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Cohort study: Prognostic value of stromal tumor-infiltrating lymphocytes in young, node-negative, triple-negative breast cancer patients who did not receive (neo)adjuvant systemic therapy.
7 Apr, 2022 | 08:09h | UTC
Commentary on Twitter
Out now @JCO_ASCO huge effort of our team and @TILsWorkGroup: Excellent prognosis of TNBC pts with high TILs even without chemo! Chemo de-escalation trials urgently needed! # bcsm https://t.co/42eUZaA2vo
— MarleenKokLab (@lab_kok) March 31, 2022
M-A: Immediate and sustained outcomes and moderators associated with metacognitive training for psychosis.
7 Apr, 2022 | 08:10h | UTC
Recommendations for reporting results of diagnostic genomic testing.
7 Apr, 2022 | 08:02h | UTC
RCT: In patients undergoing intraarterial treatment for stroke, functional outcomes after 3 months were similar with general anesthesia vs. sedation.
7 Apr, 2022 | 08:00h | UTC
Commentary on Twitter
Previous speculations have considered the relationship between anesthetic strategy and patient outcomes. Now, new research suggests general #anesthesia and #sedation produce comparable outcomes after endovascular treatment for stroke. https://t.co/ggLRO8Or3W pic.twitter.com/dLLGA4Vmgk
— Anesthesiology (@_Anesthesiology) March 24, 2022
Systematic Review: Algorithm‐based pain management for people with dementia in nursing homes.
7 Apr, 2022 | 07:52h | UTCAlgorithm‐based pain management for people with dementia in nursing homes – Cochrane Library
Systematic Review: Epidemiology of musculoskeletal manifestations in pediatric inflammatory bowel disease.
7 Apr, 2022 | 07:55h | UTC
Major burns: part 2. Anesthesia, intensive care and pain management.
7 Apr, 2022 | 07:59h | UTCMajor burns: part 2. Anaesthesia, intensive care and pain management – BJA Education
See also: Major burns: Part 1. Epidemiology, pathophysiology and initial management.
Expert Consensus: Stepwise diagnostic approach for patients with uveitis.
7 Apr, 2022 | 07:53h | UTC
Systematic Review: Brivaracetam add‐on therapy for drug‐resistant epilepsy.
7 Apr, 2022 | 07:50h | UTCBrivaracetam add‐on therapy for drug‐resistant epilepsy – Cochrane Library
Summary: Brivaracetam add-on therapy for drug-resistant epilepsy – Cochrane Library
Systematic Review: Gases for establishing pneumoperitoneum during laparoscopic abdominal surgery.
7 Apr, 2022 | 07:49h | UTCGases for establishing pneumoperitoneum during laparoscopic abdominal surgery – Cochrane Library
Observational study suggests a fourth dose of the Pfizer vaccine provided additional protection against severe disease in patients 60 years of age or older during the Omicron wave in Israel.
6 Apr, 2022 | 10:59h | UTCProtection by a Fourth Dose of BNT162b2 against Omicron in Israel – New England Journal of Medicine
Commentary: Mixed Bag for Fourth Dose of Pfizer Vaccine vs Omicron— Real-world data show less infection and severity, but long-term benefit less clear – MedPage Today (free registration required)
Related:
Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.
U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.
[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.
Covid-19: Fourth vaccine doses—who needs them and why?
[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.
Commentary on Twitter
Just published @NEJM
4th dose vaccine protection in >620,000 people vs 3-doses in >620,000, all age 60+, Omicron wave, Israel
—4-fold lower rate of severe disease, no waning at 6 weeks
—2-fold lower rate of infection, rapidly wanedhttps://t.co/g8uGMXGHD6 pic.twitter.com/D7WHywTI1j— Eric Topol (@EricTopol) April 5, 2022
Retrospective cohort study: Waning COVID-19 vaccine effectiveness for Pfizer and CoronaVac in Malaysia.
