Chest Medicine
[Press release – not published yet] Lab study suggests a third dose (booster) of the Pfizer–BioNTech vaccine may be necessary to provide an adequate immune response to the Omicron variant.
9 Dec, 2021 | 10:29h | UTCPress release: Pfizer and Biontech provide update on Omicron variant
Commentaries:
Omicron likely to weaken COVID vaccine protection – Nature
Pfizer-BioNTech says COVID booster should protect against Omicron – CIDRAP
Covid: Pfizer says booster shot promising against Omicron – BBC
Large observational study in Israel showed a third dose (booster) of the Pfizer–BioNTech vaccine reduced the rates of confirmed Covid-19 and severe illness compared to a two-dose regimen.
9 Dec, 2021 | 10:32h | UTCProtection against Covid-19 by BNT162b2 Booster across Age Groups – New England Journal of Medicine
Editorial: Booster Doses and Prioritizing Lives Saved
As 57 countries report Omicron cases, Pfizer says its boosters offer protection – but WHO cautions more research is needed.
9 Dec, 2021 | 10:28h | UTCSee also: Covid: Vaccines should work against Omicron variant, WHO says – BBC
Multiple early studies find notable Omicron vaccine evasion.
9 Dec, 2021 | 10:26h | UTCMultiple early studies find notable Omicron vaccine evasion – CIDRAP
Related: A first, small study suggests Omicron is a larger threat to Covid-19 immunity than other variants.
RCT: Among children between the ages of 6 and 11 years with uncontrolled moderate-to-severe asthma, add-on Dupilumab reduced exacerbations and improved lung function.
9 Dec, 2021 | 10:21h | UTCDupilumab in Children with Uncontrolled Moderate-to-Severe Asthma – New England Journal of Medicine
New Zealand to ban smoking for next generation in bid to outlaw habit by 2025 – “New legislation means the legal smoking age will increase every year, to create a smoke-free generation of New Zealanders”.
9 Dec, 2021 | 10:12h | UTCNew Zealand to ban smoking for next generation in bid to outlaw habit by 2025 – The Guardian
Update in the diagnosis and management of acute pulmonary embolism for the non-respiratory physician.
9 Dec, 2021 | 10:00h | UTC
Modern day management of a unilateral pleural effusion.
9 Dec, 2021 | 09:58h | UTCModern day management of a unilateral pleural effusion – Clinical Medicine Journal
Interstitial lung disease on the acute take for the non-respiratory physician.
9 Dec, 2021 | 09:57h | UTC
Review: Diagnosis and management of non-cystic fibrosis bronchiectasis.
9 Dec, 2021 | 09:53h | UTCDiagnosis and management of non-cystic fibrosis bronchiectasis – Clinical Medicine Journal
Review: Lung cancer for the non-respiratory physician.
9 Dec, 2021 | 09:54h | UTCLung cancer for the non-respiratory physician – Clinical Medicine Journal
WHO recommends against the use of convalescent plasma to treat COVID-19.
8 Dec, 2021 | 10:24h | UTCNews Release: WHO recommends against the use of convalescent plasma to treat COVID-19 – World Health Organization
See Guidance: WHO’s living guidelines on COVID-19 therapeutics
Infographic: A living WHO guideline on drugs for covid-19 – The BMJ
Commentary on Twitter (thread – click for more)
Convalescent plasma is a transfusion of blood plasma from someone who has recovered from #COVID19, and is used as a treatment for COVID19 https://t.co/Bobq7OTDGq pic.twitter.com/pfO1sFvUpJ
— World Health Organization (WHO) (@WHO) December 7, 2021
A first, small study suggests Omicron is a larger threat to Covid-19 immunity than other variants.
