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Clinical trial 2y update | Avelumab first-line maintenance for advanced urothelial carcinoma

2 May, 2023 | 13:30h | UTC

Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Results From the JAVELIN Bladder 100 Trial After ≥2 Years of Follow-Up – Journal of Clinical Oncology

Original Article: Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma – New England Journal of Medicine

 


RCT | Liso-cel, a CAR T-Cell therapy, significantly improves outcomes in large B-Cell lymphoma second-line treatment

2 May, 2023 | 13:28h | UTC

Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the phase 3 TRANSFORM study – Blood

Commentary: Lisocabtagene Maraleucel Bests Standard Care in LBCL – Cancer Therapy Advisor

 


M-A | Pain management interventions for the treatment of chronic low back pain

2 May, 2023 | 13:26h | UTC

Pain Management Interventions for the Treatment of Chronic Low Back Pain: A Systematic Review and Meta-Analysis – The Clinical Journal of Pain

 


CONSORT Harms 2022 statement, explanation, and elaboration: updated guideline for the reporting of harms in randomized trials

2 May, 2023 | 13:25h | UTC

CONSORT Harms 2022 statement, explanation, and elaboration: updated guideline for the reporting of harms in randomized trials – Journal of Clinical Epidemiology

 


RCT | Ventilation approaches in one-lung ventilation and pulmonary complications after major lung resection surgery

2 May, 2023 | 13:23h | UTC

One-lung ventilation and postoperative pulmonary complications after major lung resection surgery. A multicenter randomized controlled trial – Journal of Cardiothoracic and Vascular Anesthesia

 

Commentary on Twitter

 


Clinical aspects of snakebite envenoming and its treatment in low-resource settings

2 May, 2023 | 13:21h | UTC

Clinical aspects of snakebite envenoming and its treatment in low-resource settings – The Lancet (free registration required)

 


M-A | Low-dose triple and quadruple antihypertensives outperform monotherapy in blood pressure reduction

28 Apr, 2023 | 13:23h | UTC

Efficacy and Safety of Low-Dose Triple and Quadruple Combination Pills vs Monotherapy, Usual Care, or Placebo for the Initial Management of Hypertension: A Systematic Review and Meta-analysis – JAMA Cardiology (free for a limited period)

Commentary: Low-Dose Polypills Top Other Approaches for Initial BP Control: Meta-analysis – TCTMD

Related: #ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).

 


Oral anticoagulation in patients with advanced CKD and atrial fibrillation: beyond anticoagulation

2 May, 2023 | 13:20h | UTC

Oral Anticoagulation in Patients With Advanced Chronic Kidney Disease and Atrial Fibrillation: Beyond Anticoagulation – Mayo Clinic Proceedings

 


AHA Scientific Statement | Assessing popular diets in relation to 2021 American Heart Association dietary recommendations

28 Apr, 2023 | 13:21h | UTC

Popular Dietary Patterns: Alignment With American Heart Association 2021 Dietary Guidance: A Scientific Statement From the American Heart Association – Circulation

Top Things to Know: Popular Dietary Patterns: Alignment with AHA 2021 Dietary Guidance – American Heart Association

 

Commentary on Twitter

 


Cohort Study | Risk of multiple morbidities across the lifespan in people with Down syndrome or intellectual disabilities

28 Apr, 2023 | 13:19h | UTC

Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records – The Lancet Public Health

 

Commentary from the author on Twitter (thread – click for more)

 


Global burden of chronic respiratory diseases and risk factors, 1990–2019

28 Apr, 2023 | 13:17h | UTC

Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019 – eClinicalMedicine

News Release: Chronic respiratory disease is third leading cause of death globally with air pollution killing 1.3 million people – IHME

 

Commentary on Twitter (thread – click for more)

 


RCT | Molecular point-of-care testing for gastroenteritis reduced isolation time but increased antibiotic use

28 Apr, 2023 | 13:15h | UTC

Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial – The Lancet Infectious Diseases

Commentary: Molecular testing in suspected infectious diarrhoea—the value of negative results – The Lancet Infectious Diseases

 


CHEST/AARC/ATS/CTS Research Statement | Effect of race and ethnicity on pulmonary function testing interpretation

