All Posts | Links Medicus - Free Medical News & Perspective

1/📌Precipitous decline in #SARSCoV2 antibodies: study participants who'd been infected and had detectable antibodies were retested 60 days later. 94% showed antibody decline & 28% had no detectable antibodies. They had "seroreverted". How that impacts reinfection risk is unknown pic.twitter.com/QsvQTE9jVH

— Dr. Ali Nouri (@AliNouriPhD) November 25, 2020

Should COVID-19 vaccines be mandatory? Two experts discuss

26 Nov, 2020 | 09:05h | UTC

Should COVID-19 vaccines be mandatory? Two experts discuss – The Conversation

Testing sewage can give school districts, campuses and businesses a heads-up on the spread of COVID-19

26 Nov, 2020 | 09:03h | UTC

Testing sewage can give school districts, campuses and businesses a heads-up on the spread of COVID-19 – The Conversation

Opinion: “The AstraZeneca Covid Vaccine Data Isn’t Up to Snuff”

26 Nov, 2020 | 09:02h | UTC

The AstraZeneca Covid Vaccine Data Isn’t Up to Snuff – Wired

Commentaries: A timeline of the oxford-Astrazeneca Covid-19 vaccine trials – by Hilda Bastian AND After Admitting Mistake, AstraZeneca Faces Difficult Questions About Its Vaccine – The New York Times AND AstraZeneca manufacturing error clouds vaccine study results – Associated Press

Practice recommendations for the management of the most common forms of secondary hypertension, including primary aldosteronism, renovascular hypertension, pheochromocytoma, Cushing’s syndrome, and sleep apnea

26 Nov, 2020 | 08:59h | UTC

Practice Recommendations for Diagnosis and Treatment of the Most Common Forms of Secondary Hypertension – High Blood Pressure & Cardiovascular Prevention

Meta-analysis: Among the treatment interventions to maintain abstinence from alcohol in primary care, acamprosate was the only intervention with enough evidence of benefit

26 Nov, 2020 | 08:55h | UTC

Treatment interventions to maintain abstinence from alcohol in primary care: systematic review and network meta-analysis – The BMJ

Commentary on Twitter

Acamprosate was the only intervention with enough evidence of benefit for maintaining alcohol abstinence and acceptability up to 12 months after detoxification in primary care settings, concludes new #BMJResearch https://t.co/K7FutIC3yd

— The BMJ (@bmj_latest) November 25, 2020

Cohort study suggests there is no need to choose first-line drug treatment for hypertension according to age and ethnicity – guidelines could be simplified

26 Nov, 2020 | 08:56h | UTC

First line drug treatment for hypertension and reductions in blood pressure according to age and ethnicity: cohort study in UK primary care – The BMJ

Commentary: Study questions blood pressure drug guidance based on age and ethnicity – British Medical Journal AND Laurie Tomlinson: Shining a light into medicine’s dusty corners – The BMJ Opinion AND UK’s NICE Guidelines for Hypertension Tx Based on Age, Ethnicity May Need Updating – Physician’s Weekly AND

Commentary on Twitter

Current UK guidance on drug treatment for high blood pressure, which differs depending on a patient’s age and ethnicity, could be simplified in line with other international guidelines, suggests new @bmj_latest research @SarahJoSinnott https://t.co/bWLhXoFnV4

— The BMJ (@bmj_latest) November 21, 2020

Randomized trial: Nebulized magnesium does not benefit children with acute refractory asthma treated in the emergency department

26 Nov, 2020 | 08:58h | UTC

Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: Nebulized Magnesium Of Little Value for Emergency Tx of Kids’ Asthma Attacks – Physician’s Weekly

Commentary on Twitter

This RCT found that nebulized magnesium does not decrease hospitalization for children with refractory acute asthma in the emergency department, compared to albuterol or placebo https://t.co/9NjgPztY6V @sickkids #VisualAbstract

— JAMA (@JAMA_current) November 24, 2020

Randomized trial: Convalescent Plasma does not improve clinical status or overall mortality in severe Covid-19 pneumonia

25 Nov, 2020 | 09:17h | UTC

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia – New England Journal of Medicine

Commentary: New trial of convalescent plasma for covid-19 falls flat, another setback for hyped treatment – Brief19

Commentary on Twitter

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia ⁦@NEJM⁩ A well conducted RCT shows no significant differences in clinical status or overall mortality between patients treated with CP and those who received placebo. https://t.co/C6NylbO2At

— Carlos del Rio (@CarlosdelRio7) November 24, 2020

Cluster-randomized trial: Postexposure hydroxychloroquine does not prevent Covid-19 in healthy persons exposed to a PCR-positive case patient

25 Nov, 2020 | 09:15h | UTC

A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19 – New England Journal of Medicine

Commentary on Twitter

Another RCT in @NEJM of outpatient treatment with Hydroxychloroquine in high risk folks to prevent COVID transmission

No benefit

But about 10X rate of adverse events in HCQ group

Happy to keep studying HCQ

But it really doesn't look like it workshttps://t.co/9nAfir0CMX

— Ashish K. Jha, MD, MPH (@ashishkjha) November 24, 2020

[Preprint] Study shows cloth face coverings help protect both wearers and those nearby. Study design represents conditions closer to real-world use, with the control of laboratory testing

25 Nov, 2020 | 09:11h | UTC

Study shows cloth face coverings help protect both wearers and those nearby – Virginia Tech

Original study: Inward and outward effectiveness of cloth masks, a surgical mask, and a face shield – medRxiv

