All Posts
Recommendations for including or reviewing patient reported outcome endpoints in grant applications.
12 Jul, 2021 | 01:12h | UTC
Viewpoint | 7-1-7: an organizing principle, target, and accountability metric to make the world safer from pandemics.
9 Jul, 2021 | 10:21h | UTC
Commentary on Twitter
#COVID19 makes it possible and necessary to review lessons learnt and develop a framework to prepare for future epidemics, writes Thomas Frieden et al.
In this Viewpoint, they propose a 7-1-7 target for outbreak detection, notification, and response: https://t.co/TACjUplpmF pic.twitter.com/4uaxxgxJq2
— The Lancet (@TheLancet) July 7, 2021
Consensus Statement: Guidance for health care leaders during the recovery stage of the COVID-19 pandemic.
9 Jul, 2021 | 10:20h | UTCCommentary: Experts issue pandemic-recovery guidance for health leaders – CIDRAP
Commentary on Twitter
32 experts in healthcare, health leadership, and public health from 17 countries collaborated to create a novel evidence- and expertise-informed framework of leadership imperatives during the recovery stage of the #COVID19 pandemic https://t.co/3gDKZIERBv
— JAMA Network Open (@JAMANetworkOpen) July 8, 2021
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization.
9 Jul, 2021 | 10:16h | UTCReduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization – Nature
Commentaries: Study highlights need for full Covid vaccination to protect against Delta variant – STAT AND How does the Delta variant dodge the immune system? Scientists find clues. – The New York Times
Commentary on Twitter (thread – click for more)
Just published @Nature
Delta variant protection by mRNA and AZ vaccines requires 2-doses, little neutralizing antibody (nAb) with 1-dose, and insufficient nAb with prior covidhttps://t.co/TOgJdMe0g6 pic.twitter.com/KWLb9rBZ44— Eric Topol (@EricTopol) July 8, 2021
CDC: Use of mRNA COVID-19 vaccine after reports of myocarditis among vaccine recipients – “Continued use of mRNA COVID-19 vaccines in all recommended age groups will prevent morbidity and mortality from COVID-19 that far exceed the number of cases of myocarditis expected”.
9 Jul, 2021 | 10:17h | UTC
Commentary on Twitter
In a new @CDCMMWR, the Advisory Committee on Immunization Practices recommends everyone 12 & older get a #COVID19 vaccine. The benefits of vaccination in preventing illness & death outweigh the rare risk of heart inflammation after vaccination. More: https://t.co/iPjbhU5jeV. pic.twitter.com/IggrZ4DX7L
— CDC (@CDCgov) July 6, 2021
After the pandemic: perspectives on the future trajectory of COVID-19.
9 Jul, 2021 | 10:18h | UTCAfter the pandemic: perspectives on the future trajectory of COVID-19 – Nature
Perspective | “‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality”.
9 Jul, 2021 | 10:13h | UTC‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality – Science (a few articles per month are free)
Will COVID become a disease of the young? – “A growing share of infections among unvaccinated youths in countries with high vaccination rates is putting the spotlight on the role of young people in the pandemic”.
9 Jul, 2021 | 10:14h | UTCWill COVID become a disease of the young? – Nature
AHA Scientific Statement: Diagnosis and Management of Myocarditis in Children.
9 Jul, 2021 | 10:10h | UTCNews release: Viruses are the most common cause of myocarditis in children, experts offer guidance – American Heart Association
Top Things to Know: Diagnosis and Management of Myocarditis in Children
2021 ACR Guideline for the Management of ANCA–Associated Vasculitis.
9 Jul, 2021 | 10:09h | UTC
WHO: Countries urged to reopen with caution as world surpasses four million COVID deaths.
9 Jul, 2021 | 10:12h | UTCSee also: WHO: World at perilous point in pandemic – CIDRAP
Related commentary on Twitter (thread – click for more)
I’m struggling with how best to stress how fragile the global situation is, so I’ll be blunt:
Each week >2.6 million cases and >53,000 deaths are reported to @WHO
Reported, meaning that there are many others.
Stop and think about that.
(Short thread⬇️) pic.twitter.com/OyQK98DkjR
— Maria Van Kerkhove (@mvankerkhove) July 6, 2021
M-A: Acid suppression medications during hospitalization is a risk factor for recurrence of Clostridioides difficile infection.
9 Jul, 2021 | 09:59h | UTC
RCT: MRI can cut overdiagnoses in prostate-cancer screening by half.
