All Posts
RCT: Effect of Camrelizumab vs. placebo added to chemotherapy on survival and progression-free survival in patients with advanced or metastatic esophageal squamous cell carcinoma.
15 Sep, 2021 | 08:51h | UTCEffect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma—Renewed Enthusiasm and a Lingering Challenge – JAMA Oncology (free for a limited period)
Commentary on Twitter
Among patients with advanced or metastatic esophageal squamous cell carcinoma, the addition of camrelizumab to chemotherapy, compared with placebo and chemotherapy, significantly improved overall survival and progression-free survival https://t.co/DAlhmtgvv1
— JAMA (@JAMA_current) September 14, 2021
Review | Recommendations and Nutritional Considerations for Female Athletes: Health and Performance.
15 Sep, 2021 | 08:49h | UTC
Management of high-risk pulmonary embolism in pregnancy.
15 Sep, 2021 | 08:43h | UTCManagement of high-risk pulmonary embolism in pregnancy – Thrombosis Research
Systematic Review: Does hair removal before surgery prevent infections after surgery?
15 Sep, 2021 | 08:47h | UTCSummary: Does hair removal before surgery prevent infections after surgery? – Cochrane Library
Original study: Preoperative hair removal to reduce surgical site infection – Cochrane Library
Commentary on Twitter
https://twitter.com/CochraneUK/status/1433731563318042624
An update on prevention of malaria in travelers.
15 Sep, 2021 | 08:39h | UTCAn update on prevention of malaria in travelers – Therapeutic Advances in Infectious Disease
Related: CDC Yellow Book
RCT: Prophylactic steroids prevent hypocalcemia and voice dysfunction in patients undergoing thyroidectomy.
15 Sep, 2021 | 08:44h | UTCUse of Prophylactic Steroids to Prevent Hypocalcemia and Voice Dysfunction in Patients Undergoing Thyroidectomy: A Randomized Clinical Trial – JAMA Otolaryngology – Head & Neck Surgery (link to abstract – $ for full-text)
Author interview: Prophylactic Steroids for Postthyroidectomy Hypocalcemia and Voice Dysfunction
Commentary: IV Steroid Before Thyroidectomy Prevents Complications — One dose of dexamethasone reduced hypocalcemia, voice issues – MedPage Today (free registration required)
Commentary on Twitter
This RCT with 192 patients found that pre-op dexamethasone resulted in a reduction in hypocalcemia at 24 hrs post-op by 24% and reduction in voice dysfunction at 24 hrs by 25%. Strong evidence in supporting a pre-op 8mg dose of dexamethasone @JAMAOto https://t.co/UIt18DXclN
— Jay Piccirillo, MD (@PiccirilloJay) September 5, 2021
Report: Fully vaccinated people account for 1.2% of England’s Covid-19 deaths.
14 Sep, 2021 | 10:07h | UTCFully vaccinated people account for 1.2% of England’s Covid-19 deaths – The Guardian
Original Report: Deaths involving COVID-19 by vaccination status, England: deaths occurring between 2 January and 2 July 2021 – Office for National Statistics
COVID-19 vaccine efficacy does not support boosters for general population, review concludes.
14 Sep, 2021 | 10:08h | UTCNews release: COVID-19 vaccine efficacy does not support boosters for general population, review concludes – The Lancet
Original article: Considerations in boosting COVID-19 vaccine immune responses – The Lancet
Commentaries:
FDA experts among group opposing US booster shot plan – Associated Press
FDA vaccine regulators argue against Covid-19 vaccine boosters in new international review – STAT
Global experts pan wider use of COVID vaccine booster dose – CIDRAP
Boosters Are ‘Not Appropriate’ – Reach Unvaccinated First – Health Policy Watch
Data Doesn’t Support Need for COVID-19 Vaccine Boosters: Experts – HealthDay
Update on the management of overactive bladder.
15 Sep, 2021 | 08:42h | UTCUpdate on the management of overactive bladder – Therapeutic Advances in Urology
Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.
14 Sep, 2021 | 10:05h | UTCCovid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors – BBC
See also: Covid-19: Children aged 12-15 should be offered vaccine, say UK’s chief medical officers – The BMJ
Massive numbers of new COVID–19 infections, not vaccines, are the main driver of new coronavirus variants.
14 Sep, 2021 | 09:56h | UTC
Review | The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology.
14 Sep, 2021 | 09:58h | UTCThe next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology – Nature Medicine
Commentary on Twitter
Important paper. Monitoring virus evolution and assessing variants is critical to guide the response.
Science, collaboration, analyses, sharing, discussion, action, repeat
Proud @WHO provided technical and financial support for it. #COVID19 https://t.co/M7v8dmIy6q https://t.co/j1VOgBhw6Y
— Maria Van Kerkhove (@mvankerkhove) September 10, 2021
Blood Glucose Monitoring in Adults and Children with Diabetes: Update 2021.
