Chest Medicine
Review: Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS.
8 Jul, 2021 | 09:01h | UTC
Commentary on Twitter
Physiology-to-bedside overview about non-invasive ventilatory support in AHRF & #ARDS
➡️spontaneous breathing: benefits/harms
➡️how to make spontaneous effort non‑injurious?
➡️optimizing HFNO & NIV
➡️monitoring to detect failure & be protective
➡️evidencehttps://t.co/KPW2u8akhA pic.twitter.com/yKVxrYaFmZ— Intensive Care Medicine (@yourICM) July 7, 2021
M-A: Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 – “The 4% absolute risk reduction in mortality from 25% to 21% with IL-6 inhibition added to glucocorticoids may not translate to patients with a lower baseline mortality risk and likely do not justify the additional expense and risk for toxicities for patients hospitalized with modest oxygen requirements and a stable clinical course (from editorial)”.
7 Jul, 2021 | 09:02h | UTCEditorial: IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19: Who, When, and How? – JAMA
Commentaries: Interleukin-6 antagonists improve outcomes in hospitalised COVID-19 patients – King’s College London AND WHO advises 2 monoclonal antibodies for severe COVID – CIDRAP
Commentary on Twitter (thread – click for more)
https://twitter.com/msh_manu/status/1412473073715056645
A living WHO guideline on drugs for covid-19 – interleukin-6 receptor blockers are now recommended for patients with severe or critical covid-19.
7 Jul, 2021 | 09:03h | UTCA living WHO guideline on drugs for covid-19 – The BMJ
Commentary on Twitter
The latest version of this @WHO living guidance provides a strong recommendation for interleukin-6 (IL-6) receptor blockers (tocilizumab or sarilumab) in patients with severe or critical covid-19. Read the updated WHO guideline on drugs for #COVID19 https://t.co/FUb9yzFRwo
— The BMJ (@bmj_latest) July 6, 2021
WHO recommends life-saving interleukin-6 receptor blockers for COVID-19 and urges producers to join efforts to rapidly increase access – “These are the first drugs found to be effective against COVID-19 since corticosteroids were recommended by WHO in September 2020”.
7 Jul, 2021 | 09:00h | UTC
Commentary on Twitter (thread – click for more)
🆕 treatment recommendation from WHO:
WHO recommends life-saving interleukin-6 receptor blockers to treat #COVID19 and urges producers to join efforts to rapidly increase access.👉https://t.co/h4IcZad2VA pic.twitter.com/YXPkuBVwY4
— World Health Organization (WHO) (@WHO) July 6, 2021
M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.
7 Jul, 2021 | 08:52h | UTC
RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.
6 Jul, 2021 | 10:16h | UTCCommentary: Ivermectin: balance of evidence shows no significant benefit against Covid-19 – MSN News
Related: Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”. AND Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”. AND Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials AND RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19
Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians.
6 Jul, 2021 | 10:21h | UTC
Joint COVAX Statement on the Equal Recognition of Vaccines – COVAX urges all government authorities to recognize as fully vaccinated all people who have received COVID-19 vaccines that have been deemed safe and effective by WHO.
5 Jul, 2021 | 02:39h | UTCJoint COVAX Statement on the Equal Recognition of Vaccines – World Health Organization
Commentary on Twitter (thread – click for more)
#COVAX urges all government authorities to recognize as fully vaccinated all who have received #COVID19 vaccines approved by WHO or one of 11 approved Stringent Regulatory Authorities, when making decisions on who is able to travel or attend events.
👉https://t.co/udYVrYTdMg pic.twitter.com/DihCPUmS8F
— World Health Organization (WHO) (@WHO) July 1, 2021
CDC Report: Underlying medical conditions and severe illness among 540,667 adults hospitalized with COVID-19, March 2020–March 2021.
5 Jul, 2021 | 02:40h | UTC
Commentary on Twitter
A new report finds that obesity, diabetes with complication, and the presence of multiple chronic conditions were the strongest chronic risk factors for death from #COVID19 among hospitalized adults. Learn more: https://t.co/KzsarYhHYA. pic.twitter.com/c0vd8ANqa0
— CDC (@CDCgov) July 1, 2021
Opinion | Covid is a greater risk to young people than the vaccines.