9 Jul, 2021 | 10:03h | UTCMRI-Targeted or Standard Biopsy in Prostate Cancer Screening – New England Journal of Medicine (link to abstract – $ for full-text)
News release: MRI can cut overdiagnoses in prostate-cancer screening by half – Karolinska Institutet
Related articles: RCT: MRI-targeted biopsy safely reduces the need for biopsy in more than one-third of men at risk for prostate cancer AND Meta-Analysis: Negative Predictive Value of MRI in the Detection of Clinically Significant Prostate Cancer AND Study: MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis AND Review: The Use of MRI and PET Imaging Studies for Prostate Cancer Management AND Meta-Analysis: MRI plus Targeted Biopsy vs. Systematic Biopsy Alone for the Diagnosis of Prostate Cancer AND Cochrane Review: MRI Pathway vs. Systematic Biopsy for Detecting Prostate Cancer AND Meta-analysis: Clinical Utility of MRI in the Decision-making Process Before Radical Prostatectomy AND Research: Biparametric MRI (simpler, faster) May Be Used to Exclude Aggressive Disease and Avoid Unnecessary Biopsies in Men with Clinical Suspicion of Prostate Cancer AND Research: MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis AND Multiparametric MRI in the Detection of Clinically Significant Prostate Cancer
M-A: Comparative efficacy and safety of vancomycin, linezolid, tedizolid, and daptomycin in treating patients with suspected or proven complicated skin and soft tissue infections.
9 Jul, 2021 | 09:57h | UTC
Commentary on Twitter
🆕💥 Network Meta-Analysis @InfectDis_Ther
20 RCTs N=7804
Comparative Efficacy& Safety of Vancomycin,Linezolid,Tedizolid, and Daptomycin in Treating Patients with Suspected or Proven cSSTI
Linezolid was superior to vancomycin in improving clinical successhttps://t.co/qlZfXoWfaa pic.twitter.com/tO3sIoOMY4— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 20, 2021
Podcast | Heavy menstrual bleeding, anticoagulation & coagulopathy in menstruating patients.
9 Jul, 2021 | 09:56h | UTC
M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.
9 Jul, 2021 | 10:02h | UTCCommentary: New analysis finds muscle relaxant drugs to be largely ineffective for low back pain – News Medical
Related studies: M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain AND RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain AND M-A: Little benefit from antidepressants for low back pain AND Meta-analysis: Little benefit from antidepressants for the treatment of back pain and osteoarthritis AND ACP/AAFP Guideline: Nonpharmacologic and pharmacologic management of acute pain from non–low back, musculoskeletal injuries in adults
Commentaries on Twitter
Muscle relaxants are largely ineffective for #lowback #pain. They might increase the risk of side effects.
Published today in @bmj_latest ⬇️
Proud to be a part of this excellent team led by @AidanCashin
Paper: https://t.co/4p7gd7PJIe pic.twitter.com/3CLvL7JUfI
— Hayley Leake (@HayleyLeake) July 8, 2021
This systematic review found very low certainty evidence that muscle relaxant drugs for the treatment of acute low back pain might provide a small and not clinically meaningful improvement in pain intensity at two weeks or less @Pain_NeuRa https://t.co/HGwN4Oekrq
— The BMJ (@bmj_latest) July 8, 2021
Systematic Review: Pre‐emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery.
9 Jul, 2021 | 09:50h | UTC
Systematic Review: Altered dietary salt intake for people with chronic kidney disease.
9 Jul, 2021 | 09:52h | UTCAltered dietary salt intake for people with chronic kidney disease – Cochrane Library
Summary: Altered dietary salt intake for adults with chronic kidney disease – Cochrane Library
Commentary on Twitter
https://twitter.com/CochraneUK/status/1410873135709278210
Assessment and management of cardiovascular disease in the intensive care unit.
9 Jul, 2021 | 09:54h | UTCAssessment and management of cardiovascular disease in the intensive care unit – Heart
Systematic review: Prophylactic drug management for febrile seizures in children.
9 Jul, 2021 | 09:51h | UTCProphylactic drug management for febrile seizures in children – Cochrane Library
Summary: Prophylactic drug management for febrile seizures in children
Adult-Onset Still’s Disease: Clinical Aspects and Therapeutic Approach.
9 Jul, 2021 | 09:47h | UTC
Case series: therapeutic plasma exchange in 3 patients with vaccine-induced immune thrombotic thrombocytopenia.
8 Jul, 2021 | 09:17h | UTC
Commentary on Twitter
Three patients with severe manifestations of VITT after #COVID19 vaccination had poor response to initial therapy with anticoagulants and intravenous immune globulin. Their condition improved after therapeutic plasma exchange was initiated.
— NEJM (@NEJM) July 7, 2021
Prospective national cohort in Chile showed CoronaVac effectiveness was 65.9% for symptomatic Covid-19, 87.5% for hospitalization, 90.3% for ICU admission, and 86.3% for death.
8 Jul, 2021 | 09:22h | UTCEffectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile – New England Journal of Medicine
Related: Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years. AND WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic. AND Brazilian town experiment shows mass vaccination can wipe out COVID-19.
Commentary on Twitter
https://twitter.com/hildabast/status/1412890823948079105
Mounting evidence suggests Sputnik COVID vaccine is safe and effective.
8 Jul, 2021 | 09:14h | UTCMounting evidence suggests Sputnik COVID vaccine is safe and effective – Nature
Antibiotic resistance during and beyond COVID-19.
8 Jul, 2021 | 09:09h | UTCAntibiotic resistance during and beyond COVID-19 – JAC-Antimicrobial Resistance