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ASCO 2018: Pembrolizumab vs. Chemotherapy as First-line Therapy for Advanced Non-Small Cell Lung Cancer

7 Jun, 2018 | 02:20h | UTC

Pembrolizumab (pembro) versus platinum-based chemotherapy (chemo) as first-line therapy for advanced/metastatic NSCLC with a PD-L1 tumor proportion score (TPS) ≥ 1%: Open-label, phase 3 KEYNOTE-042 study (link to abstract)

Commentaries: 2018 ASCO: KEYNOTE-042 Trial Compares Pembrolizumab With Chemotherapy as First-Line Treatment of NSCLC With PD-L1 Expression of 1% or More – The ASCO Post (free) AND ‘End of an Era’ for Chemo in Non-Small Cell Lung Cancer – Medscape (free registration required)

 


ASCO 2018: Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma

7 Jun, 2018 | 02:21h | UTC

Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma – New England Journal of Medicine (free)

Editorial: Cytoreductive Nephrectomy — Patient Selection Is Key (free)

Commentaries: 2018 ASCO: Carmena Trial Compares Nephrectomy Plus Adjuvant Sunitinib vs Sunitinib Alone in Metastatic RCC – The ASCO Post (free) AND In Advanced Kidney Cancer, Surgery No Longer Sole Standard of Care – Medscape (free registration required)

 


ASCO 2018: Low-Dose Maintenance Chemotherapy in Rhabdomyosarcoma

7 Jun, 2018 | 02:16h | UTC

Low-Dose Maintenance Chemotherapy in Rhabdomyosarcoma – The ASCO Post (free)

 


Research: Affordability and Price Increases of New Cancer Drugs in Clinical Guidelines

7 Jun, 2018 | 02:18h | UTC

Affordability and Price Increases of New Cancer Drugs in Clinical Guidelines, 2007–2016 – Cancer Spectrum (free) (via @oncology_bg see Tweet)

 


ASCO 2018: Ibrutinib plus Rituximab in Waldenström’s Macroglobulinemia

7 Jun, 2018 | 02:19h | UTC

Phase 3 Trial of Ibrutinib plus Rituximab in Waldenström’s Macroglobulinemia – New England Journal of Medicine (free)

Commentary: Ibrutinib/Rituximab Improves PFS in Waldenström’s Macroglobulinemia – ASCO Daily News (free)

 


Editorial: Marketing Personalized Cancer Treatments Requires Careful Language

7 Jun, 2018 | 02:17h | UTC

Marketing personalized cancer treatments requires careful language – Nature (free)

Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)

“Therapies tailored to individual tumors must not be oversold”.

 


ASCO 2018: Blood Test Shows Potential as a Detection Tool for Early-Stage Lung Cancer

7 Jun, 2018 | 02:15h | UTC

Blood Test Shows Potential as a Detection Tool for Early-Stage Lung Cancer – The ASCO Post (free)

Commentary: Biotech Firm Grail Takes The First Steps In Its Quest For A Blood Test For Cancer – Forbes (free) AND Questions about a ‘simple blood test’ to screen for cancer prompt revealing answer: It’s complicated – Health News Review (free)

 


Perspective: Tracing Spread of Zika Virus in the Americas

6 Jun, 2018 | 22:00h | UTC

Tracing Spread of Zika Virus in the Americas – NIH Director’s Blog (free)

Original Article: Genomic Epidemiology Reconstructs the Introduction and Spread of Zika Virus in Central America and Mexico – Cell Host & Microbe (free)

 


Performing CPR? Humming the Macarena Could Help

6 Jun, 2018 | 21:58h | UTC

Performing CPR? Humming the Macarena could help – The Guardian (free)

Related Commentary: La Macarena could be the answer to staying alive, heart study finds – The Telegraph (free)

“Using the song “La Macarena” to keep time improves the quality of chest compressions during cardiopulmonary rescuscitation” (via @kamleshkhunti see Tweet)

 


Is There a Doctor Aboard? Airlines Often Hope Not

6 Jun, 2018 | 21:57h | UTC

Is There a Doctor Aboard? Airlines Often Hope Not – Bloomberg (free)

 


Guideline: Promoting Enteral Nutrition via a Nutrition Bundle

6 Jun, 2018 | 21:58h | UTC

New Nutrition Guidelines: Promoting Enteral Nutrition via a Nutrition Bundle – Critical Care Nurse (free)

Commentary: New guidelines address all components of nutrition for critically ill patients – News Medical (free)

 


Predatory Journals Are Such a Big Problem It’s Not Even Funny

6 Jun, 2018 | 21:55h | UTC

Predatory Journals Are Such a Big Problem It’s Not Even Funny – HIV and ID Observations (free)

 


