Chest Medicine
Viewpoint: Vaping—Seeking Clarity in a Time of Uncertainty
8 Nov, 2019 | 08:28h | UTCVaping—Seeking Clarity in a Time of Uncertainty – JAMA (free for a limited period)
Author Interview: Vaping—Seeking Clarity in a Time of Uncertainty (free audio)
Related: “EVALI” (e-cigarette, or vaping, product use-associated lung injury): CDC Updates Guidance and Creates New Name (free)
Cardiovascular Risk of Electronic Cigarettes: A Review of Preclinical and Clinical Studies
8 Nov, 2019 | 08:22h | UTCCommentaries: Vaping not worth potential heart risk, researchers say – Ohio State University (free) AND Vaping risks significant, says new review – News Medical (free) AND E-cigs may damage the heart, study says – MedicalXpress (free)
Meta-Analysis: Effect of Lung Recruitment Maneuver on Oxygenation, Physiological Parameters and Mortality in ARDS Patients
8 Nov, 2019 | 08:00h | UTCRelated: Alveolar recruitment in acute respiratory distress syndrome: should we open the lung (no matter what) or may accept (part of) the lung closed? – Intensive Care Medicine (free) AND Recruitment maneuver does not provide any mortality benefit over lung protective strategy ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis and systematic review of the randomized controlled trials – Journal of Intensive Care (free) AND Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free study and editorial)
Systematic Review: Strategies to Reduce Non-ventilator-associated Hospital-acquired Pneumonia
8 Nov, 2019 | 08:14h | UTC
Guidelines for the Prevention and Treatment of Acute Altitude Illness
6 Nov, 2019 | 08:41h | UTCRelated: Interventions for treating acute high altitude illness – Cochrane Library (free) AND Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs – Cochrane Library (free) AND Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs – Cochrane Library (free) AND Interventions for preventing high altitude illness: Part 3. Miscellaneous and non‐pharmacological interventions – Cochrane Library (free) AND Acute high-altitude sickness – European Respiratory Review (free) AND High-altitude illness: Management approach – Turkish Journal of Emergency Medicine (free)
[Abstract Only] Randomized Trial: Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest
7 Nov, 2019 | 08:24h | UTCPrevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Routine Antibiotics Help Ventilated Patients After Cardiac Arrest – MedPage Today (free registration required)
Guidelines on Long-term Home Non-invasive Ventilation for Management of COPD
4 Nov, 2019 | 01:26h | UTCSource: EvidenceAlerts
Study: Flavored Tobacco Ban Associated with Reduced Use by Youth
6 Nov, 2019 | 08:12h | UTCShort-Term Impact of a Flavored Tobacco Restriction: Changes in Youth Tobacco Use in a Massachusetts Community – American Journal of Preventive Medicine (free for a limited period)
Commentaries: Restricting flavored tobacco could curb youth use – Reuters (free) AND A tale of two cities: Impact of reducing teens’ access to flavored tobacco products – Elsevier (free) AND One town’s flavor ban seemed to work to cut youth tobacco use – CNN (free)
Related Opinion: Ban Flavored E-Cigarettes to Protect Our Children (free commentaries)
Podcast: Random Pearls in Pulmonary Medicine and Critical Care from #CHEST2019 in New Orleans
5 Nov, 2019 | 08:39h | UTC#179 CHEST 2019 Recap Part 1 – The Curbsiders Internal Medicine Podcast (free audio)
#180 CHEST 2019 Recap Part 2 from New Orleans – The Curbsiders Internal Medicine Podcast (free audio)
Systematic Review: Intra‐pleural Fibrinolytic Therapy for the Treatment of Parapneumonic Effusions and Empyema
31 Oct, 2019 | 08:18h | UTCIntra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult parapneumonic effusions and empyema – Cochrane Library (free)
Summary: Clot-busting drugs for infections of the lining of the lung – Cochrane Library (free)
[Abstract Only] Randomized Trial: Triple Therapy Effective for the Treatment of Cystic Fibrosis
1 Nov, 2019 | 10:22h | UTCElexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele – New England Journal of Medicine (link to abstract – $ for full-text)
Editorial: Realizing the Dream of Molecularly Targeted Therapies for Cystic Fibrosis (free)
Related Research: Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary: Three-drug combo improves lung function in most common genetic form of cystic fibrosis – UT Southwestern Medical Center (free)
Related Commentary on Twitter
Triple treatment of CF patients with one Phe508del allele and one minimal function allele with elexacaftor, tezacaftor and ivacaftor resulted in sustained improvement in FEV1, sweat chloride, and the number of pulmonary exacerbations. #NACFC https://t.co/ATeGlBUWCp
— NEJM (@NEJM) October 31, 2019
Study: Long-term Survival and Cause-specific Mortality of Patients Newly Diagnosed with Tuberculosis
31 Oct, 2019 | 08:27h | UTCLong-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010–15: a population-based, longitudinal study – The Lancet Infectious Diseases (free) (via @otavio_ranzani see Tweet)
Invited Commentary: Tuberculosis: an instrument of early mortality in life course (free)
Related Commentary on Twitter
Important study from Brazil! Post-tuberculosis sequelae and vulnerability are associated with excess mortality and must be addressed to mitigate the tuberculosis burden worldwide. Via @TheLancetInfDis @otavio_ranzani https://t.co/xHtEmBc4Sr
— Madhu Pai, MD, PhD (@paimadhu) October 31, 2019
Update on Oral Appliance Therapy
23 Oct, 2019 | 07:21h | UTCUpdate on oral appliance therapy – European Respiratory Review (free)
Analysis: Is Mycobacterium Tuberculosis Infection Life Long?
