Chest Medicine
Perspective: “When will WE have a vaccine?” — understanding questions and answers about Covid-19 vaccination
9 Sep, 2020 | 09:37h | UTC
Commentary on Twitter
People inquiring about Covid-19 vaccines often want to know when the public can be confident that available vaccines are safe and effective, when a vaccine will be available to people like them, and when uptake will be high enough to enable a return to prepandemic life. #COVID19
— NEJM (@NEJM) September 8, 2020
#ERScongress – [Abstract Only] Phase 2 trial of the DPP-1 inhibitor Brensocatib in bronchiectasis
9 Sep, 2020 | 09:14h | UTCPhase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis – New England Journal of Medicine
Commentary on Twitter
Original Article: Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis (WILLOW Trial) #ERScongress
— NEJM (@NEJM) September 7, 2020
#ERScongress – [Abstract Only] Inhaled Molgramostim therapy in autoimmune pulmonary alveolar proteinosis
9 Sep, 2020 | 09:16h | UTC
Commentary on Twitter
Original Article: Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis (IMPALA Trial) #ERScongress
— NEJM (@NEJM) September 7, 2020
COVID-19 is, in the end, an endothelial disease
8 Sep, 2020 | 01:11h | UTCCOVID-19 is, in the end, an endothelial disease – European Heart Journal
Commentary on Twitter
COVID as an infectious disease of the “endothelium”, the lining of blood vessels, transmitted pre-sympyomatically. Explains the sepsis syndrome; explains the clotting/bleeding; explains the kidney failure.
What a nasty, nasty disease.https://t.co/5hlfL5Iik9
— David Fisman (@DFisman) September 7, 2020
Meta-analysis: Chloroquine and Hydroxychloroquine do not improve outcomes in COVID-19
8 Sep, 2020 | 01:08h | UTCRelated Meta-analysis: Antirheumatic Disease Therapies for the Treatment of COVID‐19: A Systematic Review and Meta‐analysis – Arthritis & Rheumatology
Randomized trial: Upper airway surgery vs. medical management for patients with moderate or severe obstructive sleep apnea who failed conventional treatment
8 Sep, 2020 | 01:04h | UTCEffect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness Among Patients With Moderate or Severe Obstructive Sleep Apnea: The SAMS Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: Relief for people who struggle with CPAP masks – Flinders University
Author interview: Treating Obstructive Sleep Apnea
Editorial: Upper Airway Surgery for Obstructive Sleep Apnea (free for a limited period)
Commentary on Twitter
In this preliminary report of the SAMS RCT of adults w moderate or severe #sleepapnea in whom #CPAP failed, combined palatal and tongue surgery reduced the number of apnea-hypopnea events and sleepiness at 6 mos compared w medical management https://t.co/jiU3hMn9ju #ERSCongress
— JAMA (@JAMA_current) September 4, 2020
Coalition Covid-19 Brazil – Randomized trial: Azithromycin not beneficial for patients admitted to the hospital with severe Covid-19
6 Sep, 2020 | 22:06h | UTCInvited Commentary: Azithromycin for severe COVID-19
Commentaries on Twitter
This network of Brazilian researchers has done an AMAZING job of getting organized & answering important ?s. In this Lancet article they show in a randomized trial that #azithromycin does not improve #Covid19 outcomes. @RenatoDLopes1 https://t.co/zL7GSaVqm8
— C. Michael Gibson MD (@CMichaelGibson) September 5, 2020
New trial @TheLancet does not support the routine use of azithromycin in combination with #Hydroxychloroquine in patients with severe #COVIDー19:https://t.co/vaj1XX3dSo
— Madhu Pai, MD, PhD (@paimadhu) September 6, 2020
We have heard your message about long covid and we will act, says WHO
6 Sep, 2020 | 21:59h | UTCWe have heard your message about long covid and we will act, says WHO – The BMJ Opinion
Commentary on Twitter
I joined an inspiring meeting with #COVID19 patient groups. My colleague @mvankerkhove contacted these great advocates who strive to increase research, rehabilitation and recognition for people suffering long-term effects of the virus. @WHO is committed to supporting their goals. https://t.co/wJpYupcLjQ
— Tedros Adhanom Ghebreyesus (@DrTedros) August 22, 2020
A living WHO guideline on drugs for Covid-19
6 Sep, 2020 | 22:04h | UTCA living WHO guideline on drugs for covid-19 – The BMJ
Commentary on Twitter
NEW #RapidRec makes a strong recommendation for systemic corticosteroids in patients with severe and critical #COVID19 and a weak or conditional recommendation against systemic corticosteroids in patients with non-severe covid-19 https://t.co/p7loBk95Vm
— The BMJ (@bmj_latest) September 5, 2020
Video: Long covid: diagnosis, management, prognosis
6 Sep, 2020 | 21:58h | UTCLong covid: diagnosis, management, prognosis – The BMJ
Commentary on Twitter
#LongCovid #BMJcovid – Many patients who have relatively mild symptoms from covid-19, continue to experience these long after the usual 12 day duration.
Our panel discusses "Long covid" – it's diagnosis, management and prognosis https://t.co/hsP1TRNCt3 via @YouTube
— The BMJ (@bmj_latest) September 5, 2020
Coronavirus reinfections: Three questions scientists are asking
6 Sep, 2020 | 21:56h | UTCCoronavirus reinfections: three questions scientists are asking – Nature
Does the COVID-19 cytokine storm exist?