14 Sep, 2021 | 08:57h | UTC
Vaccines Will Not Produce Worse Variants.
14 Sep, 2021 | 09:53h | UTCVaccines Will Not Produce Worse Variants – Science
The carbohydrate-insulin model: a physiological perspective on the obesity pandemic.
14 Sep, 2021 | 08:53h | UTCNews release: Scientists claim that overeating is not the primary cause of obesity – American Society for nutrition
Commentary on Twitter (thread – click for more)
To paraphrase Mark Twain:
Reports of the death of the Carbohydrate-Insulin Model have been exaggerated.
👉17-author review @AJCNutrition
👉Deep dive on obesity mechanisms
👉Numerous hypotheses to guide constructive debateFree text👉 https://t.co/MxPAgI7dtY
Thread (0/12)👇 pic.twitter.com/VxEpAvWyZn
— Dr. David Ludwig (@davidludwigmd) September 13, 2021
M-A: Study shows significant risk of major bleeding during extended oral anticoagulant therapy for first unprovoked venous thromboembolism.
14 Sep, 2021 | 08:55h | UTCLong-Term Risk for Major Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
Long-term Anticoagulation After Unprovoked VTE: New Insights – TCTMD
Extended Anticoagulation Tied to Major Bleeding Risk – HealthDay
Commentary on Twitter
🆕 Delighted to share the MAJESTIC Study providing best available estimates for major bleeding risk during extended #anticoagulation of up to 5 years in patients with unprovoked #VTE (& clinically important subgroups), now published in @AnnalsofIM!https://t.co/Ri2EvZvffq pic.twitter.com/3jvN8mTKSi
— Faizan Khan, PhD (@FaizanK91) September 13, 2021
Opinion | Don’t make early career researchers ‘ghost authors.’ Give us the credit we deserve.
14 Sep, 2021 | 08:50h | UTCDon’t make early career researchers ‘ghost authors.’ Give us the credit we deserve – Science
Viewpoint | The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?
14 Sep, 2021 | 08:47h | UTC
One hundred years of insulin therapy.
14 Sep, 2021 | 08:52h | UTCOne hundred years of insulin therapy – Nature Reviews Endocrinology
Commentary on Twitter
To mark the centenary of the discovery of #insulin, Chantal Mathieu, Pieter-Jan Martens & Roman Vangoitsenhoven look back on the past one hundred years of insulin therapy and discuss future directions https://t.co/kYxVIpzXda #diabetes pic.twitter.com/z9uendON7w
— Nature Reviews Endocrinology (@NatureRevEndo) September 11, 2021
Antifungal Susceptibility Testing: A Primer for Clinicians.
14 Sep, 2021 | 08:46h | UTCAntifungal Susceptibility Testing: A Primer for Clinicians – Open Forum Infectious Diseases
Commentary on Twitter
New in OFID: An overview for clinicians on antifungal susceptibility testing, including testing methods and their limitations, and how results may or may not be clinically useful.
📄:https://t.co/ZhPL5oQ57F #OpenForumInfectDis #IDSAJournals @PaulSaxMD @DrJLi pic.twitter.com/wrIkBc5MPV
— IDSA (@IDSAInfo) September 11, 2021
Cohort study: Clinical characteristics and prognosis of patients with microvascular angina.
14 Sep, 2021 | 08:49h | UTCNews release: Disease of the smallest heart blood vessels is important global health problem – European Heart Journal
Editorial: Microvascular angina: quo tendimus? – European Heart Journal
Long-term report of study evaluating radiation following surgical excision for good-risk ductal carcinoma in situ.
14 Sep, 2021 | 08:44h | UTC
Commentary on Twitter
At 15 years, NRG-RTOG 9804 "good risk" breast #DCIS trial shows advantage of radiation therapy over observation to reduce #breastcancer risk https://t.co/l5OWVOb5Dg
#JCO #BCSM #radonc @NRGOnc; @MSK_RadOnc pic.twitter.com/TPAZRheoHT— Journal of Clinical Oncology (@JCO_ASCO) September 10, 2021
ESMO Guideline: Early and locally advanced non-small-cell lung cancer
14 Sep, 2021 | 08:42h | UTC
‘Do not resuscitate’ decision recorded for only 1 in 5 very sick hospitalized older patients, study finds
14 Sep, 2021 | 08:40h | UTCOriginal study: Do not attempt cardiopulmonary resuscitation (DNACPR) decisions for older medical inpatients: a cohort study – BMJ Supportive & Palliative Care
Four factors that increase the risk of vaccinated people getting COVID.
12 Sep, 2021 | 22:02h | UTCFour factors that increase the risk of vaccinated people getting COVID – The Conversation