All Posts
COVID-19 and mRNA vaccines—first large test for a new approach
4 Sep, 2020 | 02:08h | UTCCOVID-19 and mRNA Vaccines—First Large Test for a New Approach – JAMA
Forty postmortem examinations in COVID-19 Patients: Two distinct pathologic phenotypes and correlation with clinical and radiologic findings
4 Sep, 2020 | 02:05h | UTC
Commentary on Twitter
Our COVID autopsy study is now online! We describe 2 distinct pathologic phenotypes and correlate with clinical and radiologic data. So proud of this team! 💕@ColumbiaPath @AJCPjournal #pulmpath #pathology #autopsy #NYC #COVID19 #covid https://t.co/f3xhc0v1si
— Simona De Michele, MD (@SDeMicheleMD) September 3, 2020
Opinion: Herd immunity is not a strategy
4 Sep, 2020 | 02:09h | UTCHerd Immunity Is Not a Strategy – The Atlantic
Challenges in evaluating SARS-CoV-2 vaccines during the COVID-19 pandemic
4 Sep, 2020 | 02:06h | UTC
Coalition Covid-19 Brazil – Randomized trial: Dexamethasone improves outcomes in patients with Acute Respiratory Distress Syndrome and COVID-19
3 Sep, 2020 | 11:24h | UTCEditorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic
Related studies: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial – JAMA AND Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial – JAMA
Commentary: Inexpensive Steroids Can Save Lives Of Seriously Ill COVID-19 Patients – NPR
Commentary on Twitter
In this RCT, IV #dexamethasone increased the number of ventilator-free days by day 28 vs standard care alone among patients with #COVID19 and moderate or severe ARDS https://t.co/RA9G6LVRlz @ICURevisited @FlaviaSepsis @israelmaia16
— JAMA (@JAMA_current) September 2, 2020
Malignant pleural effusions: New evidence on management
4 Sep, 2020 | 02:03h | UTCMalignant pleural effusions (MPE): new evidence on management – Evidently Cochrane
Original Review: Interventions for the management of malignant pleural effusions: a network meta‐analysis – Cochrane Library
Video: Corticosteroids for COVID-19 – New Evidence of Benefit
3 Sep, 2020 | 11:21h | UTCCorticosteroids for COVID-19 – New Evidence of Benefit – JAMA
Meta-analysis: Corticosteroids for critically ill patients with COVID-19
3 Sep, 2020 | 11:23h | UTCEditorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic
Commentaries: Analysis of seven trials finds that corticosteroids reduce risk of death by 20 per cent in critically ill COVID-19 patients – University of Bristol AND Multiple studies confirm steroids can fight severe COVID-19 – MedicalXpress
Commentary on Twitter
1/8 Corticosteroids and COVID19
*Three* RCTs and a new @WHO meta-analysis add to #RECOVERY trial data that corticosteroids reduce mortality in critically ill #COVID19 patientshttps://t.co/H8c46Y5DTm— JAMA (@JAMA_current) September 2, 2020
Incidence of malformations after early pregnancy exposure to Modafinil
4 Sep, 2020 | 02:02h | UTCIncidence of Malformations After Early Pregnancy Exposure to Modafinil in Sweden and Norway – JAMA (free for a limited period)
Commentary: Narcolepsy drug did not increase risk of fetal malformation – Karolinska Institutet
Commentary on Twitter
Cohort study: Modafinil use during early pregnancy was not significantly associated with increased risk of major malformations (unexposed group = 2.1% vs. exposed = 2.6%; crude RR = 1.06; 0.35-3.26). 1st trimester only: RR = 0.44; 0.06-3.10 https://t.co/u4WsK2v31C
— P𝘧OL (@psychopharmacol) September 2, 2020
New WHO Guidance: Corticosteroids for COVID-19
3 Sep, 2020 | 11:20h | UTCCorticosteroids for COVID-19 – World Health Organization
News Release: WHO updates clinical care guidance with corticosteroid recommendations – World Health Organization
Commentaries: The WHO Now Recommends Cheap Steroids As a Life-Saving Treatment for Severe Covid-19 – Gizmodo AND Inexpensive steroids reduce deaths of hospitalized Covid-19 patients, WHO analysis confirms – STAT
Commentary on Twitter
🆕 guideline on use of dexamethasone & other corticosteroids advises:
✅ for oral or intravenous usage in treatment of patients with severe & critical #COVID19
❌ against usage in treatment of non-severe casesMore: https://t.co/eWHzRrYKvO
— World Health Organization (WHO) (@WHO) September 2, 2020
[Preprint] Randomized trial: Tocilizumab does not improve clinical status or mortality in hospitalized patients with COVID-19 pneumonia
3 Sep, 2020 | 11:19h | UTCTocilizumab in Hospitalized Patients With COVID-19 Pneumonia – medRxiv
Prevalence of depression symptoms in US adults before and during the COVID-19 pandemic