6 Sep, 2020 | 21:55h | UTCDoes the COVID-19 cytokine storm exist? – Radboud University Medical Center
Original Study: Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions – JAMA
Commentary on Twitter
Study suggests #COVID19 may not be characterized by cytokine storm. Whether anticytokine therapies will benefit patients with COVID-19 remains to be determined https://t.co/alyFUwCYRC
— JAMA (@JAMA_current) September 4, 2020
Infographic. Clinical recommendations for return to play during the COVID-19 pandemic
6 Sep, 2020 | 21:54h | UTC
Commentary on Twitter
Took a while for this to be out but excited 2 see our paper made it to infographic @BJSM_BMJ Clinical recommendations for return to play during the COVID-19 pandemichttps://t.co/rS3bCeP4Qg
Huge Collective Viewpoint by @SportswiseUK @aaashafik @GrahamHolloway4 @merseysportsmed pic.twitter.com/icYjY4D1e1— Dr Dora Papadopoulou (@Dora_Sportmed) September 4, 2020
A direct comparison of enhanced saliva to nasopharyngeal swab for the detection of SARS-CoV-2 in symptomatic patients
6 Sep, 2020 | 21:51h | UTC
Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline
6 Sep, 2020 | 21:43h | UTC
Invasive Fungal Disease complicating COVID-19: when it rains it pours
6 Sep, 2020 | 21:38h | UTCInvasive Fungal Disease complicating COVID-19: when it rains it pours – Clinical Infectious Diseases
Related study: A national strategy to diagnose COVID-19 associated invasive fungal disease in the ICU – Clinical Infectious Diseases
Commentary on Twitter
Read the fantastic editorial commentary by @martinhoenigl
Invasive Fungal Disease complicating COVID-19: when it rains it pours. #COVID19 @eurconfmedmycol #CID https://t.co/3M7NYI3zwk https://t.co/2YKpQ3x9TP— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) September 5, 2020
#ESCCongress – [Not Published Yet] Trial clarifies which patients with acute pulmonary embolism can be managed at home
6 Sep, 2020 | 21:36h | UTCNews Release: Trial clarifies which patients with acute pulmonary embolism can be managed at home – European Society of Cardiology
HESTIA Calculator: Hestia Criteria for Outpatient Pulmonary Embolism Treatment – MdCalc
sPESI Calculator: Simplified PESI (Pulmonary Embolism Severity Index) – MeCalc
Systematic review: Association between D-Dimer levels and mortality in patients with COVID-19
6 Sep, 2020 | 21:37h | UTC
Image: SARS-CoV-2 infection of airway cells
4 Sep, 2020 | 02:15h | UTCImages in Clinical Medicine: SARS-CoV-2 Infection of Airway Cells – New England Journal of Medicine
Editorial: Are we underestimating seroprevalence of SARS-CoV-2?
4 Sep, 2020 | 02:17h | UTCAre we underestimating seroprevalence of SARS-CoV-2? – The BMJ
Commentary: Are antibody tests underestimating the spread of COVID-19? – St. George’s University of London
Review: Coagulopathy of Covid-19
4 Sep, 2020 | 02:14h | UTCCoagulopathy of Coronavirus Disease 2019 – Critical Care Medicine
Commentary on Twitter
What you need to know about #Covid19 #coagulopathy is all in one place – @CCM. This will help target your anticoagulation plans for COVID care. @SCCM https://t.co/gKUbc995ra
— Lauren R. Sorce, PhD, RN, CPNP-AC/PC, FAAN, FCCM (@SCCMPresident) September 1, 2020
Forty postmortem examinations in COVID-19 Patients: Two distinct pathologic phenotypes and correlation with clinical and radiologic findings
4 Sep, 2020 | 02:05h | UTC
Commentary on Twitter
Our COVID autopsy study is now online! We describe 2 distinct pathologic phenotypes and correlate with clinical and radiologic data. So proud of this team! 💕@ColumbiaPath @AJCPjournal #pulmpath #pathology #autopsy #NYC #COVID19 #covid https://t.co/f3xhc0v1si
— Simona De Michele, MD (@SDeMicheleMD) September 3, 2020
Coalition Covid-19 Brazil – Randomized trial: Dexamethasone improves outcomes in patients with Acute Respiratory Distress Syndrome and COVID-19
3 Sep, 2020 | 11:24h | UTCEditorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic
Related studies: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial – JAMA AND Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial – JAMA
Commentary: Inexpensive Steroids Can Save Lives Of Seriously Ill COVID-19 Patients – NPR
Commentary on Twitter
In this RCT, IV #dexamethasone increased the number of ventilator-free days by day 28 vs standard care alone among patients with #COVID19 and moderate or severe ARDS https://t.co/RA9G6LVRlz @ICURevisited @FlaviaSepsis @israelmaia16
— JAMA (@JAMA_current) September 2, 2020
Malignant pleural effusions: New evidence on management
4 Sep, 2020 | 02:03h | UTCMalignant pleural effusions (MPE): new evidence on management – Evidently Cochrane
Original Review: Interventions for the management of malignant pleural effusions: a network meta‐analysis – Cochrane Library
Video: Corticosteroids for COVID-19 – New Evidence of Benefit
3 Sep, 2020 | 11:21h | UTCCorticosteroids for COVID-19 – New Evidence of Benefit – JAMA