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Cardiac xenotransplantation: challenges, evolution, and advances.
20 Jun, 2022 | 00:58h | UTCCommentary: Many Hurdles to Clear Before Cardiac Xenotransplantation Takes Off – TCTMD
Related:
In 1st, US surgeons transplant pig heart into human patient – Associated Press
Results of Two Cases of Pig-to-Human Kidney Xenotransplantation – New England Journal of Medicine (link to abstract – $ for full-text)
After a flurry of firsts, xenotransplantation is suddenly back in the spotlight – STAT
M-A: Heat exposure and cardiovascular health outcomes.
20 Jun, 2022 | 01:00h | UTC
Commentary on Twitter (thread – click for more)
New review out in @TheLancetPlanet on #heat from #climatechange and #cardiovascular #publichealth. Shows 1deg Celsius increases cardio mortality by 2.1%. https://t.co/RLsGU8dIS7
— Nicole Iroz Elardo (@NIrozElardo) June 14, 2022
Radiomic assessment of esophageal adenocarcinoma: a critical review of 18F-FDG PET/CT, PET/MRI and CT.
20 Jun, 2022 | 00:53h | UTC
Single-arm phase 2b study: MRI-guided focused ultrasound focal therapy for patients with intermediate-risk prostate cancer.
20 Jun, 2022 | 00:56h | UTCMRI-guided focused ultrasound focal therapy for patients with intermediate-risk prostate cancer: a phase 2b, multicentre study – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
In single-arm phase IIb trial of MRI-guided focused ultrasound therapy in 101 men with primary, group 2‒3 intermediate-risk untreated prostate adenocarcinomas, 88% had no evidence of group ≥2 prostate cancer in the treated area at 2 years: https://t.co/xLpqfFm8Ds #PCSM
— NatureRevClinOncol (@NatRevClinOncol) June 16, 2022
Single-arm Phase II trial: Direct-acting antivirals as primary treatment for hepatitis C virus–associated indolent Non-Hodgkin Lymphomas.
20 Jun, 2022 | 00:51h | UTC
10-year outcomes of a RCT: Time to cure for childhood and young adult Acute Lymphoblastic Leukemia is independent of early risk factors.
20 Jun, 2022 | 00:49h | UTCTime to Cure for Childhood and Young Adult Acute Lymphoblastic Leukemia Is Independent of Early Risk Factors: Long-Term Follow-Up of the UKALL2003 Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)
RCT: Routine use of intraoperative urinary catheters does not reduce the risk of postoperative urinary retention after laparoscopic inguinal hernia repair.
17 Jun, 2022 | 11:47h | UTCEffect of Intraoperative Urinary Catheter Use on Postoperative Urinary Retention After Laparoscopic Inguinal Hernia Repair: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentaries: Urinary Catheters for Inguinal Hernia Repair—The Challenges of Deimplementation of Routine Procedures – JAMA Surgery (free for a limited period)
Intraoperative Catheter Disappoints for Urinary Retention After Hernia Repair – MedPage Today (free registration required)
Author interview: Intraoperative Urinary Catheter Use and Urinary Retention After Laparoscopic Inguinal Hernia Repair – JAMA
Commentary on Twitter
In this study, intraoperative urinary catheters did not reduce the risk of postoperative urinary retention after laparoscopic inguinal hernia repair. https://t.co/6M06HxR51f
— JAMA Surgery (@JAMASurgery) June 15, 2022
AHA Scientific Statement: Revascularization for renovascular disease.
17 Jun, 2022 | 11:50h | UTCTop Things to Know: Revascularization for Renovascular Disease – American Heart Association
Commentary: When is Renovascular Hypertension Amenable to Revascularization – American Heart Association
FDA advisers OK COVID-19 vaccines for youngest kids.
17 Jun, 2022 | 11:43h | UTCFDA advisers OK COVID-19 vaccines for youngest kids – CIDRAP
See also: FDA advisers endorse 1st COVID-19 shots for kids under 5 – Associated Press
Test-negative, case–control study: Effects of previous infection and vaccination on symptomatic omicron infections.
