Chest Medicine
Meta-Analysis: ALK Inhibitors for Non-small Cell Lung Cancer
21 Feb, 2020 | 10:33h | UTC
Global Burden of Disease Study: Trends and Risk Factors of Mortality and Disability-Adjusted Life Years for Chronic Respiratory Diseases
20 Feb, 2020 | 11:00h | UTCCommentary: Sharp rise in lung disease deaths over past 27 years – OnMedica (free)
Related Commentary on Twitter
There has been an increase in deaths and disability due to chronic respiratory (lung) diseases over the past three decades, finds an analysis of data from 195 countries #BMJResearch https://t.co/FEmeZ5JjEI
— The BMJ (@bmj_latest) February 20, 2020
Study: Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI (E-Cigarette, or Vaping, Product Use–Associated Lung Injury)
20 Feb, 2020 | 10:22h | UTCVideo Summary: Vitamin E Acetate Associated with EVALI (free)
Related Report: Syndromic Surveillance for E-Cigarette, or Vaping, Product Use–Associated Lung Injury – new England Journal of Medicine (free)
See also: The EVALI and Youth Vaping Epidemics — Implications for Public Health – New England Journal of Medicine (free) AND CDC: Vaping Lung Illness Probably Caused by Vitamin E Acetate (free resources)
[Abstract Only] Meta-Analysis: Clinical Pre‐test Probability Adjusted vs. Age‐adjusted D‐dimer Interpretation Strategy for DVT Diagnosis
20 Feb, 2020 | 08:36h | UTCClinical pre‐test probability adjusted versus age‐adjusted D‐dimer interpretation strategy for DVT diagnosis: A diagnostic individual patient data meta‐analysis – Journal of Thrombosis and Haemostasis (link to abstract – $ for full-text)
Commentary: Clinical Pre-test Prob vs. Age-adjusted D-dimer for DVT – The Meta Analysis – JournalFeed (free)
Related Studies: Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability – New England Journal of Medicine (link to abstract and commentary) AND Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism: The ADJUST-PE Study – JAMA (free)
China Releases Largest Study on COVID-19 Outbreak with Over 44.000 Patients – Elderly and Sick are Most at Risk
19 Feb, 2020 | 10:23h | UTCThe Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) – China, 2020 – China CDC Weekly (free PDF – link via Forbes)
Commentaries: Coronavirus: Largest study suggests elderly and sick are most at risk – BBC (free) AND New Chinese Study Finds That The Elderly Are Most At Risk From The Coronavirus [Infographic] – Forbes (free) AND Expert reaction to WHO Director General’s statement on new paper from China detailing over 44,000 of their cases – Science Media Centre (free)
Guideline Synopsis: Management of Chronic Insomnia Disorder and Obstructive Sleep Apnea
18 Feb, 2020 | 08:25h | UTCCommentary: New VA/DoD guidelines address sleep-related issues in military personnel, veterans – University of Texas Health Science Center at San Antonio (free)
Observational Study: Empirical Anti-MRSA Antibiotic Therapy Does Not Improve Outcomes in Patients Hospitalized for Pneumonia
18 Feb, 2020 | 08:15h | UTCEmpirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia – JAMA Internal Medicine (free for a limited period)
Editorial: Overuse of Broad-Spectrum Antibiotics for Pneumonia (free for a limited period)
Related Commentary on Twitter
NEW 🔥⚡Retrospective multicenter cohort study @JAMA_current
Empirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia. #IDTwitter #medtwitter https://t.co/X0jWhMaUMT pic.twitter.com/FwNadOZrjx— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 17, 2020
Meta-Analysis: Subglottic Secretion Drainage for Preventing Ventilator-associated Pneumonia
18 Feb, 2020 | 08:01h | UTC
Current and Future Applications of Liquid Biopsy in Nonsmall Cell Lung Cancer from Early to Advanced Stages
18 Feb, 2020 | 08:02h | UTC
Extracorporeal Membrane Oxygenation for Refractory Cardiac Arrest: A Retrospective Multicenter Study
16 Feb, 2020 | 21:02h | UTC
Basic Point‐of‐care Ultrasound Framework Based on the Airway, Breathing, and Circulation Approach for the Initial Management of Shock and Dyspnea
16 Feb, 2020 | 20:46h | UTCSource: Grupo UTIclínica – HCFMUSP
CDC Guidelines for the Treatment of Latent Tuberculosis Infection
14 Feb, 2020 | 02:22h | UTCRelated: WHO Guideline: Latent TB Infection (free) AND Study: Rifampicin is Likely to be the Safest Latent Tuberculosis Infection Treatment Option (free)
Commentary: Guidelines Updated on Treating Latent TB – NEJM Journal Watch (free)
Clinical Updates: Management of Acute and Chronic Asthma in Adults in 2020
14 Feb, 2020 | 02:06h | UTCManagement of Acute Asthma in Adults in 2020 – JAMA (free for a limited period)
