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Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline.

31 Oct, 2022 | 13:50h | UTC

Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline – Annals of Oncology

 


Cohort Study | Risk factors of pancreatic cancer in patients with Type 2 DM.

31 Oct, 2022 | 13:47h | UTC

Risk Factors of Pancreatic Cancer in Patients With Type 2 Diabetes Mellitus: The Hong Kong Diabetes Study – Journal of the Endocrine Society

 


M-A | Comparison of continuous versus intermittent enteral feeding in critically ill patients.

31 Oct, 2022 | 13:48h | UTC

Comparison of continuous versus intermittent enteral feeding in critically ill patients: a systematic review and meta-analysis – Critical Care

 


Review | Optimal perfusion targets in cardiogenic shock.

31 Oct, 2022 | 13:45h | UTC

Optimal Perfusion Targets in Cardiogenic Shock – JACC: Advances

 

Commentary on Twitter

 


Evolving presentation of cardiogenic shock: a review of the medical literature and current practices.

31 Oct, 2022 | 13:46h | UTC

Evolving Presentation of Cardiogenic Shock: A Review of the Medical Literature and Current Practices – Cardiology and Therapy

 

Commentary on Twitter

 


Cohort Study | Predicting stroke in heart failure and reduced ejection fraction without atrial fibrillation.

31 Oct, 2022 | 13:42h | UTC

Predicting stroke in heart failure and reduced ejection fraction without atrial fibrillation – European Heart Journal

 

Commentary on Twitter

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

 


M-A of RCT | Combination of ulinastatin and somatostatin evaluated in acute pancreatitis.

31 Oct, 2022 | 13:44h | UTC

The combination of ulinastatin and somatostatin reduces complication rates in acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials – Scientific Reports

 


Study | No benefit from frailty screening over a geriatric-assessment-for-all approach in older patients with cancer.

31 Oct, 2022 | 13:40h | UTC

A Two-Step Frailty Assessment Strategy in Older Patients With Solid Tumors: A Decision Curve Analysis – Journal of Clinical Oncology

 


Nonsurgical options for risk reduction of contralateral breast cancer in BRCA mutation carriers with early breast cancer.

31 Oct, 2022 | 13:41h | UTC

Nonsurgical Options for Risk Reduction of Contralateral Breast Cancer in BRCA Mutation Carriers With Early-Stage Breast Cancer – Journal of Clinical Oncology (free for a limited period)

 


Post-trial follow-up | Pembrolizumab vs. chemotherapy as first-line therapy in PD-L1-expressing non–small-cell lung cancer.

31 Oct, 2022 | 13:39h | UTC

Five-Year Outcomes With Pembrolizumab Versus Chemotherapy as First-Line Therapy in Patients With Non–Small-Cell Lung Cancer and Programmed Death Ligand-1 Tumor Proportion Score ≥ 1% in the KEYNOTE-042 Study – Journal of Clinical Oncology

Original Study: Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial – The Lancet

 


RCT | Effectiveness of rTMS vs. bilateral Theta burst stimulation in older adults with depression.

31 Oct, 2022 | 13:38h | UTC

Effectiveness of Standard Sequential Bilateral Repetitive Transcranial Magnetic Stimulation vs Bilateral Theta Burst Stimulation in Older Adults With Depression: The FOUR-D Randomized Noninferiority Clinical Trial – JAMA Psychiatry

Commentary: Neurostimulation Methods Compared for Treating Depression in Seniors – HealthDay

 

Commentary on Twitter

 


Post-trial follow-up | Updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab.

31 Oct, 2022 | 13:36h | UTC

Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab – Blood

 

Commentary on Twitter

 


RCT | Sutimlimab in patients with cold agglutinin disease without recent transfusion.

31 Oct, 2022 | 13:37h | UTC

Sutimlimab in patients with cold agglutinin disease: results of the randomized placebo-controlled phase 3 CADENZA trial – Blood

Editorial: A virtuosic CADENZA played by sutimlimab – Blood

Commentary: Sutimlimab Shows Efficacy in Patients With CAD Without Recent Transfusion – AJMC

 

Commentary on Twitter

 


Case Report | Acquired Hemophilia A secondary to an immune checkpoint inhibitor.

