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Keeping best practices in critical care during COVID-19
1 Oct, 2020 | 09:08h | UTCKeeping Best Practices in Critical Care During COVID-19 – ICU Management & Practice
Commentary on Twitter
COVID-19 poses several challenges and has made it difficult to measure ICU performance.
Read the article 'Keeping Best Practices in Critical Care During COVID-19' by @f_g_zampieri 👉https://t.co/kvwlGSLBav#Covid19 #ICU #patientoutcome #FOAMcc #FOAMed pic.twitter.com/2YOhOnidxZ
— ICU Management (@ICU_Management) September 28, 2020
A systematic review and meta-analysis of published research data on COVID-19 infection-fatality rates
1 Oct, 2020 | 09:04h | UTC
Commentary on Twitter
(1/3) Excellent, rigorous review and meta-analysis of #COVID19 infection fatality ratio (IFR).
The overall IFR was 0.68% (95% CI 0.53-0.82%).
If only studies with a low risk of bias were included, the IFR rose to 0.76% (0.37-1.15%).https://t.co/F5GN0253lz https://t.co/7ucGgQ78AM pic.twitter.com/laHO3e4sl3
— Dr Zoë Hyde (@DrZoeHyde) September 30, 2020
Viewpoint: COVID-19 and heart failure with preserved ejection fraction
1 Oct, 2020 | 09:06h | UTCCOVID-19 and Heart Failure With Preserved Ejection Fraction – JAMA
New research shows older adults are still often excluded from clinical trials
1 Oct, 2020 | 09:02h | UTCNew research shows older adults are still often excluded from clinical trials – STAT
Original Study: The Exclusion of Older Persons From Vaccine and Treatment Trials for Coronavirus Disease 2019—Missing the Target – JAMA Internal Medicine
Commentary on Twitter
“It is important we have a trial population that reflects the real-world population." https://t.co/tRpo0NGL5x
— STAT (@statnews) October 1, 2020
[Abstract Only] Atezolizumab for first-line treatment of PD-L1–selected patients with non–small-cell lung cancer
1 Oct, 2020 | 08:53h | UTCCommentary: Atezolizumab Leads to Longer OS for Some Types of Advanced NSCLC, Study Says – AJMC
Invasive candidiasis in critical care: Challenges and future directions
1 Oct, 2020 | 09:00h | UTCInvasive candidiasis in critical care: challenges and future directions – Intensive Care Medicine
Commentary on Twitter
Invasive candidiasis: most common #ICU fungal infection ~40-55% mortality. Key challenges:
➡️ changing epidemiology/emergence of resistances
➡️ timely/appropriate therapy initiation/discontinuation
➡️ choosing/tailoring optimal antifungals#FOAMcc review https://t.co/tMPNcYfzwL pic.twitter.com/HvJKr0jX2o— Intensive Care Medicine (@yourICM) September 30, 2020
Systematic review: The effectiveness and cost‐effectiveness of hospital‐based specialist palliative care for adults with advanced illness and their caregivers
1 Oct, 2020 | 08:58h | UTC
Commentary on Twitter
Cochrane review on hospital-based specialist palliative care. Findings: Improved HR-QoL and patient satisfaction, reduced symptom burden and depression, and increased chances of patients dying in their preferred place. @SBajwah @cochranecollab https://t.co/wjhGp0gcbs
— Olaf Geerse (@OlafGeerse) September 30, 2020
New COVID-19 inpatient risk calculator estimates the probability of severe disease or death at hospital admission
30 Sep, 2020 | 09:51h | UTCCommentaries: COVID-19 ‘prediction model’ uses data that can help determine if patients’ conditions are likely to worsen – Johns Hopkins Medicine AND Prediction model incorporates more than 20 variables at hospital admission – Physician’s Weekly AND Patient Trajectories Among COVID-19 Hospitalized Patients – American College of Cardiology
Interactive Calculator: The COVID Inpatient Risk Calculator: CIRC
Commentary on Twitter
Lead authors Brian T. Garibaldi, MD, MEHP and Jacob Fiksel, PhD of @HopkinsMedicine developed the COVID-19 Inpatient Risk Calculator (CIRC) that uses patient data at admission to determine potential disease trajectory for #COVID19.
