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Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’.
27 May, 2021 | 08:22h | UTCNews release: Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’ – American College of Cardiology
Commentary: The Tobacco Endgame—Eradicating a Worsening Epidemic – American College of Cardiology
COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence – “viral load was tenfold higher in P.1 infections than in non-P.1”.
26 May, 2021 | 08:42h | UTC
What scientists know about new, fast-spreading coronavirus variants.
26 May, 2021 | 08:45h | UTCWhat scientists know about new, fast-spreading coronavirus variants – Nature
RCT: Immediate “kangaroo mother care” improves survival in infants with low birth weight compared to conventional care with “kangaroo mother care” initiated after stabilization.
27 May, 2021 | 08:18h | UTCCommentary: Immediate skin-to-skin contact after birth improves survival of pre-term babies – Karolisnka Institutet
Related: RCT: Community-initiated kangaroo mother care reduced the risk of moderate-to-severe maternal postpartum depressive symptoms among mothers of low-birth-weight infants in low-income areas in India AND WHO: New research highlights risks of separating newborns from mothers during COVID-19 pandemic AND Randomized Trial: Kangaroo Mother Care Improves Survival of Infants with Low Birthweight
[Preprint] Meta-analysis of RCT: Ivermectin for the treatment of COVID-19 – no effect on all-cause mortality, length of stay, or viral clearance
26 May, 2021 | 08:41h | UTC
Commentary on Twitter
🆕💥💥Preprint
Ivermectin for the treatment of #COVID19 : A systematic review & meta-analysis of RCTs
10 RCTs
1173 patients
8 RCTs➡️ Mild
1 RCT ➡️ Moderate
1 RCT➡️ Mild& mod
Ivermectin did not reduce all-cause mortality,length of stay or viral clearance https://t.co/QMx0wlfS8f pic.twitter.com/6yddqwqPF6— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 25, 2021
Study shows acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection.
26 May, 2021 | 08:37h | UTCRelated: Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes? – The Lancet Diabetes & Endocrinology AND SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment – Cell Metabolism
Commentary on Twitter
For at least 2 months after COVID-19 in people without #diabetes, glucose regulation can be abnormal, along with insulin resistance and abnormal cytokineshttps://t.co/P1xa0lx2c4 @NatMetabolism @PAOLOFIORINA @FiorinaLab pic.twitter.com/Lu7GDMjzdy
— Eric Topol (@EricTopol) May 25, 2021
Estimating infectiousness throughout SARS-CoV-2 infection course – 8% of subjects had very high viral loads, one-third of whom had little to no symptoms; in individuals infected with the B.1.1.7 variant, average viral loads were 10 times higher.
26 May, 2021 | 08:43h | UTCEstimating infectiousness throughout SARS-CoV-2 infection course – Science
Commentary: Estimating infectiousness of SARS-CoV-2: New study on viral load – Universitätsmedizin Berlin
Commentary on Twitter
Of 25,000+ people who tested positive for #COVID19 in Germany, 8% had very high viral loads; about a third of these had little to no symptoms. The results suggest asymptomatic people can be expected to be as infectious as hospitalized patients @c_drosten https://t.co/mRkzJrwFwU pic.twitter.com/vsrameCAWk
— Science Magazine (@ScienceMagazine) May 25, 2021
Methotrexate reduces immune response to mRNA COVID-19 vaccine in patients with immune-mediated inflammatory disease.
26 May, 2021 | 08:38h | UTCCommentary: Methotrexate users have a reduced immune response to mRNA COVID-19 vaccine – BMJ
Editorial | A patent waiver on COVID vaccines is right and fair.
26 May, 2021 | 08:35h | UTCA patent waiver on COVID vaccines is right and fair – Nature
Related: Analysis: Covid-19: How will a waiver on vaccine patents affect global supply?
RCT: Continuous infusion of 20% hypertonic saline does not improve neurological outcomes in patients with traumatic brain injury
26 May, 2021 | 08:22h | UTCEffect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among patients with moderate to severe traumatic brain injury, treatment with continuous infusion of 20% hypertonic saline compared with standard care did not result in a significantly better neurological status at 6 months https://t.co/zyPhO0Y2Yy
— JAMA (@JAMA_current) May 25, 2021
Addressing distress management challenges: Recommendations from the consensus panel of the American Psychosocial Oncology Society and the Association of Oncology Social Work.
26 May, 2021 | 08:18h | UTC
Opinion | Protecting Olympic Participants from Covid-19 — The Urgent Need for a Risk-Management Approach.
