Chest Medicine
Editorial: encouraging results from phase 1/2 COVID-19 vaccine trials
21 Jul, 2020 | 09:35h | UTCEncouraging results from phase 1/2 COVID-19 vaccine trials – The Lancet
Commentaries: Promising early findings for 2 more COVID-19 vaccines – CIDRAP AND Expert reaction to two vaccine candidate studies: a phase 1/2 trial of the University of Oxford’s ChAdOx1 vaccine candidate; and a phase 2 trial of China’s Ad5-vectored COVID-19 vaccine candidate – Science Media Centre
[Press release-based medicine…] Synairgen announces positive results from trial of SNG001 in hospitalized COVID-19 patients
21 Jul, 2020 | 09:27h | UTCSynairgen announces positive results from trial of SNG001 in hospitalised COVID-19 patients
Commentaries: New Treatment for Covid-19 Shows Promise, but Scientists Urge Caution – The New York Times AND Expert reaction to announcement by Synairgen that their drug SNG001 has had positive results in initial trials on COVID-19 patients – Science Media Centre AND Trial of Covid-19 drug given via inhaler ‘very promising’, say scientists – The Guardian
Phase 1/2 randomized trial: safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2
21 Jul, 2020 | 09:33h | UTCCommentaries: New study reveals Oxford coronavirus vaccine produces strong immune response – University of Oxford AND Oxford’s Covid-19 vaccine appears safe and induces immune response, early results suggest, but more research is needed – CNN AND Early Oxford-AstraZeneca Coronavirus Vaccine Data ‘Encouraging,’ Scientists Say – NPR
Related Commentary on Twitter
NEW—UK’s #COVID19 vaccine is safe and induces an immune reaction, according to preliminary results https://t.co/rDPlB9fDKr pic.twitter.com/z2t9Aubjim
— The Lancet (@TheLancet) July 20, 2020
[Preprint] Covid-19: Six clusters of symptoms could be used as a clinical prediction tool
21 Jul, 2020 | 09:25h | UTCCommentaries: Covid-19: Study reveals six clusters of symptoms that could be used as a clinical prediction tool – The BMJ AND Six distinct ‘types’ of COVID-19 identified – King’s College London AND Coronavirus symptoms fall into six different groupings, study finds – The Guardian
Randomized trial: dexamethasone in hospitalized patients with Covid-19
20 Jul, 2020 | 08:18h | UTCCommentary: Trial data support dexamethasone, but not hydroxychloroquine, for COVID-19 – CIDRAP
Related Commentary on Twitter
A randomized controlled trial testing dexamethasone for Covid-19 (the RECOVERY trial) showed that, compared with usual care, this corticosteroid drug reduced 28-day mortality in hospitalized patients. #COVID19 #SARSCoV2
— NEJM (@NEJM) July 18, 2020
The role of chest radiography in confirming Covid-19 pneumonia
20 Jul, 2020 | 08:13h | UTCThe role of chest radiography in confirming covid-19 pneumonia – The BMJ
Related Commentary on Twitter
"No single feature of covid-19 pneumonia on a chest radiograph is specific or diagnostic, but a combination of multifocal peripheral lung changes of ground glass opacity and/or consolidation, which are most commonly bilateral, may be present."#BMJEducation https://t.co/22nRTBVxmj
— The BMJ (@bmj_latest) July 19, 2020
Is coronavirus reinfection possible?
20 Jul, 2020 | 08:01h | UTCIs Coronavirus Reinfection Possible? – Self
Serology testing in the COVID-19 pandemic response
20 Jul, 2020 | 08:02h | UTCSerology testing in the COVID-19 pandemic response – The Lancet Infectious Diseases
Histopathology and ultrastructural findings of fatal COVID-19 infections
20 Jul, 2020 | 08:04h | UTC
Related Commentary on Twitter
NEW Case Series—Histopathology and ultrastructural findings of 14 fatal #COVID19 infections in Washington State shows primary pathology as diffuse alveolar damage, with virus located in the pneumocytes and tracheal epithelium @UWMedicinehttps://t.co/vZggyxhjU1 pic.twitter.com/AFeuiMiH26
— The Lancet (@TheLancet) July 17, 2020
Review: clinical presentation and management of COVID ‐19
20 Jul, 2020 | 07:51h | UTCClinical presentation and management of COVID ‐19 – Medical Journal of Australia
Palliative care for patients with severe Covid-19
17 Jul, 2020 | 08:51h | UTCPalliative care for patients with severe covid-19 – The BMJ
Coronavirus drug and treatment tracker
17 Jul, 2020 | 08:46h | UTCCoronavirus Drug and Treatment Tracker – The New York Times
RIP Hydroxychloroquine? 2 studies show no benefit in early/mild COVID-19
17 Jul, 2020 | 08:59h | UTCCommentaries: New Covid-19 study, despite flaws, adds to case against hydroxychloroquine – STAT AND Hydroxychloroquine also doesn’t help Covid-19 patients who aren’t hospitalized, new study finds – CNN
How deadly is the coronavirus? The true fatality rate is tricky to find, but researchers are getting closer
17 Jul, 2020 | 08:38h | UTC
Open letter: challenge trials for COVID-19
17 Jul, 2020 | 08:48h | UTCChallenge Trials for COVID-19 – 1 Day Sooner
Commentary: Scientists call for volunteers to be infected with the coronavirus to test vaccines – CNBC
What happens if Covid-19 symptoms don’t go away? Doctors are trying to figure it out
17 Jul, 2020 | 08:42h | UTCWhat happens if Covid-19 symptoms don’t go away? Doctors are trying to figure it out – Vox
Coronavirus: why are some people experiencing long-term fatigue?