17 Jun, 2022 | 11:44h | UTCRelated:
Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 – New England Journal of Medicine
Two new studies show vaccination provides additional protection after Covid-19 infection.
Commentary on Twitter
A study in Qatar assessed the effectiveness of previous infection, vaccination, and both against symptomatic SARS-CoV-2 caused by omicron BA.1 and BA.2 and against severe, critical, or fatal #COVID19. https://t.co/bEVD3Y1sUn pic.twitter.com/Y38a0xxead
— NEJM (@NEJM) June 15, 2022
Incubation period for monkeypox: Estimates from the Netherlands.
17 Jun, 2022 | 11:41h | UTCNews Release: Incubation period for monkeypox: Estimates from the Netherlands – European Centre for Disease Prevention and Control (ECDC)
Original Study: Estimated incubation period for monkeypox cases confirmed in the Netherlands, May 2022 – Eurosurveillance
Commentary on Twitter (thread – click for more)
Our early investigation from @rivm on the incubation period for #monkeypox is now available @Eurosurveillanc.https://t.co/Vr9AChIAOV
Main finding: the mean incubation period was 8.5 days (5th to 95th percentiles: 4.2 to 17.3 days).
Details, caveats, and a few thoughts ⬇️🧵1/
— Fumi Miura (@FuminariMiura) June 16, 2022
Does this patient with acute infectious conjunctivitis have a bacterial infection? The rational clinical examination systematic review.
17 Jun, 2022 | 11:12h | UTCDoes This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection? The Rational Clinical Examination Systematic Review – JAMA (free for a limited period)
Commentary on Twitter
In this review, bacterial conjunctivitis was more common than viral conjunctivitis in children and viral conjunctivitis was more common than bacterial conjunctivitis in adults, although the prevalence estimates were based on limited evidence. https://t.co/wJ6YXxPRem
— JAMA (@JAMA_current) June 16, 2022
Cohort Study: Association of sitting time with mortality and cardiovascular events in high-income, middle-income, and low-income countries.
17 Jun, 2022 | 11:05h | UTCAssociation of Sitting Time With Mortality and Cardiovascular Events in High-Income, Middle-Income, and Low-Income Countries – JAMA Cardiology (free for a limited period)
Commentary: Trade the chair for fresh air: Sitting time and cardio health – Simon Fraser University
Commentary from one of the authors on Twitter
Our study in 105K people from #PURE study:
🌟⬆️ sitting associated with >early death & heart disease
🌟association > in low income countries
🌟being active can counteract risk
🌟every 30 min of sitting replaced by #exercise, risk⬇️ 2%#healthy@JAMACardio: https://t.co/rR61SolkXs pic.twitter.com/ESUFXy6Pvj— Scott Lear, PhD (@DrScottLear) June 15, 2022
Post Hoc Secondary Analysis of RCT: Rivaroxaban monotherapy is associated with better outcomes vs. combination therapy with antiplatelets in patients with atrial fibrillation and stable coronary artery disease.
17 Jun, 2022 | 11:07h | UTCRivaroxaban Monotherapy vs Combination Therapy With Antiplatelets on Total Thrombotic and Bleeding Events in Atrial Fibrillation With Stable Coronary Artery Disease: A Post Hoc Secondary Analysis of the AFIRE Trial – JAMA Cardiology (free for a limited period)
Commentaries:
Antithrombotic Therapy in Atrial Fibrillation and Coronary Artery Disease: Does Less Mean More? – JAMA Cardiology (free for a limited period)
Rivaroxaban Monotherapy Linked to Lower Event Risk in Patients with AF, Stable CAD – HCPLive
Commentary on Twitter
In this post-hoc study of the AFIRE RCT, recurrent event analyses showed that rivaroxaban monotherapy was associated with lower risks of total thrombotic and/or bleeding events than rivaroxaban plus antiplatelet therapy in patients with AF and stable CAD. https://t.co/TGwatvlrKR
— JAMA Cardiology (@JAMACardio) June 15, 2022
Registry-based cohort study: Endovascular treatment vs. best medical management in acute basilar artery occlusion strokes.
