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RCT: Aumolertinib vs. Gefitinib as first-line therapy for locally advanced or metastatic non-small-cell lung cancer with EGFR Exon 19 deletion or L858R mutations.

26 May, 2022 | 10:10h | UTC

AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or Metastatic Non–Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations – Journal of Clinical Oncology

 

Commentary on Twitter

https://creativecommons.org/licenses/by-nc-nd/4.0/

 

M-A: Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide.

26 May, 2022 | 10:13h | UTC

Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis – Diabetologia

Related:

Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis – Nature Medicine

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

 

Review: Climate change and cascading risks from infectious disease.

26 May, 2022 | 10:08h | UTC

Climate Change and Cascading Risks from Infectious Disease – Infectious Diseases and Therapy

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by-nc/4.0/ license

 

Study Commentary: Expensive antiseptics and sutures do not reduce the risk of surgical infections.

26 May, 2022 | 10:05h | UTC

Expensive antiseptics and sutures do not reduce the risk of surgical infections – National Institute for Health and Care Research

Original Study: Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet

 

Commentary on Twitter

 

M-A: Can compression garments reduce the deleterious effects of physical exercise on muscle strength?

26 May, 2022 | 10:07h | UTC

Can Compression Garments Reduce the Deleterious Effects of Physical Exercise on Muscle Strength? A Systematic Review and Meta-Analyses – Sports Medicine

News Release: Do compression garments facilitate muscle recovery after exercise? – Tohoku University

 

The role of T-tubes and abdominal drains on short-term outcomes in liver transplantation – A systematic review of the literature and expert panel recommendations.

26 May, 2022 | 10:04h | UTC

The role of T-tubes and abdominal drains on short-term outcomes in liver transplantation – A systematic review of the literature and expert panel recommendations – Clinical Transplantation

 

Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.

25 May, 2022 | 11:51h | UTC

Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet

News Release: Worldwide shortage of health workers threatens effective health coverage – Institute for Health Metrics and Evaluation

 

Commentaries on Twitter

 

RCT: The addition of Metformin to standard therapy did not improve outcomes in patients with breast cancer.

25 May, 2022 | 11:49h | UTC

Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Who Will Benefit From Metformin? – JAMA Oncology

News Release: Common diabetes drug not effective against early-stage breast cancer, landmark trial reveals – Lunenfeld-Tanenbaum Research Institute

 

Retrospective Cohort Study: The incidence of ischemic stroke in patients with asymptomatic severe carotid stenosis (70% to 99%) without surgical intervention was 4.7% over 5 years.

25 May, 2022 | 11:48h | UTC

Incidence of Ischemic Stroke in Patients With Asymptomatic Severe Carotid Stenosis Without Surgical Intervention – JAMA (free for a limited period)

News Release: Low stroke risk in patients with very narrowed neck arteries – Kaiser Permanente

 

USPSTF Recommendation Statement: The current evidence is insufficient to make a recommendation about screening for impaired visual acuity in older adults.

25 May, 2022 | 11:44h | UTC

Screening for Impaired Visual Acuity in Older Adults: US Preventive Services Task Force Recommendation Statement – JAMA

Editorials:

Visual Acuity Screening in Older Adults – JAMA Ophthalmology

Screening for Impaired Visual Acuity in Older Adults – JAMA

Vision Impairment Has Implications for Aging and Health Outcomes, Beyond Ophthalmology – JAMA Network Open

Evidence Report: Screening for Impaired Visual Acuity in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Impaired Visual Acuity in Older Adults – JAMA

Author Interview: USPSTF Recommendations: Screening for Primary Open-Angle Glaucoma and Screening for Impaired Visual Acuity in Older Adults – JAMA

 

USPSTF Recommendation Statement: The current evidence is insufficient to make a recommendation about screening for primary open-angle glaucoma in adults.

25 May, 2022 | 11:46h | UTC

Screening for Primary Open-Angle Glaucoma: US Preventive Services Task Force Recommendation Statement – JAMA

Editorials:

Identifying Glaucoma in Primary Care Offices – JAMA Ophthalmology

Screening for Glaucoma – JAMA

Evidence Report: Screening for Glaucoma in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Primary Open-Angle Glaucoma – JAMA

Author Interview: USPSTF Recommendations: Screening for Primary Open-Angle Glaucoma and Screening for Impaired Visual Acuity in Older Adults

 

Effectiveness of CoronaVac in children 3 to 5 years during the SARS-CoV-2 Omicron outbreak in Chile.

25 May, 2022 | 11:42h | UTC

Effectiveness of CoronaVac in children 3 to 5 years during the SARS-CoV-2 Omicron outbreak in Chile – Nature Medicine

 

RCT: Baricitinib vs. dexamethasone for adults hospitalized with COVID-19.

