Allergy & Immunology
COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing
26 Aug, 2020 | 04:13h | UTCSee also: First Covid-19 reinfection documented in Hong Kong
BCG vaccination in infancy does not protect against COVID-19. Evidence from a natural experiment in Sweden
26 Aug, 2020 | 04:12h | UTC
Four scenarios on how we might develop immunity to Covid-19
26 Aug, 2020 | 03:58h | UTCFour scenarios on how we might develop immunity to Covid-19 – STAT
Randomized trial: Vitamin D Supplementation does not prevent severe asthma exacerbations in children with asthma and low vitamin D levels
26 Aug, 2020 | 03:52h | UTCEffect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: Compared to placebo, vitamin D has no benefit for severe asthma attacks, study finds – University of Pittsburgh School of Medicine AND Don’t count on vitamin D to ease childhood asthma – MedicalXpress
Commentary on Twitter
In this RCT, #vitaminD3 supplementation did not improve the time to a severe asthma exacerbation vs placebo in children with persistent asthma and low #vitaminD levels https://t.co/VfYXUrhyT7
— JAMA (@JAMA_current) August 25, 2020
Vaccines targeting SARS-CoV-2 tested in humans
25 Aug, 2020 | 03:56h | UTCVaccines targeting SARS-CoV-2 tested in humans – Nature Medicine
Commentary on Twitter
No #SARSCoV2 vaccine has yet to be shown to be effective or safe.
Effective = it prevents infections.
Safe = it doesn't engender serious adverse effects.https://t.co/dsyk8m6pEx@NatureMedicine
Please keep this in mind now that @US_FDA's @SteveFDA has lost all credibility pic.twitter.com/OgQIpDPv6R— Eric Topol (@EricTopol) August 24, 2020
First Covid-19 reinfection documented in Hong Kong
25 Aug, 2020 | 04:00h | UTCFirst Covid-19 reinfection documented in Hong Kong, researchers say – STAT
Commentaries: Some people can get the pandemic virus twice, a study suggests. That is no reason to panic – Science AND You can get reinfected with Covid-19 but still have immunity. Let’s explain – Vox AND Expert reaction to first reported case of COVID-19 re-infection in Hong Kong patient – Science Media Centre
Commentary on Twitter
In Hong Kong, researchers reported what appears to be the first confirmed case of Covid-19 reinfection in a 33-year-old man. The virus sequenced from his two infections didn't match, indicating the second one was not tied to the first. https://t.co/4GHd1lMRZ0
— STAT (@statnews) August 24, 2020
FDA issues emergency use authorization for convalescent plasma as potential COVID–19 treatment
25 Aug, 2020 | 03:58h | UTCCommentaries: Convalescent Plasma: The Science and the Politics – Science Translational Medicine AND Convalescent plasma: another controversial clash of politics & science – Health News Review AND Observational Study of Convalescent Plasma and FDA Response – datamethods AND FDA OKs use of convalescent plasma for COVID-1 – CIDRAP AND Is convalescent plasma safe and effective? We answer the major questions about the Covid-19 treatment – STAT
An inflammatory cytokine signature predicts COVID-19 severity and survival
25 Aug, 2020 | 03:57h | UTCAn inflammatory cytokine signature predicts COVID-19 severity and survival – Nature
Commentary: Researchers discover immune predictors of COVID-19 cases that fare the worst – The Mount Sinai Hospital
Commentary on Twitter
Elevated levels of serum IL-6 and TNF-α at the time of hospitalization are independent and significant predictors of clinical outcome in two cohorts of patients with #COVID19 #biomarker @IcahnMountSinai @SinaiImmunol @TischCancer @MiriamMerad https://t.co/syHWT6QaW0
— Nature Medicine (@NatureMedicine) August 24, 2020
Not just antibodies: B cells and T cells mediate immunity to COVID-19
25 Aug, 2020 | 03:54h | UTCNot just antibodies: B cells and T cells mediate immunity to COVID-19 – Nature Reviews Immunology
Commentary on Twitter
Concise and useful summary of the B and T cell response to #COVID19https://t.co/RQ2ABn8CYf@NatRevImmunol pic.twitter.com/Bk9IiJFfwQ
— Eric Topol (@EricTopol) August 24, 2020
