All Posts
Guideline | Malignancy risk stratification for solitary pulmonary nodule.
4 Jul, 2022 | 12:33h | UTCPharmacological treatment of early-onset schizophrenia: a critical review, evidence-based clinical guidance, and unmet needs.
4 Jul, 2022 | 12:29h | UTCGlobal burden of musculoskeletal disorders and attributable factors in 204 countries and territories: a secondary analysis of the Global Burden of Disease 2019 study.
4 Jul, 2022 | 12:24h | UTCRelated: The Global Burden of Musculoskeletal Pain—Where to From Here? – American Journal of Public Health
A guideline and checklist for initiating and managing Clozapine treatment in patients with treatment-resistant schizophrenia.
4 Jul, 2022 | 12:27h | UTCUsing the intranasal route to administer drugs to treat neurological and psychiatric illnesses: rationale, successes, and future needs.
4 Jul, 2022 | 12:26h | UTCUsing the Intranasal Route to Administer Drugs to Treat Neurological and Psychiatric Illnesses: Rationale, Successes, and Future Needs – CNS Drugs (if the link is paywalled, try this one)
RCT | Effect of levofloxacin on the efficacy and adverse events in intravesical Bacillus Calmette-Guerin treatment for bladder cancer.
4 Jul, 2022 | 12:19h | UTCRCT | CT vs. [18F]FDG-PET-CT for persistent or recurrent neutropenic fever in high-risk patients.
4 Jul, 2022 | 12:21h | UTC[18F]FDG-PET-CT compared with CT for persistent or recurrent neutropenic fever in high-risk patients (PIPPIN): a multicentre, open-label, phase 3, randomised, controlled trial – The Lancet Haematology (link to abstract – $ for full-text)
Commentary on Twitter
NEW research: [18F]FDG-PET-CT resulted in more frequent antimicrobial rationalisation than CT in patients w/ haem diseases & persistent/recurrent high-risk neutropenic fever after chemotherapy. Results of the ph3 RCT PIPPIN #radonc #hemonc https://t.co/isOPFZVVpY pic.twitter.com/PVd8yFy7Ck
— The Lancet Haematology (@TheLancetHaem) June 29, 2022
M-A | Antibiotics for preventing recurrent urinary tract infection.
4 Jul, 2022 | 12:17h | UTCBrief Review | Ventilator-associated pneumonia.
4 Jul, 2022 | 12:15h | UTCVentilator-associated pneumonia – Intensive Care Medicine (if the link is paywalled, try this one in PMC)
Commentary on Twitter
VAP, main challenges & lessons learned
➡️ epidemiology: surveillance & data from LMICs
➡️ pathophysiology
➡️ prevention bundle
➡️ gold standard for diagnosis & microbiology
➡️ treatment: appropriate/timely ABTs
➡️ MDR pathogens
➡️ #COVID19: VAP's back
📎 https://t.co/oYblI6OGLK pic.twitter.com/qXWcABsU0H— Intensive Care Medicine (@yourICM) July 1, 2022
Review | Lowering and raising serum urate levels: off-label effects of commonly used medications.
4 Jul, 2022 | 12:10h | UTCHow doctors manage conflicts with families of critically ill patients during conversations about end-of-life decisions in neonatal, pediatric, and adult intensive care.
4 Jul, 2022 | 12:13h | UTCM-A of randomized trials | Ondansetron vs. metoclopramide for managing hyperemesis gravidarum.
4 Jul, 2022 | 12:11h | UTCPhase 1 single-arm study | Oncolytic DNX-2401 virus for pediatric diffuse intrinsic pontine glioma.
4 Jul, 2022 | 12:08h | UTCOncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Oncolytic Virus Infusion Promising as Brain-Stem Glioma Treatment — Phase I trial shows encouraging OS in children with diffuse intrinsic pontine glioma – MedPage Today (free registration required)
Trends in advanced heart failure therapy: update on cardiac transplantation.
4 Jul, 2022 | 12:07h | UTCM-A of randomized trials | Tourniquet use in total knee arthroplasty and the risk of infection.
4 Jul, 2022 | 11:55h | UTCFDA warns about possible increased risk of death and serious side effects with duvelisib.
4 Jul, 2022 | 11:51h | UTCCohort Study | Novel risk prediction model to determine adverse heart failure outcomes in arrhythmogenic right ventricular cardiomyopathy.
4 Jul, 2022 | 11:53h | UTCEditorial: Predicting Heart Failure in Arrhythmogenic Right Ventricular Cardiomyopathy
2022 Guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19.
1 Jul, 2022 | 11:50h | UTCRelated:
Editorial | Circulating tumor cell burden as a component of staging in multiple myeloma: ready for prime time?
4 Jul, 2022 | 11:48h | UTCOriginal Studies:
Two new studies show no benefit of Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19.
1 Jul, 2022 | 11:49h | UTCCommentaries:
Antithrombotic Prophylaxis No Help in Outpatients With COVID — Two trials show no differences between patients who received enoxaparin vs standard of care – MedPage Today (free registration required)
Commentary on Twitter (thread – click for more)
Early in the pandemic we wondered whether antithrombotic therapy in outpatients with #COVID19 would prevent #thrombosis ❓
Several trials were started globally and the ACTIV-4B trial was previously reported⬇️ https://t.co/Q15WcZwDIA
Now, we publish the OVID and ETHIC trials🧵
— The Lancet Haematology (@TheLancetHaem) June 30, 2022
Systematic Review: Mobility training for increasing mobility and functioning in older people with frailty.
1 Jul, 2022 | 11:41h | UTC
RCT: A single immediate dose of intravenous tenecteplase is noninferior to alteplase for the treatment of patients with acute ischemic stroke.
1 Jul, 2022 | 11:44h | UTCIntravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
News Release: UCalgary researchers with the Calgary Stroke Program make another breakthrough in the treatment of stroke
Accuracy of rapid antigen vs. RT-PCR testing for SARS-CoV-2 infection in college athletes during prevalence of the Omicron variant.
1 Jul, 2022 | 11:39h | UTC
Commentary on Twitter
In this case series of college athletes returning to campus during Omicron, rapid antigen tests were 63% sensitive, >99% specific for #COVID19, similar to previous strains and less well in detecting asymptomatic #SARSCoV2. @helixcardinal @stanford_ortho https://t.co/SBPr6NQ9Na
— JAMA Network Open (@JAMANetworkOpen) June 15, 2022
Consensus Statement: Definition, diagnosis, and clinical management of non-obstructive kidney dysplasia.
1 Jul, 2022 | 11:36h | UTC
UEG and EAES rapid guideline on transanal total mesorectal excision for rectal cancer.
1 Jul, 2022 | 11:33h | UTC