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[Abstract Only] Randomized Trial: Fenfluramine Hydrochloride for the Treatment of Seizures in Dravet Syndrome
23 Jan, 2020 | 01:49h | UTCFenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Drug could reduce frequency of seizures for children with Dravet Syndrome – The Lancet (free) AND Old drug offers new hope for children with devastating disorder – World Pharma News (free)
Review: Lifetime Cardiovascular Management of Patients with Previous Kawasaki Disease
23 Jan, 2020 | 01:51h | UTCLifetime cardiovascular management of patients with previous Kawasaki disease – Heart (free)
Randomized Trial: Treatments for Neovascular Age-Related Macular Degeneration Compared
23 Jan, 2020 | 01:50h | UTC
[Abstract Only] Randomized Trial: Cabazitaxel vs. Abiraterone or Enzalutamide in Metastatic Prostate Cancer
23 Jan, 2020 | 01:48h | UTCCabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: ESMO 2019: Cabazitaxel vs Abiraterone or Enzalutamide in Previously Treated Metastatic Castration-Resistant Prostate Cancer – The ASCO Post (free)
Related Commentary on Twitter
#VisualAbstract: Cabazitaxel in Metastatic Prostate Cancer. See more NEJM Visual Abstracts now: pic.twitter.com/nUeb6dqRYi
— NEJM (@NEJM) December 26, 2019
ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated”
22 Jan, 2020 | 09:44h | UTCCommentary: Risk of kidney injury in contrast CT imaging overstated, experts say – UPI (free)
Related: Another Study Questions the Association of Contrast Use and Acute Kidney Injury (studies on the subject)
Position Paper: Diagnosis and Risk Stratification of Chest Pain Patients in the Emergency Department
22 Jan, 2020 | 09:43h | UTCDiagnosis and risk stratification of chest pain patients in the emergency department: focus on acute coronary syndromes. A position paper of the Acute Cardiovascular Care Association – European Heart Journal: Acute Cardiovascular Care (free for a limited period)
AHA Recommendations: Prehospital Activation of Hospital Resources in Patients with Suspected ST‐Segment–Elevation Myocardial Infarction
22 Jan, 2020 | 09:42h | UTC
WHO Q & A – E-cigarettes: How Risky Are They?
22 Jan, 2020 | 09:39h | UTCE-cigarettes: how risky are they? – World Health Organization (free)
Related Commentary on Twitter (Thread – Click for More)
E-cigarettes are harmful to health and are not safe.
They are particularly risky when used by adolescents. Nicotine is highly addictive & young people’s brains develop up to their mid-twenties. Exposure to nicotine can have long-lasting, damaging effects.https://t.co/S8ZHoux45e pic.twitter.com/mkx0d5GCpW— World Health Organization (WHO) (@WHO) January 21, 2020
CDC: First Travel-related Case of 2019 Novel Coronavirus Detected in United States
22 Jan, 2020 | 09:40h | UTCSee also: US detects first novel coronavirus case, in traveler – CIDRAP (free) AND China virus toll rises to nine as pandemic fears grow – Reuters (free) AND First US case of Wuhan coronavirus confirmed by CDC – CNN (free) AND How quickly does the Wuhan virus spread? – Nature (free)
[Abstract Only] Meta-Analysis: Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics May be Safe
22 Jan, 2020 | 09:31h | UTCTreatment of Uncomplicated Acute Diverticulitis Without Antibiotics: A Systematic Review and Meta-analysis – Diseases of the Colon & Rectum (link to abstract – $ for full-text)
Related: Randomized Trial: Antibiotic Avoidance Associated with Similar Long-term Outcomes in Uncomplicated Diverticulitis (randomized trials on the subject)
Randomized Trial: Hydroxyethyl Starch vs. Saline for Volume Replacement Therapy in High-Risk Patients Undergoing Major Abdominal Surgery
22 Jan, 2020 | 09:36h | UTCEffect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Hydroxyethyl Starch for Fluid Replacement Therapy in High-Risk Surgical Patients: Context and Caution (free for a limited period)
Related Cochrane Review: Colloids vs Crystalloids for Fluid Resuscitation in Critically Ill People (free)
Related Commentary on Twitter
FLASH trial published today in @JAMA_current, comparing saline versus HES in high risk surgical patients.https://t.co/5xet1jOtEA
Our accompanying editorial, which hopefully helps to contextualizing the results can be found at:https://t.co/Ebl9ieG5Sp— Fernando Zampieri (@f_g_zampieri) January 21, 2020
