Chest Medicine
Review: Pharmacologic Treatments for COVID-19
14 Apr, 2020 | 03:05h | UTCPharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review – JAMA
Video: New York City Coronavirus (COVID-19) Update
14 Apr, 2020 | 03:03h | UTCNew York City Coronavirus (COVID-19) Update – JAMA
Ethics in the Time of Coronavirus: Recommendations in the COVID-19 Pandemic
14 Apr, 2020 | 03:00h | UTC
Commentary on the New IDSA’s COVID-19 Treatment Guidelines
14 Apr, 2020 | 02:49h | UTCSee Original Guideline: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19
Study Validates Loss of Smell and Taste as Symptoms of Covid-19
14 Apr, 2020 | 02:57h | UTC
Face Masks Against COVID-19: An Evidence Review
14 Apr, 2020 | 02:52h | UTCFace Masks Against COVID-19: An Evidence Review – Preprints
Related Analysis: Face Masks for the Public During the Covid-19 Crisis
Richard Lehman’s Covid-19 Reviews
14 Apr, 2020 | 02:46h | UTCRichard Lehman’s covid-19 reviews—13 April 2020 – The BMJ Opinion
“In this weekly round-up, Richard Lehman looks at a personal selection of articles of relevance to clinicians dealing with covid-19.”
IDSA Guidelines on the Treatment and Management of Patients with COVID-19 Infection
13 Apr, 2020 | 00:27h | UTC
Related Commentary on Twitter
NEW: IDSA Guidelines on the Treatment & Management of Patients with COVID-19 Infection. These evidence-based rapid guidelines, updated in real-time, will address pressing clinical questions related to caring for patients w/ COVID-19: https://t.co/mvi9Paa8Xv #COVID19Guidelines pic.twitter.com/NKbYAbO21J
— IDSA (@IDSAInfo) April 11, 2020
Compassionate Use of Remdesivir for Patients with Severe Covid-19
13 Apr, 2020 | 00:23h | UTCCompassionate Use of Remdesivir for Patients with Severe Covid-19 – New England Journal of Medicine
Commentaries: PulmCrit – Eleven reasons the NEJM paper on remdesivir reveals nothing AND Expert reaction to a study about compassionate use of remdesivir for patients with severe COVID-19 – Science Media Centre AND What Do the New Remdesivir Data Mean? – Science Translational Medicine
Possible Algorithm to Empiric Anticoagulation in COVID-19 Based on D-Dimer
13 Apr, 2020 | 00:20h | UTCD-dimer cutoffs to predict thrombosis in COVID-19 – PulmCrit
Note: this link is not an endorsement of the algorithm.
Related Guidance: Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 – Thrombosis UK AND ISTH interim guidance on recognition and management of coagulopathy – Journal of Thrombosis and Haemostasis
Incidence of Thrombotic Complications in Critically ill ICU Patients with COVID-19
13 Apr, 2020 | 00:22h | UTCRelated Observational Studies: Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis AND Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy – Journal of Thrombosis and Haemostasis AND Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis
Implementation Guide: Optimizing Medication Management during the COVID-19 Pandemic
13 Apr, 2020 | 00:18h | UTC
Related Commentary on Twitter
Task force recommendations about managing meds in post-acute and long-term care during COVID-19. https://t.co/yoU76suVYo
Summary of recommendations in thread below:
— Mike Steinman (@MikeSteinman) April 10, 2020
Studies: Obesity Increases the Risk of Complications in Patients with Covid-19
13 Apr, 2020 | 00:14h | UTC2 – Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission – Clinical Infectious Diseases AND Commentary: In New York, obesity appears to raise COVID-19 risk – CIDRAP
Mechanical Ventilators Adapted from BiPAP machines?
13 Apr, 2020 | 00:17h | UTC- Modified Sleep Apnea Machines May Ease the Ventilator Crunch – Wired
- Mechanical ventilators based on a simple modification of CPAP and BiPAP machines – News Medical
- A NYC hospital has figured out how to turn sleep apnea machines it got from Elon Musk into ventilators for coronavirus patients – Business Insider
- Turning sleep apnea machines into ventilators – Berkley Engineering
See instructions and protocols developed by Mount Sinai Health System: Repurposing bi-level ventilators for use with intubated patients while minimizing risk to health care works during insufficient supply of conventional ventilation for patients with COVID-19
We want to learn more about this interesting initiative!