Related Article: Outpatient Management of Chronic Asthma in 2020 – JAMA (free for a limited period)
Editorial: New Therapeutic Strategies for Asthma – JAMA (free for a limited period)
[Abstract Only] Randomized Trial: Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
13 Feb, 2020 | 08:00h | UTCPlasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)
Visual Abstract: Plasma Exchange and Glucocorticoids for ANCA-Associated Vasculitis (free)
Commentary: PEXIVAS: No benefit of plasma exchange in ANCA-associated vasculitis – Medicine Matters (free)
[Abstract Only] Randomized Trial: Dexamethasone for the Treatment of Acute Respiratory Distress Syndrome
12 Feb, 2020 | 07:24h | UTCDexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Related: Meta-Analysis: Assessment of Therapeutic Interventions and Lung Protective Ventilation in Patients with Moderate to Severe Acute Respiratory Distress Syndrome (free resources on the subject)
Related Commentary on Twitter
#Dexamethasone is associated with a substantial reduction in duration of mechanical #ventilation and all-cause 60-day #mortality in patients with #ARDS
New RCT from Jesús ViIlar and colleagues https://t.co/b4sW2K0RwG pic.twitter.com/MBbeSWBo55
— The Lancet Respiratory Medicine (@LancetRespirMed) February 10, 2020
Critical Care Management of Adults with Community-acquired Severe Respiratory Viral Infection
11 Feb, 2020 | 02:25h | UTC
Systematic Review: Schistosomiasis-associated Pulmonary Arterial Hypertension
11 Feb, 2020 | 01:59h | UTC
Clinical Controversies in Anticoagulation Monitoring and Antithrombin Supplementation for ECMO
11 Feb, 2020 | 01:44h | UTC
[Abstract Only] Meta-Analysis: Corticosteroids as Adjunctive Therapy in the Treatment of Influenza
9 Feb, 2020 | 20:13h | UTCCorticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis – Critical Care Medicine (link to abstract – $ for full-text)
Mini-Review: Corticosteroids in Community-Acquired Pneumonia
7 Feb, 2020 | 08:16h | UTCCorticosteroids in Community-Acquired Pneumonia – JAMA (free for a limited period)
Related Meta-analysis: Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis – PLOS One (free) AND Adjunctive Systemic Corticosteroids for Hospitalized Community-Acquired Pneumonia: Systematic Review and Meta-Analysis 2015 Update – Scientific Reports (free)
Related Cochrane Review: Is Treatment With Corticosteroids Beneficial for People With Pneumonia? (free)
Guideline Synopsis: Diagnosis and Treatment of Adults with Community-Acquired Pneumonia
7 Feb, 2020 | 08:17h | UTCDiagnosis and Treatment of Adults with Community-Acquired Pneumonia – JAMA (free for a limited period)
See also: Treatment Algorithm (free)
Original Article: ATS/IDSA Guideline: Diagnosis and Treatment of Adults with Community-acquired Pneumonia (free resources)
Related Guideline: NICE Guideline: Management of Pneumonia in Adults (free resources)
Meta-Analysis: Association of Home Noninvasive Positive Pressure Ventilation with Clinical Outcomes in COPD
5 Feb, 2020 | 08:20h | UTCAssociation of Home Noninvasive Positive Pressure Ventilation With Clinical Outcomes in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis – JAMA (free for a limited period)
Commentary: In-home breathing device may offer hope for people with COPD – News Medical (free)
Guideline: Enhanced Recovery After Lung Surgery
4 Feb, 2020 | 08:00h | UTCRelated: Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS) – European Journal of Cardio-Thoracic Surgery (free) AND Enhanced recovery programs in lung cancer surgery: systematic review and meta-analysis of randomized controlled trials – Cancer Management and Research (free)
See also other Enhanced Recovery After Surgery (ERAS) Guidelines (free)
Ventilator-Associated Tracheobronchitis: To Treat or Not to Treat?
2 Feb, 2020 | 19:43h | UTCVentilator-Associated Tracheobronchitis: To Treat or Not to Treat? – Antibiotics (free) (via @ABsteward)
[Abstract Only] Randomized Trial: Conservative vs. Interventional Treatment for Spontaneous Pneumothorax
30 Jan, 2020 | 07:45h | UTCConservative versus Interventional Treatment for Spontaneous Pneumothorax – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: ‘Hands Off approach’ best to treat a collapsed lung – study – Voxy (free) AND Don’t Just Do Something, Stand There (Watching Spontaneous Pneumothoraces) – NEJM Journal Watch (free)
Related Commentary on Twitter
More than 250 patients with uncomplicated, primary spontaneous pneumothorax were treated conservatively or by pleural intervention. https://t.co/p13HeYt3os
— NEJM (@NEJM) January 29, 2020