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Position Paper | Perioperative antibiotic prophylaxis in skin surgery

3 Aug, 2023 | 13:39h | UTC

Perioperative antibiotic prophylaxis in skin surgery – Position paper of the Antibiotic Stewardship working group of the German Society for Dermatologic Surgery (DGDC) – Journal of the German Society of Dermatology

Part 1: Procedure- and patient-related risk factors

Part 2: Special indications and situations

 

Practice Guidance | Management of febrile neutropenia in immunocompetent children and youth

3 Aug, 2023 | 13:38h | UTC

Management of febrile neutropenia in immunocompetent children and youth – Canadian Paediatric Society

 

Systematic Review | Interstitial lung disease incidence at 11.7% in metastatic breast cancer patients using trastuzumab deruxtecan

3 Aug, 2023 | 13:36h | UTC

Incidence of interstitial lung disease and cardiotoxicity with trastuzumab deruxtecan in breast cancer patients: a systematic review and single-arm meta-analysis – ESMO Open

 

Cohort Study | Increased mortality rates in delirium tremens patients versus alcohol withdrawal or dependence

3 Aug, 2023 | 13:35h | UTC

Mortality and alcohol-related morbidity in patients with delirium tremens, alcohol withdrawal state or alcohol dependence in Norway: A register-based prospective cohort study – Addiction

 

Systematic Review | Necrotizing enterocolitis onset typically in third week for very preterm, low birthweight infants

3 Aug, 2023 | 13:33h | UTC

Age of onset of necrotising enterocolitis (NEC) and focal intestinal perforation (FIP) in very preterm and low birthweight infants: a systematic review – BMJ Open

 

M-A | Significant QOL and mental health improvements in caregivers via targeted interventions

3 Aug, 2023 | 13:28h | UTC

Interventions to improve outcomes for caregivers of patients with advanced cancer: a meta-analysis – JNCI: Journal of the National Cancer Institute

 

RCT | Risankizumab outperforms apremilast in moderate plaque psoriasis treatment

3 Aug, 2023 | 13:21h | UTC

Comparison of risankizumab and apremilast for the treatment of adult patients with moderate plaque psoriasis eligible for systemic therapy: results from a randomised, open-label, assessor-blinded phase IV (IMMpulse) study – British Journal of Dermatology

Commentary: Risankizumab Shown to be Superior to Apremilast in Treating Adults with Moderate Psoriasis – HCP Live

 

Study | Increasing alcohol-related mortality rates in US women, 1999-2020

3 Aug, 2023 | 13:20h | UTC

Trends in Alcohol-Related Deaths by Sex in the US, 1999-2020 – JAMA Network Open

Commentary: As alcohol-related deaths rise in the US, women are increasingly at risk, study shows – CNN

 

RCT | Ferric derisomaltose plus tranexamic acid may reduce blood transfusion risk by 50% in hip surgery

3 Aug, 2023 | 13:18h | UTC

Ferric derisomaltose and tranexamic acid, combined or alone, for reducing blood transfusion in patients with hip fracture (the HiFIT trial): a multicentre, 2 × 2 factorial, randomised, double-blind, controlled trial – The Lancet Haematology (link to abstract – $ for full-text)

 

RCT | No significant recurrence-free survival improvement with everolimus post-renal carcinoma surgery

3 Aug, 2023 | 13:17h | UTC

Adjuvant everolimus after surgery for renal cell carcinoma (EVEREST): a double-blind, placebo-controlled, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

RCT | Early oral antibiotic switch in low-risk neutropenic sepsis shows mixed results

3 Aug, 2023 | 13:15h | UTC

Early switch to oral antibiotic therapy in patients with low risk neutropenic sepsis (EASI-SWITCH): A randomized non-inferiority trial – Clinical Microbiology and Infection

 

Registry Analysis | Takotsubo syndrome outcomes influenced by trigger type and patient characteristics

3 Aug, 2023 | 13:14h | UTC

Trigger‐Associated Clinical Implications and Outcomes in Takotsubo Syndrome: Results From the Multicenter GEIST Registry – Journal of American Heart Association

Commentary: Takotsubo Trigger Type Matters, With Physical Shocks Linked to Worse Outcomes – TCTMD

 

Study | Frequent soccer heading linked to cognitive impairment risk in retired players

3 Aug, 2023 | 13:12h | UTC

Heading Frequency and Risk of Cognitive Impairment in Retired Male Professional Soccer Players – JAMA Network Open

Invited Commentary: Heading Frequency and Risk of Cognitive Impairment in Retired Male Professional Soccer Players – JAMA Network Open

Related:

Cohort study | Professional soccer players are at increased risk of Alzheimer’s disease and other dementias

Dementia risk in former professional footballers is related to player position and career length.

