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Expired cardiac devices may do global good, but safety unknown – A discussion of the ethics of using expired technology in parts of the world with no other options is long past due, some say.
2 Sep, 2021 | 08:16h | UTCExpired Cardiac Devices May Do Global Good, but Safety Unknown – TCTMD
Systematic review: In individuals with hemophilia A or B, there is evidence from RCTs that prophylaxis with clotting factor concentrates, as compared to on‐demand treatment, may reduce bleeding frequency.
2 Sep, 2021 | 08:17h | UTC
World leaders and experts call for significant reduction in the use of antimicrobial drugs in global food systems.
2 Sep, 2021 | 08:13h | UTCCommentary: Global group urges limits on antimicrobials in food production – CIDRAP
[Preprint] Randomized trials on non-pharmaceutical interventions for COVID-19 as of August 2021: a meta-epidemiological analysis – “Worldwide, 41 randomized trials assessing NPIs have been initiated with published results available to inform policy decisions for only 7 of them”.
1 Sep, 2021 | 10:01h | UTC
Commentary on Twitter
New Preprint: Randomized trials on non-pharmaceutical interventions for COVID-19 as of August 2021: a meta-epidemiological analysis@BessiCollab @CovidEvidence https://t.co/xZsgqegSRR
1/n
— Lars G. Hemkens (@LGHemkens) August 31, 2021
M-A: non-invasive tests for advanced fibrosis can reduce the need for biopsy in patients with non-alcoholic fatty liver disease.
2 Sep, 2021 | 08:14h | UTC
Commentary on Twitter
The long, winding and expensive road leading to highly sensitive and specific noninvasive Dx of #NASH @Gut_BMJ https://t.co/ToIkF3yTAU
— Daniel J Drucker (@DanielJDrucker) May 25, 2021
RCT: Ketamine administration in patients with acute painful sickle cell crisis was effective for pain control and reduced the cumulative morphine dose in the emergency department.
2 Sep, 2021 | 08:11h | UTCKetamine Administration for Acute Painful Sickle Cell Crisis: A Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)
[Preprint] Pfizer vaccine booster dose protection: A nationwide study from Israel – “Twelve days or more after the booster dose we found an 11.4-fold decrease in the relative risk of confirmed infection, and a >10-fold decrease in the relative risk of severe illness”.
1 Sep, 2021 | 09:59h | UTCBNT162b2 vaccine booster dose protection: A nationwide study from Israel – medRxiv
Perspective | COVID-19 boosters in rich nations will delay vaccines for all.
1 Sep, 2021 | 09:56h | UTCCOVID-19 boosters in rich nations will delay vaccines for all – Nature
Commentaries on Twitter
In @NatureMedicine, @zchagla & I ask:
Are we as a species willing to protect all humankind, or do we mostly care about optimizing protection for people in wealthy nations?https://t.co/LCS5Dxf1II pic.twitter.com/vdn4oRiYyz
— Madhu Pai, MD, PhD (@paimadhu) August 31, 2021
"There remain 3.5 billion people on this earth, nearly half of the world’s population, who have not received even a first dose of vaccine. Only 2% of the African population has received even a single dose." #Equity #COVID19 Via @NatureMedicine https://t.co/k6cG6vyQ5d pic.twitter.com/DsbWVvQ9R7
— Muin J. Khoury (@MuinJKhoury) August 31, 2021
Prioritising COVID booster shots in high income countries is unethical – until health care workers and those at high risk in low and middle income countries have been vaccinated. @paimadhu and @zchagla wrote this much better than I could – thank you! https://t.co/F89o8y9V8P
— Ben Johnson 🦠📝 (@drbenjohnson) August 31, 2021
M-A mostly of observational studies found that in patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infection Daptomycin was associated with a lower risk of clinical failure than Vancomycin, without differences in mortality.
2 Sep, 2021 | 08:10h | UTC
Why is a third COVID-19 vaccine dose important for people who are immunocompromised?
1 Sep, 2021 | 09:57h | UTCRelated:
RCT: third dose of Moderna mRNA vaccine increases immunity in transplant recipients.
COVID-19 patients at higher risk of blood clots after surgery, study shows.