5 Jul, 2021 | 02:34h | UTCCovid Is a Greater Risk to Young People Than the Vaccines – The New York Times
Counterpoint: Weighing myocarditis cases, ACIP failed to balance the harms vs benefits of 2nd doses – by Wesley Pegden AND Vaccine-Induced Myocarditis Concerns Demand Respect, Not Absolutism – Medscape (free registration required)
Commentary on Twitter
“Realize the choice is not ‘vaccinate or do nothing.’ It’s ‘vaccinate or eventually contract the coronavirus,’ and the risks that come with it.”
My latest with @celinegounder and @EMDocinTraining@NYTOpinion @acsifferlin https://t.co/wGugCuWgSs
— Jeremy Faust MD MS (ER physician) (@jeremyfaust) July 4, 2021
Roundup on Covid vaccines | A Big Hit, A Big Miss, & Mixed Vaccine Schedules: The 18-Month Mark.
5 Jul, 2021 | 02:31h | UTCA Big Hit, A Big Miss, & Mixed Vaccine Schedules: The 18-Month Mark – Absolutely Maybe Blog
Commentary on Twitter
https://twitter.com/hildabast/status/1411083833022181378
Why Covid-19 outbreaks in countries using Chinese vaccines don’t necessarily mean the shots have failed.
5 Jul, 2021 | 02:30h | UTC
What are the Sinopharm and Sinovac vaccines? And how effective are they? Two experts explain.
5 Jul, 2021 | 02:28h | UTC
RCT: Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19 – no difference in intubation rates compared to standard care.
5 Jul, 2021 | 02:24h | UTC
Germany issues world’s strongest recommendation for mixing Covid-19 vaccines.
5 Jul, 2021 | 02:27h | UTCGermany issues world’s strongest recommendation for mixing Covid-19 vaccines – CNN
Seminar | Acute respiratory distress syndrome.
5 Jul, 2021 | 01:57h | UTCAcute respiratory distress syndrome – The Lancet
[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.
2 Jul, 2021 | 11:47h | UTCMixing Covid jabs has good immune response, study finds – BBC
The 3 Simple Rules That Underscore the Danger of Delta – “Vaccines are still beating the variants, but the unvaccinated world is being pummeled”.
2 Jul, 2021 | 11:45h | UTCThe 3 Simple Rules That Underscore the Danger of Delta – The Atlantic
Vaccine-induced immune thrombotic thrombocytopenia (VITT) – a novel clinico-pathological entity with heterogeneous clinical presentations.
2 Jul, 2021 | 11:39h | UTCCommentary: Blood clots related to AstraZeneca/Oxford vaccine can be mitigated with early detection – MedicalXpress
[Press release] J&J single-shot COVID-19 vaccine generates strong, persistent activity against the rapidly spreading Delta variant and other highly prevalent SARS-CoV-2 viral variants.
2 Jul, 2021 | 11:38h | UTCCommentary: J&J Covid Shot Neutralizes Delta Variant, Company Says – Bloomberg (a few articles per month are free)
COVID-19 vaccines reduce severity, length, viral load for those who still get infected.
1 Jul, 2021 | 09:57h | UTCOriginal study: Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines – New England Journal of Medicine
Commentary on Twitter
The @CDCgov trial to rigorously assess mRNA vaccination suppression of covid infections as assessed with frequent NP swabs in nearly 4,000 participants
91% efficacy of blocking transmission of infection (2 doses); 40% reduction of viral load https://t.co/tI6LECbw42 pic.twitter.com/y85Vd9ih5A— Eric Topol (@EricTopol) June 30, 2021
RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths.
1 Jul, 2021 | 09:59h | UTCSafety and Efficacy of NVX-CoV2373 Covid-19 Vaccine – New England Journal of Medicine
Audio interview: Audio Interview: Another New Covid-19 Vaccine – New England Journal of Medicine
Related: Opinion | The mRNA vaccines are extraordinary, but Novavax is even better
Analysis: How long does covid-19 immunity last?
1 Jul, 2021 | 09:56h | UTCHow long does covid-19 immunity last? – The BMJ
Perspective | Why no one is sure if Delta is deadlier – “The variants are spreading faster, but they don’t necessarily have incentive to kill more often”.
1 Jul, 2021 | 09:52h | UTCWhy No One Is Sure If Delta Is Deadlier – The Atlantic
Long COVID or post-acute sequelae of COVID-19 (PASC): An overview of biological factors that may contribute to persistent symptoms.
30 Jun, 2021 | 10:24h | UTC