3 Sep, 2020 | 11:15h | UTCCommentaries: COVID-19 has likely tripled depression rate, study finds – Boston University School of Medicine AND Pandemic’s Emotional Hammer Hits Hard – NPR AND Depression Increases More Than Three-Fold In Wake Of Pandemic, BU Study Finds – CommonHealth
Covid-19: Study found those younger than 40 had an infection fatality ratio (IFR) of 0.01%; those 60 or older had an IFR of 1.71%
3 Sep, 2020 | 11:18h | UTC
Commentary on Twitter
Age, sex, race affect death risk from #COVID-19. @FSPH_IUPUI study found those younger than 40 had fatality rate of 0.01%; those 60 or older 1.71%—2.5 times greater than #flu https://t.co/oT4BCVbVxe. @jblackburn_phd @aaronecarroll pic.twitter.com/wE6Ti0EG6E
— Annals of Int Med (@AnnalsofIM) September 2, 2020
COVID-19 sparks 12-fold increase in remote delivery of mental health care across the US
3 Sep, 2020 | 11:13h | UTCOriginal Study: The COVID-19 Telepsychology Revolution: A National Study of Pandemic-Based Changes in U.S. Mental Health Care Delivery – American Psychologist
Virus in the blood can predict severe COVID-19
3 Sep, 2020 | 11:11h | UTCVirus in the blood can predict severe COVID-19 – Karolinska Institutet
Original Study: SARS-CoV-2 RNA in serum as predictor of severe outcome in COVID-19: a retrospective cohort study – Clinical Infectious Diseases
COVID-19 can wreck your heart, even if you haven’t had any symptoms
3 Sep, 2020 | 11:06h | UTCCOVID-19 Can Wreck Your Heart, Even if You Haven’t Had Any Symptoms – Scientific American
IDSA Podcast – Managing patients post-COVID-19: From symptoms to lasting complications
3 Sep, 2020 | 11:08h | UTC
Combining PCR and antibody tests at point of care dramatically increases COVID-19 detection
3 Sep, 2020 | 11:10h | UTCOriginal Study: Combined point of care nucleic acid and antibody testing for SARS-CoV-2 following emergence of D614G Spike Variant – Cell Reports Medicine
Fauci says COVID vaccine trials could end early if results are overwhelming
3 Sep, 2020 | 11:02h | UTCFauci Says COVID Vaccine Trials Could End Early If Results Are Overwhelming – Kaiser Health News
Randomized trial: Similar outcomes with immediate angiography vs. delayed angiography after cardiac arrest
3 Sep, 2020 | 10:58h | UTCCoronary Angiography After Cardiac Arrest Without ST Segment Elevation: One-Year Outcomes of the COACT Randomized Clinical Trial – JAMA Cardiology (free for a limited period)
Commentary: Angiography for Cardiac Arrest Survivors: No Need to Rush – MedPage Today (free registration required)
Commentary on Twitter
Coronary angiography after cardiac arrest without ST elevation. COACT Trial. Immediate angiography was not found to be superior to a strategy of delayed angiography with respect to outcomes at 1 year @JAMACardio @randreariba_rut https://t.co/07FIQjwTOQ
— Carles Falces (@CarlesFalces) September 3, 2020
[Abstract Only] CAR T-cell therapy for patients with relapsed or refractory large B-cell lymphomas
3 Sep, 2020 | 10:56h | UTCLisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study – The Lancet (link to abstract – $ for full-text)
Getting ready for the Covid-19 pandemic: Experience of a Brazilian hospital
3 Sep, 2020 | 11:00h | UTCGetting Ready for the Covid-19 Pandemic: Experience of a Brazilian Hospital – NEJM Catalyst
Randomized trial: Effect of low tidal volume vs. conventional tidal volume on postoperative pulmonary complications in patients undergoing major surgery
3 Sep, 2020 | 10:57h | UTCEffect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Normal lungs and the humans containing them don’t seem to mind how they’re ventilated (within reason). https://t.co/EdGVjm7esU
— Greg Bryson, MD, FRCPC (@glbryson) September 2, 2020
23 bus passengers contracted coronavirus from 1 infected person. No one was wearing a mask.
2 Sep, 2020 | 10:09h | UTCOriginal Study: Community Outbreak Investigation of SARS-CoV-2 Transmission Among Bus Riders in Eastern China – JAMA Internal Medicine
Commentary on Twitter
Outbreak on a bus in China is offering new evidence about SARSCoV2's airborne spread. A person on a poorly ventilated vehicle infected nearly 2 doz people even tho many weren't sitting nearby. Conclusion: mere breathing can send micro-droplets into the air https://t.co/plxzOrZLAT
— delthia ricks 🔬 (@DelthiaRicks) September 1, 2020
New #OpenWho Course: Occupational health and safety for health workers in the context of COVID-19
2 Sep, 2020 | 10:11h | UTC