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Cardiology (all articles)

Review | Management of short-term mechanical circulatory support for cardiogenic shock in adults in the intensive cardiac care unit

27 Jun, 2023 | 13:42h | UTC

Step by step daily management of short-term mechanical circulatory support for cardiogenic shock in adults in the intensive cardiac care unit: a clinical consensus statement of the Association for Acute CardioVascular Care of the European Society of Cardiology SC, the European Society of Intensive Care Medicine, the European branch of the Extracorporeal Life Support Organization, and the European Association for Cardio-Thoracic Surgery – European Heart Journal. Acute Cardiovascular Care

 

Review | Hypertension management in patients with cardiovascular comorbidities

27 Jun, 2023 | 13:39h | UTC

Hypertension management in patients with cardiovascular comorbidities – European Heart Journal

 

Commentary on Twitter

 

Review | Functional coronary angiography for the assessment of the epicardial vessels and the microcirculation

27 Jun, 2023 | 13:33h | UTC

Functional coronary angiography for the assessment of the epicardial vessels and the microcirculation – EuroIntervention

 

Commentary on Twitter

 

Secondary analysis of a RCT | Bempedoic acid reduces CV events in statin-intolerant patients with high CV risk

26 Jun, 2023 | 00:49h | UTC

Summary: This secondary analysis of a Randomized Clinical Trial (RCT) evaluated the efficacy of bempedoic acid in primary prevention of cardiovascular events among statin-intolerant patients at high cardiovascular risk. From a total of 13,970 participants, 4206 met the criteria for primary prevention and were analyzed in this study. Those allocated to receive bempedoic acid showed a significant reduction in major cardiovascular events, reflected in a hazard ratio of 0.70.

The average age of this patient cohort was 68 years, and most participants (66%) were diagnosed with diabetes. Treatment with bempedoic acid also led to a significant 21.3% reduction in low-density lipoprotein cholesterol (LDL-C) levels and a 21.5% decrease in high-sensitivity C-reactive protein levels, suggesting improved cardiovascular health.

This study underscores the potential benefits of lipid-modulating therapy for primary prevention in high-risk patients, who are often undertreated. However, it is important to note the inherent limitations of this secondary analysis. The analysis was performed on a subgroup within a larger clinical trial, which could potentially lead to false-positive findings due to multiple testing. Furthermore, the results may not generalize to younger populations, those with lower pretreatment LDL-C levels, those without diabetes, or those with a lower baseline cardiovascular risk.

Article: Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients – JAMA (free for a limited period)

Editorial: Bempedoic Acid for High-Risk Primary Prevention of Cardiovascular Disease: Not a Statin Substitute but a Good Plan B – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Study Suggests Bempedoic Acid Could Find Role in Primary Prevention – HCP Live

Original Study: RCT | Bempedoic acid shows modest reduction in cardiovascular events for statin-intolerant patients

 

RCT | Shortened head-up tilt test is non-inferior to traditional method for suspected vasovagal syncope

26 Jun, 2023 | 00:42h | UTC

Summary: The randomized clinical trial compared a short-duration head-up tilt test (HUTT) with the traditional longer-duration test for diagnosing suspected vasovagal syncope (VVS). The study involved 554 patients, half of which underwent the Fast protocol and the other half the Traditional protocol. The Fast protocol consisted of a 10-minute passive phase followed by a 10-minute nitroglycerin (NTG) phase if the passive phase yielded negative results, while the Traditional protocol included a 20-minute passive phase and a 15-minute NTG phase.

The findings showed no significant difference in the diagnostic value between the two protocols. Positive responses, identified by syncope induction amid hypotension or bradycardia, were seen in 60.3% of patients in the Fast protocol and 58.5% in the Traditional. However, there was a trend of less vasodepressor response in the Fast protocol during the passive phase.

This study suggests that the Fast HUTT protocol could replace the Traditional one, reducing test duration from 40 to 25 minutes without compromising diagnostic efficacy. However, the research didn’t assess the specificity of the Fast HUTT protocol in patients without a history of syncope, which serves as a limitation.

Article: Short-duration head-up tilt test potentiated with sublingual nitroglycerin in suspected vasovagal syncope: the fast Italian protocol – European Heart Journal (free for a limited period)

 

Commentary on Twitter

 

Review | How to treat diffuse large B-cell lymphoma: oncologic and cardiovascular considerations

26 Jun, 2023 | 00:33h | UTC

How to Treat Diffuse Large B-Cell Lymphoma: Oncologic and Cardiovascular Considerations – JACC: CardioOncology

 

Commentary on Twitter

 

Cohort Study | Risk and outcome of infective endocarditis in streptococcal bloodstream infections according to streptococcal species

22 Jun, 2023 | 15:09h | UTC

Risk and Outcome of Infective Endocarditis in Streptococcal Bloodstream Infections according to Streptococcal Species – Clinical Microbiology

 

Review | Early lead extraction for infected implanted cardiac electronic devices

22 Jun, 2023 | 15:03h | UTC

Early Lead Extraction for Infected Implanted Cardiac Electronic Devices: JACC Review Topic of the Week – Journal of the American College of Cardiology

 

SCORE2-Diabetes | 10-year cardiovascular risk estimation in type 2 diabetes in Europe

22 Jun, 2023 | 14:57h | UTC

SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe – European Heart Journal

Commentary: SCORE2- diabetes prediction model estimates the 10 year risk of cardiovascular disease in individuals with type 2 diabetes – News Medical

 

Commentary on Twitter

 

