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The Price of Knowledge: Industry-Sponsored Studies in the Era of Evidence-Based Medicine
26 Oct, 2018 | 02:06h | UTCPerspective: The Price of Knowledge: Industry-Sponsored Studies in the Era of Evidence-Based Medicine – TCTMD (free)
Organic Foods for Cancer Prevention??
26 Oct, 2018 | 02:04h | UTCAssociation of Frequency of Organic Food Consumption With Cancer Risk: Findings From the NutriNet-Santé Prospective Cohort Study – JAMA Internal Medicine (free for a limited period)
Commentaries: Organic Foods for Cancer Prevention—Worth the Investment? – JAMA Internal Medicine (free for a limited period) AND Organic food and cancer – Science Media Centre (free) AND Organic foods tied to slightly lower cancer risk – Reuters (free)
Study: Deep Neural Network Improves Fracture Detection by Clinicians
26 Oct, 2018 | 02:05h | UTC“How to reduce emergency doctor misinterpretation of wrist X-rays for fracture by nearly 50%? Deep learning AI, of course” (via @EricTopol see Tweet)
Randomized Trial: Treatments of Advanced Triple-Negative Breast Cancer Compaired
26 Oct, 2018 | 02:03h | UTCAtezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer – New England Journal of Medicine (free for a limited period)
Commentaries: Not So Fast With Immune Therapy For Breast Cancer – Forbes (free) AND Immunotherapy drugs show some promise against breast cancer – STAT (free)
“…the benefit for most women was small, raising questions about whether the treatment is worth its high cost and side effects.” (from STAT)
Study: Diagnosis of Pulmonary Embolism During Pregnancy
26 Oct, 2018 | 02:02h | UTCDiagnosis of Pulmonary Embolism During Pregnancy: A Multicenter Prospective Management Outcome Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Algorithm Rules Out Pulmonary Embolism in Pregnancy – NEJM Journal Watch (free) AND Algorithm Validated for Pulmonary Embolism Diagnosis in Pregnancy – MedPage Today (free registration required)
Randomized Trial: Energy-Dense versus Routine Enteral Nutrition in the Critically Ill
26 Oct, 2018 | 01:59h | UTCEnergy-Dense versus Routine Enteral Nutrition in the Critically Ill – New England Journal of Medicine (free for a limited period)
Energy-dense formulation for enteral delivery of nutrition was not associated with better outcomes.
Randomized Trial: Antipsychotics Ineffective for Delirium in Intensive Care Patients
26 Oct, 2018 | 02:01h | UTCHaloperidol and Ziprasidone for Treatment of Delirium in Critical Illness – New England Journal of Medicine (free for a limited period)
Editorial: Dopamine Antagonists in ICU Delirium (free for a limited period)
Commentaries: Common use of antipsychotics shown ineffective for delirium in intensive care patients – NIH News Releases (free) AND Antipsychotic Drugs Don’t Ease ICU Delirium Or Dementia – NPR (free) AND Antipsychotics ineffective for treating ICU delirium – Vanderbilt University Medical Center (free)
Related Research: Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium (free)
Randomized Trial: Decontamination Strategies and Bloodstream Infections with Antibiotic-Resistant Microorganisms in Ventilated Patients
26 Oct, 2018 | 01:57h | UTCDecontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit (free for a limited period)
“Among patients receiving mechanical ventilation in ICUs with moderate to high ABX resistance prevalence, use of chlorhexidine mouthwash, selective oropharyngeal decontamination, or selective digestive tract decontamination was not associated with reductions in ICU-acquired bloodstream infections caused by MDRGNB vs standard care” (via @JAMA_current see Tweet with visual abstract)
Study: The AI Clinician Learns Optimal Treatment Strategies for Sepsis in Intensive Care
26 Oct, 2018 | 01:56h | UTCThe Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care – Nature Medicine (free link via Critical Care Reviews)
Commentaries: AI doctor could boost chance of survival for sepsis patients – Imperial College London (free) AND Artificial intelligence system could improve survival for sepsis patients – NHS National Institute for Health Research (free)
Randomized Trial: Protocolized Weaning with Early Extubation to Noninvasive Ventilation vs Invasive Weaning Among Patients Receiving Mechanical Ventilation
26 Oct, 2018 | 01:56h | UTCEffect of Protocolized Weaning with Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Weaning From Mechanical Ventilation: What Should Be Done When a Patient’s Spontaneous Breathing Trial Fails? (free for a limited period)
“Among patients requiring mechanical ventilation in whom a spontaneous breathing trial had failed, early extubation to noninvasive ventilation did not shorten time to liberation from any ventilation.”
