All Posts | Links Medicus - Free Medical News & Perspective

Podcast | Autism spectrum disorder pearls.

4 Aug, 2022 | 13:37h | UTC

#53: Autism Spectrum Disorder – Let’s (m-) CHAT About It! – The Cribsiders

Podcast | Caring for a pediatric patient with ARDS.

4 Aug, 2022 | 13:35h | UTC

#52: The Original “Baby Lung”: PARDS with PedsCrit – The Cribsiders

M-A | The global burden of sore throat and group A Streptococcus pharyngitis.

4 Aug, 2022 | 13:33h | UTC

The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis – eClinicalMedicine

RCT | Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis.

4 Aug, 2022 | 13:28h | UTC

Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial – The Lancet Neurology (link to abstract – $ for full-text)

Commentary: Less Frequent Dosing With MS Drug Safe With No Loss of Efficacy – Medscape (free registration required)

Network M-A | Evidence synthesis evaluating body weight gain among people treating HIV with antiretroviral therapy.

4 Aug, 2022 | 13:30h | UTC

Evidence synthesis evaluating body weight gain among people treating HIV with antiretroviral therapy – a systematic literature review and network meta-analysis – eClinicalMedicine

Commentary on Twitter

A new systematic review aimed to evaluate how different #ART regimens compare with respect to body #weight gains over time and associated risk factors.

Read here: https://t.co/MHC1Ysgb34 pic.twitter.com/0djjGPmlcW

— eClinicalMedicine – The Lancet Discovery Science (@eClinicalMed) May 24, 2022

Mucinous rectal cancers: clinical features and prognosis in a population-based cohort.

4 Aug, 2022 | 13:17h | UTC

Mucinous rectal cancers: clinical features and prognosis in a population-based cohort – BJS Open

Commentary on Twitter

https://twitter.com/BjsOpen/status/1521784196255027201

M-A | Repeat hepatic resection vs. percutaneous ablation for the treatment of recurrent hepatocellular carcinoma.

4 Aug, 2022 | 13:27h | UTC

Repeat hepatic resection versus percutaneous ablation for the treatment of recurrent hepatocellular carcinoma: meta-analysis – BJS Open

Commentary on Twitter

Recurrent #HCC after resection: re-resect or ablate?
📰#systematicreview

Redo-Resection has:
– ⏫Morbidity 17% vs 3%
– ⏫ recurrence free survival (HR 0.79)
– ⚖️ overall survival (HR 0.93 (0.83-1.04))https://t.co/WWwsHNkNQ9 #SoMe4Surgery #some4hpb @SEIQuirurgica @asgbi pic.twitter.com/h4apdpY7eh

— BJS Open (@BjsOpen) May 6, 2022

RCT | Total vs. partial posterior fundoplication in the surgical repair of para-esophageal hernias: randomized clinical trial.

4 Aug, 2022 | 13:22h | UTC

Total versus partial posterior fundoplication in the surgical repair of para-oesophageal hernias: randomized clinical trial – BJS Open

Commentary on Twitter

Does wrap type affect #dysphagia #qol and #recurrence in paraoesophageal #hernia repair?#RCT n=70 Nissen vs Toupet
Partial wrap (Toupet) assoc w/reduced dysphagia, better qol. No diff recurrence rate.#some4surgery #surgicalresearch #some4ugi https://t.co/8tIvryfqYJ pic.twitter.com/47AT1lLPH8

— BJS Open (@BjsOpen) May 9, 2022

Guideline | Preventing obesity in midlife women.

3 Aug, 2022 | 14:37h | UTC

Preventing Obesity in Midlife Women: A Recommendation From the Women’s Preventive Services Initiative – Annals of Internal Medicine

News Release: Women’s Preventive Services Initiative issues guidelines for preventing obesity in midlife women – American College of Physicians

Commentary: Counseling Can Prevent Obesity in Normal, Overweight Women – HealthDay

Commentary on Twitter

New guidelines aim to prevent #obesity in midlife women. @TheWPSI recommends counseling to prevent weight gain in all women at normal or overweight BMI. Full text available at https://t.co/P8VwBWIHXe @CedarsSinai @acog pic.twitter.com/YxTQVgXj59

— Annals of Int Med (@AnnalsofIM) August 2, 2022

M-A | Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials.

3 Aug, 2022 | 14:31h | UTC

Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis – The BMJ

RECOVERY Trial | Baricitinib in patients admitted to hospital with COVID-19.

3 Aug, 2022 | 14:34h | UTC

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – The Lancet

Invited Commentary: Baricitinib in COVID-19: a coming-of-age from artificial intelligence to reducing mortality – The Lancet

Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial – medRxiv

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial – The Lancet Respiratory Medicine

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – medRxiv

WHO recommends two new drugs to treat COVID-19 – World Health Organization

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial – The Lancet Respiratory Medicine

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine

Commentary on Twitter

New @TheLancet
The largest trial of baricitinib, a JAK-inhibitor drug repurposed via #AI data mining, reduced Covid mortality and the overall reduction consistent with 8 previous RCTs (~20%)https://t.co/5fHDBBvm3Q pic.twitter.com/GDFzcU26H6

— Eric Topol (@EricTopol) July 29, 2022

Under a Creative Commons Attribution (CC BY 4.0) license

Antivirals with activity against Monkeypox: a clinically oriented review.

