Treatment for Pneumonia in Children
Commentary: Five days of antibiotics fine for children with pneumonia – McMaster University
Commentary on Twitter (thread – click for more)
This is fantastic! In outpatient community acquired pneumonia (CAP) a 5 day course of amoxicillin is just as effective as a 10 day course. A small thread follow1/6https://t.co/ewceFEe4gw
— Ricardo Quiñonez, MD, FAAP, FHM (@QuinonezRicardo) March 8, 2021
New CDC Guideline for fully vaccinated individuals says people can get together indoors without masks. Precautions should continue in public.
9 Mar, 2021 | 02:56h | UTCCommentaries: You’re fully vaccinated? The CDC says you can now have friends and family over for dinner – Vox AND CDC says fully vaccinated Americans can spend time together indoors and unmasked – STAT AND CDC Says It’s Safe For Vaccinated People To Do These Activities – WBUR AND If you got the COVID-19 vaccine, here’s what the CDC says you can do – Live Science
Report: Risk of death from Covid-19 significantly increased in countries where most are overweight
9 Mar, 2021 | 02:52h | UTCReport: COVID-19 and Obesity: The 2021 Atlas
Commentaries: Covid-19 death rates 10 times higher in countries where most adults are overweight, report finds – CNN AND Covid-19: Highest death rates seen in countries with most overweight populations – The BMJ AND Covid-19: We must tackle obesity and health inequalities in order to build back better – The BMJ Opinion AND COVID-19 Death Rates 10 Times Higher in Countries Where Most Are Overweight – HealthDay