Order Wisely Video Lectures: Appropriate Use of Tests & Treatments
26 Oct, 2018 | 01:55h | UTCOrder Wisely®: Appropriate use of tests & treatments – High Value Practice Academic Alliance (free) (via @KariTikkinen)
Comprehensive educational program that reviews appropriate use of imaging exams, lab tests, medications, transfusions and procedures to promote high-value practice.
Podcast: HIV Care for the Internist
26 Oct, 2018 | 01:48h | UTC#121 HIV Care for the Internist – Curbsiders Internal Medicine Podcast (free audio and summary)
Alex Nowbar’s Research Reviews, 22 October 2018
26 Oct, 2018 | 01:47h | UTCAlex Nowbar’s research reviews—22 October 2018 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Want to Keep Your Brain Sharp? Take Care of Your Eyes And Ears
26 Oct, 2018 | 01:46h | UTCWant To Keep Your Brain Sharp? Take Care Of Your Eyes And Ears – NPR (free)
Related Articles: Longitudinal Relationship Between Hearing Aid Use and Cognitive Function in Older Americans – Journal of the American Geriatrics Society (free) AND Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing – NPR (free)
Randomized Trial: Theophylline Not Effective at Reducing COPD Exacerbations
26 Oct, 2018 | 01:44h | UTCEffect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: TWICS results suggest no role for low-dose theophylline as add-on therapy in COPD – Medwire News (free) AND Low-Dose Theophylline Not Effective at Reducing COPD Exacerbations, Study Finds – AJMC (free)
Randomized Trial: Radiotherapy to the Primary Tumour for Newly Diagnosed, Metastatic Prostate Cancer
26 Oct, 2018 | 01:45h | UTCCommentaries: Radiotherapy for newly diagnosed oligometastatic prostate cancer – The Lancet (free) AND ESMO 2018: Local radiotherapy improves survival in metastatic prostate cancer with low disease burden – eCancer News (free) AND Radiotherapy offers hopes in advanced prostate cancer – OnMedica (free) AND Cancer trial shows treating the prostate with radiotherapy improves survival – University of Birmingham (free)
Meta-Analysis: Enteral Nutrition Provided Within 48 hours After Admission in Severe Acute Pancreatitis
26 Oct, 2018 | 01:43h | UTC
Hospital Accreditation not Associated with Better Outcomes in Observational Study
26 Oct, 2018 | 01:42h | UTCCommentaries: Joint Commission accreditation doesn’t lead to better outcomes, study shows – Modern Healthcare (free) AND Doubt cast on value of hospital accreditation in Harvard study – Healthcare Dive (free)
Randomized Trial: Corticosteroid Injection vs. Night Splints for Carpal Tunnel Syndrome
26 Oct, 2018 | 01:40h | UTCInvited Commentary: Steroid injection or wrist splint for first-time carpal tunnel syndrome? (free)
“A single corticosteroid injection shows superior clinical effectiveness at 6 weeks compared with night-resting splints, making it the treatment of choice for rapid symptom response in mild or moderate carpal tunnel syndrome presenting in primary care.”
Report: Talking About Dying
26 Oct, 2018 | 01:39h | UTCNews Release: New report asks why doctors find it so hard to talk to patients about dying (free)
Commentaries: Doctors must talk ‘honestly’ to patients about dying – OnMedica (free) AND Doctors ‘need to start early conversation with patients about dying’ – BBC (free)
Eosinophilic Esophagitis: Review and Update
26 Oct, 2018 | 01:38h | UTCEosinophilic Esophagitis: Review and Update – Frontiers in Medicine (free)
Systematic Review: Prokinetics for Functional Dyspepsia
26 Oct, 2018 | 01:36h | UTCProkinetics for functional dyspepsia – Cochrane Library (free)
Summary: Medications which promote stomach movement to relieve upper abdominal discomfort that does not have a specific cause – Cochrane Library (free)
“we are unable to say whether prokinetics are effective for the treatment of functional dyspepsia.”
Review: How Early Media Exposure May Affect Cognitive Function
26 Oct, 2018 | 01:38h | UTCRelated Article: Screen media use and ADHD-related behaviors: Four decades of research – Proceedings of the National Academy of Sciences (free)
Canadian Guideline for Physical Activity Throughout Pregnancy
26 Oct, 2018 | 01:37h | UTC
Cohort Study: Association of Cardiorespiratory Fitness With Long-term Mortality
26 Oct, 2018 | 01:35h | UTCCommentaries: Expansive New Study Says Not Exercising Is Worse for Your Health Than Smoking – TIME (free) AND Researchers show better cardiorespiratory fitness leads to longer life – MedicalXpress (free)