All Posts
Emergency Department Crowding: A Systematic Review of Causes, Consequences and Solutions
2 Sep, 2018 | 01:56h | UTCEmergency department crowding: A systematic review of causes, consequences and solutions – PLOS One (free)
Review: The Broad Spectrum of Lung Diseases in Primary Antibody Deficiencies
2 Sep, 2018 | 01:53h | UTCThe broad spectrum of lung diseases in primary antibody deficiencies – European Respiratory Review (free)
Perspective: Tickborne Diseases — Confronting a Growing Threat
2 Sep, 2018 | 01:54h | UTCTickborne Diseases — Confronting a Growing Threat – New England Journal of Medicine (free)
Perspective: Type 2 Poliovirus Detection after Global Withdrawal of Trivalent Oral Vaccine
2 Sep, 2018 | 01:46h | UTC“Wild-type transmission of poliovirus is nearly halted. To eradicate poliomyelitis, cessation of vaccine-derived poliovirus transmission must also be addressed. Strategies to accomplish this are analyzed.” (via @NEJM see Tweet)
Perspective: Embracing Technology to Save Primary Care
2 Sep, 2018 | 01:47h | UTCEmbracing Technology to Save Primary Care – NEJM Catalyst (free)
Biologic DMARD Safety Guidelines in Inflammatory Arthritis
2 Sep, 2018 | 01:51h | UTCCommentary: New BSR Guidelines on Biologic Safe Use with Inflammatory Arthritis – RheumNow (free)
Randomized Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis
31 Aug, 2018 | 03:11h | UTCPartial Oral versus Intravenous Antibiotic Treatment of Endocarditis – New England Journal of Medicine (free for a limited period)
Commentaries: Partial Oral Treatment of Endocarditis – POET – American College of Cardiology (free) AND New treatment can halve hospital stays for some patients with heart infection – ESC Press Releases (free)
ESC/EACTS Guidelines on Myocardial Revascularization
31 Aug, 2018 | 03:09h | UTC2018 ESC/EACTS Guidelines on myocardial revascularization – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)
Guideline: Practical Approaches to Clostridioides Difficile Prevention in the Neonatal Intensive Care Unit
2 Sep, 2018 | 01:46h | UTCCommentary: Guidance for preventing C. difficile in neonatal intensive care – Society For Healthcare Epidemiology of America, via EurekAlert (free)
ESC/ESH Guidelines for the Management of Arterial Hypertension
31 Aug, 2018 | 03:10h | UTC2018 ESC/ESH Guidelines for the management of arterial hypertension – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)
Fourth Universal Definition of Myocardial Infarction
31 Aug, 2018 | 03:09h | UTCFourth universal definition of myocardial infarction (2018) – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)
Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes
31 Aug, 2018 | 03:07h | UTCEffects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus – New England Journal of Medicine (free for a limited period)
Commentaries: Bleeds and benefit with aspirin balanced in patients with diabetes and no effect on cancer – ESC Press Releases (free) AND ASCEND: Aspirin Doesn’t Look Good for Primary CV Prevention in Diabetic Patients – TCTMD (free)
Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease
31 Aug, 2018 | 03:06h | UTCUse of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Aspirin Fails to Prevent CV Events in People at ‘Moderate’ Risk of Disease: ARRIVE – TCTMD (free) AND ARRIVE: New Findings Contribute to Growing Body of Evidence Surrounding Aspirin Use – American College of Cardiology (free) AND Daily Aspirin Fails to Lower CV Risk in Long-term, Primary Prevention ARRIVE Trial – Medscape (free registration required) AND Jury still out on aspirin a day to prevent heart attack and stroke – ESC Press Releases (free)
Position Statement: Recommendations for Participation in Competitive Sports of Athletes with Arterial Hypertension
31 Aug, 2018 | 03:03h | UTC
Randomized Trial: Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery
31 Aug, 2018 | 03:05h | UTCSix-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery – New England Journal of Medicine (free for a limited period)
“In moderate-to-high-risk patients undergoing cardiac surgery, six-month outcomes show that a restrictive red-cell transfusion strategy is noninferior to a liberal strategy” (via @NEJM see Tweet with Visual Abstract)
ESC Guidelines for the Management of Cardiovascular Diseases During Pregnancy
31 Aug, 2018 | 03:02h | UTC2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)
Meta-Analysis: Effectiveness of Interventions for Managing Multiple High-Burden Chronic Diseases in Older Adults
31 Aug, 2018 | 03:01h | UTCCommentaries: Care coordination improves health of older patients with multiple chronic diseases – CMAJ, via EurekAlert (free) AND Seniors healthier when medical care is coordinated – Reuters (free)
