All Posts
Causes of liver cancer are changing around the world: some up, some down.
13 Jun, 2022 | 07:54h | UTCNews Release: Causes of Liver Cancer are Changing Around the World: Some Up, Some Down – UC San Diego Health
Original Study: Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer – Cell Metabolism (link to abstract – $ for full-text)
SGLT2 inhibitor reduces the risk of hyperkalemia in patients with heart failure.
13 Jun, 2022 | 07:52h | UTCEditorial: Emerging role for SGLT2 inhibitors in mitigating the risk of hyperkalaemia in heart failure
Commentary on Twitter
More evidence that SGLT2i ⬇️ hyperK, this time in heart failure
Empagliflozin reduces:
– K>6.0: HR 0.62 95% CI 0.48–0.81
– Investigator reported hyperK or K binders, HR 0.82 95% CI 0.71-0.95
– Effect modified by GFR – larger in CKD
– Regardless of MRAshttps://t.co/t4T7II1G8p pic.twitter.com/RP1EUKXHyV— Brendon Neuen (@brendonneuen) June 12, 2022
Under a https://creativecommons.org/licenses/by-nc/4.0/ license
Study: Most males who die by suicide have no known mental health condition.
13 Jun, 2022 | 07:48h | UTCCommentary: Most Males Who Die by Suicide Have No Known Mental Health Condition – Psychiatric News Alert
Original study: Suicide Among Males Across the Lifespan: An Analysis of Differences by Known Mental Health Status – American Journal of Preventive Medicine
Cohort Study: Long-term outcomes of early use of long-acting injectable antipsychotics in schizophrenia.
13 Jun, 2022 | 07:46h | UTCLong-term Outcomes of Early Use of Long-Acting Injectable Antipsychotics in Schizophrenia – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)
Related:
Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)
Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies – The Lancet Psychiatry (link to abstract – $ for full-text)
Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies – The Lancet Psychiatry (link to abstract – $ for full-text)
Host-directed immunotherapy of viral and bacterial infections: past, present and future.
13 Jun, 2022 | 07:41h | UTCHost-directed immunotherapy of viral and bacterial infections: past, present and future – Nature Reviews Immunology (if the link is paywalled, try this one in PMC)
Commentary on Twitter
A Perspective in @NatRevImmunol reflects on the historical development of host-directed immunotherapeutic interventions for infections and how historical insights can be used in the therapy of SARS-CoV-2 and Mycobacterium tuberculosis infections. https://t.co/5WOXzePpFS pic.twitter.com/dpj1XNi2me
— Nature Portfolio (@NaturePortfolio) June 11, 2022
Case reports: thalidomide therapy in 18 patients with severe arteriovenous malformations.
13 Jun, 2022 | 07:39h | UTCCase report study of thalidomide therapy in 18 patients with severe arteriovenous malformations – Nature Cardiovascular Research (link to abstract – $ for full-text)
Systematic Review: Oxycodone for cancer‐related pain.
13 Jun, 2022 | 07:37h | UTCOxycodone for cancer‐related pain – Cochrane Library
Summary: Oxycodone for cancer-related pain in adults – Cochrane Library
Circulating tumor DNA and late recurrence in high-risk hormone receptor–positive, human epidermal growth factor receptor 2–negative breast cancer.
13 Jun, 2022 | 07:35h | UTCCommentary: Tumor DNA Assay Portends Metastatic Breast Cancer Recurrence Months in Advance — First evidence for patients in late adjuvant setting, years after initial diagnosis – MedPage Today (free registration required)
Commentary on Twitter
103 women in long-term remission from high-risk HR+/HER2- breast cancer had customized monitoring of recurrence based on ctDNA seq for tumour-associated mut. Among 8 pts MRD+ pts, 6 developed distant recurrence at a median 12.4 mo after ctDNA positivity https://t.co/aX1ruLCSbb
— NatureRevClinOncol (@NatRevClinOncol) June 9, 2022
Long-term follow-up of RCT: Decompressive craniectomy vs. standard medical care in patients with traumatic intracranial hypertension.
10 Jun, 2022 | 12:45h | UTCEvaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months: A Secondary Analysis of the RESCUEicp Randomized Clinical Trial – JAMA Neurology (free for a limited period)
Original Study: Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension – New England Journal of Medicine
Related:
The Current Status of Decompressive Craniectomy in Traumatic Brain Injury – Current Trauma Reports
Commentary on Twitter
In this study, at 24 months, patients with posttraumatic refractory intracranial hypertension managed with a decompressive craniectomy had a sustained mortality reduction and higher rates of vegetative state, severe disability, and moderate disability. https://t.co/I8GqG885jh
— JAMA Neurology (@JAMANeuro) June 9, 2022
2-year follow-up of a single-arm study: Ciltacabtagene Autoleucel, an Anti–B-cell maturation antigen chimeric antigen receptor T-cell therapy, for relapsed/refractory multiple myeloma.
13 Jun, 2022 | 07:34h | UTCOriginal Study: Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
In follow-up from CARTITUDE-1 trial of ciltacabtagene autoleucel in R/R MM, ORR was 97.9% and 82.5% had a stringent CR. 27-mo PFS was 54% and OS was 70.4% https://t.co/cnpzkg5yKM
— NatureRevClinOncol (@NatRevClinOncol) June 9, 2022
Retrospective Cohort Study: Incidence of major adverse cardiac events with immune checkpoint inhibitors.