31 Oct, 2022 | 13:34h | UTC

Acquired Hemophilia A Secondary to an Immune Checkpoint Inhibitor: A Case Report – JTO Clinical and Research Reports

Commentary: Report Details Rare Case of Acquired Hemophilia A Secondary to Immune Checkpoint Inhibition

 


Cohort Study | Association of retinal age gap with arterial stiffness and incident cardiovascular disease.

31 Oct, 2022 | 13:32h | UTC

Association of Retinal Age Gap With Arterial Stiffness and Incident Cardiovascular Disease – Stroke

Related:

Cohort Study | Artificial intelligence-enabled retinal vasculometry for prediction of cardiovascular diseases.

Retinal photograph-based deep learning predicts biological age, and stratifies morbidity and mortality risk.

An artificial intelligence system can help predict myocardial infarction through retinal scans and minimal personal information.

Study shows that the retinal age gap might be a potential biomarker of aging linked to increased mortality risk.

 


Cohort Study | Diverticular disease linked to increased risk of cancer outside the GI tract.

31 Oct, 2022 | 13:33h | UTC

Cancer risk in patients with diverticular disease: a nationwide cohort study – JNCI: Journal of the National Cancer Institute (link to abstract – $ for full-text)

News Release: Diverticular disease associated with cancer outside gastrointestinal tract – Karolinska Institutet

 


RCT | Liposomal bupivacaine transversus abdominis plane block did not reduce postoperative pain after abdominal wall reconstruction.

31 Oct, 2022 | 13:30h | UTC

The Efficacy of Liposomal Bupivacaine on Postoperative Pain Following Abdominal Wall Reconstruction: A Randomized, Double-blind, Placebo-controlled Trial – Annals of Surgery (link to abstract – $ for full-text)

 


Cohort Study | Clinical diagnosis and magnetic resonance imaging in patients with transient and minor neurological symptoms.

31 Oct, 2022 | 13:31h | UTC

Clinical Diagnosis and Magnetic Resonance Imaging in Patients With Transient and Minor Neurological Symptoms: A Prospective Cohort Study – Stroke

 

Commentary on Twitter

 


WHO Report | Fungal priority pathogens list to guide research, development and public health action.

28 Oct, 2022 | 13:31h | UTC

WHO fungal priority pathogens list to guide research, development and public health action – World Health Organization

News Release: WHO releases first-ever list of health-threatening fungi – World Health Organization

 

Commentary on Twitter (thread – click for more)

 


WHO | Global status report on physical activity 2022.

28 Oct, 2022 | 13:30h | UTC

Global status report on physical activity 2022 – World Health Organization

News Release: WHO highlights high cost of physical inactivity in first-ever global report – World Health Organization

 

Commentary on Twitter

 


RCT | Early active mobilization during mechanical ventilation in the ICU did not improve outcomes and increased adverse events.

28 Oct, 2022 | 13:28h | UTC

Early Active Mobilization during Mechanical Ventilation in the ICU – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

https://twitter.com/NEJM/status/1585246120963604481

 


RCT | Haloperidol for the treatment of delirium in ICU patients did not significantly improve outcomes.

28 Oct, 2022 | 13:29h | UTC

Haloperidol for the Treatment of Delirium in ICU Patients – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT | Spontaneous-breathing trials performed with pressure-support ventilation are no better than trials using a T-piece.

28 Oct, 2022 | 13:25h | UTC

Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Systematic Review | Support for healthy breastfeeding mothers with healthy term babies.

28 Oct, 2022 | 13:23h | UTC

Support for healthy breastfeeding mothers with healthy term babies – Cochrane Library

Summary: Support for breastfeeding mothers – Cochrane Library

 


CDC study shows healthcare workers have a low risk of infection after exposure to patients with monkeypox.

28 Oct, 2022 | 13:21h | UTC

Health Care Personnel Exposures to Subsequently Laboratory-Confirmed Monkeypox Patients — Colorado, 2022 – Morbidity and Mortality Weekly Report

Commentaries:

Clinicians at Low Risk of Acquiring Monkeypox From Patients – JAMA

Low risk of monkeypox spread noted in health workers – CIDRAP

Risk of Monkeypox Transmission Low in Health Care Settings – HealthDay

 


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