Diagnostic and prognostic value of hematological and immunological markers in COVID-19 infection: A meta-analysis of 6320 patients
25 Aug, 2020 | 03:45h | UTC
Review: The interpretation of SARS-CoV-2 diagnostic tests
24 Aug, 2020 | 00:40h | UTCThe Interpretation of SARS-CoV-2 Diagnostic Tests – Med
Case report: SARS-CoV-2 in cardiac tissue of a child with COVID-19-related multisystem inflammatory syndrome
24 Aug, 2020 | 00:38h | UTC
Commentary on Twitter
Presence of #SARSCoV2 in heart muscle and endocardial cells in an 11-year-old girl who died of cardiac complications from #COVID19. It's the 1st report of child affected by MIS-C w/ documented presence of viral particles in the hearthttps://t.co/70M8BYaQGy pic.twitter.com/5aHDtpO8SZ
— Eric Topol (@EricTopol) August 20, 2020
Perspective by Dr. Tom Frieden: Coronavirus immunity offers perils and promise
24 Aug, 2020 | 00:37h | UTCCoronavirus immunity offers perils and promise – CNN
Pediatric SARS-CoV-2: Clinical presentation, infectivity, and immune responses
21 Aug, 2020 | 02:42h | UTCCommentaries: Kids with COVID have more viral RNA in their airways than adults do – CIDRAP AND Researchers show children are silent spreaders of virus that causes COVID-19 – Massachusetts General Hospital AND Expert reaction to study claiming children are silent spreaders of SARS-CoV-2 – Science Media Centre
Evidence lags behind excitement over blood plasma as a coronavirus treatment
21 Aug, 2020 | 02:36h | UTCEvidence lags behind excitement over blood plasma as a coronavirus treatment – Nature
NEW IDSA Guidelines on serologic testing for the diagnosis of COVID-19
20 Aug, 2020 | 09:43h | UTCInfectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Serologic Testing
Commentary on Twitter
NEW IDSA Guidelines on Serologic Testing for the Diagnosis of COVID-19. These evidence-based rapid guidelines, updated in real-time, address clinical questions related to use of SARS-CoV-2 serologic tests in a variety of settings.
📄: https://t.co/GsX3A1SmV0 #COVID19Guidelines pic.twitter.com/LC0gT08k1j
— IDSA (@IDSAInfo) August 19, 2020
Perspective: Encouraging news about Coronavirus immunity
19 Aug, 2020 | 09:43h | UTCEncouraging News About Coronavirus Immunity – Science Translational Medicine
New-onset type 1 diabetes in children during COVID-19 pandemic
19 Aug, 2020 | 09:38h | UTCCommentaries: COVID-19 linked to increase in type 1 diabetes in children – Imperial College London AND Expert reaction to study linking COVID-19 to increase in type 1 diabetes in children – Science Media Centre
Perspective: What the immune response to the coronavirus says about the prospects for a vaccine
19 Aug, 2020 | 09:39h | UTCWhat the immune response to the coronavirus says about the prospects for a vaccine – Nature
Perspective: What if ‘herd immunity’ is closer than scientists thought?
18 Aug, 2020 | 07:45h | UTCWhat if ‘Herd Immunity’ Is Closer Than Scientists Thought? – The New York Times
Seven months later, what we know about Covid-19 — and the pressing questions that remain
18 Aug, 2020 | 07:53h | UTCSeven months later, what we know about Covid-19 — and the pressing questions that remain – STAT
Review: COVID-19 and multisystem inflammatory syndrome in children and adolescents
18 Aug, 2020 | 07:46h | UTC
Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
16 Aug, 2020 | 22:36h | UTCRobust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19 – Cell
Commentary on Twitter
https://twitter.com/carlheneghan/status/1294600299609559040
These Covid-19 vaccine candidates could change the way we make vaccines — if they work
14 Aug, 2020 | 01:43h | UTCThese Covid-19 vaccine candidates could change the way we make vaccines — if they work – Vox
Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes
14 Aug, 2020 | 01:44h | UTC
Commentary on Twitter
Inactivated #COVID19 #vaccine had a low rate of adverse reactions and demonstrated immunogenicity, but longer-term assessment of safety and efficacy will require phase 3 trials https://t.co/atmhXFFHSw
— JAMA (@JAMA_current) August 13, 2020