IBM’s Watson Health Wing Left Looking Poorly After ‘Massive’ Layoffs

6 Jun, 2018 | 21:56h | UTC

IBM’s Watson Health wing left looking poorly after ‘massive’ layoffs – The Register (free)

 


Cohort Study: A Simple Approach to Help Guide Diagnosis of Heart Failure with Preserved Ejection Fraction

6 Jun, 2018 | 21:51h | UTC

A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure with Preserved Ejection Fraction – Circulation (link to abstract – $ for full-text)

Commentary: H2FPEF Score for Diagnosis – American College of Cardiology (free)

 


Case-Control Study: Possible Association of Hydrochlorothiazide Use and Risk of Melanoma

6 Jun, 2018 | 21:53h | UTC

Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma – JAMA Internal Medicine (free)

Commentaries: Hydrochlorothiazide Associated with Melanoma Risk – NEJM Physician’s First Watch (free) AND Hydrochlorothiazide Tied to Increased Melanoma Risk – MedPage Today (free registration required)

This observational data suggests a possible association. Needs to be confirmed by other studies.

 


Why Thousands of AI Researchers are Boycotting the new Nature Journal

6 Jun, 2018 | 21:54h | UTC

Why thousands of AI researchers are boycotting the new Nature journal – The Guardian (free)

“The public already pays taxes that fund our research. Why should people have to pay again to read the results?” (via @ashleydfarley see Tweet)

 


Guideline: Investigation and Management of Periprosthetic Joint Infection in the Shoulder and Elbow

6 Jun, 2018 | 21:51h | UTC

Investigation and Management of Periprosthetic Joint Infection in the Shoulder and Elbow: Evidence and consensus based guidelines of the British Elbow and Shoulder Society – Shoulder & Elbow (free PDF)

 


Systematic Review: Stent Placement vs. Surgical Palliation in Malignant Gastric Outlet Obstruction

6 Jun, 2018 | 21:50h | UTC

Stent placement versus surgical palliation for adults with malignant gastric outlet obstruction – Cochrane Library (free)

Summary: Stent placement versus surgery to control symptoms of a blocked stomach outlet caused by inoperable cancer – Cochrane Library (free)

 


AUA/ASTRO/SUO Guideline: Clinically Localized Prostate Cancer

6 Jun, 2018 | 21:49h | UTC

Part I: Risk Stratification, Shared Decision Making, and Care Options – The Journal of Urology (free)

Part II: Recommended Approaches and Details of Specific Care Options – The Journal of Urology (free)

 


Research: Dieting Predicts Engagement in Multiple Risky Behaviors Among Adolescent Girls

6 Jun, 2018 | 21:46h | UTC

Dieting predicts engagement in multiple risky behaviours among adolescent Canadian girls: a longitudinal analysis – Canadian Journal of Public Health (link to abstract – $ for full-text)

Commentary: Dieting associated with risky behaviors in teenage girls – University of Waterloo, via ScienceDaily (free)

 


Randomized Trial: Once-a-Week vs Once-Every-3-Weeks Cisplatin Chemoradiation for Locally Advanced Head and Neck Cancer

6 Jun, 2018 | 21:47h | UTC

Once-a-Week Versus Once-Every-3-Weeks Cisplatin Chemoradiation for Locally Advanced Head and Neck Cancer: A Phase III Randomized Noninferiority Trial – Journal of Clinical Oncology (free)

Commentary: Once-Weekly vs Every-3-Week Cisplatin Chemoradiation in Locally Advanced Head and Neck Cancer – The ASCO Post (free)

 


Research: Rates of Infection after Colonoscopy and Endoscopy Higher Than Expected

6 Jun, 2018 | 21:48h | UTC

Rates of infection after colonoscopy and osophagogastroduodenoscopy in ambulatory surgery centres in the USA – Gut (link to abstract – $ for full-text)

Commentary: Infection Rates After Colonoscopy, Endoscopy at US Specialty Centers Are Far Higher Than Previously Thought – Johns Hopkins Medicine, via NewsWise (free)

 


Opinion: Rush to Treat Non-alcoholic Fatty Liver Disease Causing More Harm than Good

6 Jun, 2018 | 21:45h | UTC

Rush to treat liver patients causing more harm than good – The University of Leeds (free) (via @PaulGlasziou)

Original article: Too much medicine: overdiagnosis and overtreatment of non-alcoholic fatty liver disease- The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 


Review: Prognostication After Cardiac Arrest

6 Jun, 2018 | 21:42h | UTC

Prognostication after cardiac arrest – Critical Care (free)

 


Perspective: Why Egypt Is at the Forefront of Hepatitis C Treatment

6 Jun, 2018 | 21:44h | UTC

Why Egypt Is at the Forefront of Hepatitis C Treatment – The Atlantic (free)

 


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