25 May, 2022 | 11:38h | UTC

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial – The Lancet Respiratory Medicine

 

Commentary on Twitter

 

Joint consensus guidelines on the diagnosis and management of eosinophilic esophagitis in children and adults.

25 May, 2022 | 11:32h | UTC

British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults – Gut

 

Short term, relative effectiveness of four doses versus three doses of BNT162b2 vaccine in people aged 60 years and older in Israel: retrospective, test negative, case-control study.

25 May, 2022 | 11:34h | UTC

Short term, relative effectiveness of four doses versus three doses of BNT162b2 vaccine in people aged 60 years and older in Israel: retrospective, test negative, case-control study – The BMJ

Related recommendations:

Covid-19: Second boosters may benefit at-risk groups but have “minimal” impact for others, says WHO – The BMJ

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines –
European Centre for Disease Prevention and Control

Coronavirus (COVID-19) Update: FDA Authorizes Second Booster Dose of Two COVID-19 Vaccines for Older and Immunocompromised Individuals – U.S. Food & Drug Administration

 

Guidance on contrast associated acute kidney injury.

25 May, 2022 | 11:30h | UTC

Canadian Association of Radiologists Guidance on Contrast Associated Acute Kidney Injury – Canadian Association of Radiologists Journal

Related:

Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation – Radiology

SIRM-SIN-AIOM: appropriateness criteria for evaluation and prevention of renal damage in the patient undergoing contrast medium examinations—consensus statements from Italian College of Radiology (SIRM), Italian College of Nephrology (SIN) and Italian Association of Medical Oncology (AIOM) – La radiologia medica

Association of Intravenous Radiocontrast With Kidney Function: A Regression Discontinuity Analysis – JAMA Internal Medicine

 

Takotsubo Syndrome: Pathophysiology, emerging concepts and clinical implications.

25 May, 2022 | 11:28h | UTC

Takotsubo Syndrome: Pathophysiology, Emerging Concepts and Clinical Implications – Circulation

 

Commentary on Twitter

 

M-A: Comparison of ultra-low, low and high concentration local anesthetic for labor epidural analgesia.

25 May, 2022 | 11:17h | UTC

Comparison of ultra-low, low and high concentration local anaesthetic for labour epidural analgesia: a systematic review and network meta-analysis – Anaesthesia

 

Opinion: Improving efficiency in medical diagnosis.

25 May, 2022 | 11:19h | UTC

Improving Efficiency in Medical Diagnosis – JAMA (free for a limited period)

 

Cohort Study: In patients with coronary artery disease, very high HDL-C levels are paradoxically associated with higher cardiovascular and all-cause mortality.

25 May, 2022 | 11:15h | UTC

Association Between High-Density Lipoprotein Cholesterol Levels and Adverse Cardiovascular Outcomes in High-risk Populations – JAMA Cardiology (link to abstract – $ for full-text)

 

Preventing birth defects, saving lives, and promoting health equity: an urgent call to action for universal mandatory food fortification with folic acid.

25 May, 2022 | 11:12h | UTC

Preventing birth defects, saving lives, and promoting health equity: an urgent call to action for universal mandatory food fortification with folic acid – The Lancet Global Health

News Release: Researchers Urge for a World Health Assembly Resolution on Universal Mandatory Folic Acid Fortification to Prevent Disabilities and Deaths in Infants Worldwide – Emory University

 

Study Commentary: Cerebrospinal fluid biomarkers for depression.

25 May, 2022 | 10:59h | UTC

Cerebrospinal fluid biomarkers for depression – The Mental Elf

Original Study: Cerebrospinal Fluid Biomarkers in Patients With Unipolar Depression Compared With Healthy Control Individuals: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Cohort Study: Analysis of neuropsychiatric diagnoses after montelukast initiation.

25 May, 2022 | 11:05h | UTC

Analysis of Neuropsychiatric Diagnoses After Montelukast Initiation – JAMA Network Open

Related:

FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis – U.S. Food & Drug Administration

Adverse drug reactions of montelukast in children and adults – Pharmacology Research & Perspectives

 

Commentary on Twitter

 

RCT: Everolimus is not beneficial when added to adjuvant endocrine therapy in patients with high-risk hormone receptor–positive, human epidermal growth factor receptor 2–negative primary breast cancer.

25 May, 2022 | 10:57h | UTC

Everolimus Added to Adjuvant Endocrine Therapy in Patients With High-Risk Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Primary Breast Cancer – Journal of Clinical Oncology

 

Commentaries on Twitter

 

Cohort Study: Risk of venous thromboembolism in men with prostate cancer compared with men in the general population.

25 May, 2022 | 11:01h | UTC

Risk of venous thromboembolism in men with prostate cancer compared with men in the general population: a nationwide population-based cohort study in Sweden – BMJ Open

News Release: Men with prostate cancer have a higher risk of serious blood clots – BMJ

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by-nc/4.0/ license

 

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