All Posts
Guidelines on sickle cell disease: secondary stroke prevention in children and adolescents.
22 Mar, 2022 | 08:34h | UTC
Consensus Paper: Vitamin D and calcium intakes in general pediatric populations.
22 Mar, 2022 | 08:36h | UTC
Guideline Synopsis: The management of substance use disorders.
22 Mar, 2022 | 08:38h | UTC
Long-term longitudinal patterns of patient-reported fatigue after breast cancer: a group-based trajectory analysis.
22 Mar, 2022 | 08:29h | UTC
Commentary on Twitter
https://twitter.com/PTarantinoMD/status/1503916087829794816
Evaluation of glial and neuronal blood biomarkers compared with clinical decision rules in assessing the need for computed tomography in patients with mild traumatic brain injury.
22 Mar, 2022 | 08:33h | UTC
Commentary on Twitter
In this prospective cohort of mTBI/concussion patients, CCHR, NOC and blood test GFAP/UCH-L1 were equally sensitive in detecting traumatic intracranial lesions on CT but CCHR had the highest specificity; GFAP combined with CCHR detected lesions best. https://t.co/hYwxg76uu8
— JAMA Network Open (@JAMANetworkOpen) March 14, 2022
Editorial: Pig-to-human transplants take a leap toward reality.
22 Mar, 2022 | 08:31h | UTCPig-to-human transplants take a leap toward reality – Nature Medicine
RCT: Levothyroxine is not beneficial for euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss.
22 Mar, 2022 | 08:24h | UTCLevothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentary: Levothyroxine No Boon for Birth Rates in Women With Possible Thyroid Disorder – MedPage Today (free registration required)
Enabling patient choice: the “deciding not to decide” option for older adults facing dialysis decisions.
22 Mar, 2022 | 08:25h | UTCCommentary: The “Deciding Not to Decide” Option Can Improve Older Adult Patient Care – Rutgers University-New Brunswick
Phase 2 trial of Iberdomide in systemic lupus erythematosus.
22 Mar, 2022 | 08:27h | UTCPhase 2 Trial of Iberdomide in Systemic Lupus Erythematosus – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Mixed Results for Oral Lupus Drug in Phase II— Mid-stage study offers hope but also reason for caution – MedPage Today (free registration required)
Commentary on Twitter
In patients with systemic lupus erythematosus, iberdomide at the highest dose, but not at lower doses, was superior to placebo with respect to the primary end point of an SRI-4 response at 24 weeks. https://t.co/rie3SRhoew pic.twitter.com/wRre5Gp1xB
— NEJM (@NEJM) March 17, 2022
Daytime napping and Alzheimer’s dementia: A potential bidirectional relationship.
22 Mar, 2022 | 08:14h | UTCCommentaries:
Long naps may be early sign of Alzheimer’s disease, study shows – The Guardian
Excessive daytime naps may be a sign of early cognitive decline – MedicalResearch
Outcomes and safety of history-based screening for medication abortion: a retrospective multicenter cohort study.
22 Mar, 2022 | 08:11h | UTCInvited Commentary: It Is Time to Change the Standard of Medication Abortion – JAMA Internal Medicine (free for a limited period)
RCT: Safety and efficacy of AGN-190584 in individuals with presbyopia.
22 Mar, 2022 | 08:20h | UTC
Commentary on Twitter
A new proprietary formulation of pilocarpine developed to treat presbyopia met its primary endpoint in the GEMINI phase 3 clinical trial, safely and effectively improving distance-corrected mesopic near vision for hours after eye drop instillation. https://t.co/WG5DZ6XQxZ pic.twitter.com/YXnW387R7i
— JAMA Ophthalmology (@JAMAOphth) March 4, 2022
Investigating cognition in midlife.
22 Mar, 2022 | 08:13h | UTCInvestigating cognition in midlife – Alzheimer’s & Dementia
Current management of urachal carcinoma: an evidence-based guide for clinical practice.
22 Mar, 2022 | 08:09h | UTC
Evidence-based disposition of acute pancreatitis.
22 Mar, 2022 | 08:08h | UTCEvidence-Based Disposition of Acute Pancreatitis – emDocs
Related Guidelines:
Pancreatitis – National Institute for Health and Care Excellence
The incidence of breast cancer recurrence 10-32 years after primary diagnosis.
22 Mar, 2022 | 08:12h | UTC
Vitamin B3, niacinamide and reducing skin cancer risk: what does the research say?
22 Mar, 2022 | 08:03h | UTC
Phase 2 RCT: Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy.
22 Mar, 2022 | 07:59h | UTC
Commentary on Twitter
In patients with late-stage Duchenne muscular dystrophy, CAP-1002 cell therapy appears safe & effective in reducing deterioration of upper limb & cardiac function, trial suggests. Longer-term extension studies needed.
Explore full findings: https://t.co/bCLtsbuJH3 pic.twitter.com/h7vareAMC7
— The Lancet (@TheLancet) March 21, 2022
Rapid point-of-care genotyping to avoid aminoglycoside-induced ototoxicity in neonatal intensive care.
22 Mar, 2022 | 08:01h | UTCEditorial: Genetic Testing in Newborns Moves From Rare to Routine Application
Commentary on Twitter
The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity
The MT-RNR1 POCT was able to genotype the m.1555A>G variant in 26 minutes. #IDTwitter #medtwitter #TwitteRx #MedEd #PIDTwitter https://t.co/BbkpNMiNHN— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) March 21, 2022
EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis.
21 Mar, 2022 | 10:01h | UTC
Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity.
21 Mar, 2022 | 09:47h | UTC
Commentary on Twitter
Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severityhttps://t.co/iFL1AD4q2l@pvmarkov, @ArisKatzourakis & Stilianakis argue that ongoing rapid antigenic evolution is likely to produce new variants that may escape immunity and be more severe. pic.twitter.com/BddNu5DZaq
— Nature Reviews Microbiology (@NatureRevMicro) March 14, 2022
M-A: Risk of peritoneal carcinomatosis after risk-reducing salpingo-oophorectomy in BRCA1/2 pathogenic variant (PV) carriers.
22 Mar, 2022 | 07:58h | UTC
Future of clinical trial methodology.
21 Mar, 2022 | 09:59h | UTCFuture of Clinical Trial Methodology – Anesthesia & Analgesia
Commentary: Looking to the Future of Clinical Research Methodology – Anesthesia & Analgesia
Guideline: Management of chronic low back, osteoarthritic, and neuropathic pain in primary care.
21 Mar, 2022 | 10:02h | UTC
Infographic: IDSA COVID-19 outpatient treatment guidelines roadmap.
21 Mar, 2022 | 09:51h | UTCCOVID-19 Outpatient Treatment Guidelines Roadmap – Infectious Diseases Society of America
Commentary on Twitter
IDSA and @RealTimeCOVID19's new visual clinical flowchart summarizes outpatient COVID-19 treatment options and guidance.
📄:https://t.co/NTo1nNlfDr #RealTimeCOVID19 @CDCgov pic.twitter.com/CXz1tgpJ05
— IDSA (@IDSAInfo) March 19, 2022