Commentaries: Societies Update Heart Failure Management Guidelines – Heart Failure Society of America (free) AND Societies Release HF Guideline Focused Update – American College of Cardiology, Latest in Cardiology (free)
Normal-Weight Central Obesity and Risk for Mortality – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Waist circumference stronger predictor of death risk than BMI – Haelio (free) AND Forget Your BMI and Focus on This Measurement Instead – TIME (free) AND Central Obesity Ups Mortality Across BMI Range – Physician’s Briefing (free) AND Central obesity may increase mortality risk from cardiovascular disease – Cardiovascular Business (free) AND People with a normal BMI who carry weight around the middle at greatest risk of death – HealthCanal (free)
Original article: Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case–time–control study – European Heart Journal – Cardiovascular Pharmacotherapy (free)
Guidelines For Management Of Dyslipidemia And Prevention Of Cardiovascular Disease – American Association Of Clinical Endocrinologists And American College Of Endocrinology (free PDF) (RT @greg_folkers)
Updated Guideline: Prevention and Management of Cardiovascular Disease Risk in Primary Care – Toward Optimized Practice (TOP) Guidelines (free)
Practical guideline for primary care providers.
Editorial: Active commuting is beneficial for health (free)
See also: 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (free PDF) AND First fainting guidelines issued to diagnose life-threatening heart conditions – American Heart Association News (free)
β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies – JAMA Internal Medicine (link to abstract – $ for full-text)
See also: No Fetal Heart Risk from Mom’s Beta-Blocker Use – MedPage Today (free registration required)
Comparison of Recommended Eligibility for Primary Prevention Statin Therapy Based on the US Preventive Services Task Force Recommendations vs the ACC/AHA Guidelines – JAMA (link to abstract – $ for full-text)
See also: ACC/AHA vs. USPSTF statin guidelines – Cardiology News (free)
Although recommended by most guidelines for individuals at high risk, there is still some controversy over prescribing statins for primary prevention and over what patients benefit the most – see related commentary: Cholesterol-lowering statin therapy for healthy people is not as simple as ‘yes’ or ‘no’ – The Pharmaceutical Journal (free)
Adherence to the 2016 USPSTF recommendations for statin therapy, compared with the 2013 ACC/AHA guidelines, could lead to a lower number of individuals (an estimated difference of 9.3 million individuals in the U.S. population) recommended for primary prevention statin therapy.
Rapid Rule-out of Acute Myocardial Infarction with a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
See also: High-Sensitivity Troponin T Test Rules Out AMI in ED – Medscape (free registration required) AND Meta-Analysis: Single Cardiac Troponin Test Plus ECG Can Quickly Rule Out MI – Physician’s First Watch (free)
“This analysis indicates that a nonischemic ECG and a single negative High-Sensitivity Cardiac Troponin T only misses about 1 in 100 myocardial infarctions – and can provide rapid, useful information in an assessment.” (from Physician’s First Watch commentary above).
New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management18 Apr, 2017 | 14:05h | UTC
Source: Critical Care Reviews Newsletter
Source: Screen for Endocrine Hypertension, Endocrine Society Says – Medscape (free registration required)
“The statement provides guidance on screening for 15 hormonal disorders that present with hypertension and that can be potentially cured with surgery or treated with medication” (from Medscape commentary above).
Hospital Admissions for Myocardial Infarction and Stroke Before and After the Trans-Fatty Acid Restrictions in New York – JAMA Cardiology (link to abstract – $ for full-text)
Sources: Banning trans fats in New York prevented thousands of heart attacks, study finds – STAT News (free) AND Trans Fat Bans Tied to Fewer Heart Attacks and Strokes – The New York Times (10 articles per month are free)
Other localities might consider doing the same as well.
“The booming dietary-supplement industry is plagued by outlandish claims, undermining credible science, and seeding confusion”.
Effect of Baseline Nutritional Status on Long-term Multivitamin Use and Cardiovascular Disease Risk – JAMA Cardiology (link to abstract – $ required for full-text)
See also: Multivitamins may not improve heart health in men – UPI (free) AND Other recent commentary on multivitamins: Multivitamins a waste of money and just create ‘very expensive urine’ – The Guardian (free)
“Multivitamin use does not prevent major CV disease events in men, regardless of baseline nutritional status” (RT @CaulfieldTim)
Cardioselective beta-blockers, mostly atenolol and bisoprolol in this cohort, were not associated with increased risk of moderate or severe asthma exacerbations. In contrast, non-selective beta-blockers, mostly sotalol and carvedilol in this cohort, were associated with increased risk.
Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials – The Lancet (link to abstract – $ required for full-text) (RT @AnilMakam “Lower achieved blood pressure in high risk patients for cardiovascular disease do WORSE” see Tweets)
In high-risk patients, patients who achieved a systolic blood pressure < 120 mmHg or a diastolic blood pressure < 70 mmHg had HIGHER risk of complications. “These data suggest that the lowest blood pressure possible is not necessarily the optimal target for high-risk patients”
Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients – New England Journal of Medicine (link to abstract – $ required for full text)
Quick Take Video Summary: SURTAVI Study: TAVR versus Open Surgery (free)
See this and other highlights from the American College of Cardiology’s 66th Annual Scientific Session (some articles are no longer free)
This innovative technology seems to be useful for patients with aortic stenosis at high risk for surgery. In this new study, it was noninferior to surgery at 2 years of follow-up in old patients (averaged nearly 80 years) at intermediate risk. Longer follow up data will be important to see if it is a suitable alternative for younger patients.
Original article abstract ($ required for full-text): Two-Year Outcome after Endovascular Treatment for Acute Ischemic Stroke – New England Journal of Medicine
Singapore Ministry of Health Clinical Practice Guidelines: Lipids (free PDF)
See also: Inhaled Corticosteroid Use May Up Metabolic Syndrome Risk – MPR (free)
This study was presented at #ENDO2017 and hasn’t been published yet.