Study: Antibody Tests Reveal 14% are Immune to Covid-19 in German Town
13 Apr, 2020 | 00:10h | UTC- Blood tests show 14% of people are now immune to covid-19 in one town in Germany – MIT Technology Review
- COVID antibody test in German town shows 15 percent infection rate – Spectator
- Expert reaction to unpublished preliminary findings looking at the presence of antibodies to SARS-CoV-2 virus in residents of Gangelt, in Germany – Science Media Centre
The original report can be found here (in German)
Studies: Diabetes Increases the Risk of Complications in Patients with Covid-19
13 Apr, 2020 | 00:12h | UTC1 – Prevalence and impact of diabetes among people infected with SARS-CoV-2 – Journal of Endocrinological Investigation AND Commentary: Diabetes Could Increase Severity of COVID-19, Including Risk of ICU Admission and Death – MedicalResearch.com
2 – Evidence Reviews: Diabetes and risks from COVID-19 – CEBM University of Oxford AND Managing diabetes during the COVID-19 pandemic – CEBM University of Oxford
[Preprint] Factors Associated with Worse Outcomes Among 4,103 Patients with COVID-19 in New York City
13 Apr, 2020 | 00:09h | UTC
Opinion – BCG Against Coronavirus: Less Hype and More Evidence, Please
13 Apr, 2020 | 00:06h | UTCSee new Preprints suggesting caution in correlating BCG vaccination policies with COVID-19 incidence and mortality:
- [Preprint] BCG protects against COVID-19? A word of caution – medRxiv
- [Preprint] Exercising caution in correlating COVID-19 incidence and mortality rates with BCG vaccination policies due to variable rates of SARS CoV-2 testing – medRxiv
- [Preprint] Association Between BCG Policy is Significantly Confounded by Age and is Unlikely to Alter Infection or Mortality Rates – medRxiv
See previous studies suggesting a benefit from BCG vaccination:
- Observational Studies: Countries with Universal BCG Vaccination Policy May Have Reduced Mortality from COVID-19 (preprints on the subject)
Updated Guidance on Personal Protective Equipment (PPE) for Clinicians
13 Apr, 2020 | 00:02h | UTCUpdated guidance on Personal Protective Equipment (PPE) for clinicians – Intensive Care Society
Related: Clinical guidance for intensive care and anesthetics AND COVID-19: guidance for health professionals – GOV.UK
COVID-19 Testing: The Threat of False-Negative Results
13 Apr, 2020 | 00:04h | UTCCOVID-19 Testing: The Threat of False-Negative Results – Mayo Clinic Proceedings
Commentary: False-negative COVID-19 test results may lead to false sense of security – Mayo Clinic
New Clinical Score: Prediction for Progression Risk in Patients with COVID-19 Pneumonia
12 Apr, 2020 | 23:58h | UTCPrediction for Progression Risk in Patients with COVID-19 Pneumonia: the CALL Score – Comorbidity; older Age; Lower lymphocyte; and higher Lactate dehydrogenase at presentation were independent high-risk factors for COVID-19 progression. (via @veselov78 see Tweet)
NICE Publishes new COVID-19 Guidelines on Cystic Fibrosis, COPD and Dermatological Conditions
10 Apr, 2020 | 03:22h | UTCSee New COVID-19 Rapid Guidelines: Community-based care of patients with chronic obstructive pulmonary disease (COPD) AND Cystic fibrosis AND Dermatological conditions treated with drugs affecting the immune response
See Other COVID-19 Rapid Guidelines: Severe asthma AND Managing suspected or confirmed pneumonia in adults in the community AND Rheumatological autoimmune, inflammatory and metabolic bone disorders AND Managing symptoms (including at the end of life) in the community AND Critical care in adults AND Hematopoietic stem cell transplantation AND Dialysis service delivery AND Delivery of radiotherapy AND Delivery of systemic anticancer treatments
Meta-Analysis: Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples
10 Apr, 2020 | 03:03h | UTCCommentary: Gastrointestinal Aspects of COVID-19 – NEJM Journal Watch
Analysis: Face Masks for the Public During the Covid-19 Crisis
10 Apr, 2020 | 02:58h | UTCFace masks for the public during the covid-19 crisis – The BMJ
Commentary: Time to encourage people to wear face masks as a precaution, say experts – The BMJ
Related: Covid-19: What is the evidence for cloth masks? – The BMJ AND Covid-19: Should cloth masks be used by healthcare workers as a last resort? – The BMJ
“- The precautionary principle states we should sometimes act without definitive evidence, just in case
– Whether masks will reduce transmission of covid-19 in the general public is contested
– Even limited protection could prevent some transmission of covid-19 and save lives
– Because covid-19 is such a serious threat, wearing masks in public should be advised”
See also: CDC Now Recommends Wearing Cloth Face Coverings in Public Settings (statement and commentaries)
Managing the Supportive Care Needs of Those Affected by COVID-19
10 Apr, 2020 | 03:01h | UTCManaging the supportive care needs of those affected by COVID-19 – European Respiratory Journal