17 Jun, 2022 | 11:03h | UTCEndovascular Treatment Versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results From the ATTENTION Multicenter Registry – Circulation (free for a limited period)
Commentary on Twitter
#ResearchLetter In 2134 patients with basilar artery occlusion #stroke, endovascular treatment was associated with improved functional capacity. The effect was more pronounced in patients with more debilitating symptoms #AHAJournals https://t.co/wy4uFocYlR pic.twitter.com/TIBRVAXRhE
— Circulation (@CircAHA) June 10, 2022
Cohort Study: Association of screening with digital breast tomosynthesis vs. digital mammography with risk of interval invasive and advanced breast cancer.
17 Jun, 2022 | 11:09h | UTCAssociation of Screening With Digital Breast Tomosynthesis vs Digital Mammography With Risk of Interval Invasive and Advanced Breast Cancer – JAMA (free for a limited period)
Editorial: Digital Breast Tomosynthesis and Detection of Interval Invasive and Advanced Breast Cancers – JAMA (free for a limited period)
News Release: 3-D Mammography Technique Benefits Some Women, Not All – University of California San Francisco
NICE Guideline: Reducing sexually transmitted infections.
16 Jun, 2022 | 11:15h | UTCReducing sexually transmitted infections – National Institute for Health and Care Excellence
#CCR22 – RCT: High-flow nasal cannula therapy met criteria for noninferiority compared to CPAP for the liberation from respiratory support in acutely ill children in the ICU.
16 Jun, 2022 | 11:10h | UTCEffect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among acutely ill children clinically assessed to require noninvasive respiratory support in a pediatric critical care unit, HFNC met the criterion for noninferiority compared with CPAP for time to liberation from respiratory support. https://t.co/WvU2fKLDOJ #CCR22
— JAMA (@JAMA_current) June 16, 2022
#CCR22 – RCT: Intravenous Vitamin C increases the risk of death or persistent organ dysfunction in adults with sepsis in the intensive care unit.
16 Jun, 2022 | 11:13h | UTCRelated:
Commentary on Twitter
https://twitter.com/NEJM/status/1536991910006468608
#CCR22 – RCT: Among critically ill patients undergoing tracheal intubation, administering a 500 ml fluid bolus did not decrease the incidence of severely low blood pressure, cardiac arrest, or death.
16 Jun, 2022 | 11:08h | UTCEffect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this randomized clinical trial, among critically ill adults undergoing tracheal intubation, administration of a fluid bolus did not significantly decrease the incidence of cardiovascular collapse. https://t.co/vPkfgLBF1n #CCR22
— JAMA (@JAMA_current) June 16, 2022
Inappropriate sinus tachycardia: etiology, pathophysiology, and management.
16 Jun, 2022 | 11:05h | UTC
Perspective | Viruses that were on hiatus during Covid are back — and behaving in unexpected ways.
16 Jun, 2022 | 11:06h | UTCViruses that were on hiatus during Covid are back — and behaving in unexpected ways – STAT
Review: The physiological underpinnings of life-saving respiratory support.
16 Jun, 2022 | 11:03h | UTCThe physiological underpinnings of life-saving respiratory support – Intensive Care Medicine
Commentary on Twitter
Physiology of life-saving respiratory support:
➡️historical overview
➡️pathophysiology of respiratory failure
Invasive mechanical ventilation & extracorporeal support #ECLS #ECMO:
➡️rationale
➡️implementation
➡️iatrogenic consequences
➡️future#FOAMcc
📎 https://t.co/EEvfpqVKIa pic.twitter.com/4t7wl53Jpz— Intensive Care Medicine (@yourICM) June 12, 2022
Interventions in acute intracranial surgery: an evidence-based perspective.
16 Jun, 2022 | 10:59h | UTCInterventions in Acute Intracranial Surgery: An Evidence-Based Perspective – World Neurosurgery
M-A: Acute or subacute, the optimal timing for uncomplicated Type B aortic dissection.
16 Jun, 2022 | 10:46h | UTC