All Posts
How to avoid harm with feeding critically ill patients: a synthesis of viewpoints of a basic scientist, dietitian and intensivist
10 Jul, 2023 | 13:34h | UTC
RCT | Atezolizumab in platinum-ineligible NSCLC elevates median survival to 10.3 months vs. 9.2 months with chemotherapy
10 Jul, 2023 | 13:33h | UTCFirst-line atezolizumab monotherapy versus single-agent chemotherapy in patients with non-small-cell lung cancer ineligible for treatment with a platinum-containing regimen (IPSOS): a phase 3, global, multicentre, open-label, randomised controlled study – The Lancet (link to abstract – $ for full-text)
News Release: Immunotherapy for ‘difficult to treat’ lung cancer patients improves long-term survival – University College London
RCT | Perioperative nivolumab plus chemotherapy increases pathological response vs. chemotherapy alone in stage III NSCLC
10 Jul, 2023 | 13:27h | UTCPerioperative Nivolumab and Chemotherapy in Stage III Non–Small-Cell Lung Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Addition of Neoadjuvant Nivolumab to Platinum-Based Chemotherapy in Stage III NSCLC – The ASCO Post
Commentary on Twitter
Original Article: Perioperative Nivolumab and Chemotherapy in Stage III Non–Small-Cell Lung Cancer https://t.co/DCcs0tkyPN #oncology pic.twitter.com/0zG9SUbqQj
— NEJM (@NEJM) June 30, 2023
Cohort Study | Hypertensive disorders of pregnancy linked to a 66% higher stroke risk in U.S. black women
10 Jul, 2023 | 13:31h | UTCHypertensive Disorders of Pregnancy and Risk of Stroke in U.S. Black Women – NEJM Medicine
RCT | Mirikizumab outperforms placebo in inducing and maintaining remission in ulcerative colitis
10 Jul, 2023 | 13:25h | UTCMirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Mirikizumab Bests Placebo in Treating Patients With Ulcerative Colitis – HCP Live
Commentary on Twitter
In two placebo-controlled, phase 3 trials, mirikizumab, a p19-directed anti–interleukin-23 antibody, was superior with regard to clinical remission of ulcerative colitis at 12 weeks (induction) and 40 weeks (maintenance). https://t.co/H4reu33hF1
— NEJM (@NEJM) June 28, 2023
M-A | Efficacy of varenicline versus bupropion for smoking cessation
10 Jul, 2023 | 13:23h | UTC
Podcast | Untangling catheter associated UTIs
10 Jul, 2023 | 13:21h | UTC#402 Don’t Get Caught with a CAUTI – The Curbsiders
Podcast | Updates in addiction medicine
10 Jul, 2023 | 13:17h | UTC#401 Updates in Addiction Medicine – SGIM 2023 – The Curbsiders
Consensus Paper | Subcutaneous infusions of hydration and medication in adults
7 Jul, 2023 | 16:27h | UTC
RCT | Semont-plus maneuver yields faster recovery than Epley maneuver in posterior canal BPPV
7 Jul, 2023 | 16:26h | UTCThe Semont-Plus Maneuver or the Epley Maneuver in Posterior Canal Benign Paroxysmal Positional Vertigo: A Randomized Clinical Study – JAMA Neurology (link to abstract – $ for full-text)
See also: Visual Abstract
Videos:
Demonstration of the Semont-Plus Self-maneuver for Right Posterior Canal Canalithiasis
Semont-Plus Maneuver for Right Posterior Canal Benign Paroxysmal Positional Vertigo
Demonstration of the Epley Self-maneuver for a Right Posterior Canal Canalithiasis
Commentary: Semont-plus Meneuver Offered Faster Recovery for Benign Paroxysmal Positional Vertigo – Neurology Today
RCT | Weekly Tirzepatide outperforms placebo in weight management for type 2 diabetes patients
7 Jul, 2023 | 16:24h | UTCTirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary: Tirzepatide triumphs in significant weight reduction for people with type 2 diabetes – News Medical
Review | Post-COVID Conditions
7 Jul, 2023 | 16:21h | UTCPost-COVID Conditions – Mayo Clinic Proceedings
Review | Management of premature ventricular complexes in the outpatient setting
7 Jul, 2023 | 16:22h | UTCManagement of Premature Ventricular Complexes in the Outpatient Setting – Mayo Clinic Proceedings
RCT | Personalized eHealth program hastens return to normal activity post major abdominal surgery
7 Jul, 2023 | 16:20h | UTCInvited Commentary: Individualising the recovery process through eHealth – The Lancet Digital Health
Consensus Paper | Adult cardiac surgery-associated acute kidney injury
7 Jul, 2023 | 16:18h | UTC
Consensus Paper | Methotrexate for inflammatory skin disease in pediatric patients
7 Jul, 2023 | 16:16h | UTC
Consensus Paper | The place of new antibiotics for Gram-negative bacterial infections in intensive care
7 Jul, 2023 | 16:15h | UTC
Single-arm study | Pirtobrutinib exhibits efficacy in CLL patients after failure of covalent BTK inhibitor treatment
7 Jul, 2023 | 16:14h | UTCPirtobrutinib after a Covalent BTK Inhibitor in Chronic Lymphocytic Leukemia – New England Journal of Medicine (link to abstract – $ for full-text)
News release from the manufacturer: New England Journal of Medicine Publishes BRUIN Phase 1/2 Trial Data for Pirtobrutinib in BTK Inhibitor Pre-Treated Adult Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma – Lilly
Review | Cardiovascular outcomes in patients with diabetes and kidney disease
7 Jul, 2023 | 16:13h | UTC
Cohort Study | Incidence and risk factors of postoperative urinary retention after inguinal hernia repair
7 Jul, 2023 | 16:11h | UTCGlobal Incidence and Risk Factors Associated With Postoperative Urinary Retention Following Elective Inguinal Hernia Repair: The Retention of Urine After Inguinal Hernia Elective Repair (RETAINER I) Study – JAMA Surgery (link to abstract – $ for full-text)
Review | Acute-on-chronic liver failure
7 Jul, 2023 | 16:09h | UTCAcute-on-chronic liver failure: far to go—a review – Critical Care
Related:
EASL Clinical Practice Guidelines on acute-on-chronic liver failure – Journal of Hepatology
Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU
Review | Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome
7 Jul, 2023 | 16:08h | UTCDiabetes detection in women with gestational diabetes and polycystic ovarian syndrome – The BMJ
RCT | Brachytherapy alone sufficient for intermediate-risk prostate cancer, no FFP improvement with additional EBRT
7 Jul, 2023 | 16:06h | UTCEffect of Brachytherapy With External Beam Radiation Therapy Versus Brachytherapy Alone for Intermediate-Risk Prostate Cancer: NRG Oncology RTOG 0232 Randomized Clinical Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)
Review | Surgical treatment options for male stress urinary incontinence
7 Jul, 2023 | 16:03h | UTC
Review | Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA): two sides of the same coin
7 Jul, 2023 | 16:01h | UTCHES and EGPA: Two Sides of the Same Coin – Mayo Clinic Proceedings