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M-A | Head-to-head trials comparing sulfonylureas and low hypoglycemic risk antidiabetic drugs.

11 Nov, 2022 | 13:38h | UTC

Systematic review and meta-analysis of head-to-head trials comparing sulfonylureas and low hypoglycaemic risk antidiabetic drugs – BMC Endocrine Disorders

 

M-A | The response of subgroups of patients with schizophrenia to different antipsychotic drugs.

11 Nov, 2022 | 13:13h | UTC

The response of subgroups of patients with schizophrenia to different antipsychotic drugs: a systematic review and meta-analysis – The Lancet Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter (thread – click for more)

https://twitter.com/TheLancetPsych/status/1579748713962278913

 

Retrospective Cohort Study | Perinatal outcomes associated with ICP in twin pregnancies were worse than singletons.

11 Nov, 2022 | 13:36h | UTC

Perinatal outcomes associated with ICP in twin pregnancies were worse than singletons: an almost 5-year retrospective cohort study – BMC Pregnancy and Childbirth

 

Single-arm P1/2 study | Iberdomide plus dexamethasone in heavily pretreated late-line relapsed or refractory multiple myeloma.

11 Nov, 2022 | 13:05h | UTC

Iberdomide plus dexamethasone in heavily pretreated late-line relapsed or refractory multiple myeloma (CC-220-MM-001): a multicentre, multicohort, open-label, phase 1/2 trial – The Lancet Haematology (link to abstract – $ for full-text)

 

Commentaries on Twitter

 

SR | The availability, cost, and affordability of essential medicines for asthma and COPD in low- and middle-income countries.

11 Nov, 2022 | 13:04h | UTC

The availability, cost, and affordability of essential medicines for asthma and COPD in low-income and middle-income countries: a systematic review – The Lancet Global Health

Invited Commentary: Access to essential respiratory medications remains elusive in LMICs – The Lancet Global Health

 

Phase 2 RCT | Efficacy of Bemarituzumab in patients with FGFR2b-selected gastric or gastro-esophageal junction adenocarcinoma.

11 Nov, 2022 | 13:02h | UTC

Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study – The Lancet Oncology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Cohort Study | Premenopausal bilateral oophorectomy linked to increased risk of Parkinsonism and Parkinson Disease.

11 Nov, 2022 | 12:56h | UTC

Association of Premenopausal Bilateral Oophorectomy With Parkinsonism and Parkinson Disease – JAMA Network Open

News Release: Removal of Both Ovaries in Younger Women Associated with Increased Risk of Parkinson’s – Discovery’s Edge

 

RCT | Volatile anesthesia did not significantly reduce postoperative delirium compared to IV anesthesia in cardiac valve surgery.

11 Nov, 2022 | 12:59h | UTC

Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial – Anesthesia & Analgesia (link to abstract – $ for full-text)

 

Single-arm phase 1b study | Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma.

11 Nov, 2022 | 13:00h | UTC

Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial – The Lancet Oncology (link to abstract – $ for full-text)

 

M-A | Medication reviews and deprescribing as a single intervention in falls prevention.

11 Nov, 2022 | 12:53h | UTC

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

 

WHO Report | A blueprint for dementia research.

10 Nov, 2022 | 14:17h | UTC

A blueprint for dementia research – World Health Organization

News Release: Launch of WHO’s first blueprint for dementia research – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

NICE Guideline Update | Colonoscopic surveillance in adults with inflammatory bowel disease or adenomas.

10 Nov, 2022 | 14:16h | UTC

Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn’s disease or adenomas – National Institute for Health and Care Excellence

Related:

British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines – Gut

Consensus Statement: U.S. Multi-Society Task Force on Colorectal Cancer now suggests average-risk CRC screening begins at age 45.

USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.

ACG Clinical Guidelines: Start colorectal cancer screening at 45

Evidence-based clinical practice guidelines for management of colorectal polyps – Journal of Gastroenterology

Meta-analysis: Risk of colorectal cancer and cancer related mortality after detection of low-risk or high-risk adenomas, compared with no adenoma, at index colonoscopy

Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer – Gastroenterology

Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Digestive Oncology (ESDO) Guideline – Endoscopy

 

RCT | Intermediate-dose no better than low-dose LMWH in pregnant and post-partum women with previous thromboembolism.

10 Nov, 2022 | 14:12h | UTC

Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)

 

Commentary from the author on Twitter (thread – click for more)

 

RCT | Monofilament suture is no better than braided suture to improve pregnancy outcomes after vaginal cervical cerclage.

