Chest Medicine
COVID-19 and Renin Angiotensin Blockers: Current Evidence and Recommendations
20 Apr, 2020 | 00:00h | UTCCOVID-19 and Renin Angiotensin Blockers: Current Evidence and Recommendations – Circulation
Commentary: COVID-19 and Renin Angiotensin Blockers – American College of Cardiology
Coronavirus: Nine in 10 Dying Have Existing Illness
17 Apr, 2020 | 02:20h | UTCCoronavirus: Nine in 10 dying have existing illness – BBC
Original Report: Deaths involving COVID-19, England and Wales: deaths occurring in March 2020 – Office for National Statistics
Study Commentary: Hydroxychloroquine Fails First Meaningful RCT
17 Apr, 2020 | 02:25h | UTCHydroxychloroquine fails first meaningful RCT – PulmCrit
Original Study: Hydroxychloroquine for Covid-19: No Benefit in New Open-label, Randomized Trial
Related Commentary: Hydroxychloroquine in the management of critically ill patients with COVID-19: the need for an evidence base – The Lancet Respiratory Medicine
Pathological Evidence of Pulmonary Thrombotic Phenomena in Severe COVID-19
17 Apr, 2020 | 02:24h | UTC* We congratulate the authors for this significant contribution to the understanding of this disease.
Meta-Analysis: Hematologic, Biochemical and Immune Biomarker Abnormalities Associated with Severe Illness and Mortality in COVID-19
17 Apr, 2020 | 02:22h | UTC“non-survivors compared to survivors had more significant increases in WBC count, total bilirubin, creatine kinase, serum ferritin, and interleukin 6 (IL-6), and more significant decreases in lymphocyte count and platelet count.”
Innovation and Transformation in the Response to Covid-19: Seven Areas Where Clinicians Need to Lead
17 Apr, 2020 | 02:11h | UTC
Chest CT and Coronavirus Disease (COVID-19): A Critical Review of the Literature to Date
17 Apr, 2020 | 02:08h | UTC
German Recommendations for Critically Ill Patients with COVID 19
17 Apr, 2020 | 02:02h | UTC
Neurologic Features in Severe SARS-CoV-2 Infection
16 Apr, 2020 | 02:56h | UTCNeurologic Features in Severe SARS-CoV-2 Infection – New England Journal of Medicine
Related Study: Neurologic Manifestations Common in Hospitalized Patients with Covid-19 (study and commentaries)
Podcast: Caring for Patients with Covid-19
16 Apr, 2020 | 02:57h | UTCAudio Interview: Caring for Patients with Covid-19 – New England Journal of Medicine
Review: Hematological Findings and Complications of COVID‐19
16 Apr, 2020 | 02:40h | UTCHematological findings and complications of COVID‐19 – American Journal of Hematology
Video: Visualizing Speech-Generated Oral Fluid Droplets with Laser Light Scattering
16 Apr, 2020 | 02:59h | UTCCommentaries: Droplets and Aerosols in the Transmission of SARS-CoV-2 – New England Journal of Medicine AND Simply speaking could transmit coronavirus, new study suggests – STAT
NIH Study Validates Decontamination Methods for Re-use of N95 Respirators
16 Apr, 2020 | 02:50h | UTCNews Release: NIH study validates decontamination methods for re-use of N95 respirators – NIH News Releases
Original Study: [Preprint] Assessment of N95 respirator decontamination and re-use for SARS-CoV-2 – medRxiv
COVID-19: The Case for Health-care Worker Screening to Prevent Hospital Transmission
16 Apr, 2020 | 02:53h | UTCCOVID-19: the case for health-care worker screening to prevent hospital transmission – The Lancet
Related Commentary on Twitter
Every #healthcare worker must be tested for #COVID19 (should have been weeks ago, and needs to be serially assessed going forward). This isn't happening. The case is well laid out here today:
https://t.co/pS9MYfZdJw@TheLancet by @TheCrick's @CharlesSwanton and colleagues @UCL pic.twitter.com/d4VPmI5LwQ— Eric Topol (@EricTopol) April 15, 2020
Study Confirms Substantial Presymptomatic Transmission of Covid-19
16 Apr, 2020 | 02:52h | UTCTemporal dynamics in viral shedding and transmissibility of COVID-19 – Nature Medicine