27 Oct, 2019 | 23:44h | UTCIs Mycobacterium tuberculosis infection life long? – The BMJ (free)
Commentaries: Tuberculous infection is not life-long in most people – University of Pennsylvania School of Medicine (free) AND In the absence of a true test for latent TB we need shorter, safer preventive treatments – The BMJ Opinion (free)
Related Commentary on Twitter
People with immunoreactivity to tuberculosis are thought to have lifelong asymptomatic infection and remain at risk for active tuberculosis. Is this assumption valid? Marcel A Behr and colleagues argue that most of these people are no longer infected https://t.co/LlRcMNlriJ
— The BMJ (@bmj_latest) October 27, 2019
Things We Do for No Reason: Supplemental Oxygen for Patients without Hypoxemia
27 Oct, 2019 | 23:40h | UTCSee other articles in the series: Choosing Wisely: Things We Do For No Reason (free)
Related: Oxygen therapy for acutely ill medical patients: a clinical practice guideline – The BMJ (free) AND Oxygen Treatment in Intensive Care and Emergency Medicine – Deutsches Ärzteblatt International (free) AND Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary) AND A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less? – BioMed Research International (free)
Cohort Study: Occupational Exposure to Disinfectants Linked to Increased Incidence of COPD Among Nurses
25 Oct, 2019 | 08:36h | UTCCommentaries: Are Disinfectants Putting Nurses at Risk of COPD? – HealthDay (free) AND Nurses Exposed to Chemical Disinfectants May Have Greater Risk Of COPD – MedicalResearch.com (free)
Related Research: Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction (link to abstract and commentaries)
Study: Cigarette Type May Influence Lung Cancer Incidence and Mortality
24 Oct, 2019 | 08:21h | UTCAssociation of Cigarette Type With Lung Cancer Incidence and Mortality: Secondary Analysis of the National Lung Screening Trial – JAMA Internal Medicine (free for a limited period)
Commentaries: Lung cancer incidence and mortality varies by cigarette type – OnMedica (free) AND Lung cancer risk 40% greater in unfiltered cigarette smokers – Healio (free registration required)
Systematic Review: Mobile Phone Text Messaging and App‐based Interventions for Smoking Cessation
24 Oct, 2019 | 08:36h | UTCMobile phone text messaging and app‐based interventions for smoking cessation – Cochrane Library (free)
Summary: Can programmes delivered by mobile phones help people to stop smoking? – Cochrane Library (free)
State of the Art Review: New Advances in the Management of Pulmonary Sarcoidosis
23 Oct, 2019 | 08:20h | UTCNew advances in the management of pulmonary sarcoidosis – The BMJ (free for a limited period)
Related Review: Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis – Mayo Clinic Proceedings: Innovations, Quality & Outcomes (free)
[Abstract Only] Study: Life-Gained–Based vs. Risk-Based Selection of Smokers for Lung Cancer Screening
23 Oct, 2019 | 07:57h | UTCLife-Gained–Based Versus Risk-Based Selection of Smokers for Lung Cancer Screening – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Lung cancer screening based on gains in life expectancy could maximize benefits – ACP Internist (free) AND Life-gained selection approach could expand benefits of lung cancer screening – Medwire News (free)
Review: Treating Restless Legs Syndrome in the Context of Sleep Disordered Breathing Comorbidity
23 Oct, 2019 | 07:19h | UTC
Comorbidities in Idiopathic Pulmonary Fibrosis: An Underestimated Issue
23 Oct, 2019 | 07:20h | UTC
Review: Pulmonary Complications of Immune Checkpoint Inhibitors in Patients with Nonsmall Cell Lung Cancer
23 Oct, 2019 | 07:18h | UTCRelated: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)
Update on Management of Stable COPD
22 Oct, 2019 | 08:01h | UTCUpdate on management of stable chronic obstructive pulmonary disease – Journal of Thoracic Disease (free)
Related Guidelines: 2019 Global Strategy for Prevention, Diagnosis and Management of COPD – GOLD Reports 2019 (free PDF) AND Chronic obstructive pulmonary disease in over 16s: diagnosis and management – National Institute for Health and Care Excellence (free)
Podcast: Tuberculosis Updates
22 Oct, 2019 | 08:05h | UTC#178 Tuberculosis Updates with Laila Woc-Colburn MD – The Curbsiders Internal Medicine Podcast (free audio)