Allergy & Immunology
Review: Eosinophilic Esophagitis.
6 Oct, 2021 | 09:51h | UTCEosinophilic Esophagitis: A Review – JAMA (free for a limited period)
Related:
Clinical Guidelines for the Management of Eosinophilic Esophagitis
Eosinophilic Esophagitis: Review and Update
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
3 Oct, 2021 | 22:49h | UTCCovid-19 vaccination: evidence of waning immunity is overstated – The BMJ
Related:
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.
Clinical practice guideline on immune checkpoint inhibitor-related adverse events.
24 Sep, 2021 | 08:55h | UTCRelated:
NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities (several resources on the subject)
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment (several resources on the subject)
Randomized phase 1/2 trial: Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in children and adolescents aged 3–17 years.
23 Sep, 2021 | 10:16h | UTC
Systematic review: Clinical characteristics of multisystem inflammatory syndrome in adults.
23 Sep, 2021 | 10:12h | UTC
Commentary on Twitter
Multisystem inflammatory syndrome has been reported in adults worldwide but may be hard to distinguish from acute biphasic #COVID19 and postacute sequelae of COVID-19. More research is needed to understand this emerging clinical entity. https://t.co/OnerzsZKVB
— JAMA Network Open (@JAMANetworkOpen) September 22, 2021
An FDA panel says only high-risk Americans and those 65+ should get covid boosters.
19 Sep, 2021 | 23:45h | UTCAn FDA Panel Says Only High-Risk Americans And Those 65+ Should Get COVID Boosters – NPR
See also:
5 reasons why FDA advisers did not recommend Covid-19 booster shots for everyone – CNN
Top doctors say not so fast to Biden’s boosters-for-all plan – Associated Press
Related:
Third shot: UK to offer COVID booster jabs to over 50s.
COVID-19 vaccine efficacy does not support boosters for general population, review concludes.
COVID vaccine effects wane over time but still prevent death and severe illness.
What’s the evidence for COVID-19 booster shots?
COVID vaccine immunity is waning — how much does that matter? – “As debates about booster shots heat up, what’s known about the duration of vaccine-based immunity is still evolving”.
19 Sep, 2021 | 23:40h | UTCCOVID vaccine immunity is waning — how much does that matter? – Nature
Case series: Vaccine-induced thrombocytopenia with severe headache may precede cerebral venous sinus thrombosis by several days – patients with severe headache 5 to 20 days after adenovirus vector vaccination against Covid-19 should undergo immediate testing for thrombocytopenia and d-dimer levels and, if available, testing for anti–PF4–heparin IgG antibodies.
16 Sep, 2021 | 10:14h | UTCVaccine-Induced Thrombocytopenia with Severe Headache – New England Journal of Medicine
Commentary on Twitter
Experience with 11 patients suggests that elements of VITT (severe headache, elevated d-dimer levels, and positivity for anti-PF4 antibodies) after ChAdOx1 nCoV-19 vaccination may precede VITT. #Covid19Vaccines #COVID19 #SARSCoV2 #IDTwitter https://t.co/mzBgjJIE6l pic.twitter.com/wGqb1gKFXk
— NEJM (@NEJM) September 15, 2021
COVID vaccine effects wane over time but still prevent death and severe illness.
16 Sep, 2021 | 10:10h | UTCCOVID vaccine effects wane over time but still prevent death and severe illness – The Conversation
Related:
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.
An observational study in Israel suggests additional protection from a 3rd dose of the Pfizer vaccine in individuals 60 years of age or older.
16 Sep, 2021 | 10:13h | UTCProtection of BNT162b2 Vaccine Booster against Covid-19 in Israel – New England Journal of Medicine
COVID-19 vaccine efficacy does not support boosters for general population, review concludes.
14 Sep, 2021 | 10:08h | UTCNews release: COVID-19 vaccine efficacy does not support boosters for general population, review concludes – The Lancet
Original article: Considerations in boosting COVID-19 vaccine immune responses – The Lancet
Commentaries:
FDA experts among group opposing US booster shot plan – Associated Press
FDA vaccine regulators argue against Covid-19 vaccine boosters in new international review – STAT
Global experts pan wider use of COVID vaccine booster dose – CIDRAP
Boosters Are ‘Not Appropriate’ – Reach Unvaccinated First – Health Policy Watch
Data Doesn’t Support Need for COVID-19 Vaccine Boosters: Experts – HealthDay
What’s the evidence for COVID-19 booster shots?
12 Sep, 2021 | 22:05h | UTCWhat’s the evidence for COVID-19 booster shots? – Canadian Medical Association Journal
COVID infections may give more potent immunity than vaccines – but that doesn’t mean you should try to catch it.
