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Summary: In this open-label, randomized study involving 501 men who have sex with men (MSM) and transgender women, researchers investigated the effectiveness of postexposure doxycycline in preventing bacterial sexually transmitted infections (STIs), specifically gonorrhea, chlamydia, and syphilis. Participants with a previous STI in the past year, either taking preexposure prophylaxis (PrEP) against HIV or living with HIV, were randomly assigned to receive 200 mg of doxycycline within 72 hours after condomless sex or standard care without doxycycline. STI testing was performed quarterly, with the primary end point being the incidence of at least one STI per follow-up quarter.

Results demonstrated a significant reduction in STI incidence in both the PrEP and persons living with HIV cohorts who received doxycycline. Overall, the combined incidence of these three STIs was lower by two thirds with doxycycline postexposure prophylaxis compared to standard care. The study also reported five grade 3 adverse events but no serious adverse events attributed to doxycycline. This finding supports the use of doxycycline postexposure prophylaxis among MSM with recent bacterial STIs.

Article: Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Doxycycline after sex found to reduce STI incidence in gay men, transgender women – CIDRAP

Commentary on Twitter

In an open-label, randomized study involving men who have sex with men, doxycycline use after high-risk sexual exposure reduced the incidence of sexually transmitted infections (chlamydia, gonorrhea, and syphilis). https://t.co/tYOj8FLEy2 pic.twitter.com/bzNyvwzYS7

— NEJM (@NEJM) April 5, 2023

Cohort Study | Third trimester ultrasound reduces undiagnosed breech presentations

12 Apr, 2023 | 13:27h | UTC

Impact of point-of-care ultrasound and routine third trimester ultrasound on undiagnosed breech presentation and perinatal outcomes: An observational multicentre cohort study – PLOS Medicine

Commentary: Timely Ultrasound Can ID Undiagnosed Breech Presentations – HealthDay

M-A | Association of inhaled corticosteroids with all-cause mortality risk in patients with COPD

12 Apr, 2023 | 13:25h | UTC

Association of Inhaled Corticosteroids With All-Cause Mortality Risk in Patients With COPD: A Meta-analysis of 60 Randomized Controlled Trials – Chest (link to abstract – $ for full-text)

Commentary on Twitter

ICS-based inhaled therapy of longer than 6 months associated with reduction in all-cause mortality risk in patients with #COPD in a meta-analysis of 60 RCTs. Read the full original research in the January issue: https://t.co/p2CwSu8aqb #journalCHEST #MedEd pic.twitter.com/0j24enQmX3

— CHEST® Journal (@journal_CHEST) January 20, 2023

Review | Revised definition of pulmonary hypertension and approach to management

12 Apr, 2023 | 13:22h | UTC

Revised Definition of Pulmonary Hypertension and Approach to Management: A Clinical Primer – Journal of the American Heart Association

The ‘Ten Commandments’ of the 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension – European Heart Journal

Pulmonary hypertension: An update of Dx and Tx guidelines – Journal of Family Practice

Medications for the treatment of pulmonary arterial hypertension: a systematic review and network meta-analysis – European Respiratory Review

Recent advances in the management of pulmonary hypertension with interstitial lung disease – European Respiratory Review

The physiological basis of pulmonary arterial hypertension – European Respiratory Journal

Topic-Based, Recent Literature Review on Pulmonary Hypertension – Mayo Clinic Proceedings

Twenty‐four-hour ambulatory blood pressure profile in patients with reflex syncope vs. matched controls

12 Apr, 2023 | 13:21h | UTC

Twenty‐Four‐Hour Ambulatory Blood Pressure Profile in Patients With Reflex Syncope and Matched Controls – Journal of the American Heart Association

Cohort Study | Association of the AHA’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality

12 Apr, 2023 | 13:20h | UTC

Association of the American Heart Association’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality: prospective cohort study – BMC Medicine

Commentaries:

Life’s Essential 8: Higher cardiovascular health scores linked to reduced mortality risks – News Medical

The American Heart Association’s life essential 8 scores to predict cardiovascular health – Physician’s Weekly

SR | Experiences and perceptions of cash transfers for health

12 Apr, 2023 | 13:23h | UTC

Experiences of conditional and unconditional cash transfers intended for improving health outcomes and health service use: a qualitative evidence synthesis – Cochrane Library

Summary: Experiences and perceptions of cash transfers for health – Cochrane Library

RCT | Zolbetuximab plus mFOLFOX6 in CLDN18.2+ HER2- advanced gastric or gastro-oesophageal junction adenocarcinoma

Cohort Study | Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer

M-A | Efficacy of postpartum pharmacologic thromboprophylaxis

RCT | Safety of Fezolinetant for vasomotor symptoms associated with menopause

The earlier the better: an RCT of treatment timing effects for toddlers on the autism spectrum

RCT | 10-year results show low-dose tamoxifen reduces noninvasive breast cancer recurrence

RCT | Hydroxyurea for secondary stroke prevention in children with sickle cell anemia

SR | Blood pressure control for diabetic retinopathy

SR | Device‐modified trabeculectomy for glaucoma

SR | Exercise‐based rehabilitation programs for pulmonary hypertension

SR | Mechanical methods for induction of labor

SR | Inhaled corticosteroids versus placebo for stable chronic obstructive pulmonary disease

SR | Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)

SR | Nebulized hypertonic saline solution for acute bronchiolitis in infants

Review | Diagnosis and management of prediabetes

RCT | Doxycycline postexposure prophylaxis effective in preventing gonorrhea, chlamydia, and syphilis in MSM

Cohort Study | Third trimester ultrasound reduces undiagnosed breech presentations

M-A | Association of inhaled corticosteroids with all-cause mortality risk in patients with COPD

Review | Revised definition of pulmonary hypertension and approach to management

Twenty‐four-hour ambulatory blood pressure profile in patients with reflex syncope vs. matched controls

Cohort Study | Association of the AHA’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality

SR | Experiences and perceptions of cash transfers for health

ASCO Policy Statement on biosimilar and interchangeable products in oncology

Low back pain of disc, sacroiliac joint, or facet joint origin: a diagnostic accuracy systematic review

Guideline | Management of systemic lupus erythematosus

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