Study: Neurodegenerative Disease Mortality Increased Among Former Professional Soccer Players

 

Commentary on Twitter

 

Review | Diagnosing delirium in perioperative and intensive care medicine

3 Aug, 2023 | 13:09h | UTC

Diagnosing delirium in perioperative and intensive care medicine – Current Opinion in Anesthesiology

 

Review | Atypical hyperplasia of the breast: Clinical cases and management strategies

3 Aug, 2023 | 13:07h | UTC

Atypical hyperplasia of the breast: Clinical cases and management strategies – Cleveland Clinic Journal of Medicine

 

WHO | Seven out of 10 people protected by at least one tobacco control measure

2 Aug, 2023 | 14:14h | UTC

News Release: Seven out of 10 people protected by at least one tobacco control measure – World Health Organization

See also: MPOWER measures

Report: WHO report on the global tobacco epidemic, 2023: protect people from tobacco smoke – World Health Organization

Commentaries:

While Anti-Smoking Policies Cover 70% of Global Population, Taxation is Under-Utilised – Health Policy Watch

Expert reaction to WHO report on the global tobacco epidemic 2023 – Science Media Centre

 

Commentary on Twitter

 

USPSTF Draft Statement | Insufficient evidence for screening children under 5 years for speech and language delay

2 Aug, 2023 | 14:13h | UTC

Speech and Language Delay and Disorders in Children: Screening – U.S. Preventive Services Task Force

Commentary:

USPSTF issues statement on speech, language disorder screenings for all children up to 5 years – Contemporary Pediatrics

USPSTF: Evidence Lacking for Screening for Speech Delays in Young Children – HealthDay

 

Perspective | The most important trial in modern cardiology (Critical appraisal of the ISCHEMIA trial)

2 Aug, 2023 | 14:11h | UTC

Chapter 3: The Most Important Trial in Modern Cardiology – Sensible Medicine

See also:

Chapter 1: What Does it Mean to Discover a Coronary Blockage? – By Dr John Mandrola

Chapter 2: On the meaning of a coronary blockage – By Dr John Mandrola

Related/Original Articles:

ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease

ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease

ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease

ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease

Follow-up of the ISCHEMIA trial | Similar survival after invasive vs. conservative management of stable coronary disease.

ISCHEMIA Trial 2ry Analysis | Patients with CCD and daily/weekly angina seem to benefit most from complete revascularization

 

Meta-analysis | Even low levels of alcohol consumption may increase blood pressure

2 Aug, 2023 | 14:07h | UTC

Alcohol Intake and Blood Pressure Levels: A Dose-Response Meta-Analysis of Nonexperimental Cohort Studies – Hypertension

News Release: Routinely drinking alcohol may raise blood pressure even in adults without hypertension – AHA Newsroom

 

Evidence Review | AA and other 12-step programs outperform CBT for alcohol use disorder

2 Aug, 2023 | 14:05h | UTC

Alcohol dependence: evidence and experience on 12 steps to recovery – Evidently Cochrane

Original study: Alcoholics Anonymous and other 12‐step programs for alcohol use disorder – Cochrane Library

 

Guideline on multimodal rehabilitation for patients with post-intensive care syndrome

2 Aug, 2023 | 14:04h | UTC

Guideline on multimodal rehabilitation for patients with post-intensive care syndrome – Critical Care

 

Commentary from the author on Twitter

 

2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease

2 Aug, 2023 | 14:02h | UTC

The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease – Arthritis & Rheumatology

Commentary: 2023 ACR/EULAR Criteria for Calcium Pyrophosphate Deposition Disease – RheumNow

 

BSH guideline for anticoagulant management of pregnant individuals with mechanical heart valves

2 Aug, 2023 | 14:01h | UTC

British Society for Haematology guideline for anticoagulant management of pregnant individuals with mechanical heart valves – British Journal of Haematology

 

RCT | Multiple sclerosis disease-modifying therapy continuation versus discontinuation in older individuals

2 Aug, 2023 | 14:00h | UTC

Risk of new disease activity in patients with multiple sclerosis who continue or discontinue disease-modifying therapies (DISCOMS): a multicentre, randomised, single-blind, phase 4, non-inferiority trial – The Lancet Neurology (link to abstract – $ for full-text)

Commentaries:

Study investigates risk when discontinuing therapy for MS patients over 55 – CU Anschutz Medical Campus

Discontinuing Multiple Sclerosis Therapies at Age 55 or Older – NEJM Journal Watch

 

Debate | Do all patients with asymptomatic severe aortic stenosis need valve replacement?

2 Aug, 2023 | 13:58h | UTC

Great debate: all patients with asymptomatic severe aortic stenosis need valve replacement – European Heart Journal

 

Commentary on Twitter

 

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