10 Sep, 2021 | 05:29h | UTCOriginal study and commentary: [Preprint] Observational data suggests natural immunity after a SARS-CoV-2 infection confers longer lasting and stronger protection compared to vaccine-induced immunity.
India’s DNA COVID vaccine is a world first – more are coming.
10 Sep, 2021 | 05:30h | UTCIndia’s DNA COVID vaccine is a world first – more are coming – Nature
Perspective | What we actually know about waning immunity.
10 Sep, 2021 | 05:26h | UTCWhat We Actually Know About Waning Immunity – The Atlantic
[Preprint] RCT: Additional heterologous vs. homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination.
9 Sep, 2021 | 09:55h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1435720202147143680
Kids and COVID: why young immune systems are still on top.
7 Sep, 2021 | 21:46h | UTCKids and COVID: why young immune systems are still on top – Nature
[Preprint] M-A of 12.011.447 individuals finds individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection.
7 Sep, 2021 | 21:42h | UTC
Commentary on Twitter
A new systematic review of over 12 million people from 54 studies at up to 8 months following Covid. >90% prevalence of IgG antibodies, reinfection 0.2% (an 81% risk reduction) https://t.co/ljir4DV1zU ("did not examine evidence for immunity against the new variants") pic.twitter.com/pT7A2KA9FV
— Eric Topol (@EricTopol) September 7, 2021
Extended intervals and extra doses of the AstraZeneca vaccine are associated with increased immunogenicity.
7 Sep, 2021 | 10:56h | UTCInvited commentary: Longer intervals and extra doses of ChAdOx1 nCoV-19 vaccine
Commentaries on Twitter
(thread – click for more)
Substudy suggests extended interval (up to 45 wks) before 2nd dose of ChAdOx1 nCoV-19 leads to increased antibody titres, offering more flexibility in vaccine schedules.
Extended interval before 3rd dose resulted in further increase in immune responses. https://t.co/J3xOwSSYMN pic.twitter.com/8GotDI4ctS
— The Lancet (@TheLancet) September 2, 2021
(thread – click for more)
New @TheLancet
The heightened immune response to longer spacing @AstraZeneca 1st -> 2nd vaccine doses and the response 3rd booster dose, with high neutralizing antibodies and T cellshttps://t.co/A2UcPVIFYP pic.twitter.com/zfYaW0T8Yf— Eric Topol (@EricTopol) September 1, 2021
Opinion | Video: Immunity is the only way through a pandemic (w/Dr. Monica Gandhi).
7 Sep, 2021 | 10:45h | UTCImmunity Is The Only Way Through A Pandemic (w/Dr. Monica Gandhi) – ZDoggMD
EU agency says to focus on vaccines first not booster shots.
3 Sep, 2021 | 10:34h | UTCEU agency says to focus on vaccines first not booster shots – Associated Press
See also: European officials say COVID-19 booster isn’t urgent – CIDRAP
RCT: In patients with Immune Thrombocytopenia, the addition of Mycophenolate Mofetil to a standard glucocorticoid regimen reduced refractory or relapsed disease but was associated with decreased quality of life outcomes regarding physical function and fatigue.
3 Sep, 2021 | 10:15h | UTC
Review | COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.
2 Sep, 2021 | 10:06h | UTC
Commentary on Twitter
NEW REVIEW—COVID-19 and immune-mediated inflammatory diseases
Filippo Fagni and colleagues @UniFAU review the effect of disease and treatment on #COVID19 outcomes and #vaccine responseshttps://t.co/ue8XnDF1sM #LancetRheumatology @KorayTascilar pic.twitter.com/Yrk4SmeSbE
— The Lancet Rheumatology (@TheLancetRheum) August 27, 2021
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
2 Sep, 2021 | 10:05h | UTCWaning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar – medRxiv
Related:
Studies: COVID vaccine protection waning against infection but not hospitalization.
Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.
Commentary on Twitter (thread – click for more)
The evidence of mRNA vaccine effectiveness (VE) waning grows: large Qatar experience shows substantial 5 month attrition for symptomatic infection VE below 50% and, to a lesser extent, vs hospitalization and deathhttps://t.co/4lIG68Bxm0 pic.twitter.com/rnyo0Si3RP
— Eric Topol (@EricTopol) August 27, 2021
[Preprint] Pfizer vaccine booster dose protection: A nationwide study from Israel – “Twelve days or more after the booster dose we found an 11.4-fold decrease in the relative risk of confirmed infection, and a >10-fold decrease in the relative risk of severe illness”.
1 Sep, 2021 | 09:59h | UTCBNT162b2 vaccine booster dose protection: A nationwide study from Israel – medRxiv