26 May, 2021 | 08:33h | UTC
Short review: Diagnosis and management of acute respiratory distress syndrome
26 May, 2021 | 08:19h | UTC
Commentary on Twitter
#ARDS is an important priority in our ICUs at the moment. Our @CMAJ review looks at diagnosis, and provides a guideline-based approach to management, along with a discussion on #COVID19 ARDS.
A great primer for those new to ARDS!
OPEN ACCESS Link: https://t.co/saVdFT6Wyn pic.twitter.com/HbhoYbeG3u
— Shannon Fernando (@shanfernands) May 25, 2021
State-of-the-Art Review: Clinical approach to cardiovascular toxicity of oral antineoplastic agents
26 May, 2021 | 08:20h | UTCSummary: Cardiovascular Toxicity of Oral Antineoplastic Agents – American College of Cardiology
M-A: Prokinetics may improve tolerance to gastric feeding to some extent in critically ill adults.
26 May, 2021 | 08:16h | UTC
Admission respiratory status predicts mortality in COVID-19 – hypoxemic patients (oxygen saturation less than 92%) had a 1.8- to 4.0-fold increased mortality risk; those with respiratory rates over 22 breaths per minute were at 1.9- to 3.2-fold elevated mortality risk.
25 May, 2021 | 08:56h | UTCAdmission respiratory status predicts mortality in COVID-19 – Influenza and Other Respiratory Virus
Commentaries: COVID-19 mortality associated with 2 signs easily measured at home – University of Washington School of Medicine AND Low oxygen levels, shallow breathing tied to COVID death – CIDRAP
2 signs easily measured at home can indicate increased Covid mortality risk—respiration rate & blood-oxygen saturation. Both are distinctly predictive of higher mortality. Anyone receiving a positive Covid test can easily monitor for these signs at home https://t.co/8n7oc0d4E4 pic.twitter.com/02ysVaElsL
— delthia ricks 🔬 (@DelthiaRicks) May 24, 2021
RCT: Manual rotation of occiput posterior fetal positions at the start of the second stage of labor does not increase the rate of vaginal delivery without instrumental assistance.
26 May, 2021 | 08:17h | UTC
M-A: A biofeedback‐guided program or pelvic floor muscle electric stimulation can improve early recovery of urinary continence after radical prostatectomy.
26 May, 2021 | 08:13h | UTC
The IMF says ending the COVID-19 pandemic is possible by vaccinating at least 40% of the population in all countries by the end of 2021, and at least 60% by the first half of 2022 at the cost of $50 billion.
25 May, 2021 | 08:58h | UTCA Proposal to End the COVID-19 Pandemic – IMFBlog
Commentary: IMF says ending COVID-19 pandemic possible at cost of some $50 billion – Reuters
Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19.
25 May, 2021 | 08:55h | UTCSummary: Is vitamin D an effective and safe treatment for COVID-19? – Cochrane Library
Perspective | Coronavirus: so many variants, but vaccines are still effective.
25 May, 2021 | 08:46h | UTCCoronavirus: so many variants, but vaccines are still effective – The Conversation
Secondary analysis of RCT finds Tocilizumab was beneficial to patients hospitalized with Covid-19 if CRP levels were greater than 15.0 mg/dL, but not if CRP levels were 15.0 mg/dL or less.
25 May, 2021 | 08:52h | UTC
Mild COVID-19 induces lasting antibody protection, study finds.
25 May, 2021 | 08:51h | UTCOriginal study: SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans – Nature
Commentary on Twitter (thread – click for more)
Just published @nature
After even mild covid infections there are, in addition to memory B cells, bone marrow plasma cells are induced to provide long-term protection > 1 yrhttps://t.co/zVfUFvciVk
@TheBcellArtist @WUSTLmed
(NB vaccination still provides further protection) pic.twitter.com/rUd8pMAP1T— Eric Topol (@EricTopol) May 24, 2021
WHO: At least 115,000 health workers have died from COVID
25 May, 2021 | 08:49h | UTCAt least 115,000 health workers have died from COVID: WHO – MedicalXpress
AHA/ASA Guideline: Prevention of stroke in patients with previous stroke and transient ischemic attack – prevention efforts should be based on the cause of the first ischemic event.
25 May, 2021 | 08:43h | UTCNews Release: Risk of second stroke can be reduced with prevention efforts based on cause of first stroke – American Heart Association