28 Apr, 2023 | 13:10h | UTC

Effect of Race and Ethnicity on Pulmonary Function Testing Interpretation: A CHEST/AARC/ATS/CTS Evidence Review and Research Statement – Chest

Commentary: Pulmonary Testing Based on Race, Ethnicity Found Flawed – Medscape (free registration required)

 


RCT | Albuterol–budesonide pressurized metered dose inhaler in patients with mild-to-moderate asthma

28 Apr, 2023 | 13:13h | UTC

Albuterol–budesonide pressurized metered dose inhaler in patients with mild-to-moderate asthma: results of the DENALI double-blind randomized controlled trial – Chest

Related study: Albuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma – New England Journal of Medicine

 


Single-arm study | Blinatumomab added to chemotherapy in infant lymphoblastic leukemia

28 Apr, 2023 | 13:08h | UTC

Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia – New England Journal of Medicinev (link to abstract – $ for full-text)

News Release: Immunotherapy strongly improves prognosis of babies with leukemia – Princess Máxima Center

 

Commentary on Twitter

https://twitter.com/NEJM/status/1651335340916109313

 


Survey | What symptoms come first in degenerative cervical myelopathy?

28 Apr, 2023 | 13:05h | UTC

Targeting earlier diagnosis: What symptoms come first in Degenerative Cervical Myelopathy? – PLOS One

Commentary: Identifying the initial symptoms to degenerative cervical myelopathy – 2 minute medicine

 


Review | Multidisciplinary management in the treatment of intrahepatic cholangiocarcinoma

28 Apr, 2023 | 13:03h | UTC

Multidisciplinary management in the treatment of intrahepatic cholangiocarcinoma – CA: A Cancer Journal for Clinicians

 


Criteria for placental examination for obstetrical and neonatal providers

28 Apr, 2023 | 13:06h | UTC

Criteria for placental examination for obstetrical and neonatal providers – American Journal of Obstetrics & Gynecology

 


Single-arm trial | Retroperitoneal lymph node dissection as first-line treatment for early metastatic seminoma shows 81% 2-Year RFS

28 Apr, 2023 | 13:02h | UTC

Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy – Journal of Clinical Oncology

News Release: Surgery proves effective alternative to chemotherapy and radiation for early metastatic testicular cancer – Keck Medicine of USC

Commentary: Retroperitoneal Lymph Node Dissection for Early Metastatic Testicular Seminoma – The ASCO Post

 


Guideline | Transient global amnesia

28 Apr, 2023 | 12:59h | UTC

Guideline “Transient Global Amnesia (TGA)” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): S1-guideline – Neurological Research and Practice

 


Review | Should RAAS blockade therapy be continued in patients with advanced renal disease?

28 Apr, 2023 | 13:00h | UTC

Should RAAS blockade therapy be continued in patients with advanced renal disease? – MDedge

 


Position Statement | Transthoracic echocardiographic assessment of the heart in pregnancy

28 Apr, 2023 | 12:57h | UTC

Transthoracic Echocardiographic Assessment of the Heart in Pregnancy—a position statement on behalf of the British Society of Echocardiography and the United Kingdom Maternal Cardiology Society – Echo Research & Practice

 


M-A | Immune checkpoint inhibitors vs. chemotherapy in the 2nd-line treatment of advanced esophageal squamous cell carcinoma

28 Apr, 2023 | 12:56h | UTC

Efficacy and safety of immune checkpoint inhibitors versus chemotherapy in the second-line treatment of advanced esophageal squamous cell carcinoma: a meta-analysis and systematic review – Journal of Thoracic Disease

 


Pre-Post Study | Machine learning informs mortality risk, increases advanced care planning rates in hospitalized patients

28 Apr, 2023 | 12:54h | UTC

Advanced Care Planning for Hospitalized Patients Following Clinician Notification of Patient Mortality by a Machine Learning Algorithm – JAMA Network Open

 

Commentary on Twitter

 


Rapid reviews methods series | Involving patient and public partners, healthcare providers and policymakers as knowledge users

28 Apr, 2023 | 12:52h | UTC

Rapid Reviews Methods Series: Involving patient and public partners, healthcare providers and policymakers as knowledge users – BMJ Evidence-Based Medicine

 


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