Link: https://t.co/i1e1ek7wO7. @Bedsidemedicine pic.twitter.com/wQLctHHYrn
— Annals of Int Med (@AnnalsofIM) September 22, 2020
[Abstract Only] Nationwide cohort study in Sweden shows HPV vaccination linked to reduced risk of invasive cervical cancer
1 Oct, 2020 | 08:56h | UTCHPV Vaccination and the Risk of Invasive Cervical Cancer – New England Journal of Medicine
News Release: HPV vaccine effective against cervical cancer – Karolinska Institutet
Low risk of SARS-CoV-2 transmission by fomites in real-life conditions
30 Sep, 2020 | 09:48h | UTC
Commentary on Twitter
A reassuring note about lack of virus being cultured from surfaces, fomites, even in the hospital setting, pointing against this mode of transmission https://t.co/iMhzB6nvqQ @TheLancetInfDis pic.twitter.com/zJDuhc3BBC
— Eric Topol (@EricTopol) September 29, 2020
Proposed clinical criteria for COVID-19-associated hyperinflammatory syndrome
30 Sep, 2020 | 09:50h | UTC
Commentary on Twitter
Defining and grading the clinical hyperinflammatory syndrome with #COVID19 and how this cytokine storm relates to outcomes https://t.co/6Ngp3OHZJx @TheLancetRheum @Intermountain pic.twitter.com/bDGwKpjOI4
— Eric Topol (@EricTopol) September 29, 2020
Recent increase in COVID-19 cases reported among adults aged 18–22 years in the US
30 Sep, 2020 | 09:44h | UTCCommentary: CDC Documents Increase in Coronavirus Cases Among Young Adults – U.S.News
Commentary on Twitter
New @CDCMMWR shows #COVID19 infections among 18-22 year-olds increased more than 50% from early August to early Sept. Everyone needs to help slow the spread of COVID-19. Wear a mask, stay 6 feet from others, wash hands often, & stay home when sick. https://t.co/OLCkD1v23I pic.twitter.com/hu7R5QFlpb
— CDC (@CDCgov) September 29, 2020
Preventing and responding to COVID-19 on college campuses
30 Sep, 2020 | 09:47h | UTCPreventing and Responding to COVID-19 on College Campuses – JAMA
Multiple COVID-19 clusters on a university campus
30 Sep, 2020 | 09:46h | UTCCommentary: Student gatherings, congregate living contribute to rapid coronavirus spread at universities: CDC – The Hill
Commentary on Twitter
A new @CDCMMWR details rapid spread of #COVID19 at a university shortly after opening. Many of the cases were linked to residence halls, fraternities/sororities, off-campus apartments, & athletic teams. Learn more: https://t.co/TVDq49frkF. pic.twitter.com/MBz6HMH3Qg
— CDC (@CDCgov) September 29, 2020
CDC study shows a substantial increase in COVID-19 rates among school-aged children in the US
30 Sep, 2020 | 09:43h | UTCCommentaries: Coronavirus Rates For Teens Are Nearly Double Rate For Children, CDC Finds – Forbes AND Research shows substantial increase in COVID-19 rates in children, especially adolescents – ABC News
Commentary on Twitter
(1/7) Study of #COVID19 in US children. 277,285 cases were reported between 1 March and 19 September. Incidence higher in adolescents compared to young children (although more adolescents were tested). 1.2% were hospitalised (0.1% ICU), and 0.02% died.https://t.co/NjNFBRRyYg pic.twitter.com/83G6Y6oqyF
— Dr Zoë Hyde (@DrZoeHyde) September 29, 2020
Intensive care unit acquired muscle weakness in COVID-19 patients
30 Sep, 2020 | 09:39h | UTCIntensive care unit acquired muscle weakness in COVID-19 patients – Intensive Care Medicine
Commentary on Twitter
#ICU acquired muscle weakness in #COVID19 frequently occurring in critically ills on prolonged sedation. Price to pay for rigorous protective MV? follow-up essential to offer tailored rehab, trying to reduce long-term impact on functional status. #ICUrehab https://t.co/anf0WE0W4w pic.twitter.com/MdnNzYuTN8
— Intensive Care Medicine (@yourICM) September 28, 2020
When young people get COVID-19, infections soon rise among older adults
30 Sep, 2020 | 09:41h | UTCWhen Young People Get COVID-19, Infections Soon Rise Among Older Adults – NPR
“rising infections among young adults preceded increases in COVID-19 — by four to 15 days — among people over the age of 60.”