Randomized Trial: Renal Denervation + Catheter Ablation Reduces Recurrence Compared to Catheter Ablation Alone in Patients with Paroxysmal Atrial Fibrillation and Hypertension
22 Jan, 2020 | 09:34h | UTCEffect of Renal Denervation and Catheter Ablation vs Catheter Ablation Alone on Atrial Fibrillation Recurrence Among Patients with Paroxysmal Atrial Fibrillation and Hypertension: The ERADICATE-AF Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Improving Outcomes in Patients With Atrial Fibrillation and Hypertension (free for a limited period)
Managing Clinical Uncertainty: A Teachable Moment
22 Jan, 2020 | 09:33h | UTCManaging Clinical Uncertainty: A Teachable Moment – JAMA Internal Medicine (free for a limited period)
Meta-Analysis of Direct Oral Anticoagulants Randomized Trials: Double vs. Triple Antithrombotic Therapy in Patients with Atrial Fibrillation Following Percutaneous Coronary Intervention
22 Jan, 2020 | 09:28h | UTCRelated: Meta-analysis: Double Anti-thrombotic Therapy Safer than Triple Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease (studies on the subject)
Review: Enhancing Recovery in Pediatric Major Abdominal Surgery
22 Jan, 2020 | 09:26h | UTCRelated Reviews: Review of the enhanced recovery pathway for children: perioperative anesthetic considerations – Canadian Journal of Anesthesia (free) AND Embracing change: the era for pediatric ERAS is here – Pediatric Surgery International (free) AND Preparing Enhanced Recovery After Surgery for implementation in pediatric populations – Journal of Pediatric Surgery (free)
Opinion: Our Best Weapons Against Cancer are Not Magic Bullets
22 Jan, 2020 | 09:23h | UTCOur best weapons against cancer are not magic bullets – Nature (free)
[Abstract Only] Systematic Review: No Benefit from Flexible Titration Above Minimum Licensed Dose in Prescribing Antidepressants for Major Depression
22 Jan, 2020 | 09:27h | UTCNo benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review – Acta Psychiatrica Scandinavica (link to abstract – $ for full-text)
Related Meta-analysis: Optimal Dose of Antidepressants in Major Depression – The Lancet Psychiatry (free study and commentaries)
Systematic Review: Treatments for Preventing Recurrence of Infection with Pseudomonas Aeruginosa in People with Cystic Fibrosis
22 Jan, 2020 | 09:22h | UTCTreatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis – Cochrane Library (free)
Summary: Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis – Cochrane Library (free)
Systematic Review: Interventions for Chronic Palmoplantar Pustulosis
22 Jan, 2020 | 09:21h | UTCInterventions for chronic palmoplantar pustulosis – Cochrane Library (free)
Summary: Treating long-term palmoplantar pustulosis (pustules on the hands and feet) – Cochrane Library (free)
Glucocorticoids in Elite Sport: Current Status, Controversies and Innovative Management Strategies
22 Jan, 2020 | 09:17h | UTC
Perspective – Childhood Obesity Is a Major Problem. Research Isn’t Helping.
22 Jan, 2020 | 09:20h | UTCChildhood Obesity Is a Major Problem. Research Isn’t Helping. – The New York Times (10 articles per month are free)
“Something is missing with many study methods.”
Cohort Study: Second-generation Antipsychotics and Pregnancy Complications
22 Jan, 2020 | 09:18h | UTC
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment
22 Jan, 2020 | 09:15h | UTCRelated: Cardiotoxicity of immune checkpoint inhibitors – ESMO Open (free) AND Cardiotoxicity from immune checkpoint inhibitors – IJC Heart & Vasculature (free) AND Cardiovascular toxicity of immune checkpoint inhibitors in cancer patients: A review when cardiology meets immuno-oncology – Journal of the Formosan Medical Association (free) AND Immune-Checkpoint Inhibitor-Induced Fulminant Myocarditis and Cardiogenic Shock – JACC: CardioOncology (free)
Study: Concurrent Prenatal Drinking and Smoking Increases Risk for Sudden Infant Death Syndrome
22 Jan, 2020 | 09:18h | UTCCommentary: Combined prenatal smoking and drinking greatly increases SIDS risk – NIH News Releases (free)
Becoming a Parent: A Systematic Review and Meta‐analysis of Changes in BMI, Diet, and Physical Activity
22 Jan, 2020 | 09:13h | UTC