8 Dec, 2021 | 10:22h | UTCOriginal Study: SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection – medRxiv
Commentary from the author on Twitter (thread – click for more)
We have completed our first experiments on neutralization of Omicron by Pfizer BNT162b2 vaccination elicited immunity
Manuscript available at https://t.co/rGaEB9GdmS
and should be available on medRxiv in the coming days
— Alex Sigal (@sigallab) December 7, 2021
See also (thread – click for more)
New work from AHRI's @sigallab strongly suggests that the SARS-CoV-2 #Omicron variant escapes antibody immunity induced by the Pfizer vaccine, but that considerable immunity is retained in people who were both vaccinated & previously infected. https://t.co/AZWi3qexin pic.twitter.com/3phPFyKEPh
— Africa Health Research Institute (@AHRI_News) December 7, 2021
RCT: In patients with severe Covid-19, high-flow oxygen therapy reduced the likelihood of invasive mechanical ventilation and decreased the time to clinical recovery compared to conventional oxygen therapy.
8 Dec, 2021 | 10:15h | UTCRelated:
Phase 2 RCT: Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule.
8 Dec, 2021 | 10:12h | UTCInvited Commentary: Booster doses for inactivated COVID-19 vaccines: if, when, and for whom – The Lancet Infectious Diseases
Video | COVID-19 Update: Omicron Variant.
8 Dec, 2021 | 10:09h | UTCCOVID-19 Update: Omicron Variant – JAMA
Beyond Omicron: what’s next for COVID’s viral evolution.
8 Dec, 2021 | 10:06h | UTCBeyond Omicron: what’s next for COVID’s viral evolution – Nature
ESC Position Paper: Optimal follow-up after acute pulmonary embolism.
8 Dec, 2021 | 10:02h | UTC
Commentary on Twitter
Do you routinely discuss how/when to resume sporting activities and traveling with your PE patients? Or future cardiovascular risk? Check this recent ESC/ERS position paper on optimal follow-up of acute PE for these and other key aspects of counselling: https://t.co/KEQ7FnFwXX
— Erik Klok (@Erik_Klok_MD) December 7, 2021
Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
8 Dec, 2021 | 09:47h | UTC
The risk of postoperative complications following major elective surgery in active or resolved COVID-19 in the United States – Major, elective surgery 0–4 weeks after Covid-19 is associated with greatly increased risk of postoperative complications; surgery performed 4–8 weeks after infection is still associated with an increased risk of pneumonia.
7 Dec, 2021 | 10:23h | UTCRelated:
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.
Position statement: Perioperative management of post-COVID-19 surgical patients.
Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce.
7 Dec, 2021 | 10:12h | UTC
S2k guideline: diagnosis and treatment of carbon monoxide poisoning.
7 Dec, 2021 | 08:48h | UTCS2k guideline diagnosis and treatment of carbon monoxide poisoning – German Medical Science
Clinical Review: Management of pneumonia in critically ill patients.
7 Dec, 2021 | 08:41h | UTCManagement of pneumonia in critically ill patients – The BMJ
Six different COVID-19 boosters are safe and increase immunity when given after two doses of AstraZeneca or Pfizer-BioNTech, with significant variations in immune responses, UK trial shows.
5 Dec, 2021 | 23:57h | UTCCommentaries:
Six different COVID-19 boosters induce variable immune response – CIDRAP
Covid booster shots significantly strengthen immunity, trial finds – The Guardian
Commentary on Twitter
NEW—Six different COVID-19 boosters are safe and increase immunity when given after two doses of #AstraZeneca or #Pfizer-BioNTech, with large variations in immune responses, UK trial shows. https://t.co/ktUp1m2Rsb pic.twitter.com/wlwxcLYDm1
— The Lancet (@TheLancet) December 2, 2021
European data on Omicron: Out of 109 cases confirmed so far, all cases for which there is available information on severity were either asymptomatic or mild.
5 Dec, 2021 | 23:50h | UTC
Commentary on Twitter:
EUROPEAN EQUIVALENT OF CDC AS OF THIS AM: "All cases [of Omicron] for which there is available information on severity were either asymptomatic or mild. No deaths have been reported among these cases so far.". But let's keep on watching. https://t.co/3jHm4Wezi8
— Monica Gandhi MD, MPH (@MonicaGandhi9) December 3, 2021