Commentary on Twitter
A recent CDC report confirms what many public health experts have been warning: Coronavirus cases in young adults lead to infections in older and more vulnerable people — who are more likely to be hospitalized and die from COVID-19.https://t.co/r89dOJrTWj
— NPR (@NPR) September 29, 2020
Investigational COVID-19 vaccine well-tolerated and generates immune response in older adults
30 Sep, 2020 | 09:36h | UTCOriginal Article: Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults – New England Journal of Medicine
Commentary on Twitter
The Moderna mRNA vaccine, which elicited antibodies and T cells specific for the Covid-19 virus in adults 55 years of age or younger, elicited similarly high levels of neutralizing-antibody and CD4 T-cell responses in older adults. #COVID19 #SARSCoV2
— NEJM (@NEJM) September 29, 2020
What people get wrong about herd immunity, explained by epidemiologists
30 Sep, 2020 | 09:38h | UTCWhat people get wrong about herd immunity, explained by epidemiologists – Vox
Editorial – Stress ulcer prophylaxis: Is mortality a useful endpoint?
30 Sep, 2020 | 09:31h | UTCStress ulcer prophylaxis: Is mortality a useful endpoint? – Intensive Care Medicine
Commentary on Twitter
Stress ulcer prophylaxis: restrict to highest GI bleeding risk #ICU pts; still uncertainties on harmful effects (ie PK interactions?). Early EN, effective if low-risk + reducing underfeeding, to be encouraged. https://t.co/2EOsefikFc
Referring Wang et al https://t.co/MXnfHYyoJ4 pic.twitter.com/Xz8wmTzn62
— Intensive Care Medicine (@yourICM) September 29, 2020
WHO publishes pricing policy guideline to improve affordable access to medicines
30 Sep, 2020 | 09:33h | UTCNews release: WHO publishes pricing policy guideline to improve affordable access to medicines – World Health Organization
Original Guideline: WHO guideline on country pharmaceutical pricing policies – World Health Organization
Commentary on Twitter
The 🆕 guideline covers 🔟 pricing policy approaches, incl.:
✔️ External & internal reference pricing
✔️ Value-based pricing
✔️ Promoting price transparency
✔️ Tendering & negotiation
✔️ Pooled procurement
✔️ Cost-plus pricing
…and more👉 https://t.co/XYqUYStolJ pic.twitter.com/T7vDMUmfBK
— World Health Organization (WHO) (@WHO) September 29, 2020
Less than 10% of US population has COVID-19 antibodies, data show
29 Sep, 2020 | 10:12h | UTCLess than 10% of US population has COVID-19 antibodies, data show – CIDRAP
Original Study: Prevalence of SARS-CoV-2 antibodies in a large nationwide sample of patients on dialysis in the USA: a cross-sectional study – The Lancet
Commentary on Twitter
NEW Research—Nationwide cross-sectional analysis of US patients receiving dialysis finds fewer than 10% of people had #COVID19 antibodies by July 2020, and fewer than 10% of those with antibodies had been diagnosed by antigen or PCR testing https://t.co/QWPMO0gCr3 pic.twitter.com/v2K66uLLID
— The Lancet (@TheLancet) September 26, 2020
Mass screening of asymptomatic persons for SARS-CoV-2 using saliva
29 Sep, 2020 | 10:13h | UTCMass screening of asymptomatic persons for SARS-CoV-2 using saliva – Clinical Infectious Diseases
Commentary: COVID-19: Saliva tests could detect silent carriers – Hokkaido University
Perspective: COVID-19 is not a pandemic. It is a syndemic
29 Sep, 2020 | 10:11h | UTCOffline: COVID-19 is not a pandemic – The Lancet
Commentary on Twitter
"#COVID19 is not a pandemic. It is a syndemic. The syndemic nature of the threat we face means that a more nuanced approach is needed if we are to protect the health of our communities."
This week's Offline column by our Editor-in-Chief @richardhorton1 https://t.co/Y9qgQM7PkO
— The Lancet (@TheLancet) September 28, 2020
COVID-19 vaccine may not need to be fully effective to benefit public health
29 Sep, 2020 | 10:06h | UTCOriginal Report: Modelling the allocation and impact of a COVID-19 vaccine – Imperial College London
Commentary on Twitter
Even an imperfect, partially effective vaccine against COVID-19 could have a substantial public health benefit if rolled out in 2021
https://t.co/DDkHarm0KS— Imperial School of Public Health (@ImperialSPH) September 28, 2020