17 Jul, 2020 | 08:40h | UTCCoronavirus: why are some people experiencing long-term fatigue? – The Conversation
[Preprint] RECOVERY trial: effect of hydroxychloroquine in hospitalized patients with COVID-19
16 Jul, 2020 | 08:39h | UTC
Related Commentary on Twitter (Thread – Click for more)
HYDROXYCHLOROQUINE – Recovery trial results finally out – and hopefully puts nail in coffin. Out of 4700 people randomized… HCQ did NOT lower #covid19 mortality. It anything it was trending in wrong direction. Thread 🧵 https://t.co/6Iu0NEejON pic.twitter.com/6l85Nmz4id
— Eric Feigl-Ding (@DrEricDing) July 15, 2020
Covid-19: experts criticize claim that remdesivir cuts death rates
16 Jul, 2020 | 08:31h | UTCCovid-19: Experts criticise claim that remdesivir cuts death rates – The BMJ
Related Commentary on Twitter
Experts have criticised pharmaceutical firm Gilead Sciences after it released data suggesting that its antiviral drug remdesivir can reduce death rates for patients with covid-19. They say the research is intrinsically flawed @MartinLandray https://t.co/a1q2FxMa7C
— The BMJ (@bmj_latest) July 14, 2020
ATS Guideline: Initiating pharmacologic treatment in tobacco-dependent adults
16 Jul, 2020 | 08:20h | UTCCommentary: ATS releases new practice guideline on treating tobacco dependence in adult smokers – News Medical
Study: universal masking in a health care system was associated with a significantly lower rate of SARS-CoV-2 positivity among health care workers
15 Jul, 2020 | 08:33h | UTCEditorial: Universal Masking to Prevent SARS-CoV-2 Transmission—The Time Is Now – JAMA
Commentaries: CDC director: We can control virus in 4 to 8 weeks if everyone in the US wears a mask – Business Insider AND CDC Director: It’s Time For Universal Masking To End Covid-19 Pandemic – Forbes
Absence of apparent transmission of SARS-CoV-2 from two stylists after exposure at a hair salon with a universal face covering policy
15 Jul, 2020 | 08:29h | UTCCommentary: How two hairstylists with COVID-19 saw 139 clients without passing on the virus – CTV
Related Commentary on Twitter
Absence of Apparent Transmission of SARS-CoV-2 from Two Stylists… https://t.co/6EyzHmLGDv via @CDCgov. What’s the take home message? FACE MASKS WORK! #WearAMaskSaveALife
— Carlos del Rio (@CarlosdelRio7) July 14, 2020
An mRNA vaccine against SARS-CoV-2 — preliminary report
15 Jul, 2020 | 08:25h | UTCAn mRNA Vaccine against SARS-CoV-2 — Preliminary Report – New England Journal of Medicine
Editorial: The Covid-19 Vaccine-Development Multiverse – New England Journal of Medicine
Commentaries: Experimental COVID-19 vaccine safe, generates immune response – NIH News Release AND First data for Moderna Covid-19 vaccine show it spurs an immune response – STAT
CHEST Supplement: an overview of study design and statistical considerations
15 Jul, 2020 | 08:18h | UTCHomepage: An Overview of Study Design and Statistical Considerations – CHEST
- Introduction
- Statistical Analysis and Reporting Guidelines for CHEST
- Sample Size Estimation in Clinical Research: From Randomized Controlled Trials to Observational Studies
- Using Causal Diagrams to Improve the Design and Interpretation of Medical Research
- A Framework for the Evaluation of Statistical Prediction Models
- A Practical Overview and Reporting Strategies for Statistical Analysis of Survival Studies
- Considerations for Reporting and Reviewing Studies Including Health-Related Quality of Life
- A Practical Overview of Case-Control Studies in Clinical Practice
- Cross-Sectional Studies: Strengths, Weaknesses, and Recommendations
- Cohort Studies: Design, Analysis, and Reporting
- Randomized Controlled Trials
- Economic Evaluation Studies
- Meta-Analysis
- Studies of Medical Tests: Design and Analytical Considerations
- A Bioinformatics Crash Course for Interpreting Genomics Data
Researchers develop COVID-19 mortality risk calculator
14 Jul, 2020 | 08:33h | UTCResearchers develop COVID-19 mortality risk calculator – News Medical
Original Study [Preprint]: COVID-19 Mortality Risk Assessment: An International Multi-Center Study – medRxiv
See Calculator: COVID Analytics
Related Commentary on Twitter
Our team developed and validated a new COVID-19 mortality risk score using data from 33 hospitals across four different countries. I am very proud of this international collaboration. The paper is now available on medrxiv: https://t.co/VGEPJYqbEf
— Agni Orfanoudaki (@AgniOrfanoudaki) July 10, 2020