Related: Ten Recommendations: Designing a High-Performing Health Care System for Patients with Complex Needs (free Guidance and related perspectives) AND Multimorbidity: A Priority for Global Health Research (free research and commentaries)
Clinical Report: Implications of Marijuana Use During Pregnancy and Breastfeeding
31 Aug, 2018 | 02:57h | UTCNews Release: Counsel against marijuana use in pregnancy, breastfeeding – American Academy of Pediatrics (free)
Related Article: Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk – Pediatrics (free)
Commentaries: A Modern Conundrum for the Pediatrician: The Safety of Breast Milk and the Cannabis-Using Mother – Pediatrics (free) AND Marijuana study finds THC in breast milk up to 6 days after mom’s use – CNN (free) AND Pediatricians Put It Bluntly: Motherhood And Marijuana Don’t Mix – Kaiser Health News (free) AND Clinical report provides guidance on marijuana use in pregnancy and lactation – 2 Minute Medicine (free)
A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure with Preserved Ejection Fraction
31 Aug, 2018 | 03:00h | UTCA Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction – Circulation (free) (via @CircAHA see Tweet with Infographic)
Editorial: H2FPEF Score: At Last, a Properly Validated Diagnostic Algorithm for Heart Failure With Preserved Ejection Fraction (free)
Randomized Trial: Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus
31 Aug, 2018 | 02:58h | UTCEffects of n−3 Fatty Acid Supplements in Diabetes Mellitus – New England Journal of Medicine (free for a limited period)
Commentaries: Fish oils do not prevent heart attack or strokes in people with diabetes – ESC News Releases (free) AND Omega-3 Fatty Acids Fail to Reduce CVD Events in Diabetic Patients: ASCEND – TCTMD (free)
Related Cochrane Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (link to abstract and commentaries)
Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free study and commentary)
Study: Evaluating the Replicability of Social Science Experiments
31 Aug, 2018 | 02:50h | UTCEvaluating the replicability of social science experiments in Nature and Science between 2010 and 2015 – Nature Human Behavior (free for a limited period)
Commentaries: More social science studies just failed to replicate. Here’s why this is good – VOX (free) AND High-profile journals put to reproducibility test – Nature News (free) AND ‘Replication crisis’ spurs reforms in how science studies are done – ScienceNews (free) AND The Science Behind Social Science Gets Shaken Up—Again – WIRED (Free) AND In Psychology And Other Social Sciences, Many Studies Fail The Reproducibility Test – NPR (free)
“We replicated 21 social science experiments in Science or Nature. We succeeded with 13. Replication effect sizes were half of originals.” (via @BrianNosek see Tweet)
Guideline Synopsis: Diagnosis and Treatment of Clostridium difficile Infection
31 Aug, 2018 | 02:51h | UTCDiagnosis and Treatment of Clostridium difficile Infection – JAMA (free for a limited period) (via @ABsteward and @Abraham_RMI)
Original Guideline: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free)
CHEST Guideline: Antithrombotic Therapy for Atrial Fibrillation
31 Aug, 2018 | 02:56h | UTCAntithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report (free PDF)
News Release: The American College of Chest Physicians updates their antithrombotic therapy guidelines for patients with atrial fibrillation (free)
Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome
31 Aug, 2018 | 02:49h | UTCCommentaries: Diagnosing myocardial infarction: a highly sensitive issue – The Lancet (free) AND Hs-TnI in Suspected ACS: High-STEACS Trial – American College of Cardiology (free) AND Is High Sensitivity Troponin Too Sensitive? – NEJM Journal Watch (free)
“Introduction of a high-sensitivity cardiac troponin I assay reclassified 1 in 6 patients with previously undetected myocardial necrosis, but did not lead to improved clinical outcomes in this large randomised trial” (via @chapdoc1 see Tweet)
“Very important study. What’s weird is that the “better” (more sensitive) troponin assays get, the less helpful the test becomes at the bedside. Look for a coming tsunami of iatrogenesis from overzealous evaluation of troponin bumps.” (via @drjohnm see Tweet)
Guideline: Management of Hypertensive Emergencies
31 Aug, 2018 | 02:45h | UTCESC Council on hypertension position document on the management of hypertensive emergencies – European Heart Journal – Cardiovascular Pharmacotherapy (free) (@Abraham_RMI)
“Patients that lack acute hypertension-mediated end organ damage to the heart, retina, brain, kidneys, or large arteries do not have a hypertensive emergency and can be treated with oral BP-lowering agents and usually discharged after a brief period of observation.”