13 Jun, 2022 | 07:32h | UTCRelated:
Cardiotoxicity of immune checkpoint inhibitors – ESMO Open
Cardiotoxicity from immune checkpoint inhibitors – IJC Heart & Vasculature
RCT: Marine Omega-3 Fatty acid supplementation does not reduce the incidence of dry eye disease in healthy adults.
10 Jun, 2022 | 12:25h | UTCEfficacy of Marine ω-3 Fatty Acid Supplementation vs Placebo in Reducing Incidence of Dry Eye Disease in Healthy US Adults: A Randomized Clinical Trial – JAMA Ophthalmology (free for a limited period)
Invited Commentary: Another Disappointment for ω-3 Fatty Acid and Dry Eye Disease – JAMA Ophthalmology (free for a limited period)
Commentary on Twitter
In this randomized clinical trial, daily supplementation with marine omega-3 fatty acids (1 gram) for a median of 5.3 years had no significant effect on the incidence of diagnosed #dryeyedisease (DED) or reported DED symptoms. https://t.co/iTBONh6CZK
— JAMA Ophthalmology (@JAMAOphth) June 9, 2022
Another study suggests the Omicron variant is associated with a reduced risk of Multisystem Inflammatory Syndrome in Children compared to previous SARS-CoV-2 variants.
10 Jun, 2022 | 12:38h | UTCRelated study: Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel – JAMA AND Commentary: Kids’ COVID syndrome—MIS-C—less severe in Omicron – CIDRAP
Commentary on Twitter
Study found that the risk of multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection during the #Omicron wave substantially lower compared to previous #SARSCoV2 variants. https://t.co/GYrz9XA72Z
— JAMA Pediatrics (@JAMAPediatrics) June 8, 2022
Cohort Study: Neurodevelopmental outcomes at 1 year in infants of mothers who tested positive for SARS-CoV-2 during pregnancy.
10 Jun, 2022 | 12:14h | UTCCommentaries:
Commentary on Twitter
This cohort study of #SARSCoV2 exposure in utero found preliminary evidence that maternal SARS-CoV-2 may be associated with neurodevelopmental sequelae in some offspring. https://t.co/dYdoJbNOdl
— JAMA Network Open (@JAMANetworkOpen) June 9, 2022
M-A: Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections.
10 Jun, 2022 | 12:00h | UTC
Review: The burden and risks of emerging complications of diabetes mellitus.
10 Jun, 2022 | 12:04h | UTCThe burden and risks of emerging complications of diabetes mellitus – Nature Reviews Endocrinology
Commentary on Twitter
New content online: The burden and risks of emerging complications of diabetes mellitus https://t.co/mWcYa7TsKz
— Nature Reviews Endocrinology (@NatureRevEndo) June 6, 2022
Guidance Statement: Surgical triage and timing for patients with COVID undergoing thoracic surgery.
10 Jun, 2022 | 11:58h | UTC
Review: Pathophysiology and mechanism of long COVID.
10 Jun, 2022 | 11:55h | UTCPathophysiology and mechanism of long COVID: a comprehensive review – Annals of Medicine
Guideline on management of diabetes-related foot infection.
10 Jun, 2022 | 11:51h | UTCRelated:
[Preprint] Largest study to date on long COVID identifies a broad list of diagnoses.
10 Jun, 2022 | 11:53h | UTCStudy Commentary: Largest study to date on long COVID identifies a broad list of diagnoses – News Medical
Commentary on Twitter
🚨 The arguably largest #LongCovid study to date with millions of participants shows the increased risk of various symptoms after infection and the risk of having to take medications. https://t.co/DSvRcKVKIs pic.twitter.com/uUQxK1VQLv
— Jonas R. Kunst (@kunstjonas.bsky.social) (@KunstJonas) May 23, 2022
Guidelines to diagnose and treat peri-levator high-5 anal fistulas: Supralevator, suprasphincteric, extrasphincteric, high outersphincteric, and high intrarectal fistulas.
10 Jun, 2022 | 11:42h | UTC
Consensus Statement: Dietary interventions to treat type 2 diabetes in adults with a goal of remission.
10 Jun, 2022 | 11:46h | UTCCommentary: Whole, plant-based diet most effective for type 2 diabetes remission, ACLM says – ACP Diabetes
Comparison of strategies to conserve iodinated intravascular contrast media for computed tomography during a shortage.
10 Jun, 2022 | 11:21h | UTCComparison of Strategies to Conserve Iodinated Intravascular Contrast Media for Computed Tomography During a Shortage – JAMA (free for a limited period)
News Release: Amid Global Shortage, Study Shows How to Cut Contrast Dye Use 83% – University of California, San Francisco (UCSF)
Commentary on Twitter
This modeling study estimated that intravenous contrast use for CT scans could be reduced by approximately 80% by using a combination of dose-reduction strategies. https://t.co/hlnvkdEECS
— JAMA (@JAMA_current) June 9, 2022
Neck circumference measurement for surveillance and early detection of hemorrhage after thyroidectomy: a diagnostic accuracy study.
10 Jun, 2022 | 11:39h | UTCNeck Circumference Measurement for Surveillance and Early Detection of Hemorrhage After Thyroidectomy: A Diagnostic Accuracy Study – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)
Commentary on Twitter
Study evaluated neck circumference measurements as a diagnostic tool to improve patient’s safety in thyroid surgery. An increase of 7% or more seemed to be specific for post-thyroidectomy hemorrhage along with other clinical signs. https://t.co/HQqjv3svRx #thyroidectomy
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) June 9, 2022
Long-term results of RCT: Radiotherapy to the prostate for men with metastatic prostate cancer.
10 Jun, 2022 | 11:10h | UTC