1 Sep, 2021 | 09:54h | UTCCOVID-19 patients at higher risk of blood clots after surgery, study shows – CIDRAP
Original study: SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study – Anaesthesia
Related:
ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.
Position statement: Perioperative management of post-COVID-19 surgical patients.
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
COVID may be most infectious 2 or 3 days around symptom onset.
1 Sep, 2021 | 09:51h | UTCCOVID may be most infectious 2 or 3 days around symptom onset – CIDRAP
AGA clinical practice update on the diagnosis and management of atrophic gastritis.
1 Sep, 2021 | 09:45h | UTC
Commentary on Twitter
AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis 👌🏻👌🏻@AGA_Gastro @AmerGastroAssn #GITwitter https://t.co/MihpPoVR2b pic.twitter.com/e3MJ6aIQML
— Eric Kauffman Ortega (@eric_kauff) August 26, 2021
Study: Patients, not staff, source of most hospital COVID spread.
1 Sep, 2021 | 09:52h | UTCStudy: Patients, not staff, source of most hospital COVID spread – CIDRAP
Original article: Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections – eLife
NICE Guideline: Assessment and management of chronic kidney disease.
1 Sep, 2021 | 09:47h | UTC
Study shows that current definitions of chronic kidney disease overestimate the CKD burden in older individuals and results in overdiagnosis.
1 Sep, 2021 | 09:43h | UTCAccounting for Age in the Definition of Chronic Kidney Disease – JAMA Internal Medicine (free for a limited period)
Invited commentary: Overdiagnosis of Chronic Kidney Disease in Older Adults—An Inconvenient Truth – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter
Should the definition of chronic kidney disease be changed to consider the physiological eGFR decline that is associated with ageing?
A new publication says yes!
To learn more visit: https://t.co/BfVrSGQ9fv pic.twitter.com/3Dpd8MDJDr
— Chronic Disease Care (@ICDC_Research) August 31, 2021
Recommendations for standards of monitoring during anaesthesia and recovery 2021.
1 Sep, 2021 | 09:44h | UTCRecommendations for standards of monitoring during anaesthesia and recovery 2021 – Anaesthesia
Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment.
1 Sep, 2021 | 08:56h | UTC
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management.
1 Sep, 2021 | 09:04h | UTC
Brain and other central nervous system tumor statistics, 2021 – There were few improvements in the care of Glioblastoma in the past 4 decades. Specifically, the 5-year survival only increased from 4% to 7%.
1 Sep, 2021 | 08:58h | UTCBrain and other central nervous system tumor statistics, 2021 – CA: A Cancer Journal for Clinicians
Review: Initial antimicrobial management of sepsis – immediate, empiric, broad-spectrum therapy is key, but it must be accompanied by a commitment to de-escalation and antimicrobial stewardship.
1 Sep, 2021 | 08:59h | UTCInitial antimicrobial management of sepsis – Critical Care
RCT: Severe malaria among young African children dramatically reduced through seasonal vaccination and preventative drug combination.
1 Sep, 2021 | 09:02h | UTCOriginal article: Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention – New England Journal of Medicine
Commentary: Malaria trial shows ‘striking’ 70% reduction in severe illness in children – The Guardian
Related: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal
Cohort study: A strategy combining a rapid antigen test and chest CT was effective in ruling out COVID-19 in the emergency department.
31 Aug, 2021 | 09:00h | UTC
WHO Issues COVID-19 Digital ‘Vaccine Pass’ Guidelines – But Stresses These Should Not be Requirements for Travel.
31 Aug, 2021 | 09:02h | UTC
Study shows young children gained weight during the pandemic.
31 Aug, 2021 | 08:59h | UTCNews release: Young children gained weight during the pandemic – Kaiser Permanente
Original study: Changes in Body Mass Index Among Children and Adolescents During the COVID-19 Pandemic – JAMA
Commentary on Twitter
#KPResearch showed significant weight gain occurred during COVID-19 pandemic among youth in Southern California, especially among youngest kids.
Research: @KPSCalResearch & @UMchear
In @JAMANetwork
Authors incl @CKoebnickPhD @RohmDeborah @MargoSidell https://t.co/IqiUxo75bW pic.twitter.com/8XA7G6J3Bu— Kaiser Permanente Research (@KPSCalResearch) August 27, 2021