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Our SGLT2 Trialists Consortium meta-analysis *the largest ever* in @TheLancet https://t.co/YlWkRQTDAW

Definitive evidence that SGLT2i ⬇️:
– Kidney failure
– AKI
– CV death
– All-cause death

Regardless of diabetes

Led by @NatalieStaplin @RichardHaynes3 @willkidney #AHA22 pic.twitter.com/uAX15mD9XY

— Brendon Neuen (@brendonneuen) November 6, 2022

Under a Creative Commons Attribution (CC BY 4.0) License

RCT | Indobufen vs. aspirin on top of clopidogrel after coronary drug-eluting stent implantation.

11 Nov, 2022 | 14:03h | UTC

Indobufen or Aspirin on Top of Clopidogrel after Coronary Drug-eluting Stent Implantation (OPTION): a Randomized, Open-label, Endpoint-blinded, Non-inferiority Trial – Circulation

Commentary on Twitter

#OriginalResearch simpub #AHA2022 #CIRCAHA22: In this #RCT, indobufen + clopidogrel DAPT compared with aspirin + clopidogrel DAPT significantly reduced the risk of 1-year net clinical outcomes, mainly driven by a reduction in bleeding events without an ….https://t.co/ctk1fwhXt2 pic.twitter.com/vFPS6gvpjN

— Circulation (@CircAHA) November 6, 2022

RCT | Comparison of acupuncture vs. sham acupuncture in the treatment of aromatase inhibitor–related joint pain.

15 Nov, 2022 | 12:47h | UTC

Comparison of Acupuncture vs Sham Acupuncture or Waiting List Control in the Treatment of Aromatase Inhibitor–Related Joint Pain: A Randomized Clinical Trial – JAMA Network Open

Commentary: Aromatase inhibitors and acupuncture in breast cancer: Spinning a negative study, four years later – Science-based Medicine

Commentary on Twitter

https://twitter.com/JAMANetworkOpen/status/1591113526222913538

RCT | Early routine use of ECMO fails to improve outcomes in patients with cardiogenic shock.

11 Nov, 2022 | 14:01h | UTC

Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial – Circulation

Commentaries:

Early use of ECMO devices to support adults with cardiogenic shock did not improve clinical outcomes – News Medical/American Heart Association

Early ECMO No Better Than Watch-and-Wait Approach in Cardiogenic Shock – TCTMD

Immediate Use of ECMO Did Not Improve Outcomes in Patients with Cardiogenic Shock – HCP Live

Commentary on Twitter

#OriginalResearch simpub #AHA2022: In this #RCT immediate implementation of VA-ECMO in patients with cardiogenic shock did not improve clinical outcomes compared with an early conservative strategy which allowed downstream use of… #CIRCAHA22 #AHAJournals https://t.co/03qVyC0Vgl pic.twitter.com/WRNDsAZfpD

— Circulation (@CircAHA) November 6, 2022

RCT | Helicobacter pylori eradication may prevent peptic ulcer bleeding in older patients prescribed aspirin in primary care.

11 Nov, 2022 | 14:00h | UTC

Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial – The Lancet

News Release: Cutting the risk of stomach bleeding, occasionally caused by regular aspirin use – University of Nottingham

Commentary on Twitter

New @TheLancet – the HEAT trial of H pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (1/4)https://t.co/9SlP3y6DGf #gitwitter #medtwitter

— Rob Brierley (@Rob__Brierley) November 4, 2022

RCT | Dual endothelin antagonist Aprocitentan is effective for resistant hypertension.

11 Nov, 2022 | 13:59h | UTC

Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentaries:

Endothelin Receptor Antagonist Effective in Resistant Hypertension: PRECISION – TCTMD

Parallel-Group, Phase 3 Study With Aprocitentan in Subjects With Resistant Hypertension – PRECISION – American College of Cardiology

RCT | Shortened course of radiation therapy safe and effective for men with high-risk prostate cancer.

11 Nov, 2022 | 13:55h | UTC

[News release – not published yet] Shortened course of radiation therapy safe and effective for men with high-risk prostate cancer – American Society for Radiation Oncology (ASTRO) Annual Meeting

Phase 2RCT | Baxdrostat reduces BP in patients with treatment-resistant hypertension.

11 Nov, 2022 | 13:57h | UTC

Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Big Drops in Blood Pressure With Baxdrostat: BrigHTN Phase II Study – TCTMD

New Drug Helps Tame Uncontrolled High Blood Pressure – HealthDay

RCT | A small study tested Apixaban’s efficacy and safety versus a Vitamin K-antagonist in patients on chronic hemodialysis.

11 Nov, 2022 | 13:52h | UTC

A Randomized Controlled Trial Comparing Apixaban to the Vitamin K-antagonist Phenprocoumon in Patients on Chronic Hemodialysis: The AXADIA-AFNET 8 study – Circulation

RCT | Efficacy of Safinamide as add-on therapy to Levodopa in patients with Parkinson’s disease with motor fluctuations.

11 Nov, 2022 | 13:53h | UTC

The XINDI Study: A Randomized Phase III Clinical Trial Evaluating the Efficacy and Safety of Safinamide as Add-On Therapy to Levodopa in Chinese Patients with Parkinson’s Disease with Motor Fluctuations – CNS Drugs

SR | Biomarkers as point‐of‐care tests to guide use of antibiotics in people with acute respiratory infections in primary care.

11 Nov, 2022 | 13:47h | UTC

Biomarkers as point‐of‐care tests to guide prescription of antibiotics in people with acute respiratory infections in primary care – Cochrane Library

SR | Not enough evidence for routine use of antifibrinolytic therapy (e.g., tranexamic acid) in aneurysmal subarachnoid hemorrhage.

11 Nov, 2022 | 13:50h | UTC

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage – Cochrane Library

RCT | No benefit from a model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients.

11 Nov, 2022 | 13:46h | UTC

Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial – Intensive Care Medicine

Commentary on Twitter

Individualising beta-lactam ABTs/ciprofoxacin therapy in #ICU using model-informed precision dosing vs standard dosing, multicentre 🇳🇱 RCT
No evidence for clinical effect of MIPD on LOS or other secondary outcomes in critically ill pts#FOAMcc @yourICM
🗞️https://t.co/6HzLBBnFdU pic.twitter.com/uErsHNAV5p

— Intensive Care Medicine (@yourICM) November 9, 2022

Phase 2b RCT | Efficacy and safety of Bepirovirsen in chronic Hepatitis B infection.

11 Nov, 2022 | 13:44h | UTC

Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary on Twitter

In a phase 2 trial, bepirovirsen, an antisense oligonucleotide that targets all hep B virus (HBV) messenger RNAs, resulted in sustained loss of hep B surface antigen and HBV DNA in 9 to 10% of participants with chronic HBV infection. #TLM22 #LiverTwitter https://t.co/krJcMEDhIX pic.twitter.com/SistuAocZO

— NEJM (@NEJM) November 8, 2022