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ASH 2023 Guidelines for management of venous thromboembolism | Thrombophilia testing

1 Jun, 2023 | 12:22h | UTC

American Society of Hematology 2023 Guidelines for Management of Venous Thromboembolism: Thrombophilia Testing – Blood Advances

AASLD-IDSA Guideline | Updated 2023 recommendations for the testing, management, and treatment of Hepatitis C virus infection

1 Jun, 2023 | 12:21h | UTC

Hepatitis C Guidance 2023 Update: AASLD-IDSA Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection – Clinical Infectious Diseases

RCT | Dupilumab improves lung function and reduces exacerbations in COPD patients with elevated eosinophils

1 Jun, 2023 | 12:20h | UTC

Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Dupilumab Improves Outcomes for COPD, Type 2 Inflammation in Randomized Trial – HCP Live

Commentary on Twitter

Presented at #ATS2023: In the BOREAS trial, dupilumab resulted in a lower annualized rate of exacerbations than placebo among patients with COPD and an elevated blood eosinophil count. Full trial results: https://t.co/9IWZr3YqsN

— NEJM (@NEJM) May 21, 2023

SR | Individual‐level interventions for reducing occupational stress in healthcare workers

1 Jun, 2023 | 12:18h | UTC

Individual‐level interventions for reducing occupational stress in healthcare workers – Cochrane Library

News Release: Stress-management interventions may help individual healthcare workers for at least a year – Cochrane Library

Phase 2b RCT | Danuglipron, an oral GLP-1R agonist, reduces body weight and improves glycemic control in type 2 diabetes

1 Jun, 2023 | 12:17h | UTC

Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA Network Open

Commentary: What is the efficacy, safety, and tolerability of novel danuglipron in adults with type two diabetes? – News Medical

SR | Systematic review finds 16.4-36.18 severe bleedings, 7.62-8.5 perforations per 10,000 colonoscopies

1 Jun, 2023 | 12:15h | UTC

An Estimate of Severe Harms Due to Screening Colonoscopy: A Systematic Review – The Journal of the American Board of Family Medicine

Expert Consensus | Nephrotoxic potential of 195 medications in the non-intensive care setting

1 Jun, 2023 | 12:14h | UTC

Expert Consensus on the Nephrotoxic Potential of 195 Medications in the Non-intensive Care Setting: A Modified Delphi Method – Drug Safety

Consensus Paper | Organ donation in the surgical ICU

1 Jun, 2023 | 12:12h | UTC

Organ donation in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document – Trauma Surgery & Acute Care Open

M-A | Noninvasive ventilation in patients with acute hypoxemic respiratory failure

1 Jun, 2023 | 12:11h | UTC

Noninvasive ventilation in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis of randomized controlled trials – Scientific Reports

M-A | Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters

1 Jun, 2023 | 12:10h | UTC

Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters: a systematic review and dose–response meta-analysis – Acta Obstetricia et Gynecologica Scandinavica

RCT | JAK inhibitor Upadacitinib shows superiority over placebo for moderate-to-severe Crohn’s disease

1 Jun, 2023 | 12:08h | UTC

Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)

SR | Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome

1 Jun, 2023 | 12:06h | UTC

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review – BMC Medicine

Cohort Study | Associations of menstrual cycle regularity and length with cardiovascular diseases

1 Jun, 2023 | 12:07h | UTC

Associations of Menstrual Cycle Regularity and Length With Cardiovascular Diseases: A Prospective Study From UK Biobank – Journal of the American Heart Association

News Release: Long or short menstrual cycles linked to higher risk of CVD including atrial fibrillation – American Heart Association

Review | Deprescribing interventions for gabapentinoids in adults

1 Jun, 2023 | 12:05h | UTC

Deprescribing interventions for gabapentinoids in adults: a scoping review – British Journal of Clinical Pharmacology

Guideline | Onychomycosis

1 Jun, 2023 | 12:01h | UTC

Guideline onychomycosis – Journal of the German Society of Dermatology

RCT | Adapted mindfulness training shows efficacy in reducing elevated office blood pressure

1 Jun, 2023 | 12:03h | UTC

Effect of Adapted Mindfulness Training in Participants With Elevated Office Blood Pressure: The MB‐BP Study: A Randomized Clinical Trial – Journal of the American Heart Association

Cluster RCT | Point-of-care CRP testing cuts antibiotic prescriptions in respiratory illnesses in primary care

1 Jun, 2023 | 11:58h | UTC

Implementation of point-of-care testing of C-reactive protein concentrations to improve antibiotic targeting in respiratory illness in Vietnamese primary care: a pragmatic cluster-randomised controlled trial – The Lancet Infectious Diseases

Commentary: Use of CRP testing reduced antibiotics for respiratory infections, trial finds – CIDRAP

Effects of ketogenic diet on health outcomes: an umbrella review of meta-analyses of randomized clinical trials

1 Jun, 2023 | 11:56h | UTC

Effects of ketogenic diet on health outcomes: an umbrella review of meta-analyses of randomized clinical trials – BMC Medicine

SR | Prevalence of clinical signs, symptoms and comorbidities at diagnosis of acromegaly

1 Jun, 2023 | 11:52h | UTC

Prevalence of clinical signs, symptoms and comorbidities at diagnosis of acromegaly: a systematic review in accordance with PRISMA guidelines – Pituitary

Study finds potential glaucoma risk in patients using calcium channel blockers

1 Jun, 2023 | 11:51h | UTC

Association of systemic medication use with glaucoma and intraocular pressure: the E3 Consortium – Ophthalmology

Commentary: Calcium Channel Blocker Use Associated with Higher Prevalence of Glaucoma – HCP Live

Cardiac toxicities in multiple myeloma: an updated and a deeper look into the effect of different medications and novel therapies

1 Jun, 2023 | 11:48h | UTC

Cardiac toxicities in multiple myeloma: an updated and a deeper look into the effect of different medications and novel therapies – Blood Cancer Journal

RCT | Prophylactic platelet transfusion reduces CVC-related bleeding in patients with platelets 10-50 K/mm³

31 May, 2023 | 14:20h | UTC

Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Research from Amsterdam UMC shows that the bottom has been reached in restrictive blood transfusion policy – Amsterdam University Medical Centers

Commentary on Twitter

Withholding of prophylactic platelet transfusion before CVC placement in pts with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority & resulted in more CVC-related bleeding events than prophylactic platelet transfusion.

— NEJM (@NEJM) May 27, 2023

RCT | Early initiation of DOACs not statistically superior to later use in atrial fibrillation-related stroke

31 May, 2023 | 14:17h | UTC

Early versus Later Anticoagulation for Stroke with Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

ELAN: Early DOACs Safe, May Help After Ischemic Stroke in AF Patients – TCTMD

Early Versus Late Initiation of Direct Oral Anticoagulants in Post-Ischemic Stroke Patients With Atrial Fibrillation – ELAN – American College of Cardiology

Commentary on Twitter

Late breaking at #ESOC2023: In the ELAN trial, the estimated incidence of stroke, systemic embolism, hemorrhage, or death was 2.8 percentage points lower to 0.5 percentage points higher with early than with later use of direct oral anticoagulants. Full results:

— NEJM (@NEJM) May 24, 2023