All Posts | Links Medicus - Free Medical News & Perspective

How applicable is the single-dose liposomal amphotericin B (AMBITION regimen) for HIV-associated cryptococcal meningitis to high-income settings?

Very, argue leaders of the @ambitioncm2020 trial in @CIDJournal https://t.co/eUlWG0t1Xv pic.twitter.com/8JGBU1oWeO

— Ilan Schwartz is on🦋 (@GermHunterMD) September 27, 2022

Under a https://creativecommons.org/licenses/by/4.0/ license

Phase 1 study | GPRC5D-Targeted CAR T Cells for patients with heavily pretreated Multiple Myeloma.

29 Sep, 2022 | 13:25h | UTC

GPRC5D-Targeted CAR T Cells for Myeloma – New England Journal of Medicine (link to abstract – $ for full-text)

M-A | Carbon dioxide laser vs. vaginal estrogen for genitourinary syndrome of menopause.

29 Sep, 2022 | 13:24h | UTC

Comparison of Severity of Genitourinary Syndrome of Menopause Symptoms After Carbon Dioxide Laser vs Vaginal Estrogen Therapy: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary on Twitter

Vaginal laser and vaginal estrogen therapy showed similar improvement in genitourinary symptoms in this systematic review and meta-analysis of RCTs. #Research https://t.co/PpAf77CqKS

— JAMA Network Open (@JAMANetworkOpen) September 21, 2022

RCT | ShangRing vs. Mogen clamp for early infant male circumcision in eastern sub-Saharan Africa.

29 Sep, 2022 | 13:23h | UTC

ShangRing versus Mogen clamp for early infant male circumcision in eastern sub-Saharan Africa: a multicentre, non-inferiority, adaptive, randomised controlled trial – The Lancet Global Health

Invited Commentary: Can the ShangRing bring us closer to endorsing early infant male circumcision in sub-Saharan Africa? – The Lancet Global Health

RCT | Pembrolizumab vs. placebo as adjuvant therapy for completely resected stage IB–IIIA non-small-cell lung cancer.

29 Sep, 2022 | 13:22h | UTC

Pembrolizumab versus placebo as adjuvant therapy for completely resected stage IB–IIIA non-small-cell lung cancer (PEARLS/KEYNOTE-091): an interim analysis of a randomised, triple-blind, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentaries:

Adjuvant Pembrolizumab in Patients With Completely Resected Stage IB to IIIA NSCLC – The ASCO Post

Adjuvant Pembrolizumab Prolongs DFS in Resected Non-Small Cell Lung Cancer – Cancer Therapy Advisor

Commentary on Twitter

New Research in @TheLancetOncol—Pembrolizumab improves disease-free survival vs placebo in completely resected, PD-L1-unselected, stage IB–IIIA #NSCLC

From Prof Mary O’Brien & colleagues https://t.co/Azqb8WTOwp pic.twitter.com/141bhAPtg5

— The Lancet Respiratory Medicine (@LancetRespirMed) September 13, 2022

RCT | Immunogenicity and safety of one-dose human papillomavirus vaccine vs. two or three doses.

29 Sep, 2022 | 13:21h | UTC

Immunogenicity and safety of one-dose human papillomavirus vaccine compared with two or three doses in Tanzanian girls (DoRIS): an open-label, randomised, non-inferiority trial – The Lancet Global Health

Invited Commentary: HPV vaccines: when one plus one equals three – The Lancet Global Health

RCT: Single-dose HPV vaccination found effective among young African women.

Three-year follow-up of 2-dose versus 3-dose HPV vaccine

Opinion: A Single-dose HPV Vaccine Would Have a Big Impact on Cancer Prevention

Another Observational Study Suggests One Dose of HPV Vaccine may be Enough

Another Study Suggesting One Dose of HPV Vaccine may be Effective for Prevention of Cervical Cancer

Comparison of different human papillomavirus (HPV) vaccines and the number of doses administered to prevent HPV-related disease in females and males – Cochrane Library

Large Observational Study Suggests One Dose of HPV Vaccine May Be as Effective as Three

USPSTF Recommendation Statement | Screening for Syphilis infection in nonpregnant adolescents and adults.

28 Sep, 2022 | 13:52h | UTC

Screening for Syphilis Infection in Nonpregnant Adolescents and Adults: US Preventive Services Task Force Reaffirmation Recommendation Statement – JAMA

Editorial:

Resurgence of Syphilis in the US—USPSTF Reaffirms Screening Guidelines – JAMA Dermatology

The Critical Need to Modernize Syphilis Screening – JAMA

Screening for Syphilis in Nonpregnant Adults and Adolescents – JAMA Network Open

Evidence Report: Screening for Syphilis Infection in Nonpregnant Adults and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

JAMA Patient Page: Screening for Syphilis

Author Interview: USPSTF Recommendation: Syphilis Screening in Nonpregnant Adolescents and Adults

Commentary: USPSTF Recommends Syphilis Screening for At-Risk Persons – HealthDay

RCT | High-flow nasal cannula oxygen did not reduce mortality in patients with respiratory failure due to COVID-19.

28 Sep, 2022 | 13:51h | UTC

Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19: The SOHO-COVID Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: High-Flow Oxygen Fails to Reduce Mortality due to COVID-19 Respiratory Failure – HCP Live

Cohort Study | The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality.

28 Sep, 2022 | 13:49h | UTC

The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank – European Journal of Preventive Cardiology

Commentary: Expert reaction to study on coffee drinking and increased longevity – Science Media Centre

“However, with observational research like this, you can’t be sure what direction the relationship goes e.g. does coffee make you healthy or do inherently healthier people consume coffee?” (from Science Media Centre)