3 Aug, 2022 | 14:26h | UTC

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

WHO chief advises men who have sex with men to reduce partners to limit exposure to monkeypox – CNN

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

Review | Diagnosis, treatment, and prevention of Malaria in the US.

3 Aug, 2022 | 14:27h | UTC

Diagnosis, Treatment, and Prevention of Malaria in the US: A Review – JAMA (free for a limited period)

Audio Clinical Review: Diagnosis, Treatment, and Prevention of Malaria in the US – JAMA

Cohort Study | Association between gout flare and subsequent cardiovascular events among patients with gout.

3 Aug, 2022 | 14:30h | UTC

Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout – JAMA (free for a limited period)

Editorial: Cardiovascular Events and Gout Flares – JAMA (free for a limited period)

News Release: Flare-ups of gout are linked to heart attack and stroke – University of Nottingham

Commentary: Association Between Gout Flare and Subsequent Cardiovascular Events – American College of Cardiology

Cohort Study | Association of higher-dose fluoroquinolone therapy with serious adverse events in older adults with advanced chronic kidney disease.

3 Aug, 2022 | 14:22h | UTC

Association of Higher-Dose Fluoroquinolone Therapy With Serious Adverse Events in Older Adults With Advanced Chronic Kidney Disease – JAMA Network Open

Evidence Synthesis | Deprescribing medicines in older people living with multimorbidity and polypharmacy.

3 Aug, 2022 | 14:20h | UTC

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

Designing Infographics | Visual representations for enhancing education, communication, and scientific research.

3 Aug, 2022 | 14:24h | UTC

Designing Infographics: Visual Representations for Enhancing Education, Communication, and Scientific Research – Journal of Korean Medical Science

Creating Effective Infographics and Visual Abstracts to Disseminate Research and Facilitate Medical Education on Social Media

As scientists take to Twitter, study shows power of ‘visual abstract’ graphics – Scienmag

Deep learning electrocardiographic analysis for detection of left-sided valvular heart disease.

3 Aug, 2022 | 14:19h | UTC

Deep Learning Electrocardiographic Analysis for Detection of Left-Sided Valvular Heart Disease – Journal of the American College of Cardiology

Commentary from the author on Twitter (thread – click for more)

Out today in @JACCJournals, our ValveNet study shows a ML model can detect mod-severe left sided valve disease from ECG. This model is currently running live in our health system daily. Now let me tell you everything wrong with it! A brief 🧵 https://t.co/rjtZxxTLt9 pic.twitter.com/oZKDDnZqYU

— Pierre Elias, MD (@PierreEliasMD) August 1, 2022

Guideline | Male lower urinary tract symptoms/benign prostatic hyperplasia.

3 Aug, 2022 | 14:17h | UTC

UPDATE – 2022 Canadian Urological Association guideline on male lower urinary tract symptoms/benign prostatic hyperplasia (MLUTS/BPH) – Canadian Urological Association Journal

AUA Guidelines: Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia.

Podcast: LUTS, BPH, and Urinary Incontinence Triple Distilled – The Curbsiders

Prostatic arterial embolization for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia – Cochrane Library

Minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia: a network meta‐analysis – Cochrane Library

Phosphodiesterase inhibitors for treatment of urinary problems in men with benign prostatic hyperplasia – Cochrane Library

Thulium laser transurethral vaporesection of the prostate versus transurethral resection of the prostate for men with lower urinary tract symptoms or urinary retention (UNBLOCS): a randomised controlled trial – The Lancet

Guideline | Androgen deprivation therapy: adverse events and management strategies.

3 Aug, 2022 | 14:15h | UTC

UPDATE – Canadian Urological Association guideline on androgen deprivation therapy: Adverse events and management strategies (Full-text) – Canadian Urological Association Journal

RCT | Effect of graded sensorimotor retraining on pain intensity in patients with chronic low back pain.

3 Aug, 2022 | 14:08h | UTC

Effect of Graded Sensorimotor Retraining on Pain Intensity in Patients With Chronic Low Back Pain: A Randomized Clinical Trial – JAMA (free for a limited period)

News release: An effective new treatment for chronic back pain targets the nervous system – University of New South Wales

Commentary on Twitter

A graded sensorimotor retraining intervention, compared with a sham procedure and attention control, resulted in a statistically significant improvement in pain intensity at 18 weeks. https://t.co/MXO89JeOSe pic.twitter.com/0A865RWW85

— JAMA (@JAMA_current) August 2, 2022

Consensus statements for pharmacological management, monitoring of therapies, and comorbidity management of psoriatic arthritis.

3 Aug, 2022 | 14:09h | UTC

Consensus statements for pharmacological management, monitoring of therapies, and comorbidity management of psoriatic arthritis in the United Arab Emirates – International Journal of Rheumatic Diseases

RCT | Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction.

3 Aug, 2022 | 14:06h | UTC

Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial – European Society of Cardiology

Commentary on Twitter

No one wants to add meds just so you can add more meds. BUT, adding patiromer in select patients with HFrEF so you can optimize GDMT sure is compelling… 🤔 https://t.co/79gSEwon4y

— ATRIUM Cardiology (@ATRIUMRx) July 29, 2022