Observational study: Neuraxial anesthesia for lower limb revascularization surgery was associated with decreased 30-day mortality and hospital length of stay compared with general anesthesia

26 Nov, 2020 | 08:53h | UTC

Association between neuraxial anaesthesia or general anaesthesia for lower limb revascularisation surgery in adults and clinical outcomes: population based comparative effectiveness study – The BMJ

Commentary: Spinal/epidural anesthesia associated with increased survival in leg artery bypass surgery – The Ottawa Hospital

Commentary from the author on Twitter (thread – Click for more)

1/New in @bmj_latest our observational study demonstrating association of spinal anesthesia with ⬇️mortality & ⬇️complications in lower limb revascularization https://t.co/kqHLbRxju5
-OR mortality 0.68 (0.57-0.83)
ARR 0.7% (NNT 139)
-OR complications 0.73 (0.63-0.85) pic.twitter.com/jMEYaiMYPP

— Dan McIsaac (@mcisaac_d) November 25, 2020

With more data on its COVID-19 vaccine, Russian institute offers new evidence of success

25 Nov, 2020 | 09:13h | UTC

With more data on its COVID-19 vaccine, Russian institute offers new evidence of success – Science

News release: SECOND interim analysis of clinical trial data showed a 91.4% efficacy for the Sputnik V vaccine on day 28 after the first dose; vaccine efficacy is over 95% 42 days after the first dose – Sputnik V

Commentaries: Expert reaction to press release reporting the second interim analysis of the efficacy of the Sputnik V vaccine – Science Media Centre AND Russia says Sputnik V virus vaccine 95% effective – MedicalXpress

Opinion: “Children may transmit coronavirus at the same rate as adults: what we now know about schools and COVID-19”

25 Nov, 2020 | 09:09h | UTC

Children may transmit coronavirus at the same rate as adults: what we now know about schools and COVID-19 – The Conversation

Commentary from the author on Twitter

I've written a new article describing what we know about children, schools, & #COVID19.

➡️ Children & adults are equally susceptible, & likely transmit the virus at the same rate.

➡️ Schools are a driver of the second wave in Europe, Canada, & elsewhere.https://t.co/25T9HwHBlt

— Dr Zoë Hyde (@DrZoeHyde) November 24, 2020

Latest COVID-19 guidelines come out against bamlanivimab, remdesivir

25 Nov, 2020 | 09:10h | UTC

Latest COVID-19 guidelines come out against bamlanivimab, remdesivir – ACP Internist

Systematic review: Financial payments from the pharmaceutical industry is associated with more physician prescribing of the drug made by the company that they got the payments from

25 Nov, 2020 | 09:07h | UTC

Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing? A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Financial payments from drug industry associated with physician prescribing – American College of Physicians

Commentary from the author on Twitter (thread – click for more)

"Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing?"
Our latest on physician-industry COI is out today in @AnnalsofIM!

Not to bury the lede, the answer is "yes."
Thread to follow.https://t.co/2lfAjWSQuq
1/

— Aaron Mitchell (@TheWonkologist) November 24, 2020

Randomized trial: Prednisone is an effective short-term preventive therapy in patients with episodic cluster headache

25 Nov, 2020 | 09:01h | UTC

Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

Commentary from the author on Twitter

Finally published online! After countless years and a lot of work our study on prednisone for the treatment of episodic cluster headache. Thanks to all the many people that were involved in this study, Very proud!!! #PredCH #Clusterheadache https://t.co/d88TUWTY5i

— Mark Obermann (@ProfObermann) November 25, 2020

Randomized trial: Colorectal cancer screening with repeated fecal immunochemical tests detects more colorectal cancer and advanced adenomas compared to screening sigmoidoscopy

25 Nov, 2020 | 09:05h | UTC

Colorectal cancer screening with repeated fecal immunochemical test versus sigmoidoscopy: baseline results from a randomized trial – Gastroenterology (link to abstract – $ for full-text)

USPSTF Statement recommends regular behavioral counseling on healthy diet and physical activity to prevent cardiovascular disease

25 Nov, 2020 | 08:59h | UTC

Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors – US Preventive Services Task Force

Editorial: USPSTF Recommendations for Behavioral Counseling in Adults With Cardiovascular Disease Risk Factors: Are We Ready? – JAMA Network Open

Author interview: Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors

JAMA Patient Page: Counseling on Healthy Diet and Physical Activity to Prevent Cardiovascular Disease

Kids’ COVID cases on the rise, but most are mild, new studies show

24 Nov, 2020 | 09:35h | UTC

Kids’ COVID cases on the rise, but most are mild, new data show – CIDRAP

Study 1: National Trends of Cases of COVID-19 in Children Based on US State Health Department Data – Pediatrics

Study 2: Assessment of 135 794 Pediatric Patients Tested for Severe Acute Respiratory Syndrome Coronavirus 2 Across the United States – JAMA Pediatrics

Diagnosis, management, and pathophysiology of arterial and venous thrombosis in COVID-19

24 Nov, 2020 | 09:34h | UTC

Diagnosis, Management, and Pathophysiology of Arterial and Venous Thrombosis in COVID-19 – JAMA

Commentary on Twitter

Arterial and venous thrombosis are common in #COVID19, especially in critically ill patients. Thromboprophylaxis should be considered for all hospitalized patients with COVID-19 in the absence of contraindications https://t.co/sjqL7MqGLX

— JAMA (@JAMA_current) November 23, 2020

Stay Updated in Your Specialty