Acute heart failure: differential diagnosis and treatment

21 Jun, 2023 | 13:37h | UTC

Acute heart failure: differential diagnosis and treatment – European Heart Journal Supplements

Related: Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician’s Guide – Journal of Clinical Medicine

 

Consensus Statement | Anatomy, imaging, and nomenclature of congenital aortic root malformations

21 Jun, 2023 | 13:25h | UTC

Expert Consensus Statement: Anatomy, Imaging, and Nomenclature of Congenital Aortic Root Malformations – Cardiology in the Young

 

Position statement | Gastrointestinal bleeding and endoscopic procedures in patients on antiplatelet and/or anticoagulant therapy

21 Jun, 2023 | 13:22h | UTC

Position statement from the Indian Society of Gastroenterology, Cardiological Society of India, Indian Academy of Neurology and Vascular Society of India on gastrointestinal bleeding and endoscopic procedures in patients on antiplatelet and/or anticoagulant therapy – Indian Journal of Gastroenterology (if the link is paywalled, try this one)

 

RCT | No superior recovery with minithoracotomy over sternotomy in mitral valve repair

20 Jun, 2023 | 12:51h | UTC

Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Mitral valve repair: How a minimally invasive approach compares to conventional surgery – Cardiovascular Business

 

Cohort Study | Five-year safety and efficacy of leadless pacemakers

20 Jun, 2023 | 12:40h | UTC

Five-year safety and efficacy of leadless pacemakers in a Dutch cohort – Heart Rhythm

 

RCT | Testosterone replacement does not appear to increase cardiovascular events in hypogonadal men at high risk

19 Jun, 2023 | 14:13h | UTC

Cardiovascular Safety of Testosterone-Replacement Therapy – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Cleveland Clinic-Led Trial Finds Testosterone-Replacement Therapy Does Not Increase Incidence of Major Adverse Cardiac Events for Men with Low Testosterone – Cleveland Clinic

 

Commentary on Twitter

 

Review | Role of GLP1 receptor agonists in achieving weight loss and improving CV outcomes in people with overweight and obesity

19 Jun, 2023 | 13:40h | UTC

Role of Glucagon‐Like Peptide‐1 Receptor Agonists in Achieving Weight Loss and Improving Cardiovascular Outcomes in People With Overweight and Obesity – Journal of the American Heart Association

 

RCT | Mild hypercapnia after cardiac arrest shows no improvement in neurological outcomes vs. normocapnia

16 Jun, 2023 | 14:15h | UTC

Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: New data supports current management of CO2 levels in cardiac arrest patients – UCD Dublin

 

Perspective | Benefits and pitfalls of social media in cardiology

16 Jun, 2023 | 14:13h | UTC

Impact of Social Media and Multimedia Platforms: View From the JACC: Case Reports SoMe Editors – JACC: Case Reports

 

Commentary on Twitter

 

Brief Review | Why is cuff size so important and other factors that affect accurate blood pressure measurement

16 Jun, 2023 | 14:12h | UTC

Why Is Cuff Size So Important and Other Factors That Affect Accurate Blood Pressure Measurement – American College of Cardiology

 

Single-center cohort study | Low-risk PE patients with concerning CT findings – increased hospitalization, but no increased risk of mortality

16 Jun, 2023 | 13:49h | UTC

Adverse Clinical Outcomes Among Patients With Acute Low-risk Pulmonary Embolism and Concerning Computed Tomography Imaging Findings – JAMA Network Open

Commentary: Acute Low-Risk Pulmonary Embolism and Concerning CT Findings – American College of Cardiology

 

M-A | Similar death rates in left main disease patients treated with PCI or CABG, both in patients with and without ACS

15 Jun, 2023 | 14:59h | UTC

Percutaneous Coronary Intervention vs Coronary Artery Bypass Graft Surgery for Left Main Disease in Patients With and Without Acute Coronary Syndromes: A Pooled Analysis of 4 Randomized Clinical Trials – JAMA Cardiology (link to abstract – $ for full-text)

Commentary: CABG and PCI Comparable in ACS Patients With Left Main CAD – TCTMD

 

SR | Management of postpartum hypertensive disorders of pregnancy

14 Jun, 2023 | 14:37h | UTC

Management of Postpartum Hypertensive Disorders of Pregnancy – Agency for Healthcare Research and Quality

 

AHA Scientific Statement | Contaminant metals as cardiovascular risk factors

13 Jun, 2023 | 14:04h | UTC

Contaminant metals as cardiovascular risk factors: a scientific statement from the American Heart Association – Journal of the American Heart Association

News Release: Chronic exposure to lead, cadmium and arsenic increases risk of cardiovascular disease – American Heart Association

Top Things to Know: Contaminant Metals as CV Risk Factors – American Heart Association

Commentary: Toxic Metals: The Poisons that are “Killing Us Softly” – American Heart Association

 

Commentary on Twitter

 

Consensus Statement | Three-dimensional transesophageal echocardiography

13 Jun, 2023 | 14:02h | UTC

Three-dimensional transoesophageal echocardiography: how to use and when to use—a clinical consensus statement from the European Association of Cardiovascular Imaging of the European Society of Cardiology – European Heart Journal – Cardiovascular Imaging

 

Machine learning proves effective in predicting left ventricular hypertrophy through ECG analysis, study shows

13 Jun, 2023 | 13:57h | UTC

Predicting left ventricular hypertrophy from the 12-lead electrocardiogram in the UK Biobank imaging study using machine learning – European Heart Journal – Digital Health

 

Commentary on Twitter

 

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