6 Apr, 2022 | 10:57h | UTC
Commentary on Twitter
@ICR_NIH RECoVam's
Waning COVID-19 Vaccine Effectiveness for BNT162b2 and CoronaVac in Malaysia in IJID.https://t.co/QwNSRQBKOq• Against infections, both wane after 3-5 months
• Against ICU admission, CoronaVac wane
• Against death, both retain considerable effectiveness— Dr Kalai Peariasamy (@drkalai61) March 22, 2022
Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.
6 Apr, 2022 | 10:52h | UTC
Commentary on Twitter
In this cohort study, the incidence rate of #SARSCoV2 infection with Omicron variant was 6 to 8 times that of Delta variant in children younger than 5 years, but severe clinical outcomes were less frequent than with Delta variant. https://t.co/UKiMEznXtX
— JAMA Pediatrics (@JAMAPediatrics) April 1, 2022
M-A: Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives.
6 Apr, 2022 | 10:55h | UTC
RCT: Effects of clazosentan on cerebral vasospasm–related morbidity and all-cause mortality after aneurysmal subarachnoid hemorrhage.
6 Apr, 2022 | 10:47h | UTC
RCT: Cabotegravir (intramuscular injections every 8 weeks) for the prevention of HIV-1 in women.
6 Apr, 2022 | 10:51h | UTCCabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial – The Lancet (link to abstract – $ for full-text)
Related:
FDA approves first injectable treatment for HIV pre-exposure prevention.
RCT: Injectable long-acting Cabotegravir for HIV prevention in cisgender men and transgender women.
Review and M-A: pulmonary rehabilitation for Post-Covid.
6 Apr, 2022 | 10:42h | UTC
Global, regional, and national trends in opioid analgesic consumption from 2015 to 2019.
6 Apr, 2022 | 10:49h | UTCNews Release: Global disparities persist in opioid painkiller access – University College London
Invited Commentary: Closing the global pain divide: balancing access and excess – The Lancet Public Health
Commentary on Twitter (article and images under a Creative Commons Attribution (CC BY 4.0 license)
Just Out @TheLancetPH 🚨
Global #opioids consumption increased from 2015 to 2019‼️#Disparities in opioid💊consumption remained, indicating potential inadequate access to essential pain relief in countries with low consumption🌐https://t.co/bkcdgLy3ZP pic.twitter.com/RUGl1gbiTw— Gil Morgan, MD (@weoncologists) April 1, 2022
RCT: Oral Roxadustat vs. Epoetin Alfa for treating anemia in patients with chronic kidney disease on dialysis.
6 Apr, 2022 | 10:45h | UTCRelated:
Randomized Trials: Evaluation of New Treatment for Anemia of Chronic Kidney
Cohort study and updated meta-analysis: greater dietary cholesterol and egg consumption linked to increased risk of overall and CVD mortality.
6 Apr, 2022 | 10:41h | UTC
Guideline: Revision of pharmacological treatment recommendations for cancer pain.
6 Apr, 2022 | 09:49h | UTC
Canadian recommendations on prostate cancer screening and early diagnosis.
6 Apr, 2022 | 09:47h | UTCSee also: Summary of changes
Review: Antiseizure medications for adults with epilepsy.
6 Apr, 2022 | 10:25h | UTCAntiseizure Medications for Adults With Epilepsy: A Review – JAMA (free for a limited period)
Audio Clinical Review: Epilepsy Diagnosis and Treatment in Adults – JAMA
Cohort Study: Recipient and donor outcomes after living-donor liver transplant for unresectable colorectal liver metastases.
6 Apr, 2022 | 10:23h | UTCCommentaries:
Living-Donor Liver Transplant Promising for CRC With Liver Mets – HealthDay
Commentary on Twitter
Study suggests living-donor liver transplant is a promising option for meticulously selected patients with unresectable colorectal cancer liver metastases. https://t.co/p6Jbzb73DL
— JAMA Surgery (@JAMASurgery) March 30, 2022
Review: Metabolic flexibility and its impact on health outcomes.
6 Apr, 2022 | 10:08h | UTCMetabolic Flexibility and Its Impact on Health Outcomes – Mayo Clinic Proceedings