Commentaries: People might be most infectious with coronavirus before they show symptoms, study suggests – CNN AND Expert reaction to a study looking at the timing of SARS-CoV-2 transmission – Science Media Centre
Evidence Based Management Guideline for the COVID-19 Pandemic
16 Apr, 2020 | 02:48h | UTC
Study: Some Social Distance May Need to Continue Until 2022
15 Apr, 2020 | 03:47h | UTCProjecting the transmission dynamics of SARS-CoV-2 through the postpandemic period – Science
Commentaries: Coronavirus distancing may need to continue until 2022, say experts – The Guardian AND Harvard Researchers Say Some Social Distancing May Be Needed Into 2022 – Bloomberg AND Researchers Say Social Distancing To Prevent Coronavirus May Need To Continue Until 2022 – Forbes AND Some social distancing may be needed into 2022 to keep coronavirus in check, new study says – STAT
Related Commentary on Twitter
They had me at "Prolonged or intermittent social distancing may be necessary into 2022." An important new @Sciencemagazine paper on what to expect in the #COVID19 "post pandemic" periodhttps://t.co/x1KlVanIxo @mlipsitch @yhgrad @StephenKissler and colleagues @HarvardChanSPH pic.twitter.com/mq2QIWvfgk
— Eric Topol (@EricTopol) April 14, 2020
New ATS Guideline: Pharmacologic Management of COPD
15 Apr, 2020 | 03:49h | UTCCommentary: New COPD Guidelines Issued – NEJM Journal Watch
Ending Coronavirus Lockdowns Will be a Dangerous Process of Trial and Error
15 Apr, 2020 | 03:45h | UTCEnding coronavirus lockdowns will be a dangerous process of trial and error – Science
Related: ‘Suppress and lift’: Hong Kong and Singapore say they have a coronavirus strategy that works – Science AND Opinions on Lifting Coronavirus Pandemic Lockdowns (opinions and report) AND Scott Gottlieb on how, and when, to end social distancing – Vox
Review by Dr. Martin Tobin – Basing Respiratory Management of Coronavirus on Physiological Principles
15 Apr, 2020 | 03:36h | UTC
Related Commentary on Twitter (Thread – Click for More)
some pearls from an article by Martin Tobin about when to intubate patients with COVID (yep, the same one who edited Tobin's textbook on mechanical ventilation)… (#1/6)
(full article: https://t.co/YNeETU077D) pic.twitter.com/bpkEsJ6m2R— 𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊 (@PulmCrit) April 14, 2020
Hydroxychloroquine for Covid-19: No Benefit in New Open-label, Randomized Trial
15 Apr, 2020 | 03:42h | UTC[Preprint] Hydroxychloroquine in patients with COVID-19: an open-label, randomized, controlled trial – medRxiv
See also just published observational study (Preprint): No evidence of clinical efficacy of hydroxychloroquine in patients hospitalized for COVID-19 infection with oxygen requirement: results of a study using routinely collected data to emulate a target trial – medRxiv
Related Commentary on Twitter
#COVID19 Here comes another dataset of #Hydroxychloroquine from an open-label randomized controlled trial in Chinahttps://t.co/qW93wMDILK
No difference in 28-day #coronavirus negative conversion rate for HCQ + SOC vs SOC
No difference in 28-day symptoms alleviation rate either pic.twitter.com/pOsBSQWeuO
— Andy Biotech (@AndyBiotech) April 14, 2020
FDA Issues Emergency Use Authorization to Decontaminate Millions of N95 Respirators
15 Apr, 2020 | 03:38h | UTCCommentary: FDA clears N95 decontamination process that could clean up to 4 million masks per day – Tech Crunch
CEBM Oxford COVID-19 Evidence Updates:
15 Apr, 2020 | 03:32h | UTC“Current data do not support the use of hydroxychloroquine for prophylaxis or treatment of COVID-19.”
- How can pandemic spreads be contained in care homes?
- Editor’s commentary: Rapid reviews of PPE – an update
- “When will it be over?”: An introduction to viral reproduction numbers, R0 and Re
Review: Diagnosis and Management of Obstructive Sleep Apnea
15 Apr, 2020 | 03:14h | UTCDiagnosis and Management of Obstructive Sleep Apnea: A Review – JAMA (free for a limited period)
Review: Diagnostic Testing for SARS-CoV-2
14 Apr, 2020 | 03:06h | UTC