10 Nov, 2022 | 14:14h | UTC

Monofilament suture versus braided suture thread to improve pregnancy outcomes after vaginal cervical cerclage (C-STICH): a pragmatic randomised, controlled, phase 3, superiority trial – The Lancet

Invited Commentary: Suture choice for cervical cerclage – The Lancet (free registration required)

News Release: Single stranded suture threads could prevent pregnancy infection complications, C-STICH trial finds – University of Birmingham

Video Summary: Major trial finds purse-string wire in surgery can reduce miscarriage and stillbirth – University of Birmingham

Commentary: Monofilament Suture Not Superior for Vaginal Cervical Cerclage – HealthDay

 

Commentary on Twitter (thread – click for more)

 

Study | In hypertensive disorders of pregnancy, the levels of angiogenic factors may stratify the risk of severe preeclampsia.

10 Nov, 2022 | 14:11h | UTC

Circulating Angiogenic Factor Levels in Hypertensive Disorders of Pregnancy – NEJM Evidence

 

Commentary on Twitter

 

RCT | Mindfulness-based stress reduction vs. escitalopram for the treatment of adults with anxiety disorders.

10 Nov, 2022 | 14:09h | UTC

Mindfulness-Based Stress Reduction vs Escitalopram for the Treatment of Adults With Anxiety Disorders: A Randomized Clinical Trial – JAMA Psychiatry (free for a limited period)

Commentaries:

Mindfulness worked as well for anxiety as drug in study – Associated Press

Meditation works as well as a popular drug to reduce anxiety, study finds – NPR

 

Commentary on Twitter

 

Cohort Study | Study shows subclinical Hyperthyroidism is linked to an increased risk of fractures.

10 Nov, 2022 | 14:08h | UTC

Association Between Subclinical Thyroid Dysfunction and Fracture Risk – JAMA Network Open

Commentary: Does Subclinical Hyperthyroidism Raise Fracture Risk? – Medscape (free registration required)

 

Commentary on Twitter

 

On the natural history of coronary artery disease: a longitudinal nationwide serial angiography study.

10 Nov, 2022 | 14:03h | UTC

On the Natural History of Coronary Artery Disease: A Longitudinal Nationwide Serial Angiography Study – Journal of the American Heart Association

 

RCT | Tamponade dressing does not reduce bleeding or pain compared to no dressing after hemorrhoidectomy.

10 Nov, 2022 | 14:06h | UTC

Tamponade dressing versus no dressing after haemorrhoidectomy: multicentre, randomized clinical trial – BJS Open

 

Commentary on Twitter

 

Cohort Study | Surveillance of long-term outcomes of devices after endovascular abdominal aortic aneurysm repair.

10 Nov, 2022 | 14:00h | UTC

Use of linked registry claims data for long term surveillance of devices after endovascular abdominal aortic aneurysm repair: observational surveillance study – The BMJ

 

Commentary on Twitter

https://twitter.com/bmj_latest/status/1584922859822014466

 

Editorial | The urgent need to recognize and properly address prenatal-onset group B Streptococcus disease.

10 Nov, 2022 | 13:59h | UTC

The urgent need to recognize and properly address prenatal-onset group B Streptococcus disease – International Journal of Infectious Diseases

 

M-A | Bioresorbable vascular scaffolds are inferior compared to conventional drug-eluting stents across time.

10 Nov, 2022 | 13:57h | UTC

Bioresorbable vascular scaffolds versus conventional drug-eluting stents across time: a meta-analysis of randomised controlled trials – openheart

 

Commentary on Twitter

 

RCT | Effect of local anesthetic infiltration on postoperative pain after laparoscopic cholecystectomy.

10 Nov, 2022 | 13:56h | UTC

Effect of local anaesthetic infiltration on postoperative pain after laparoscopic cholecystectomy: randomized clinical trial – BJS Open

 

Commentary on Twitter

 

RCT | Effects of a narrative-based psychoeducational intervention to prepare patients for responding to acute MI.

10 Nov, 2022 | 13:51h | UTC

Effects of a Narrative-Based Psychoeducational Intervention to Prepare Patients for Responding to Acute Myocardial Infarction: A Randomized Clinical Trial – JAMA Network Open

 

RCT | Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases.

10 Nov, 2022 | 13:54h | UTC

Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

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